Agricultural waste is rich in bioactive molecules. In evaluating the viability of circular models for the development of health-promotional substances and final products, it is important to highlight that the processing industry of fruits and other valuable herbal materials generates a considerable number of by-products and waste containing health-promoting components. These by-products can be utilized purposefully used in pharmaceuticals and related areas for the development of health promotional products. The linear utilization of agricultural waste results in the loss of a range of valuable bioactive compounds, including polyphenols (anthocyanins, flavonoids, phe-nolic acids, and related compounds), antioxidants from other groups, as well as phytosterols, tocopherols and fatty acids. As an illustrative example, the waste materials of species belonging to the Vaccinium genus represent a notable secondary resource that can be purposefully applied to the development of health-promoting substances. The fruits of these wasted herbal materials have been found to contain reliable polyphenols, which play a pivotal role in the prevention of various chronic conditions, including precancerous conditions, inflammatory diseases and other ailments. In addition, the fruits of blackberries, elderberries, and purple corn which are similarly rich in anthocyanins also provide a promising avenue for further developments. Phenolic compounds suitable for recycling are also found in sugarcane harvesting by-products. Tomato waste contains a significant amount of the valuable carotenoid lycopene. The additional value of the above-mentioned fruit processing by-products may attribute to specified physiological functions, which, if used properly, can contribute to the prevention of certain diseases, and improving of quality of life. This review assessed the scope and gaps in the existing principles on the isolation of health-promoting substances from herbal secondary materials.

German chamomile (Matricaria chamomilla L.) is an essential oil-content medicinal plant widely used worldwidely. The aim of this study was (1) to gain knowledge of the phytochemical composition and the analgesic and soporific activity of M. chamomilla flowers extract and its amino acid preparations, (2) to predict the mechanisms of their effects by molecular docking, and (3) to develop aqueous printing gels and novel 3D-printed oral dosage forms for M. chamomilla flowers extracts. In total 22 phenolics and 14 amino acids were identified and quantified in the M. chamomilla extracts. The in-vivo animal studies with rodents showed that the oral administration of such extracts revealed the potential for treating of sleep disorders and diseases accompanied by pain. Amino acids were found to potentiate these effects. Glycine enhanced the analgesic activity the most, while lysine and β-alanine improved the soporific activity. The molecular docking analysis revealed a high probability of GABAA and NMDA receptor antagonism and COX-1,2 inhibition by the extracts. A polyethylene oxide (PEO) based gel composition with the M. chamomilla extracts were proposed for preparing a novel 3D-printed dosage form for the oral administration. These 3D-printed extract preparations can be used for example in dietary supplement applications.

Pineapple weed (Matricaria discoidea DC.) is a widely spread plant in Europe and North America. In ethnomedicine, it is well known for its anti-inflammatory and spasmolytic activity. The aim of the research was to develop novel methods of M. discoidea herb complex processing for creating the essential oil and the dry extracts and to investigate their phytochemical composition. Moreo-ver, the molecular docking of main substances and in vivo their soporific and analgesic activity were studied. The essential oil and two dry extracts from M. discoidea were prepared. Total 16 phenolic compounds (7 flavonoids, 7 hydroxycinnamic, 2 phenolic acids) in the dry extracts were identified by means of UPLC-MS/MS. In the essential oil 9 main terpenoids were identified by gas chromatography (GC). We showed that the phenolics extraction from the present herb was successful by using 70% ethanol in a triple extraction and in the range of 1:14-1:16. The in-vivo studies with rodents showed analgesic activity of M. discoidea extracts and the improvements in the sleep of animals. The dry extracts of M. discoidea herb did not show any toxicity. The molecular docking showed the high probability of COX-1,2 inhibition and NMDA receptor antagonism induced by the extracts.