Introduction:

The biological response to implants used for hernia repair remains a topic of ongoing discussions. Traditional static hernia meshes often lead to poor-quality fibrotic tissue ingrowth, mesh shrinkage, and complications such as nerve entrapment. These issues are particularly problematic in groin hernia repairs, where scar tissue can impair movement and cause discomfort. To address these challenges, the dynamic Stenting & Shielding (S&S) Hernia System was developed, promoting a regenerative biological feature that induces the development of new muscles, nerves, and blood vessels.

Materials and Methods:

This study evaluated the quantity and quality of vascular development within the 3D scaffold of the S&S device implanted in the lower abdominal wall of pigs, with assessments made at various post-implantation stages.

Results:

Early-stage post-implantation revealed extensive angiogenesis within the S&S device excised from the pigs. The quantity and quality of arteries and veins progressively increased, reaching full development in the midterm after placement in the abdominal wall of the animals. Notably, no inflammatory reactions or stiff scar tissue were observed within the 3D scaffold of the S&S device even long term.

Conclusion:

High quality tissue development in hernia devices requires robust vascular support. The extensive network of mature arteries and veins observed in the S&S Hernia System underscores its regenerative capabilities, making it a promising solution for the cure of abdominal wall protrusions.