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Reham Atallah, Jürgen Gindlhuber, Wolfgang Platzer, Thomas Bärnthaler, Eva Tatzl, Wolfgang Toller, Jasmin Strutz, Sonja Rittchen, Petra Luschnig, Ruth Birner-Gruenberger, Christian Wadsack, Akos Heinemann

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Succinate; SUCNR1; GDM; Placenta; Endothelial cells, Angiogenesis

Online: 20 October 2021 (12:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0254.v1

Environmental Assessment of Compaction and Transportation of Municipal Solid Waste in Patna, India

Yash Aryan, Deval Singh, Anil Kumar Dikshit

Subject: Engineering, Civil Engineering Keywords: compaction; environmental impacts; life cycle assessment; municipal solid waste; transportation

Online: 18 October 2021 (15:34:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0209.v1

Combination Breeding and Marker-Assisted Selection to Develop Late Blight Resistant Potato Cultivars

Mariya P. Beketova, Nadezhda A. Chalaya, Nadezhda M. Zoteyeva, Alena A. Gurina, Mariya A. Kuznetsova, Miles Armstrong, Ingo Hein, Polina E. Drobyazina, Emil E. Khavkin, Еlena V. Rogozina

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Rpi-genes; parental lines; hybrid progeny; dRenSeq; SCAR markers.

Online: 14 October 2021 (08:38:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0192.v1

A Novel Framework for Predictive Modeling and Optimization of Powder Bed Fusion Process

Mallikharjun Marrey, Ehsan Malekipour, Hazim El-Mounayri, Eric Faierson, Mangilal Agarwal

Subject: Engineering, Mechanical Engineering Keywords: Additive manufacturing; powder bed fusion; optimization framework; predictive models; neural network; intelligent parameters selection; energy density optimization; mechanical properties optimization

Online: 13 October 2021 (10:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0190.v1

Sleep Habits and Disorders among School Students in the Jazan Region, Saudi Arabia

Majed Ibrahim Hakami, Ismail Abdullah Juraybi, Abdullah Ali Jaafari, Ali Mohammed Al Ibrahim, Alhassan Mahdi Kariri, Ali Mahdi Kariri, Basim Yahya Khawaji, Almonther Hussain Wassly, Siraj Omer Wali, Faris Fahad Alhejaili, Mohammed Jeraiby

Subject: Medicine And Pharmacology, Other Keywords: Sleep habits; Sleep disorders; Students: Academic achievement.

Online: 13 October 2021 (08:26:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0143.v1

Information Technology for the Intelligent Analysis of Labor Market and Educational Content Matching

A. N. Poletaykin, S. G. Sinitsa, L. F. Danilova, Y. V. Shevtsova, N. A. Dvurechenskaya

Subject: Engineering, Control And Systems Engineering Keywords: field of professional activity; parsing; educational content; professional requirements; ontology; content markup; intelligent analysis

Online: 8 October 2021 (13:24:14 CEST)

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Working Paper ARTICLE

Probing Electron Properties in ECR Plasmas Using X-Ray Bremsstrahlung and Fluorescence Emission

Bharat Mishra, Angelo Pidatella, Alessio Galatà, Sándor Biri, Richárd Rácz, Eugenia Naselli, Maria Mazzaglia, Giuseppe Torrisi, David Mascali

Subject: Physical Sciences, Applied Physics Keywords: ECR plasmas; warm electrons; self-consistent simulations; experimental benchmarking; volumetric and space-resolved spectra; X-ray fluorescence; bremsstrahlung; ray-tracing Monte Carlo techniques

Online: 5 October 2021 (08:58:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0062.v1

Gene Profile Analysis and Molecular-Physiological Evaluation of Tomato Genotypes Under Drought Stress

Rahele Ghanbari Moheb Seraj, Masoud Tohidfar, Asadollah Ahmadikhah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Bioinformatics analysis; Drought stress; Gene expression; Physiological parameters; Tomato; Transcriptome.

Online: 4 October 2021 (15:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0483.v1

Design and Analysis of a Helium-Assisted Hybrid Drone for Flight Time Enhancement

Geronimo Macias, Kooktae Lee

Subject: Engineering, Mechanical Engineering Keywords: Hybrid Drone; Helium UAV; Drone Design; Flight Time Increase; UAV Stability and Performance Analysis

Online: 29 September 2021 (09:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0382.v1

Comparative Research of Microstructure and Mechanical Properties of Stainless-Structural Steel Dissimilar Welds

Saulius Baskutis, Jolanta Baskutiene, Regita Bendikiene, Antanas Ciuplys, Karolis Dutkus

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: stainless steel; metal inert gas welding; dissimilar welds; microstructure; mechanical properties

Online: 22 September 2021 (11:56:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0377.v1

