The occurrence of Leptospira in mammals is an indicator for assessing potential health risks, particularly in tropical regions. Understanding their hosts' habitat characteristics and spatial occurrence is essential to surveil them. This study aimed to determine the characteristics of the peridomiciles associated with the spatial occurrence of Leptospira hosts. We inventoried the characteristics of the peridomiciles. Blood serum was gathered from dogs, opossums, and rodents for a microagglutination essay to detect exposure to several serogroups of Leptospira. A generalized linear model with binomial distribution helped estimate risk ratios and 95% confidence intervals between a seropositive animal's occurrence and the peridomiciles' characteristics. For estimates with the occurrence of one or more seropositive animals, a multinomial model was fitted. The seroprevalence in rodents was 81.8%; in opossums 31.2%; and 56.5% for dogs. The most frequent serogroup in dogs and rodents was Canicola. In opossums, the seroreaction was against Tarassovi, Ballum, Sejroe, and Cynopteri. Results showed that the peridomicile area (m2), the geographic polygon, and the accumulation of plastic containers (PET) were characteristics related to the occurrence of seropositive animals. The results revealed that the peridomicile's characteristics and spatial distribution in the locality help explain the occurrence of Leptospira hosts.