1. Introduction
The Susceptible-Infectious-Recovered (SIR) model is the simplest of the compartmental models used for the mathematical modeling of infectious diseases in order to reproduce or predict the temporal evolution of infectious diseases in human populations. Originally developed nearly hundred years ago [
1,
2] it lately has become very popular and widespread [
3,
4,
5,
6,
7,
8,
9,
10,
11,
12,
13,
14,
15,
16,
17,
18,
19,
20,
21,
22,
23,
24,
25,
26,
27,
28,
29,
30,
31,
32,
33,
34,
35,
36,
37,
38,
39,
40,
41,
42,
43] due to its successful applications to the outbreaks of the corona virus in many countries [
44]. The considered population of
initially susceptible persons is assigned to the three compartments
(susceptible),
(infectious), or
(recovered/removed). Persons from the population may progress between these compartments described by the time-dependent infection (
and recovery
) rates.
The three respective population fractions obey the sum constraint condition
at any time, and their temporal evolution is given by the SIR-equations
Besides numerical solutions it is of high interest to derive analytical solutions of the underlying dynamical SIR-equations. In the most general case of a time-dependent ratio
between the recovery and the infection rate analytical approximate solutions were derived [
45,
46] which are very accurate if the cumulative fraction of infections
is small compared to unity at all times.
Recently, new analytical solutions became available [
47,
48] for an arbitrary time dependence of the infection and recovery rates, provided that the ratio between the two rates is independent of time, for two different types of initial conditions. We refer to these in the following as KSSIR solutions. The utility of the KSSIR solutions were proven by their successful application to past waves of the corona virus [
47]. However, in both cases the KSSIR solutions could only be given in inverse form
involving an integral, that had to be approximated by second-order polynomials (see [
47] for details). Here we consider an alternative approach to the KSSIR solution that avoids the inverse form adopting the semi-time initial conditions [
49,
50,
51,
52,
53,
54,
55,
56,
57,
58,
59]
with
denoting the initial seed infection fraction of the population.
Two quantities are of particular interest in studies of infections [
60,
61,
62,
63,
64,
65,
66,
67,
68,
69,
70,
71,
72,
73,
74,
75,
76,
77,
78,
79,
80,
81,
82,
83,
84,
85,
86,
87,
88,
89,
90,
91,
92,
93,
94,
95,
96,
97,
98,
99,
100,
101]:
- (1)
the differential rate of newly infected persons from the desease
which, with a delay time
of about a week, determines the death rate
, where the mortality rate
f is of the order
–
varying for different mutants of the Covid virus and different countries [
102].
also determines the hospitalization rate of seriously infected persons.
- (2)
the fraction of infected persons
determines the peak time of required clinical resources in the host country of the considered population [
103].
Both quantities
and
first increase in time, undergo a maximum and drop at late times. While exact analytical formulas for the peak time
and the peak rate of new infections
are available in the KSSIR-model, several different approximations for the peak time
and the peak fraction of infected persons
have been derived [
103]. It is one purpose of the present study to derive exact expressions for
and
.
2. Reduction of the General SIR-Equations
By introducing the reduced time
for arbitrary but given real time dependent infection rates
and the ratio
the SIR-equations (
1)-(
3) can be written as
subject to initial conditions
From the invariant
we obtain with Equation (
5) in the form
for the differential rate of newly infected persons from the desease
with the initial value
. The invariant (
) cumulative distribution corresponding to
is given by
where the initial condition
had been used, in accord with Equation (
8).
2.1. Reduction
Equation (
7a) readily yields
whereas Equation (7b) provides
which with the initial condition on
integrates to
Combining Equations (
11) and (
13) with
then leads to the single nonlinear differential equation
for
. Equation (
16) integrates to
where we made use of the initial condition
.
2.2. Stationary Ratio
Throughout this study a stationary ratio (
6) is assumed, i.e.,
often is referred to as inverse reproduction number. The derived exact analytical solutions then hold for stationary infection and recovery rates as well as for any time-dependent infection rate
provided the recovery rate
has the same time variation while its absolute value can be different.
For a stationary ratio Equations (14) and (
16)–(
17) simplify to
In earlier work [
48] Equations (7) were solved exactly in inverse form as
allowing important conclusions on the final values of the fractions
(see
Appendix A for details). Here we will follow a different approach avoiding the necessary inversion of solution (
20) to derive
. However, the noted exact results from
Appendix A will be used below to check the validity of the alternative solution.
