Background: Evaluate the level of physical activity, the levels of oxidative stress and sleep quality of patients with obstructive sleep apnea. Methods: Cross-sectional study with two groups: OSAG (Obstructive Sleep Apnea Group) (n = 15) and CG (Control Group) (n = 22). Both groups completed Pittsburgh Sleep Quality Index (PSQI), the International Physical Activity Questionnaire (IPAQ). To determine the rates of Malondialdehyde (MDA) and Glutathione (GSH), blood was collected. Results: The OSAG presented a higher body mass index (BMI) (32.44 ± 4.79; CG: 27.68 ± 5.36 kg∕m²), higher neck (39.67 ± 3.52; CG: 36.27 ± 3.74 cm) and abdominal circumference (105.4 ± 11.09; CG: 94.45 ± 11.96 cm), and higher levels of MDA (5.18 ± 1.33; CG: 1.18 ± 0.92 nmol∕mL). No significant difference of levels between the groups in GSH (OSAG: 125.99 ± 28.18; CG: 118.44 ± 16.52 μmol/g Hb), IPAQ score (OSAG: 3170 ± 1936; CG: 2907 ± 2411 MET-min∕week) and PSQI categories) was found. Conclusion: Both groups were physically active and had poor sleep quality. However, only OSAG has higher BMI, cervical and abdominal circumference. Conclusions: Both groups were physically active and had poor sleep quality. However, only OSAG has higher BMI, cervical and abdominal circumference.