Version 1
: Received: 4 November 2024 / Approved: 6 November 2024 / Online: 7 November 2024 (09:21:18 CET)
How to cite:
McCash, L. Mechanistic Insights into Protein Synthesis Pathways and Amino Acid Interplay in Muscle Growth and Resistance Training: A Molecular Analysis. Preprints2024, 2024110498. https://doi.org/10.20944/preprints202411.0498.v1
McCash, L. Mechanistic Insights into Protein Synthesis Pathways and Amino Acid Interplay in Muscle Growth and Resistance Training: A Molecular Analysis. Preprints 2024, 2024110498. https://doi.org/10.20944/preprints202411.0498.v1
McCash, L. Mechanistic Insights into Protein Synthesis Pathways and Amino Acid Interplay in Muscle Growth and Resistance Training: A Molecular Analysis. Preprints2024, 2024110498. https://doi.org/10.20944/preprints202411.0498.v1
APA Style
McCash, L. (2024). Mechanistic Insights into Protein Synthesis Pathways and Amino Acid Interplay in Muscle Growth and Resistance Training: A Molecular Analysis. Preprints. https://doi.org/10.20944/preprints202411.0498.v1
Chicago/Turabian Style
McCash, L. 2024 "Mechanistic Insights into Protein Synthesis Pathways and Amino Acid Interplay in Muscle Growth and Resistance Training: A Molecular Analysis" Preprints. https://doi.org/10.20944/preprints202411.0498.v1
Abstract
Muscle hypertrophy relies on efficient protein synthesis, modulated by amino acid availability and signalling pathways such as mTOR, which activate muscle growth at a cellular level (Kimball et al., 2002). This study investigates the role of essential amino acids, particularly leucine and branched-chain amino acids (BCAAs), in promoting protein synthesis during resistance training. Using stable isotope labelling and molecular assays, protein synthesis rates were analysed in muscle biopsies post-intervention (Atherton & Smith, 2012). mTOR and associated pathways (e.g., S6K1) were assessed via Western blotting and RT-qPCR to quantify pathway activation (Drummond et al., 2009). Findings show a direct relationship between amino acid levels and increased anabolic signalling, providing data-driven insights into molecular responses essential for muscle adaptation (Phillips et al., 2005). This research underscores targeted amino acid supplementation as a potential strategy to enhance hypertrophic outcomes in resistance training (Tipton et al., 2001).
Keywords
Muscle Hypertrophy, Protein Synthesis, Amino Acids, mTOR Pathway, Data Analysis, Resistance Training, Molecular Biology
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
