This article champions a decolonial praxis that seeks to fundamentally reconfigure the moral, organizational, and institutional foundations of the academic research enterprise. Departing from the Eurocentric rationalities and technocratic orientations that have long defined the modern university, this transformative framework centers the marginalized epistemologies and subaltern knowledge systems of the Global South and Indigenous communities. By excavating the complex histories and ongoing legacies of colonial science, the article lays bare the entrenched power hierarchies and epistemic injustices that have systematically suppressed non-Western ways of knowing. In response, it champions a radical pluralism that empowers diverse epistemes as vital sources of insight, resilience, and emancipatory potential essential for navigating our cascading global crises. Beyond the mere valorization of marginalized knowledge systems, the article also catalyzes a profound reconfiguration of the research enterprise's modalities and organizational structures. By championing collaborative, place-based, and community-embedded modes of knowledge co-production, it directly challenges the extractive, exclusionary, and technocratic tendencies of the traditional university model. Ultimately, this decolonial praxis holds the power to catalyze a radical renewal of the social contract linking academic inquiry and societal transformation - unleashing the emancipatory potential of knowledge in service of global justice, ecological regeneration, and collective flourishing.