Ecotoxicity and Associated Threat of Polycyclic Aromatic Hydrocarbons (PAHs) to Biodiversity: A Review

Idris Umar Zungum, Tijjani Sabiu Imam

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Polycyclic Aromatic Hydrocarbons (PAHs); Ecotoxicity; Biodiversity; Public Health,; Environmental safety

Online: 22 September 2021 (11:39:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0306.v1

Growth and Hierarchy of Cities in Algeria: Application of the Rank-Size Rule

Ahmed Bousmaha, Salah Zeraib, Nassira Benhassine, Yacine Kouba

Subject: Social Sciences, Urban Studies And Planning Keywords: urbanization; urban growth urban hierarchy; urban system

Online: 17 September 2021 (11:22:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0295.v1

Eating Disorder Symptoms and Body Image in Adolescents from Public Schools in Brazil

Roges Ghidini Dias, Ricardo Rodrigo Rech, Ricardo Halpern

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Obesity; Eating Disorder; Body Image; Adolescents.

Online: 16 September 2021 (16:34:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0289.v1

BRD9 Expression, Alteration, Survival And Pathway Analysis In 11 Independent Prostate Cancer Cohorts

Nafisa Barma, Timothy C Stone, Lina Maria Carmona Echeverria, Susan Heavey

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: BRD9; Prostate Cancer; SWI/SNF; Survival; pathways; signal transduction; human cohorts; targeted therapy

Online: 16 September 2021 (13:51:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0237.v1

Pearson’s Correlation and Trend Analysis for Physico-Chemical Parameters of Mansagar Lake, Jaipur

Yuvraj Singh, Manish Kumar Jain

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Mansagar Lake; Physico-chemical parameters; Water quality investigation; Trend analysis; Pearson’s correlation analysis

Online: 14 September 2021 (11:38:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0175.v1

ɤ-TiAl Alloy: Tensile Creep Deformation Behaviour and Creep Life at 832^°C

Mainak Saha

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: ɤ-TiAl; Monkman-Grant parameter; Coble creep; Nabarro-Herring creep

Online: 9 September 2021 (10:59:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0150.v1

Low-cost moulage in Healthcare Simulation: Review of Its Use, Utility, and Perceptions

Aamena Jariwala, Youness Zidoun, Jalal Alfroukh, Sharon Mascarenhas, Nabil Zary

Subject: Social Sciences, Education Keywords: medical moulage; low-cost; healthcare simulation; simulation-based learning

Online: 8 September 2021 (12:39:35 CEST)

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Background: Simulation plays a crucial role in health studies, as it helps medical students apply their theoretical knowledge in real-life situations. Moulage is one of the techniques that helps in making simulation more realistic or high-fidelity. It uses special effects to emulate wounds for a better understanding of what the wound is like visually. Still, moulage is expensive, time-consuming, resource-intensive, and requires the training of staff, which is why we need to find low-cost substitutes for moulage materials. Method: When searching the database “PubMed” for the terms “Low-cost and Medical moulage”, we retrieved 222 studies, out of which when excluding results not related to low-cost, we obtained 62 studies, from which when removing studies that do not contain information regarding moulage, we found two papers, after referring to citations and cited articles of those papers, we ended up with six studies. Based on the selected articles and additional articles sourced from their reference list, a total of 11 studies were included in the review. Results: We understand that moulage is a technique that helps make simulations come alive, but the resources required to use it are at times, expensive, which is why we need to find methods to do low-cost moulage, and many studies address that it can be as simple as using homemade ingredients. Students from a previous study have talked about their opinions regarding the realistic component of moulage and whether if it is any different from other moulages. Most of the students agreed that the moulage ranked well in face and content validity. However, further innovations must be introduced in the field to be widely spread and lead to newer opportunities. Conclusion: Although the research done under moulage is limited, it is accepted that moulage is helpful for simulation-based studies and that low-cost moulage can help make medical studies a better experience for students studying it. Students have a favorable opinion on the realistic aspect of the low-cost moulage applied to them. Newer methods can be introduced to moulage, and it can be implemented in low-income countries.

Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0126.v1

Promoting Simulation-Based Learning through Low-Cost Simulators: Development, Skills Targeted and Implementation

Inaaya Fatima Khan, Youness Zidoun, Sharon Mascarenhas, Nabil Zary

Subject: Social Sciences, Education Keywords: Medical Education; Simulation; Low-Cost; Task trainers; procedural trainers

Online: 7 September 2021 (12:06:27 CEST)

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Background: Simulations have historically aided training programs by providing a realistic and holistic replication of professional scenarios and procedures. Simulations have developed over the past 40 years to include varying fidelities and modalities of simulation. Learning in a simulation-centered environment has benefits, ranging from improved patient care to specific skills acquisition while catering to students’ numerous and varied learning approaches. Simulation is a multifaceted field that benefits all parties, the teachers, the learners, and the patients. The application of simulation to medical education and its amalgamation with other modes and substitutes allows for a more integrated learning and testing curriculum that advances the current trajectory of medical education. Such developments, however, are limited to resource rich areas, leaving behind low-middle income countries to use traditional, less evolved methodologies and practices. This review aimed to explore different aspects of simulation and focus specifically on low-cost task trainers and their accessibility. Method: The purpose of the study was to assess the accessibility of low-cost task trainers in terms of cost-effectiveness, distribution, validation, and frequency within specific specialties. To do so, 84 PubMed publications have been screened, and 39 filtered research studies have collected the necessary data. After analyzing the papers, we classified the following information – process, specialization, validation (y/n), costs, development location, and year of publication. Results: After carefully analyzing the accumulated data from the selected 39 publications, we found that most studies (i.e., 6 out of 39) were published in 2020. Emergency Medicine was the most common specialty for which low-cost trainers were developed (9 out of 39 procedural simulators); Otolaryngology followed this with 8 out of 39 trainers and general surgery with 7/39 of the task-trainers. The price ranges fluctuated and fell within the price bracket of USD 0 to USD 400 collectively. Our review also uncovered the concentration of development of such innovations solely in high income countries (HICs). Conclusion: Simulation is an invaluable tool applicable to a diverse range of phases of medical education. Future conjunction of simulation with low-cost substitutes along with increased encouragement and enthusiasm towards developing cost effective simulation-based learning environments (SBLEs) with the reserves and requirements of these areas in mind may prove to be a reliable option for low and middle resource settings

Preprint REVIEW | doi:10.20944/preprints202109.0103.v1

Keypoints to a Successful Newborn Hearing Screening. Thirty Years of Experience and Innovations

Jose Miguel Sequi Canet, Juan Brines Solanes

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neonatal hearing screening; Otoacoustic emissions; Deafness; Newborn screening.

Online: 6 September 2021 (13:57:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0080.v1

Foreign Language Effect on Decision-Making when Compared to Native and Second Language

Pratibha Ahirwal, Mahak Kothari, Veeky Baths

Subject: Social Sciences, Cognitive Science Keywords: Foreign Language effect; decision-making; native language; second language; risk-taking

Online: 6 September 2021 (09:47:03 CEST)

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Working Paper REVIEW

Consumer Valuation of and Attitudes Towards Novel Foods Produced with New Plant Engineering Techniques: A Review

John. C Beghin, Christopher R. Gustafson

Subject: Business, Economics And Management, Economics Keywords: new plant engineering techniques (NPETs); new breeding techniques (NBTs); genome editing; gene editing; cisgenic; willingness to pay (WTP)

Online: 1 October 2021 (12:55:10 CEST)

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Working Paper REVIEW

Obesity – An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Erind Gjermeni, Anna Kirstein, Florentien Kolbig, Michael Kirchhof, Linnaeus Bundalian, Julius L. Katzmann, Ulrich Laufs, Matthias Blüher, Antje Garten, Diana Le Duc

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: obesity; diabetes mellitus; anti-obesity drugs; obesity metabolism; energy balance

Online: 1 September 2021 (17:29:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0562.v1

In vitro 3D Model of Female Reproductive Tract: An Overview and Future Aspect

Arnaud Martino Capuzzo

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: female reproductive tract; organoid; co-culture; crosstalk; blastocyst

Online: 31 August 2021 (11:19:56 CEST)

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Working Paper ARTICLE

Data-Oriented Language Implementation of Lattice-Boltzmann Method for Dense and Sparse Geometries

Tadeusz Tomczak

Subject: Computer Science And Mathematics, Computer Science Keywords: parallel programming; CUDA; GPU; LBM

Online: 31 August 2021 (11:18:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0612.v2

Beyond Journals and Peer Review: Towards a More Flexible Ecosystem for Scholarly Communication

Michael Wood

Subject: Social Sciences, Library And Information Sciences Keywords: Academic journals; Growth of knowledge; Non-peer review; Paradigm change; Peer review; Scholarly communication; Science communication; Simplicity

Online: 30 August 2021 (12:02:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0523.v1

The Distributions of Sums for Shanker, Akash, Ishita, Pranav, Rani, and Ram Awadh

Afshin Yaghoubi

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Akash distribution; Ishita distribution; Pranav distribution; Ram Awadh distribution; Rani ‎distribution; Shanker distribution

Online: 27 August 2021 (13:55:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0487.v1

Barriers and Facilitators of eHealth Adoption among Patients in Uganda – A Quantitative Study

