As urban areas face increasing challenges, integrating smart infrastructure, particularly IoT and AI technologies, has become vital for enhancing resilience. This study focuses on Baltimore as a case study to explore how scalable and adaptable smart infrastructure solutions can address diverse urban needs within a mid-sized U.S. city. Through a comprehensive review of Baltimore’s socioeconomic indicators and the development of a composite resilience score, this paper identifies key factors that facilitate or hinder the scalability and adaptability of smart infrastructure in economically and demographically varied urban contexts. The resilience score provides a quantitative measure of urban resilience, enabling the analysis of trends and dependencies among socioeconomic indicators over time. Findings reveal critical roles for both community engagement and policy support in adapting technologies to local needs, while economic and technical factors influence the scalability of IoT and AI projects. Based on these insights, the study proposes a framework that offers practical guidance for expanding Baltimore’s smart infrastructure in ways that are economically feasible, technically viable, and socially inclusive. This framework aims to assist Baltimore’s policymakers, urban planners, and technologists in advancing resilient, scalable solutions that align with the city's unique infrastructure needs and resource constraints.