Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics

Kyeong-Seo Moon
,
Grace Choi
ORCID logo ,
Su-Bin Jung
,
Hyo-Jin Kim
,
Jun-Gyu Park
,
Yong Min Kwon
ORCID logo ,
Eun-Seo Cho
,
Mi Yeong Shin
,
Jae-Yeong Yu
,
Ji Ae Choi
,
Yeong-Bin Baek
* ORCID logo ,
Sang-Ik Park
* ORCID logo
Version 1 : Received: 8 March 2024 / Approved: 11 March 2024 / Online: 11 March 2024 (08:58:53 CET)

How to cite: Moon, K.-S.; Choi, G.; Jung, S.-B.; Kim, H.-J.; Park, J.-G.; Kwon, Y. M.; Cho, E.-S.; Shin, M. Y.; Yu, J.-Y.; Choi, J. A.; Baek, Y.-B.; Park, S.-I. Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics. Preprints 2024, 2024030554. https://doi.org/10.20944/preprints202403.0554.v1 Moon, K.-S.; Choi, G.; Jung, S.-B.; Kim, H.-J.; Park, J.-G.; Kwon, Y. M.; Cho, E.-S.; Shin, M. Y.; Yu, J.-Y.; Choi, J. A.; Baek, Y.-B.; Park, S.-I. Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics. Preprints 2024, 2024030554. https://doi.org/10.20944/preprints202403.0554.v1

Abstract

The influenza virus has been the primary cause of the pandemic, posing a constant threat to human society. Due to its genetic evolution and continuous outbreak, antiviral research currently focuses on exploring a novel lead agent. A comprehensive antiviral screening discovered a marine bacterium whose extract exerted excellent efficacy against influenza viruses. Parerythrobacter sp. M20A3S10, a novel strain under the family Erythrobacteraceae, could produce carotenoids exhibiting antiviral and anticancer activity by enhancing the cellular immune system. Post-treatment of M20A3S10 extract showed outstanding therapeutic indexes: against influenza virus A/PR8 (H1N1) [selectivity index (SI) = 24.0], A/Wisconsin/15/2009 (H3N2) (SI = 30.1) and B/Florida/78/2015 (SI = 38.2). Comparably, the effectiveness was demonstrated against Zika virus (ZIKV) and dengue virus type 2 (DENV2) with an SI of 22.5 and 24.1, respectively, namely broad-spectrum activity. Of note, the antiviral responses resulted from the common replication mechanism between IAV, ZIKV, and DENV2. The stimulation of apoptosis-mediated cellular immunity prevented the viral release and protected the host, suggesting that switching from necroptosis to apoptosis is a novel antiviral target. Although the specific compound affecting the antiviral activity was not identified, its promising efficacy with broad activity will contribute to developing a strategy for preventing future pandemics.

Keywords

marine bacterium; influenza virus; Zika virus; dengue virus; apoptosis; broad antiviral activity

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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