Mine tailings are a byproduct of mineral extraction and often pose an environmental challenge due to the contamination of soil and water bodies with dissolved metals. However, this type of waste offers the opportunity for the recovery of valuable metals such as silver (Ag). In the present investigation, an integral analysis of a sample of tailings was carried out, addressing its granulometry, elemental composition, neutralization potential (NP) and acid potential (AP), as well as its mineralogy; for the dissolution of silver from this type of waste. For this purpose, thiourea (CH₄N₂S) was used as a leaching agent due to its low toxicity and potassium oxalate (K₂C₂O₄) as an organic additive to improve the leaching of the silver phases (argentite and polybasite) present in the tailings. The effects of CH₄N₂S and K₂C₂O₄ concentrations, temperature, and pH on the leaching efficiency of silver (Ag), copper (Cu), iron (Fe), and arsenic (As) were systematically studied. The results revealed that the maximum silver dissolution rate reached 90.75% under optimal conditions: 0.2 M L⁻¹ of thiourea, 0.2 M L⁻¹ of potassium oxalate, at 35°C and a pH of 2.