Version 1
: Received: 4 November 2024 / Approved: 4 November 2024 / Online: 5 November 2024 (11:15:15 CET)
How to cite:
Che Mohd Nassir, C. M. N.; Che Ramli, M. D.; Mohamad Ghazali, M.; Jaffer, U.; Abdul Hamid, H.; Mehat, M. Z.; Hein, Z. M. The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Preprints2024, 2024110255. https://doi.org/10.20944/preprints202411.0255.v1
Che Mohd Nassir, C. M. N.; Che Ramli, M. D.; Mohamad Ghazali, M.; Jaffer, U.; Abdul Hamid, H.; Mehat, M. Z.; Hein, Z. M. The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Preprints 2024, 2024110255. https://doi.org/10.20944/preprints202411.0255.v1
Che Mohd Nassir, C. M. N.; Che Ramli, M. D.; Mohamad Ghazali, M.; Jaffer, U.; Abdul Hamid, H.; Mehat, M. Z.; Hein, Z. M. The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Preprints2024, 2024110255. https://doi.org/10.20944/preprints202411.0255.v1
APA Style
Che Mohd Nassir, C. M. N., Che Ramli, M. D., Mohamad Ghazali, M., Jaffer, U., Abdul Hamid, H., Mehat, M. Z., & Hein, Z. M. (2024). The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Preprints. https://doi.org/10.20944/preprints202411.0255.v1
Chicago/Turabian Style
Che Mohd Nassir, C. M. N., Muhammad Zulfadli Mehat and Zaw Myo Hein. 2024 "The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease" Preprints. https://doi.org/10.20944/preprints202411.0255.v1
Abstract
The human microbiota constitutes a very complex ecosystem of microorganisms inhabiting both the inside and outside of our bodies, in which health maintenance and disease modification are the main regulatory features. The recent explosion of microbiome research has begun to detail its important role in neurological health, particularly concerning cerebral small vessel disease (CSVD), a disorder associated with cognitive decline and vascular dementia. This narrative review represents state-of-the-art knowledge of the intimate, complex interplay between microbiota and brain health through the gut-brain axis (GBA) and the emerging role of the glymphatic system dysfunction (glymphopathy) and circulating cell-derived microparticles (MPs) as mediators of these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, vascular dysfunction, and impaired waste clearance in the brain which are critical factors in the pathogenesis of CSVD. Further, we discuss lifestyle factors that shape the microbiota composition and functionality, focusing on sleep as a modifiable risk factor in neurological disorders. This narrative review places recent microbiome research into a neuroscientific and vascular perspective to establish future therapeutic avenues in targeting the microbiota to improve brain health and reduce the burden of CSVD.
Keywords
Microbiota; gut-brain axis; microparticles; cerebral small vessel disease; sleep; glymphatic system
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
