ARTICLE
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doi:10.20944/preprints202401.1406.v1
Subject:
Biology And Life Sciences,
Parasitology
Keywords:
Leishmania infectivity in mammalian hosts; inserts of leishmaniases and coinfections in companion animals; clinical and histopathologic features of natural zoonotic canine leishmaniasis; cell communication by parasite-derived extracellular vesicles; in vitro models advance to target parasite-secreted lipid bound vesicles
Online: 19 January 2024 (03:14:14 CET)
ARTICLE
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doi:10.20944/preprints202301.0489.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
multidrug resistance; MDR; EPB (Xenorhabdus; (X. budapestensis; X. szentirmaii; X. innexii); and Photorhabdus) species); CFCM (cell-free conditioned media); NR-AMP (non-ribosomal-templated antimicrobial peptides); anti-microbial; (anti-bacterial; - anti-coccidial; -anti-protist; - activity; cytotoxicity; in vitro; in situ (local) bioavailablity; XENOFOOD; allometry
Online: 27 January 2023 (06:21:56 CET)
REVIEW
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doi:10.20944/preprints202403.0720.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
early onset gastrointestinal malignancies; young adult cancer; early onset colorectal cancer; early onset esophageal cancer; esophageal adenocarcinoma; esophageal squamous cell carcinoma; early onset gastric cancer; early onset pancreatic cancer; early onset liver cancer; gastrointestinal malignancy; hepatocellular carcinoma; BRCA mutation; ATM mutation; MLH1; MSH2; MSH6; PRSS1; early onset biliary malignancy
Online: 12 March 2024 (14:33:15 CET)
ARTICLE
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doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)