In Cuba, Xanthosoma spp., are propagated asexually (rhizomes or cormels), because this plant species rarely or never produces inflorescences, which has limited their ability to produce botanical seeds. However, the Genetic Improvement Program (GIP) of the Research Institute of Tropical Roots and Tuber Crops (INIVIT by Spanish abbreviation) have as objective to investigate methods that allowed flowering induction of Xanthosoma spp. plant and consequently the production of seeds botanical. Under controlled conditions, Gibberellic Acid (GA3) was applied via injection at concentrations of 500, 750, and 1000 mg.L−1 and VIUSID® Agro at a concentration of 0.2 mL.L−1 via foliar spraying and a control (without GA3 and VIUSID® Agro). Results showed that the emission of inflorescences and seeds occurred in all the accessions evaluated at the concentration of 1000 mg.L−1 of GA3 plus VIUSID® Agro. In addition, the botanical seeds reached a total mass of 10.6 g, a length of less than 1.5 mm and a 92% of germination and the seed color varied from light yellow to dark yellow. These findings constitute the first scientific evidence of obtaining botanical seeds of Xanthosoma spp. in Cuba, which strengthens the genetic diversity and sexual reproductive capacity and the possibility of producing new varieties.