(1) Background: The recovery method would be important and decisive in the training system. This study aimed to assess the effects of various post-training recovery methods on muscle damage and strength indicators in Paralympic powerlifting athletes; (2) Methods: For this, a crossover study was conducted involving eleven male athletes (25.4±3.3 years, 70.3±12.1 kg). Muscle damage was assessed using blood biochemical markers (cytokines: Th1/Th2 - IL-6, IL-10, and TNF-) and isometric force indicators, including Maximum Isometric Force (MIF), Time to MIF, and Rate of Force Development. These assessments were performed before, immediately after, and at 24 and 48 hours after the recovery protocol: a) Passive Recovery (RP) or b) Cold-Water immersion (CWI). The main results indicated that maximum isometric strength (MIF) significantly improved after 48 hours of CWI application (p<0.05; for all comparison); (3) Results: The analysis of biochemical markers did not yield significant differences between the recovery methods at different time points (p>0.05). There was a significant increase in IL-6 2 hours after (p=0.045) for the CWI condition; (4) Conclusions: CWI significantly improved post-resistance training muscle damage and strength in Paralympic powerlifting athletes.