Background: School-aged children may benefit from education interventions focused on healthy eating and physical activity to improve their quality of life. Objective: To review the available scientific evidence on food and nutrition education (FNE) in Spanish-speaking countries for the prevention of excess weight in school-aged children (6-12 y). Methods: Relevant evidence was searched between April and August 2021. The searches were conducted using MEDLINE, Google Scholar, and SciELO. The primary search for articles focused on the experience of FNE interventions in Spanish-speaking countries. Results: Overall, 518 articles were found and 33 studies were eligible for data extraction. Forty two percent of the studies had a focus on FNE and 64 percent were focused on describing the eating habits of schoolchildren. Nutritional assessments (anthropometric) were found frequently with 91 percent and 30 percent of the studies focused on physical activity. All interventions focused on preventing or reducing overweight and obesity in school-age children. Educational, cognitive, dietary and physical activity practices were described, being educational the most frequent intervention. Conclusion: Interventions reported positive effects of FNE interventions to improve knowledge and practices of healthy lifestyles in school-age children.