Version 1
: Received: 26 July 2023 / Approved: 27 July 2023 / Online: 27 July 2023 (10:23:16 CEST)
How to cite:
Mirmazhari, S. P.; Abdi, M. J.; Mosadeghrad, A. H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S. Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1
Mirmazhari, S. P.; Abdi, M. J.; Mosadeghrad, A. H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S. Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints 2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1
Mirmazhari, S. P.; Abdi, M. J.; Mosadeghrad, A. H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S. Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1
APA Style
Mirmazhari, S. P., Abdi, M. J., Mosadeghrad, A. H., Abedini Bonab, R., Amani Babadi, A., Rigi, G., Shahrokhi, S. Z., Chamanara, M., Amodio, N., & Heidari, R. (2023). Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints. https://doi.org/10.20944/preprints202307.1901.v1
Chicago/Turabian Style
Mirmazhari, S. P., Nicola Amodio and Reza Heidari. 2023 "Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer" Preprints. https://doi.org/10.20944/preprints202307.1901.v1
Abstract
The Myc gene, widely studied in numerous cancer types, serves as a pivotal regulator of crucial cellular processes implicated in tumorigenesis, such as cell growth, proliferation, invasion, metastasis, and therapy resistance. LncRNAs have been identified as relevant partners of Myc. LncRNAs modulate chromatin structure and function, transcription, splicing, stability, and translation of mRNAs, thereby emerging as pivotal regulators in cell differentiation, metabolism, signaling. An intricate crosstalk exists between Myc and lncRNAs in a wide range of cancers, wherein they can physically and functionally interact through direct and indirect mechanisms. Some lncRNAs can regulate Myc activity at post-transcriptional level, affecting its stability, translation, or interactions with other proteins, thus acting as oncogenes, while others act as tumor suppressors. On the other hand, Myc can target numerous lncRNA genes and modulate their expression, affecting the expression of downstream targets involved in tumorigenesis. Given the significant role of the Myc-lncRNA network in various cancer types, exploring therapeutic strategies targeting these crucial cellular regulators is of utmost importance. This review article focuses on breast cancer, analyzing those lncRNAs influencing Myc as well as the Myc-regulated lncRNAs.
Keywords
MYC; LncRNAs; miRNA; Breast Cancer
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.