Version 1
: Received: 5 November 2024 / Approved: 6 November 2024 / Online: 7 November 2024 (10:14:44 CET)
How to cite:
Alaamri, S.; Serafi, A. S.; Hussain, Z.; Bafail, S. K.; Bafail, M. A.; Demirkhanyan, L.; Gondi, C. S.; Sohail, S. Overweight-Related Hypertension in Middle-Aged Men: Pathophysiological Impact of Serum Leptin, TNF-α, IL-6, Cholesterol and Testosterone. Preprints2024, 2024110459. https://doi.org/10.20944/preprints202411.0459.v1
Alaamri, S.; Serafi, A. S.; Hussain, Z.; Bafail, S. K.; Bafail, M. A.; Demirkhanyan, L.; Gondi, C. S.; Sohail, S. Overweight-Related Hypertension in Middle-Aged Men: Pathophysiological Impact of Serum Leptin, TNF-α, IL-6, Cholesterol and Testosterone. Preprints 2024, 2024110459. https://doi.org/10.20944/preprints202411.0459.v1
Alaamri, S.; Serafi, A. S.; Hussain, Z.; Bafail, S. K.; Bafail, M. A.; Demirkhanyan, L.; Gondi, C. S.; Sohail, S. Overweight-Related Hypertension in Middle-Aged Men: Pathophysiological Impact of Serum Leptin, TNF-α, IL-6, Cholesterol and Testosterone. Preprints2024, 2024110459. https://doi.org/10.20944/preprints202411.0459.v1
APA Style
Alaamri, S., Serafi, A. S., Hussain, Z., Bafail, S. K., Bafail, M. A., Demirkhanyan, L., Gondi, C. S., & Sohail, S. (2024). Overweight-Related Hypertension in Middle-Aged Men: Pathophysiological Impact of Serum Leptin, TNF-α, IL-6, Cholesterol and Testosterone. Preprints. https://doi.org/10.20944/preprints202411.0459.v1
Chicago/Turabian Style
Alaamri, S., Christopher S Gondi and Sumera Sohail. 2024 "Overweight-Related Hypertension in Middle-Aged Men: Pathophysiological Impact of Serum Leptin, TNF-α, IL-6, Cholesterol and Testosterone" Preprints. https://doi.org/10.20944/preprints202411.0459.v1
Abstract
The age and sex specific data of the worldwide prevalence of hypertension (HT) shows that it is an important health challenge and requires to be screened, prevented and treated with high priority. One of the major causes of HT is the transition of normal weight status to overweight (OW) status and obesity in a population that leads to cardiovascular disease (CVD) and other disorders. A variety of factors/ variables are involved in the development of HT and OW related hypertension (OHT). We proposed the present study to consult the middle-aged men (age range: 51-60 years) having HT and OHT along with normal control (NC; age range: 51-60 years) men for investigating the two samples comparisons, analysis of variance and correlations of serum leptin (Lep), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), serum testosterone (ST), total cholesterol (TC) and other variables in NC (n: 98; high normal weight BMI: 23-24.9 kg/m2, HT (n: 97; high normal weight BMI: 23-24.9 kg/m2) and OHT (n: 97; high overweight BMI: 28-29.9 kg/m2) subjects. Significant variations were obtained for the comparisons of TNF-α, Lep, ST and TC for the subject groups. The OHT vs. NC showed significant difference for ST. The OHT vs. NC and OHT vs. HT gave significant variation for IL-6. One-way ANOVA revealed significant change for TNF-α, Lep, IL-6, ST and TC levels among groups. Significant and positive linear associations were obtained for each other for TNF-α, Lep, TC and IL-6. The HT and OHT subject groups presented non-significant negative linear correlations for ST plotted against TC. Significant and negative linear association was found for ST plotted against each of Lep, TNF-α and IL-6. Conclusively, the current report provides pathophysiological evidence of the interactive role of serum Lep, TNF-α, ST, TC and IL-6 in middle-aged men with hypertension and overweight-related hypertension.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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