Preprint Article Version 1 This version is not peer-reviewed

Homology Analysis of Multidrug-Resistant Acinetobacter Baumannii Genes in Different Regions of Xinjiang

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Version 1 : Received: 1 November 2024 / Approved: 4 November 2024 / Online: 5 November 2024 (10:53:45 CET)

How to cite: Luo, B.; Li, Z. Homology Analysis of Multidrug-Resistant Acinetobacter Baumannii Genes in Different Regions of Xinjiang. Preprints 2024, 2024110167. https://doi.org/10.20944/preprints202411.0167.v1 Luo, B.; Li, Z. Homology Analysis of Multidrug-Resistant Acinetobacter Baumannii Genes in Different Regions of Xinjiang. Preprints 2024, 2024110167. https://doi.org/10.20944/preprints202411.0167.v1

Abstract

Background: The prevalence of multidrug-resistant Acinetobacter baumannii is gradually increasing globally, posing a serious burden on patients and society, which is a significant public health issue.Testing the homology of multidrug-resistant Acinetobacter baumannii clones in hospitals in Xinjiang autonomous region can enable the hospital infection control department to better monitor the source and prevent the spread of drug-resistant characteristics. Method: Multidrug resistant Acinetobacter baumannii detected in intensive care units of 9 urban hospitals in Xinjiang autonomous region were collected. After drug sensitivity testing, DNA was extracted, and homology analysis was performed. Conclusion: 72 strains of carbapenem resistant Acinetobacter baumannii were multi drug resistant; The resistance rate of this bacterium to polymyxin B (1.3%) and tigecycline (1.7%) was low. The genotype of type 3 was unique to Urumqi; Type 4 is mainly distributed in Changji and Hotan, showing a unique significant band; Type 2 appeared in Urumqi and Hotan, and type 1 was prevalent throughout Xinjiang. It is distributed in all regions, and the similarity coefficient is 99%.

Keywords

dcineiobacier baumannii.;bacterial clone;multi-drug resistance;homology; spread

Subject

Medicine and Pharmacology, Clinical Medicine

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