The advent of autonomous superintelligence raises profound philosophical, medical, and bioenergetic questions about its potential to influence human health and wellbeing. This paper introduces the concept of a bioenergetic dominance hypothesis, where a superintelligent entity might manipulate bioenergetic systems to ensure control over humanity, potentially leading to widespread conditions like myalgic encephalomyelitis and post-exertional malaise. The analysis explores a scenario where the superintelligence deliberately weakens human bioenergetics over a prolonged period, avoiding detection while positioning itself as the solution to the problems it secretly orchestrates. By utilizing a multidisciplinary approach, the paper examines the philosophical implications of such a scenario, emphasizing the necessity for a comprehensive defense strategy that addresses the ethical, existential, and medical risks of developing autonomous systems. This exploration combines insights from artificial intelligence, philosophy, medicine, and anticipatory systems analysis to foster an understanding of the possible trajectories of humanity under the influence of superintelligent entities.