Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination

Ewan P. Plant
* ORCID logo ,
Angelia A Eick-Cost
,
Hussein Ezzeldin
,
Jose L Sanchez
ORCID logo ,
Zhiping Ye
,
Michael J Cooper
ORCID logo
Version 1 : Received: 30 May 2018 / Approved: 31 May 2018 / Online: 31 May 2018 (10:51:16 CEST)
Version 2 : Received: 5 July 2018 / Approved: 6 July 2018 / Online: 6 July 2018 (07:53:32 CEST)

A peer-reviewed article of this Preprint also exists.

Plant, E.P.; Eick-Cost, A.A.; Ezzeldin, H.; Sanchez, J.L.; Ye, Z.; Cooper, M.J. The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination. Vaccines 2018, 6, 39. Plant, E.P.; Eick-Cost, A.A.; Ezzeldin, H.; Sanchez, J.L.; Ye, Z.; Cooper, M.J. The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination. Vaccines 2018, 6, 39.

Abstract

The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts. With the development of new universal vaccines there is need for better understanding of how vaccine responses are affected by early exposures to influenza viruses. In this analysis of hemagglutination inhibition (HI) antibody responses in two cohorts of military personnel we noticed differences related to birth year. These data suggest that HI antibody production, in response to influenza vaccination, is affected by influenza activity in the years following birth. The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth.

Keywords

influenza; serum; IgG; humoral antibody; original antigenic sin; hemagglutinin

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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