3. Exact Solution
3.1. Ansatz
The ansatz
in terms of the Lambert [
104] function
(see Appendix G of ref. [
105]) and yet unspecified constants
a and
b provides for Equation (19c)
Note that the ansatz (
21) is equivalent to
Next, we will determine the constants
a and
b and thus prove that the ansatz (
21) fulfills the differential equation (19c). Applying the defining equation for the Lambert function
yields for Equation (
22)
Hence for its derivative with respect to
, with
one obtains
where we used the differential equation
for Lambert functions. The Equation (28) can be written as
which is solved by
In order for the solution (30) to be consistent with Equation (23) one has to demand that
. Consequently, the exact solution is given by
where we still have to determine the constant
a and the lower integration limit from the initial condition and we have to identify the appropriate branch of the Lambert function.
If we re-use
and
, then we can determine
a from Equation (27) evaluated at
,
or equivalently
With Equation (
24) written as
Equation (33) can be solved for
a and provides
with
from Equation (A9) in
Appendix A.
To conclude, Equation (
21) is formally solved by
but we have to make this more precise, as the Lambert function
W has two branches,
and
.
For positive
and
the argument of the Lambert function is negative because
. Recall that
for
, where the two Lambert branches meet. Let
and
denote the peak time and peak amplitude of
. The peak amplitude
is determined by the solution of
, and thus given by
For times up to peak time the solution (36) applies, using the non-principal branch of Lambert’s function,
with the peak time
determined by
Over this interval
monotonically increases from
to
. Beyond peak time, the solution is determined by
Over this remaining interval
monotonically decreases towards
.
The respective slopes below and above the peak time are obtained by taking the derivative with respect to
of Equations (38) and (40) providing
and
respectively. At very large times the latter approaches
since
.
3.2. Resulting Fractions
Using the notation
and
with
for
and
for
, respectively, and
with negative
, the solutions Equations (41)–(42) read
Then, according to Equation (
15) one finds
so that with
in agreement with the exact KSSIR result (A10a). Using
one obtains for the first derivative of Equation (46) with respect to
where we used Lambert’s equation (28). Inserting Equations (46) and (49) yields for Equation (
11)
where we used Equation (19b), thus correctly reproducing the earlier Equation (
13). Obviously, the fraction of infected persons peaks at
, because of its dependence
, and its maximum value is given by
Consequently, one finds for the rate of new infections (
9)
where in the last step we used Equation (19d), and the corresponding cumulative fraction of infected persons
Likewise, the sum constraint (7d) leads to
As
we derive
reproducing exactly the earlier noted properties (A8) and (A10).
We thus have expressed all quantities of interest, the fractions as well as the differential rate of new infections and its corresponding cumulative number in terms of the function and its first and second derivatives. These expressions are exact. It remains to derive the direct reduced time dependence of the function which is done approximately for large and small times in the following sections.
4. Approximated for Large and Small Times
4.1. Large Times
We note that the function
in Equation (44) has values
so that
. For such small values of
Z we then use as approximation
shown in
Figure 1 in comparison to the exact variation. As can be seen the agreement is sufficient, and the approximation exact at the terminals.
The approximation (57) then yields for Equation (40)
where we substituted
. The upper integration limit is given by
where the second approximation holds for small values of
. It is shown in
Figure 2 as a function of
. The upper integration limit is thus smaller than unity provided
, corresponding to
in agreement with
Figure 2.
For such values of
we approximate
to obtain with
for the integral (58)
With the substitution
one finds for the last equation
After straightforward algebra Equation (64) leads to
with the constant
defined by
Equation (65) readily provides as approximation at large times
We note that Equation (67) correctly provides
as
.
The slope of the approximation (67) is
providing for its limiting slope
which
Figure 3 compares favorably well with the exact limiting slope given by Equation (43).
It is tempting to use approximation (67) to calculate the corresponding
as in Equation (69) and
to infer directly the three fractions
S,
I and
R as well as the differential rate
j at large times. However, this produces incorrect results as can be seen with the resulting
implying
which is finite but slightly disagrees with the exact final value (47), as shown in
Figure 4.
The proper way to continue is to only use Equation (67) as an approximation for
and to insert it in the earlier general expressions for the fractions. With this approximation we obtain for Equation (44)
and consequently for the fraction (46)
which in contrast to the incorrect Equation (72) now correctly approaches
. For later use we note
Likewise, the fraction (50) at large times is given by
reproducing correctly
. The rate of new infections (
9) then is
4.2. Small Times
Figure 5.
Time evolution of the functions , , , and . (a) Numerical from (14) (solid) compared with from (67) and (85) (dashed), using from Equation (68), from Equation (66), from (82), from (62), from (39), from (37). The red bullet marks . (b) Numerical (solid) compared with from Equations (76) and (88). The red bullet marks from Equations (39) and (51). (c) Numerical (solid) compared with from Equations (87) and (74). The red bullet marks (47). (d) Numerical (solid) compared with from Equations (93) with according to Equation (94). The red filled bullet marks according to Equations (103) and (106). Parameters: and mentioned in the left panel.
