Global climate has undergone significant changes in the past 50-60 years. The transition from stable climate conditions to current warming has significantly influenced permafrost landscapes and infrastructure in cold regions. Arctic and Subarctic landscapes had distinct reactions to these changes. The objective of this study is to analyze the regional aspects of climate and permafrost changes in Yakutia's Arctic and subarctic regions from the past 50-60 years. Our analysis focused on climate change patterns during different periods, including cold period, pre-warming, and modern warming. We analyzed data on mean annual air temperature, thawing and freezing indices, and precipitation. During these periods, we determined the reaction's characteristics in various landscape regions. The most significant impact on permafrost began in the mid-2000s, as our observations confirmed. Global warming directly causes permafrost temperature to rise, the active layer to thicken, and cryogenic processes to develop. The conducted research provides the information needed to study the effects of global warming on permafrost and adapt socio-economic conditions in northern Yakutia.