Hasifah Kasujja Namatovu, Agnes Rwashana Semwanga

Subject: Computer Science And Mathematics, Information Systems Keywords: Barriers; Facilitators; eHealth; Adoption; Patients

Online: 25 August 2021 (10:51:48 CEST)

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Working Paper ARTICLE

The Analysis and the Measurement of Poverty: An Interval Based Composite Indicator Approach

Carlo Drago

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: poverty; composite indicators; interval data; symbolic data

Online: 24 August 2021 (15:46:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0472.v1

Internet Addiction and Sleep Problems among Russian Adolescents: A Field School-Based Study

Sergey Tereshchenko, Edward Kasparov, Marina Smolnikova, Margarita Shubina, Nina Gorbacheva, Olga Moskalenko

Subject: Social Sciences, Psychology Keywords: adolescents; Internet addiction; game addiction; social media addiction; sleep problems; daytime sleepiness

Online: 24 August 2021 (14:07:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0442.v1

Energy Metabolism in Relation to Diet and Physical Activity: A South Asian Perspective

Siti Narsito Wulan, Qaisar Raza, Hera Sisca Pramita, Erryana Martati, Jaya Mahar Maligan, Uma Mageshwari, Itrat Fatima, Guy Plasqui

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: energy metabolism; South Asian; diet; physical activity

Online: 23 August 2021 (13:26:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0401.v1

Generation and Mitigation of Conducted Electromagnetic Interference in Power Converters – A Big Picture

Arnold de Beer

Subject: Engineering, Electrical And Electronic Engineering Keywords: Power Converters; Power Electronics; Electromagnetic Interference; EMI; Noise; Differential Mode; DM; Common Mode; CM; Imbalance Difference Model; Boost Converter

Online: 19 August 2021 (10:43:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0379.v1

Life Prediction and Experimental Validation of a 3d Printed Dental Titanium Ti64ELI Implant

Lebogang Clerrence Lebea, Harry Ngwangwa, Dawood Desai, Fulufhelo Nemavhola

Subject: Engineering, Mechanical Engineering Keywords: Fatigue; oblique loading; axial loading; finite element analysis; 3D-printed dental implant

Online: 18 August 2021 (13:54:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0367.v1

Differences in Citation Patterns across Areas, Article Types and Age Groups of Researchers

Marcelo Mendoza

Subject: Social Sciences, Library And Information Sciences Keywords: Citation patterns; Age groups of researchers; Types of publications.

Online: 17 August 2021 (15:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0428.v2

Euler's Totient Function, the Mangoldt Function, and a Sequence of Mertens Function Values

Darrell Cox, Sourangshu Ghosh, Eldar Sultanow

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Mobius function; Mangoldt function; summatory totient function

Online: 17 August 2021 (08:22:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0317.v1

Impacts of COVID-19 on Diverse Farm Systems in Tanzania and South Africa

Hemant G Tripathi, Harriet E Smith, Steven M. Sait, Susannah M. Sallu, Stephen Whitfield, Astrid Jankielsohn, William E Kunin, Ndumiso Mazibuko, Bonani Nyhodo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: COVID-19; Africa; food systems; agriculture

Online: 16 August 2021 (10:47:45 CEST)

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Emerging information on the interactions between the COVID-19 pandemic and global food systems has highlighted how the pandemic is accentuating food crises across Africa. Less clear, however, are how the impacts differ between farming systems. Drawing on 50 key informant interviews with farmers, village leaders and extension officers, in South Africa and Tanzania, we identify the effects of COVID-19 and associated measures to curb the spread of the disease on farming production systems, the coping mechanisms adopted by farmers, and explore their longer-term plans for adaptation. We focus on a diverse range of production systems, from small-scale mixed farming systems in Tanzania, to large-scale corporate farms in South Africa. Our findings highlight how COVID-19 restrictions have interrupted the supply chains of agricultural inputs and commodities, increasing the storage time for produce, decreasing income and purchasing power, and reducing labour availability. Farmers’ responses were heterogeneous, with highly diverse small-scale farming systems and those less engaged with international markets least affected by the associated COVID-19 measures. Large-scale farmers were most able to access capital to buffer short-term impacts, whereas smaller-scale farms shared labour, diversified to subsistence produce and sold assets. However, compounded shocks, such as recent extreme climate events, limited the available coping options, particularly for smaller-scale and emerging farmers. The study highlights the need to understand the characteristics of farm systems to better equip and support farmers, particularly in contexts of uncertainty. We propose that policy actions should focus on (i) providing temporary relief and social support and protection to financially vulnerable stakeholders, (ii) job assurance for farmworkers, and engaging an alternative workforce in farming, (iii) investing in farming infrastructure, such as storage facilities, digital communication tools, and extension services, and iv) supporting diversified agroecological farming systems.