Figure 5.
Time evolution of the functions , , , and . (a) Numerical from (14) (solid) compared with from (67) and (85) (dashed), using from Equation (68), from Equation (66), from (82), from (62), from (39), from (37). The red bullet marks . (b) Numerical (solid) compared with from Equations (76) and (88). The red bullet marks from Equations (39) and (51). (c) Numerical (solid) compared with from Equations (87) and (74). The red bullet marks (47). (d) Numerical (solid) compared with from Equations (93) with according to Equation (94). The red filled bullet marks according to Equations (103) and (106). Parameters: and mentioned in the left panel.
For small times where
we expand the double-exponential function on the right-hand side of Equation (19c) to first order as
so that Equation (19c) becomes
fulfilling the correct initial condition
. Setting
Equation (79) reduces to
with the solution
Therefore
The two integration constants
and
are determined by the conditions
and
yielding
Consequently
Since
guarantees, according to Equations (44) and (46), that
implying
, with the approximation (85) also
is in agreement with Equation (75).
For general small times Equation (44) subjected to the approximation Equation (85a) provides
so that Equation (46) leads to
Likewise, the fraction (50) at small times is given by
reproducing correctly
. The rate of new infections (
9) then is
We recall that Equation (39) determines
so that for given values
and
all parameters are fixed.
In most applications the initial fraction of infected persons
is very small. Hence for reduced times
one can further approximate
to obtain for the function (85b)
i.e., one may replace
in Equations (86)–(89) by
with
from Equation (37).
5. Results
5.1. Rate of New Infections
According to Equations (77) and (89) with our earlier notation the rate of new infections at all reduced times is given by
with
We note that
In the last column of
Figure 5 we compare this rate of new infections based on
from Equation (90) with the exact numerical solution for
and several choices of the parameter
. One notices excellent agreement between the analytical and numerical curves in all three cases.
Figure 6.
Extremum of . (102) versus (a) and (b) . Shown are the cases of (solid) and (dashed). For this plot , but the plots are basically unaffected by for .
Figure 6.
Extremum of . (102) versus (a) and (b) . Shown are the cases of (solid) and (dashed). For this plot , but the plots are basically unaffected by for .
The rate of new infections (93) attains its maximum for a vanishing first derivative
where we used Equations (48) and (28). Thus the maximum occurs at
given by the solution of
Taking the exponential of the last equation leads to
where we used Equation (
24). Setting
one can cast Equation (98) into the form
with the solution
and consequently
where we introduced
. Applying Equation (34) then provides
where Equation (
24) and
for positive values
has been used. The maximum is then given by
where we inserted Equation (101). Equation (103) agrees exactly with the well-known KSSIR expression (
A14) only if
, i.e., only if the non-principal branch of the Lambert functions
in the solution (102) is chosen. The second solution
involving the principal branch
can be ruled out as it provides values of
smaller than unity, as can be seen by the dashed curves in
Figure 6 that reside clearly outside of the possible values of
according to Equation (95b).
In
Figure 6 we calculate from Equation (102)
as a function of
for
. It can be seen that
is always greater than unity. Because of the property (95a) this indicates that the peak time of the rate of new infections
occurs at times smaller than
and is given by the solution of the Equation
where we used Equation (
24), so that
With the approximation (92) one obtains
In
Figure 7 the ratio
is displayed as a function of
for
. The ratio always is smaller than unity demonstrating that the rate of new infections peaks before the fraction of infected persons in agreement also with the second and fourth columns in
Figure 5.
Figure 7.
Ratio of peak times. Numerical
(solid black) compared with this ratio using the analytical expression Equation (
A15) with
from Equation (
A13) (thick green), which is well approximated by the simpler Equations (93) and (39) with
according to Equation (94). For this figure,
.
Figure 7.
Ratio of peak times. Numerical
(solid black) compared with this ratio using the analytical expression Equation (
A15) with
from Equation (
A13) (thick green), which is well approximated by the simpler Equations (93) and (39) with
according to Equation (94). For this figure,
.
5.2. Peak Time of Fraction of Infected Persons
The peak time
of the fraction of infected persons is of particular interest [
70,
75,
89,
110,
111,
112,
113,
114,
115,
116,
117,
118,
119,
120]. According to Equation (50) this peak time
coincides with
given exactly by Equation (39). Consequently, we can compare this exact peak time with approximants derived before [
103].
Figure 8 demonstrates in the first column that the analytical equation (
38) coincides with the numerically calculated peak time
. While the earlier SK-I approximant (shown in the third column) provides acceptable agreement in a wide range of parameter values, the MT-approximant (shown in the second column) is less accurate.
