The present work deals with the study of the gravitational collapsing phenomenon of spherically symmetric massive stars with a Λ parameterization A collapsing model with a cosmological constant of the form Λ=β(θ ̇/3+θ^2/9) has been considered. In this model, exact solutions of the Einstein field equations (EFEs) are obtained using the $\Lambda$ parametrization and the junction conditions. All the physical and geometrical quantities are calculated in terms of the Schwarzschild mass M and areal radius R of spherically symmetric stars. Consequently, we have approximated the masses and radii of different stars to estimate the value of the model parameter β. We discuss the collapsing process and singularity formation for these stars and observe that all the physical and geometrical parameters of the model heavily depend on the model parameter β. We further discuss spacetime singularity through the development of apparent horizons.

Salmonella causes various type of disease worldwide with a remarkable pace. Salmonella enteric serotype typhi (S. typhi), a gram-negative bacterium (only cause disease in man) is the mainly causative agent of Typhoid fever. Typhoid fever is most common in poor and unprivileged developing countries of Asia and Africa. One of the major components of virulence factors produced during salmonella infection is Lipid A, which acts as a potent human immuno-modulator bacterial endotoxin. Regulation of Lipid A biosynthetic pathway occurs at second step, catalyzed by LpxC, a Zn2+ dependent metalloamidase. Systematic Screening of a pool of drug datasets like natural products library from Zinc database, Asinex database, Thiophene analogues fruitfully provided us 3 potent lead molecules s1_dl_mseq2, s1_ll_mseq2, and s2_ll_mseq8 which actively binds with LpxC enzyme and could be developed into sound inhibitors of LpxC enzyme after the application of drug development and processing strategies. Wet lab experimentation is required to validate these results for further use.