Preprint ARTICLE | doi:10.20944/preprints202108.0303.v2

Ten Simple Rules for FAIR Sharing of Experimental and Clinical Data with the Modeling Community

Matthias König, Jan Grzegorzewski, Martin Golebiewski, Henning Hermjakob, Mike Hucka, Brett Olivier, Sarah Keating, David Nickerson, Falk Schreiber, Rahuman Sheriff, Dagmar Waltemath

Subject: Biology And Life Sciences, Other Keywords: data sharing; FAIR

Online: 19 November 2021 (08:38:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0210.v1

Kidney Pathology and Outcomes in Anca-Associated Vasculitis: Retrospective Analysis of 85 Patients

Elena Zakharova, Anastasiia Zykova, Tatyana Makarova, Eugenia Leonova, Ekaterina Stolyarevich

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: microscopic polyangiitis; granulomatosis with poliangiitis; eosinophilic granulomatosis with poliangiitis; kidney biopsy; pauci-immune focal and segmental necrotizing and crescentic glomerulonephritis; tubular atrophy and interstitial fibrosis; kidney survival

Online: 10 August 2021 (07:59:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0200.v1

Review of Pharmacological Properties of Channa Striatus (Haruan) In Diabetes and Cardiovascular Complications

Ahmad Khusairi Azemi, Sagir Mustapha, Mustapha Mohammed, Aida Hanum Ghulam Rasool, Reezal Ishak, Abdull Manan Mat Jais, Siti Safiah Mokhtar

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: antioxidant; anti-inflammatory; cardiovascular; Channa striatus; diabetes

Online: 9 August 2021 (14:59:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0167.v1

LED Induced Microglial Activation and Rise in Caspase3 Shows Reorganization in the Retina

Boglárka Balogh, Gergely Szarka, Ádám J Tengölics, Gyula Hoffmann, Béla Völgyi, Tamás Kovács-Öller

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: LED; light; retina; microglia; caspase; apoptosis; Bcl-2; BAX; degeneration

Online: 6 August 2021 (14:04:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0104.v1

Exploring Quantitative Metagenomics Studies Using Oxford Nanopore Sequencing: A Computational and Experimental Protocol

Rohia Alili, Eugeni Belda, Phuong Le, Thierry Wirth, Jean-Daniel Zucker, Edi Prifti, Karine Clement

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: quantitative metagenomics; microbiome; obesity; gut microbiota; microbial DNA extraction; sequencing; Simulation; Oxford Nanopore Technologies; MinION

Online: 4 August 2021 (09:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0101.v1

The Smart City Ontology 2.0: Assessing the Components and Interdependencies of City Smartness

Nicos Komninos, Anastasia Panori, Christina Kakderi

Subject: Business, Economics And Management, Accounting And Taxation Keywords: intelligent city; smart city; smart ecosystem; ontology; city smartness

Online: 4 August 2021 (08:38:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0022.v1

Comparative Study and Overview of Field-oriented Control Techniques for 6-phase PMSM

Marek Furmanik, Lukáš Gorel, Daniel Konvičný, Pavol Rafajdus

Subject: Engineering, Automotive Engineering Keywords: permanent-magnet motors; electrical drives; torque and speed control; multiphase machine; 6-phase machine; field-oriented control; multiphase variable speed drive

Online: 2 August 2021 (11:52:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0013.v1

Telework, Hybrid Work and the United Nation’s Sustainable Development Goals: Towards Policy Coherence

Magnus Moglia, John Hopkins, Anne Bardoel

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Telework; hybrid work; working from home; sustainability; UN Sustainable Development Goals; policy coherence

Online: 2 August 2021 (10:09:08 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202107.0667.v1

Hybrid Active-and-Passive Relaying Model for 6G-IoT Greencom Networks with SWIPT

Sumit Gautam, Sourabh Solanki, Shree Krishna Sharma, Symeon Chatzinotas, Björn Ottersten

Subject: Engineering, Automotive Engineering Keywords: 5G and beyond/6G wireless networks; greencom; IoT; passive repeater; relaying systems; SWIPT

Online: 29 July 2021 (14:30:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0642.v1

COVID-19 and Kidney Injury: Could Renin-Angiotensin Components Crosstalk with Immune Responses?