6. Summary and Conclusions
We have derived a near-exact analytical solution of the statistical Susceptible-Infectious-Recovered (SIR) epidemics model for a constant ratio (referred to as KSSIR case) of infection () to recovery () rates in the semi-time case which is particularly appropriate for modeling the temporal evolution of later (than the first) pandemic waves when a greater population fraction from the first wave has been infected. By introducing the dimensionless reduced time variable the derived solution holds for stationary rates as well as for the case of the same real time-dependency of the recovery and infection rates. The accuracy of the analytical solutions is confirmed by comparison with the exact numerical solutions of the SIR equations. Exact as well as accurately approximative solutions serve dual important purposes: first, they are suitable benchmarks for numerical codes, and secondly, they allow us to understand the fundamental behavior and functional patterns of epidemic outbursts as well as the decisive role of parameters.
The newly developed KSSIR-solution is not of inverse form as the known KSSIR solutions in the literature but rather directly expresses the three fractions , and and thus the rate of new infections exactly in terms of the same function . With respect to the reduced time these fractions depend on two parameters: predominantly on the ratio and only weakly on the usually very small initial fraction of infected persons. With respect to real time additionally the predescribed time dependent infection rate enters via the reduced time. These exact expressions involve the principal and non-principal branches of the Lambert functions, which routinely are available in mathematical software packages such as Python (scipy), Excel, Matlab and Mathematica, above and below the peak time of the function which agrees with the peak time of the rate of infections . The newly developed solution correctly reproduces all known exact expressions of the earlier KSSIR solution including the final values of , , and . It also provides exact analytical formulas for the peak time and the maximum fraction . These allow to check the accuracy of earlier derived approximants for . In particular it is shown that the rate of new infections peaks before the fraction of infected persons.
The derived near-exact solution is not entirely exact because the reduced time dependence of obeying a nonlinear integro-differential equation is only obtained approximately for small and large times with respect to . At small reduced times where the approximation is based on the expansion of a double-exponential function to first-order, whereas at large reduced times an accurate simple approximation of the principal Lambert function is employed. The resulting rate of new infections correctly reproduces the known exact maximum rate of new infections.
Author Contributions
R.S.: conceptualization, methodology, formal analysis, writing-reviewing and editing; M.K.: methodology, formal analysis, software, writing-reviewing and editing, visualization. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Informed Consent Statement
Not applicable.
Data Availability Statement
All data are enclosed with this publication.
Conflicts of Interest
The authors declare no conflict of interest
Appendix A. Inverse KSSIR-Solution of Earlier Work
For stationary ratios (
18) Equation (7c) immediately integrates to
where we used
from Equation (
10) so that also
With these expressions the sum constraint (7c) then reads
implying
With the initial condition
Equation (
A4) readily is solved in inverse form as
This solution (
A5) generalizes the known analytical solutions in the literature [
1,
2,
121] as it holds for arbitrary time-dependence of the infection rate
. The mentioned known solutions can be reproduced with Equation (
A5) by setting
on its left-hand side resulting from a constant injection rate
.
Taking the derivative with respect to
highlights the fact that the inverse integrand in (
A5) is nothing but the differential rate of newly infected persons in terms of
, i.e.,
It has been noted before that important exact properties of the KSSIR-solution (
A5) can be inferred without doing the inversion to
.
Appendix A.1. Final and Maximum Values
The solution (
A5) indicates that the maximum value
is attained when the denominator of the respective integrand vanishes, i.e.,
Consequently,
where
is the principal solution of Lambert’s equation and
The knowledge of
from Equation (
A8) immediately yield
Appendix A.2. Peak Differential Rate
Likewise, the maximum of the differential rate (
A6) occurs when the derivative
vanishes. With Equation (
A6) one finds
yielding for
the transcendental equation
which is solved in terms of the non-principal Lambert function as
with
from (
A9). Inserting Equation (
A13) in Equation (
A6) and making use of Equation (
A12) yields for the maximum value in reduced time
According to Equation (
A5) the peak time of the differential rate (
A6) is given by
For a maximum to occur at finite positive times
, the derivative
has to be positive at times
. With Equations (
A11) - (
A12) we readily find
Since the requirement of a maximum
to exist at positive times is identical to the requirement of a positive
at
, we can insert
into the last equality in the first line of Equation (A16) to find
implying
For inverse reproduction numbers
greater than
, the daily rate is monotonically decreasing at all times from its initial value
(decay phase). Contrary, for
the daily rate of newly infected persons attains a maximum at a finite positive time (peak case). At
the daily rate starts in its maximum at
, and then decreases, while
S,
R and
J approach their final values below unity.
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