Review
Version 1
Preserved in Portico This version is not peer-reviewed
An Update of Molecular Basis of Telomere Biology Diseases
Version 1
: Received: 16 February 2021 / Approved: 17 February 2021 / Online: 17 February 2021 (09:34:55 CET)
How to cite: Vertecchi, E.; Iuzzolino, A.; Salvati, E. An Update of Molecular Basis of Telomere Biology Diseases. Preprints 2021, 2021020351. https://doi.org/10.20944/preprints202102.0351.v1 Vertecchi, E.; Iuzzolino, A.; Salvati, E. An Update of Molecular Basis of Telomere Biology Diseases. Preprints 2021, 2021020351. https://doi.org/10.20944/preprints202102.0351.v1
Abstract
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. In a classic view, telomere biology impinges on intracellular signaling pathways regulating DNA damage repair and cell cycle arrest, but new roles of telomeric proteins and transcripts emerge from recent literature. Telomere biology diseases are human disorders associated to telomere attrition. This review wants to overview the recent findings in the field of telomere’s metabolism and to deepen molecular mechanisms of inherited and acquired telomeropathies, explaining new critical connections between telomeric factors and disease pathogenesis
Keywords
telomeres; shelterins; telomere biology diseases; cancer; dyskeratosis
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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