Bernard Nsengimana, Yu Jin, Yuting Jia, Wenqiang Wei, Shaoping Ji

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; RAS; acute kidney injury; immune response

Online: 29 July 2021 (10:20:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0575.v1

Detection and Attribution of Lake Victoria’s Water-Level Fluctuations in a Changing Climate

Obed M. Ogega, James Mbugua, Herbert O. Misiani, Maurice Nyadawa, Enrico Scoccimarro, Hussen S. Endris

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Lake Victoria; Climate change; Return periods; Detection and Attribution; DAMIP; CMIP6

Online: 26 July 2021 (13:42:00 CEST)

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This study investigated the influence of land-use and precipitation change and variability on Lake Victoria’s water-level fluctuations. Extreme precipitation events, corresponding to extreme water-levels, over the lake and its catchment area were identified and their return periods estimated by fitting them into a generalized extreme value (GEV) distribution. Using general circulation models from the 6^th phase of the Coupled Model Intercomparison Project (CMIP6)’s Detection & Attribution Model Intercomparison Project (DAMIP), an assessment of the potential contribution of human-induced climate change on the observed precipitation patterns over the study area was done. The greatest precipitation anomalies for the period 1900-2020 were recorded in 1961’s October-December (OND) season and 2019’s June-August (JJA) and OND seasons, corresponding to the period when the highest water-levels were recorded in Lake Victoria. While land-use change in the study domain was observed, extended and unusually heavy June to December 2019 precipitation bore the greatest responsibility for the 2019/2020 high water-levels in Lake Victoria. The OND precipitation event of 2019 was a 1-in-52-year event compared to the 1961’s 1-in-693 years. Differences in return periods at various parts of the lake imply a high spatial climate variability within the lake itself. An analysis of the fraction of attributable risk (FAR) showed natural variability to have a greater influence on the JJA and OND precipitation patterns over Lake Victoria than human-induced climate change. However, variability over the land area of the study domain was mainly driven by human-induced climate change rather than natural variability, implying a unique climate system over Lake Victoria. Findings from the current study enhance the understanding of Lake Victoria’s water budget and motivate for further research to inform effective strategies on the planning and use of Lake Victoria’s water resources in a changing climate.

Preprint ARTICLE | doi:10.20944/preprints202107.0561.v1

Mid-Latitude Mesospheric Zonal Wave 1 and Wave 2 in Winter 2020–2021

Yu Shi, Oleksandr Evtushevsky, Valerii Shulga, Gennadi Milinevsky, Andrew Klekociuk, Yulia Andrienko, Wei Han

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: zonal planetary wave; polar vortex; mesosphere; stratosphere; major sudden stratospheric warming

Online: 26 July 2021 (10:14:10 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202107.0492.v1

Rochelle Salt Based Ferroelectric and Piezoelectric Composite Produced with Simple Additive Manufacturing Techniques

Etienne Lemaire, Damien Thuau, Jean-Baptiste De Vaulx, Nicolas Vaissiere, Atli Atilla

Subject: Engineering, Automotive Engineering Keywords: ecofriendly; piezoelectric; composite; material; 3Dprinting

Online: 21 July 2021 (12:12:24 CEST)

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Working Paper ARTICLE

Mechanical Design and Performance Analyses of a Rubber-Based Peristaltic Micro-Dosing Pump

Thomas Zehetbauer, Andreas Plöckinger, Carina Emminger, Umut D. Çakmak

Subject: Engineering, Automotive Engineering Keywords: hydraulic pump; micro-dosing; peristaltic; hyper-elasticity; viscoelasticity; holistic design methodology; elastomer compound

Online: 21 July 2021 (10:12:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0455.v1

“Motorcycle Ambulance” the Policy to Promote Health and Sustainable Development in Large Cities

Korakot Apiratwarakul, Takaaki Suzuki, İsmet Çelebi, Somsak Tiamkao, Vajarabhongsa Bhudhisawasdi, Chatkane Pearkao, Kamonwon Ienghong

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: emergency health services; emergency medical services; motorcycles; health policy; cardiac arrest; response time; two-wheelers; ambulances

Online: 20 July 2021 (14:49:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0448.v1

Moral Identity and Subjective Well-being: The Mediating Role of Identity Commitment Quality

Peng Cui, Yanhui Mao, Yufan Shen, Jianhong Ma

Subject: Social Sciences, Psychology Keywords: moral identity; subjective well-being; identity commitment quality; internalization; symbolization

Online: 20 July 2021 (11:52:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0427.v1

Waste LED Lamp Characterization: A Call for More Consistent and Well-Documented Study

Sm Rahman, Bertrand Larratte, Stéphane Pompidou, Thècle Alix

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Solid waste management; LED lamp; characterization protocol; recycling; LED waste management

Online: 20 July 2021 (09:25:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0408.v1

Analysis of Tidal Accelerations in the Solar System and in Extrasolar Planetary Systems

Klaus Paschek, Arthur Roßmann, Michael Hausmann, Georg Hildenbrand

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: tidal forces, numeric simulation, acceleration vectors, multi-planetary system, extrasolar planets/planet systems

Online: 19 July 2021 (11:50:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0379.v1

Epidemiological Surveillance of Eye Disease and People Awareness in the Abruzzo Region, Italy

Leonardo Mastropasqua, Rossella D'Aloisio, Alessandra Mastrocola, Fabiana Perna, Luca Cerino, Loredana Cerbara, Filippo Cruciani, Lisa Toto

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Population screening; eye disease; prevalence; awareness

Online: 16 July 2021 (14:36:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0270.v1

Computer-aided Design of Peptidomimetic Inhibitors of falcipain-3: QSAR and Pharmacophore Models

Boris D. Bekono, Akori Esmel, Brice Dali, Fidele Ntie-Kang, Melalie Keita, Luc Calvin Owono Owono, Eugene Megnassan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: drug design; falcipain; malaria; peptidomimetics; Plasmodium falciparum; virtual screening; pharmacophore.

