A 62-year-old male was diagnosed with B-CLL and treated with Fludarabine-containing regimen which maintained the disease in partial response. Nine years after diagnosis, a rapidly growing systemic lymphadenopathy was observed, and a biopsy specimen revealed the presence of typical Hodgkin/Reed–Sternberg (HRS) cells, surrounded by T-lymphocytes and CLL cells. Sequencing analysis of the germline CDR3 region of the IGH gene showed that the HRS cells were clonally unrelated to the preexisting CLL cells and the HRS cells were composed of five different clones, leading to the molecular diagnosis of de novo lymphocyte-rich classic Hodgkin LPDs with SLL. Because the initial treatment was neither effective for classic Hodgkin LPDs nor for SLL, Bendamustine, Rituximab (BR) was started and complete remission was achieved, which has continued for more than one year so far. BR may be a good therapeutic option for both entities without causing hematological toxicity.

The bi- or multi-nucleated Reed-Sternberg cell (RS) is the diagnostic cornerstone of EBV-positive and EBV-negative classical Hodgkin lymphoma (cHL). cHL is a germinal center (GC) derived B-cell disease. Hodgkin cells (H) are the mononuclear precursors of RS. An experimental model has to fulfill three conditions to qualify as common pathogenic denominator: i) to be of germinal center-derived B-cell origin, ii) to be EBV-negative to avoid EBV latency III expression, and iii) to support permanent LMP1 expression upon induction. These conditions are unified in the EBV-, Diffuse Large B-Cell Lymphoma (DLBCL) cell line BJAB-tTA-LMP1. 3D reconstuctive nanotechnology revealed spatial, quantititive and qualitative disturbance of telomere/shelterin interactions in mononuclear H-like cells, further progression during transition to RS-like cells, including progressive complexity of the karytotype with every mitotic cycle, due to BBF (breakage/bridge/fusion) events. The findings of this model were confirmed on diagnostic patient samples and correlate with clincal outcome. Moreover, in vitro signficant disturbance of the lamin AC/telomere interaction progressively occured. In summary, our research over the past three decades identifed cHL as the first lymphoid maligancy driven by a disturbed telomere/shelterin/lamin AC interaction, generating the diagnostic RS. Our findings may act as trailblazer for tailored therapies in refractory cHL.

Reed (Phragmites autralis) is a plant species with a seasonal reproductive cycle, it has a very high biomass in U Minh Thuong National Park. This characteristic that management of forest fire is dificult in Vietnam. To evaluate height, diameter, density, growth, biomass of fresh and dry, biochar on reed plants; it include plant, stem, leaves, flowers; analysis indicators of growth, biomass, biochar on reed. compare chemical indicators of peat and biochar in U Minh Thuong and Kien Luong of Mekong Delta. Relationship of peat chemical with growth and biomass. Study adsorption from reed biochar with pig urine and inorganic chemical of nitrogen and phosphorus. Study on types of peatland thickness, each one had 5 plots, investigated height (Ht), diameter of stem (D0.0); weigh part of plants, stems, leaves and flowers. the soil samples collected on investigated 20 plots, biochar is analyzed for its chemical composition, then the biochar is adsorbed with pig urine and phosphorus and nitrogen inorganic. The results evaluated fresh biomass on parts of reed plant, dry biomass and biochar on parts of them. Results height 3.39 – 4.74 m, diemeter 1.8 – 3.17 cm, biomass 0.04 – 0.1 m3 / m2, weight 15.46 – 20.54 kg / m2. The dry weight / plant 127.34 – 358.58 g, a dry plant trunk 79.55 – 217.78 g, a dry plant leaves 33.78 – 112.16 g, a dry plant flowers 4.4 – 19.64 g. A plant Biochar 26.16 – 73.57 g, a trunk biochar 14.41 – 39.44 g, a leaf biochar 8.16 – 22.59 g, a flower biochar 2.59 – 11.54 g, Peat analysis, indicators decrease P2O5, SO42-, NH4+ and increase are pH, humic acid, N%, K2O, Fe2+. Compare biochar indicators of U Minh Thuong and Kien Luong indicators higher are 9/11 as humic acid, OM%, Ash%, C%, N%, P%, K%, Ca%, Mg%. Indicators lower are as pH and SiO. Reed biochar can adsorption the pig urine as ammonium, nitrate, nitrogen, phosphorus and it also adsorption inorganic as nitrogen and phosphorus. This discovery it is possible to propose the use of data for environment treatment and application of biochar fertilizer for agriculture in region.

We consider a coded compressed sensing protocol for unsourced massive random access (URA) that concatenates a shared Patterned Reed-Muller (PRM) inner codebook to an outer error-correction code. In this paper, an iterative list PRM projection algorithm is proposed to supplant the signal detector associated with the inner PRM sequences. In particular, we first propose an enhanced paths-saving algorithm called list PRM projection detection for the single-user scenario that keeps multiple candidates for the first few layers to remedy the risk of spreading errors. On this basis, we further propose an iterative list PRM projection algorithm for the multi-user scenario. The vectors for PRM codes and channel coefficients are jointly detected in an iterative manner, which offers significant improvements regarding the convergence rate for signal recovery. Furthermore, the performances of the proposed algorithms are analyzed mathematically, and we verified that the theoretical simulations are consistent with the numerical simulations. Finally, we concatenate the inner PRM codes that employ the iterative list detection to two practical error-correction outer codes. According to the simulation results, we conclude that the packetized URA with the proposed iterative list projection detection works better than benchmarks in terms of the number of active users it can support in each slot and the amount of energy needed per bit to meet an expected error probability.

The present study evaluates mold fungal resistance of newly developed loose-fill thermal insulation materials from wheat straw, corn stalk and water reed. Three different processing methods of raw materials was performed by mechanical crushing (Raw, ≤ 20 mm), thermal-mechanical pulping (TMP) using 4% NaOH and steam explosion pulping (SEP). An admixture of boric acid (8%) and tetraborate (7%) was applied to all processed substrates due to their anti-fungal properties. Additionally, the fourth sample group was prepared from SEPs of all raw species without boric acid and tetraborate (SEP*) as control. Samples from all treatments were separately inoculated by 5 different fungal species and incubated in darkness for 28 days at 28 ℃ and RH >90%. The highest resistance to the colonization of mold fungi was achieved by TMP and SEP processing coupled with addition of boric acid and tetraborate, where molds infest only around 35% to 40% of the inoculated sample area. The lowest mold fungi resistance was detected for Raw and SEP* samples, each ~75% that was affected by rich amount of accessible nutrients, suggesting that boric acid and tetraborate additives alone did not prevent mold fungal growth as effective as in combination with TMP and SEP treatments. Together, the achieved fungal colonization scores after combined fungicide and pulping treatments are acceptable for the application of various renewable materials in future thermal insulation product development.