Version 1
: Received: 4 November 2024 / Approved: 5 November 2024 / Online: 6 November 2024 (07:26:49 CET)
How to cite:
Trigo, G.; Coelho, M.; Ferreira, C. B.; Melosini, M.; Lehmann, I. S.; Reis, C. P.; Gaspar, M. M.; Santos, S. Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways. Preprints2024, 2024110319. https://doi.org/10.20944/preprints202411.0319.v1
Trigo, G.; Coelho, M.; Ferreira, C. B.; Melosini, M.; Lehmann, I. S.; Reis, C. P.; Gaspar, M. M.; Santos, S. Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways. Preprints 2024, 2024110319. https://doi.org/10.20944/preprints202411.0319.v1
Trigo, G.; Coelho, M.; Ferreira, C. B.; Melosini, M.; Lehmann, I. S.; Reis, C. P.; Gaspar, M. M.; Santos, S. Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways. Preprints2024, 2024110319. https://doi.org/10.20944/preprints202411.0319.v1
APA Style
Trigo, G., Coelho, M., Ferreira, C. B., Melosini, M., Lehmann, I. S., Reis, C. P., Gaspar, M. M., & Santos, S. (2024). Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways. Preprints. https://doi.org/10.20944/preprints202411.0319.v1
Chicago/Turabian Style
Trigo, G., Maria Manuela Gaspar and Susana Santos. 2024 "Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways" Preprints. https://doi.org/10.20944/preprints202411.0319.v1
Abstract
Background: Recent advancements have highlighted the potential of cannabis and its phy-tocannabinoids (pCBs) in skin health applications. These compounds, through their interac-tion with the endocannabinoid system (ECS), show promise for skin health products. Their ability to regulate inflammation, oxidative stress, and cellular proliferation makes them bene-ficial in addressing skin issues like inflammation, scarring, healing, acne, and aging, posi-tioning them as valuable tools for innovative skincare solutions.
Methods: We investigated the cellular and molecular effects of proprietary pCB-based for-mulations on ECS modulation, inflammation, and skin regeneration. Using human dermal fibroblasts (HDF) and keratinocytes (HaCat), we assessed the formulations in both pre-treatment and treatment scenarios following exposure to stress-inducing agents. Key molecular markers were analyzed to tackle their efficacy in mitigating inflammation and promoting structural integrity and regeneration.
Results: Our findings show that these formulations significantly reduce inflammation, pro-mote skin regeneration, and improve structural functions. In vivo studies confirmed that the formulations were well-tolerated and led to noticeable improvements in skin health, including enhanced barrier function.
Conclusions: This study demonstrates the safety and efficacy of pCB-based formulations for cosmeceutical applications. By combining molecular analysis with in vivo testing, our research provides new insights into the therapeutic potential of pCBs for managing various skin con-ditions.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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