Online: 12 July 2021 (14:48:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0263.v1

Research on Regional Economic Innovation-driven Development and Spatial Characteristics in Sichuan Province

Hong Wang, Ming-ning Lu, Za-mo Er

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Regional Economic; Innovation-driven; Development; Spatial Characteristics

Online: 12 July 2021 (13:42:16 CEST)

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Working Paper REVIEW

Impact of Climate Change Hazard: Carbon Risk on Stock Returns and Asset Pricing

Ume Salma Akbar, Niaz Ahmed Bhutto, Suresh Kumar Oad Rajput

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Climate change risk; carbon dioxide; asset pricing modeling

Online: 12 July 2021 (12:01:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0203.v1

Polymorphisms of Genes Related to Phase-II Metabolism and the Resistance of Clopidogrel

Abdullah Alkattan, Ahmed alkhalifah, Eman Alsalameen, Fatimah Alghanim, Nashwa Radwan

Subject: Medicine And Pharmacology, Hematology Keywords: Polymorphism; genes; phase-II metabolism; glutathione; clopidogrel resistance

Online: 8 July 2021 (13:30:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0183.v1

Effects of Phenylpyruvate on the Growth Performance and Intestinal Microbiota in Broiler Chicken

Mir Zulqarnain Talpur, Peng Wentong, Yuxian Zeng, Peipei Xie, Jincheng Li, Haijun Zhang, Gang Shu, Qingyan Jiang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: phenylpyruvate; growth performance; intestinal morphology; immunity; cecal microbiota

Online: 8 July 2021 (09:52:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0135.v1

Epigenetics: A Key to Comprehending Biotic and Abiotic Stress Tolerance in Family Poaceae

Veerala Priyanka, Neha Goel, Inderpreet Dhaliwal, Mohit Sharma, Rahul Kumar, Prashant Kaushik

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: epigenetics; epigenetic variation; chromatin changes; omics; climate-resilient crops

Online: 6 July 2021 (11:32:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0132.v1

Perceived Barriers and Facilitators of Adventurous Play in Schools: A qualitative systematic review

Rachel J Nesbit, Charlotte L Bagnall, Kate Harvey, Helen F Dodd

Subject: Social Sciences, Psychology Keywords: child; play; risky play; adventurous play; school; qualitative synthesis

Online: 6 July 2021 (11:27:45 CEST)

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Working Paper ARTICLE

Independently Dose-Responsive Association between Fetuin-a and Lean Nonalcoholic Fatty Liver Disease

Chia-Wen Lu, Yi-Chen Lee, Chien-Hsieh Chiang, Hao-Hsiang Chang, Wei-Shiung Yang, Kuo-Chin Huang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: central obesity; fetuin-A; lean NAFLD; insulin resistance

Online: 5 July 2021 (12:32:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0086.v1

Cost-Benefit Analysis of Flood Management, a Case Study of Jammu and Kashmir

Kowser Ali Jan

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Cost-benefit analysis; nature; flood management; disaster

Online: 5 July 2021 (10:08:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0061.v1

Influence of Sheep Breeds on Feed Intake, Growth Performance, Digestibility and Nitrogen Utilization

Ahmed Mohamed El-Waziry, Gamaleldin M. Mostafa Suliman, Abdullah Nasser Al-Owaimer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sheep breeds; Awassi; Najdi; Harri; Growing; Digestibility; Nitrogen retention

Online: 2 July 2021 (14:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0722.v1

Cytotoxic Evaluation of Hair Relaxers and Straighteners Actives in Human-Derived Skin Cells

Maribanyana Lebeko, Elvis Kidzeru, Ntombenhle Sishi, Jamie Pillaye, Thulisa Mkatazo, Afolake Arowolo, Nonhlanhla Khumalo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hair cosmetic toxicity; Skin models; Chemical hair straighteners actives

Online: 30 June 2021 (09:38:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0700.v1

Recent Advances in Electrochemical Chitosan-Based Chemosensors and Biosensors: Applications in Food Safety

