Version 1
: Received: 5 November 2024 / Approved: 6 November 2024 / Online: 6 November 2024 (15:03:46 CET)
How to cite:
Westerhuis, J. A.; Dudink, J.; Wijnands, B. E.; De Zeeuw, C. I.; Canto, C. B. Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents. Preprints2024, 2024110405. https://doi.org/10.20944/preprints202411.0405.v1
Westerhuis, J. A.; Dudink, J.; Wijnands, B. E.; De Zeeuw, C. I.; Canto, C. B. Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents. Preprints 2024, 2024110405. https://doi.org/10.20944/preprints202411.0405.v1
Westerhuis, J. A.; Dudink, J.; Wijnands, B. E.; De Zeeuw, C. I.; Canto, C. B. Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents. Preprints2024, 2024110405. https://doi.org/10.20944/preprints202411.0405.v1
APA Style
Westerhuis, J. A., Dudink, J., Wijnands, B. E., De Zeeuw, C. I., & Canto, C. B. (2024). Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents. Preprints. https://doi.org/10.20944/preprints202411.0405.v1
Chicago/Turabian Style
Westerhuis, J. A., Chris I. De Zeeuw and Cathrin B. Canto. 2024 "Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents" Preprints. https://doi.org/10.20944/preprints202411.0405.v1
Abstract
Many children suffer from neurodevelopmental aberrations that have long-term effects. To un-derstand the consequences of pathological processes during particular periods in neurodevelop-ment, one has to understand the differences in the developmental timelines of brain regions. The cerebellum is one of the first brain structures to differentiate during development, but one of the last to achieve maturity. This relatively long period of development underscores its vulnerability to detrimental environmental exposures throughout gestation. Moreover, as postnatal functional-ity of the cerebellum is multifaceted, enveloping sensorimotor, cognitive, and emotional domains, prenatal disruptions in cerebellar development can result in a large variety of neurological and mental health disorders. Here, we review major intrauterine insults that affect cerebellar devel-opment in both humans and rodents, ranging from abuse of toxic chemical agents such as alcohol, nicotine, cannabis and opioids, to stress, malnutrition as well as infections. Understanding these pathological mechanisms in the context of the different stages of cerebellar development in hu-mans and rodents can help us to identify critical and vulnerable periods and thereby to prevent the risk of associated prenatal and early postnatal damage that can lead to lifelong neurological and cognitive disabilities. The scope of the review is to raise awareness and to provide information for expecting parents, obstetricians, and other healthcare professionals to eventually de-sign strategies for preventing or rescuing related neurodevelopmental disorders.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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