Version 1
: Received: 4 November 2024 / Approved: 4 November 2024 / Online: 5 November 2024 (09:25:53 CET)
How to cite:
Sielczak, J. K.; Kurkowska-Jastrzębska, I.; Cudna, A.; Krawczyk, M. A Single Physical Exercise Imitating Muscle Activity During an Epileptic Seizure Causes an Increase of MMP-9 Serum Level but Does Not Increase S100B. Preprints2024, 2024110236. https://doi.org/10.20944/preprints202411.0236.v1
Sielczak, J. K.; Kurkowska-Jastrzębska, I.; Cudna, A.; Krawczyk, M. A Single Physical Exercise Imitating Muscle Activity During an Epileptic Seizure Causes an Increase of MMP-9 Serum Level but Does Not Increase S100B. Preprints 2024, 2024110236. https://doi.org/10.20944/preprints202411.0236.v1
Sielczak, J. K.; Kurkowska-Jastrzębska, I.; Cudna, A.; Krawczyk, M. A Single Physical Exercise Imitating Muscle Activity During an Epileptic Seizure Causes an Increase of MMP-9 Serum Level but Does Not Increase S100B. Preprints2024, 2024110236. https://doi.org/10.20944/preprints202411.0236.v1
APA Style
Sielczak, J. K., Kurkowska-Jastrzębska, I., Cudna, A., & Krawczyk, M. (2024). A Single Physical Exercise Imitating Muscle Activity During an Epileptic Seizure Causes an Increase of MMP-9 Serum Level but Does Not Increase S100B. Preprints. https://doi.org/10.20944/preprints202411.0236.v1
Chicago/Turabian Style
Sielczak, J. K., Agnieszka Cudna and Maciej Krawczyk. 2024 "A Single Physical Exercise Imitating Muscle Activity During an Epileptic Seizure Causes an Increase of MMP-9 Serum Level but Does Not Increase S100B" Preprints. https://doi.org/10.20944/preprints202411.0236.v1
Abstract
Abstract: The aim of the study was to evaluate two widely studied biomarkers: MMP-9 and S100B in blood serum in healthy people after physical exercise mimicking physical activity during bi-lateral tonic-clonic seizures. Both biomarkers have been shown to increase after seizures, and their serum levels tend to be higher in epilepsy patients compared to individuals without epi-lepsy.
To achieve this goal, we have developed two sets of exercises, each consisting of a tonic contrac-tion phase and a phase of alternating muscle work, lasting a total of approximately 5 minutes. Both sets of motor exercises were performed in the same group of healthy volunteers 6 months apart. Serum samples were collected before exercise, 3 hours after exercise, and the next day (time points 0, 3 hours, and 24 hours).
Our results demonstrated that both sets of motor exercises led to a similar increase in MMP-9 levels, while neither while neither affected S100B levels. No significant differences in MMP-9 levels were observed due to muscle failure. We propose that the increase in MMP-9 is primarily induced by muscle contraction and additional mechanisms observed during exercise, such as neutrophil degranulation. S100B appears to be a promising biomarker in epilepsy, as it is not induced by physical activity but does increase following seizures.
Keywords
epilepsy; seizures; metalloproteinase; physical effort; biomarkers of epilepsy
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
