Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study

Laura Akie Corrêa de Souza; Gislene Parreiras Costa; Júlia Amanda Rodrigues Fracasso; Luisa Taynara Silvério da Costa; Debora Barros Barbosa; Natalia Alves Zoppé; Júlia Marques Ribeiro; Valdecir Farias Ximenes; João Tadeu Ribeiro-Paes; Lucinéia dos Santos

doi:10.20944/preprints202411.0501.v1

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preprints.org > biology and life sciences > plant sciences > doi: 10.20944/preprints202411.0501.v1 (registering DOI)

Preprint Article Version 1 This version is not peer-reviewed

Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study

Laura Akie Corrêa de Souza

Gislene Parreiras Costa

Júlia Amanda Rodrigues Fracasso

^* ,

Luisa Taynara Silvério da Costa

Debora Barros Barbosa

Natalia Alves Zoppé

Júlia Marques Ribeiro

Valdecir Farias Ximenes

João Tadeu Ribeiro-Paes

Lucinéia dos Santos

Version 1 : Received: 6 November 2024 / Approved: 6 November 2024 / Online: 7 November 2024 (11:16:18 CET)

How to cite: Corrêa de Souza, L. A.; Parreiras Costa, G.; Fracasso, J. A. R.; da Costa, L. T. S.; Barbosa, D. B.; Zoppé, N. A.; Marques Ribeiro, J.; Ximenes, V. F.; Ribeiro-Paes, J. T.; dos Santos, L. Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study. Preprints 2024, 2024110501. https://doi.org/10.20944/preprints202411.0501.v1 Corrêa de Souza, L. A.; Parreiras Costa, G.; Fracasso, J. A. R.; da Costa, L. T. S.; Barbosa, D. B.; Zoppé, N. A.; Marques Ribeiro, J.; Ximenes, V. F.; Ribeiro-Paes, J. T.; dos Santos, L. Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study. Preprints 2024, 2024110501. https://doi.org/10.20944/preprints202411.0501.v1

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MDPI and ACS Style

Corrêa de Souza, L. A.; Parreiras Costa, G.; Fracasso, J. A. R.; da Costa, L. T. S.; Barbosa, D. B.; Zoppé, N. A.; Marques Ribeiro, J.; Ximenes, V. F.; Ribeiro-Paes, J. T.; dos Santos, L. Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study. Preprints 2024, 2024110501. https://doi.org/10.20944/preprints202411.0501.v1

APA Style

Corrêa de Souza, L. A., Parreiras Costa, G., Fracasso, J. A. R., da Costa, L. T. S., Barbosa, D. B., Zoppé, N. A., Marques Ribeiro, J., Ximenes, V. F., Ribeiro-Paes, J. T., & dos Santos, L. (2024). Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study. Preprints. https://doi.org/10.20944/preprints202411.0501.v1

Chicago/Turabian Style

Corrêa de Souza, L. A., João Tadeu Ribeiro-Paes and Lucinéia dos Santos. 2024 "Phytochemical Profile, Cytotoxicity, Anti-inflammatory, Anti-oxidant, and Anti-glycation Activity of Annona crassiflora Ex-tract: An In Vitro Study" Preprints. https://doi.org/10.20944/preprints202411.0501.v1

Abstract

Chronic inflammation and oxidative stress play significant roles in the development of various diseases like diabetes, cancer, and cardiovascular diseases. This study aimed to explore the po-tential therapeutic benefits of Annona crassiflora (Araticum-do-Cerrado) leaves, specifically fo-cusing on their anti-inflammatory, antioxidant, and anti-glycation properties. To achieve this, a hydroethanolic extract of the plant’s leaves (EHAC) was prepared and subjected to phytochemical analysis and in vitro tests to evaluate its effects. The tests included assessing its impact on fibro-blast cytotoxicity, anti-inflammatory capabilities (phagocytosis and macrophage spreading), an-tioxidant activity (DPPH and lipid peroxidation), and anti-glycation activity. The results indicated that EHAC contains high levels of phenolic compounds, including rutin and quercetin. The ex-tract demonstrated strong anti-inflammatory activity by significantly inhibiting phagocytosis and macrophage spreading. Furthermore, it exhibited high antioxidant capacity by inhibiting lipid peroxidation and scavenging free radicals. Additionally, it showed notable anti-glycation activity by completely inhibiting the formation of AGEs at the tested concentrations. The cell viability remained above 95% at concentrations up to 800 µg/mL. In conclusion, EHAC has significant therapeutic potential, and further research is warranted for its development as a phytotherapeu-tic, with the aim of preserving the biodiversity of the Brazilian Cerrado.

Keywords

Araticum-do-Cerrado; secondary metabolites; inflammation

Subject

Biology and Life Sciences, Plant Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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