Space-time evolution is briefly explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (E=cDtDV), charges (|q|= cDt) and absolute time (ct) are newly defined based on the 4-D Euclidean space. The big bang is understood by the space-time evolution of the 4-D Euclidean space but not by the sudden 4-D Minkowski space-time creation. The big bang process created the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry. Our universe is the matter universe with the negative charges of electric charge (EC), lepton charge (LC) and color charge (CC). This first universe is made of three dark matter -, lepton -, and quark - primary black holes with the huge negative charges which cause the Coulomb repulsive forces much bigger than the gravitational forces. The huge Coulomb forces induce the inflation of the primary black holes, that decay to the super-massive black holes. The dark matter super-massive black holes surrounded by the normal matters and dark matters make the galaxies and galaxy clusters. The spiral arms of galaxies are closely related to the decay of the 3-D charged normal matter black holes to the 1-D charged normal matter black holes. The elementary leptons and quarks are created by the decay of the normal matter charged black holes, that is caused by the Coulomb forces much stronger than the gravitational forces. The Coulomb forces are very weak with the very small Coulomb constants (k₁(EC) = k_dd(EC) ) for the dark matters and very strong with the very big Coulomb constants (k₂(EC) = k_nn(EC)) for the normal matters because of the non-communication of the photons between the dark matters and normal matters. The photons are charge dependent and mass independent. But the dark matters and normal matters have the similar and very weak gravitational forces because of the communication of the gravitons between the dark matters and normal matters. The gravitons are charge independent and mass dependent. Note that the three kinds of charges (EC, LC and CC) and one kind of mass (m) exist in our matter universe. The dark matters, leptons and quarks have the charge configurations of (EC), (EC,LC) and (EC,LC,CC), respectively. Partial masses of elementary fermions are calculated, and the proton spin crisis is explained. The charged black holes are not the singularities.

One of the main problems for managing global crises is to clarify and reduces drivers of systemic weaknesses to face complex emergencies. This study here analyzes the relation between public debt, healthcare expenditures and fatality rates in the presence of pandemic crises, such as COVID-19. Statistical evidence, based on a sample of European countries, here shows that high public debt over time reduces health expenditures and increases the vulnerability of countries to face emergencies, such as COVID-19 pandemic crisis. Regression analysis with a log-log model suggests that when European countries experience a 1% increase in healthcare expenditure per capita, in general they have a 1.2% reduction in the COVID-19 fatality rate. Main implications of this study to reduce the systemic risk and vulnerability to environmental threats are that countries must reduce public debt with good governance and institutions without reducing the allocation of economic resources to the healthcare sector in order to improve the preparedness to unforeseen emergencies and crises, such as pandemics, natural disasters, conflicts, and other environmental threats.

Fundamental science and applied research and technology development (RTD) are facing significant challenges that particularly compound to the notorious credibility, reproducibility, funding and sustainability crises. The underlying, serious shortcomings are substantially amplified by a metrics-obsessed publication culture, and a growing cohort of academics fishing for fairly stagnant (public) funding budgets. This work presents, for the first time, a groundbreaking strategy to successfully address these severe issues; the novel strategy proposed here leverages the distributed ledger technology (DLT) “blockchain” to capitalize on cryptoeconomic mechanisms, such as tokenization, consensus, crowdsourcing, smart contracts, reputation systems as well as staking, reward and slashing mechanisms. This powerful toolbox, which is so far widely unfamiliar to traditional scientific and RTD communities (“TradSci”), is synergistically combined with the exponentially growing computing capabilities for virtualizing experiments through digital twin methods in a future scientific “metaverse”. Project contributions, such as hypotheses, methods, experimental data, modelling, simulation, assessment, predictions and directions are crowdsourced using blockchain, and captured by so-called non-fungible tokens (“NFTs”). The so enabled, highly integrative approach, termed decentralized science (“DeSci”), is destined to move research out of its present silos, and to markedly enhance quality, credibility, efficiency, transparency, inclusiveness, sustainability, impact, and sustainability of a wide spectrum of academic and commercial research initiatives.