Retrovirus: Protein Reawakens

S Chen

doi:10.20944/preprints202203.0216.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202203.0216.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Retrovirus: Protein Reawakens

S Chen

Version 1 : Received: 13 March 2022 / Approved: 15 March 2022 / Online: 15 March 2022 (14:20:57 CET)
Version 2 : Received: 8 April 2022 / Approved: 11 April 2022 / Online: 11 April 2022 (08:43:41 CEST)
Version 3 : Received: 11 July 2022 / Approved: 12 July 2022 / Online: 12 July 2022 (08:07:43 CEST)
Version 4 : Received: 16 September 2022 / Approved: 16 September 2022 / Online: 16 September 2022 (11:45:33 CEST)
Version 5 : Received: 27 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (16:13:16 CEST)
Version 6 : Received: 26 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (09:31:10 CEST)

A peer-reviewed article of this Preprint also exists.

Shaoming Chen. Commentary on LRAs targeting NF-κB with epigenetic and mutational impacts on HIV latency. iMetaOmics e31. 2024. https://doi.org/10.1002/imo2.31 Shaoming Chen. Commentary on LRAs targeting NF-κB with epigenetic and mutational impacts on HIV latency. iMetaOmics e31. 2024. https://doi.org/10.1002/imo2.31

Abstract

The amino acid sequences ARG of gag proteins of HTLV1, HTLV2, STLV1 and STLV2 match with its primer binding site GGGGGCTCG in the 3'-to-5' direction, and the amino acid sequences SPR of gag proteins of HIV1, HIV2, SIV and FIV match with its primer binding site GGCGCCCGA in the 3'-to-5' direction, and gag, gag-pol and gag-pro-pol proteins are promising for reawaken dormant retrovirus infection. The latency-reversing drugs were involved in the process of transcription of cancer, the genome which they actually reawaken is just happened to be contained genome of the retrovirus, they are essentially false reawaken. Use proteins of retroviruses to reawaken themselves are more reliable, just like androgen receptor activates IGF1R genome.

Keywords

Retrovirus

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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