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Stick around: Cell-Cell Adhesion Molecules during Neocortical Development
Version 1
: Received: 9 December 2020 / Approved: 10 December 2020 / Online: 10 December 2020 (10:23:42 CET)
A peer-reviewed article of this Preprint also exists.
de Agustín-Durán, D.; Mateos-White, I.; Fabra-Beser, J.; Gil-Sanz, C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells 2021, 10, 118. de Agustín-Durán, D.; Mateos-White, I.; Fabra-Beser, J.; Gil-Sanz, C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells 2021, 10, 118.
Abstract
The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to stablish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contacts with additional cells. In this review, we will focus on the role of two important families of cell-cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with especial attention in the cooperative actions among the two families of C-CAMs.
Keywords
CAMs; Classical Cadherins; Nectins; Neocortical Development; Radial Glia Cells; Neurons; Neuronal Migration; Axon Targeting; Synaptogenesis; Autism/Neurodevelopmental disorders
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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