Rita Petrucci, Mauro Pasquali, Francesca Anna Scaramuzzo, Antonella Curulli

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chitosan; nanomaterials; electrochemical chemosensors; electrochemical biosensors; food safety

Online: 29 June 2021 (11:53:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0679.v1

Efficient Simulations of Propagating Flames and Fire Suppression Optimization Using Adaptive Mesh Refinement

Caelan Lapointe, Nicholas T. Wimer, Sam Simons-Wellin, Jeffrey F. Glusman, Gregory B. Rieker, Peter E. Hamlington

Subject: Engineering, Mechanical Engineering Keywords: numerical simulations; adaptive mesh refinement; fire spread; optimization

Online: 28 June 2021 (15:30:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0617.v1

Solid-State Hydrogen Storage: Materials, Systems and the Relevance of a Gender Perspective

Erika Michela Dematteis, Jussara Barale, Marta Corno, Alessandro Sciullo, Marcello Baricco, Paola Rizzi

Subject: Chemistry And Materials Science, Biomaterials Keywords: energy transition; hydrogen; hydrogen storage; metal hydride; complex hydride; hydrogen tank; social impact; gender

Online: 25 June 2021 (11:44:46 CEST)

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This paper aims at addressing the exploitation of solid-state carriers for hydrogen storage, with attention paid both to the technical aspects, through a wide review of the available integrated systems, and to the social aspects, through a preliminary overview of the connected impacts from a gender perspective. As for the technical perspective, carriers to be used for solid-state hydrogen storage for various applications can be classified into two classes: metal and complex hydrides. Related crystal structures and corresponding hydrogen sorption properties are reviewed and discussed. Fundamentals of thermodynamics of hydrogen sorption evidences the key role of the enthalpy of reaction, which determines the operating conditions (i.e. temperatures and pressures). In addition, it rules the heat to be removed from the tank during hydrogen absorption and to be delivered to the tank during hydrogen desorption. Suitable values for the enthalpy of hydrogen sorption reaction for operating conditions close to ambient (i.e. room temperature and 1-10 bar of hydrogen) are close to 30 kJ·molH2 1. The kinetics of hydrogen sorption reaction is strongly related to the microstructure and to the morphology (i.e. loose powder or pellets) of the carriers. Usually, kinetics of hydrogen sorption reaction is rather fast, and the thermal management of the tank is the rate determining step of the processes. As for the social perspective, various scenarios for the applications in different socio-economic contexts of solid-state hydrogen storage technologies are described. As it occurs with the exploitation of other renewables innovative technologies, a wide consideration of the social factors connected to these processes is needed to assess the extent to which a specific innovation might produce positive or negative impacts in the recipient socio-economic system and to explore the potential role of the social components and dynamics in fostering the diffusion of the innovation itself. Attention has been addressed to the gender perspective, in view of the enhancement of hydrogen-related energy storage systems, intended both in terms of the role of women in triggering the exploitation of hydrogen-based storage as well as to the impact of this innovation in their current conditions, at work and in daily life.

Preprint ARTICLE | doi:10.20944/preprints202106.0593.v1

Sex-Specific Differences in Toxicity Following Systemic Paclitaxel Treatment and Localized Cardiac Radiotherapy

Nicole Chmielewski Stivers, Benoit Petit, Jonathan Ollivier, Virginie Monceau, Pelagia Tsoutsou, Ana Quintela Pousa, Xiaoming Lin, Charles Limoli, Marie-Catherine Vozenin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chemotherapy; radiotherapy; sex-specificity

Online: 24 June 2021 (08:47:39 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202106.0505.v1

Attenuated Total Reflection at THz Wavelengths: Peculiarities of Total Internal Reflection and Polariscopy

Meguya Ryu, Soon Hock Ng, Vijayakumar Anand, Stefan Lundgaard, Jingwen Hu, Tomas Katkus, Dominique Appadoo, Zoltan Vilagosh, Andrew Wood, Saulius Juodkazis, Junko Morikawa

Subject: Physical Sciences, Acoustics Keywords: ATR, THz, synchrotron radiation, diagnostics, polariscopy, four polarisation method

Online: 21 June 2021 (11:28:36 CEST)

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Preprint ESSAY | doi:10.20944/preprints202106.0491.v1

Strengths and Weaknesses of Semi-Structured Interviews in Qualitative Research: A Critical Essay

Charles Kakilla

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Semi-structured Interview; SSI; In-depth interview; Strength and Weakness

Online: 21 June 2021 (08:52:20 CEST)

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Working Paper REVIEW

Energy Efficiency, Emissions, Tribological Challenges and Fluid Requirements of Electrified Passenger Car Vehicles

Robert Ian Taylor

Subject: Engineering, Automotive Engineering Keywords: Energy Efficiency; Emissions; Tribology; Lubrication; Battery Electric Vehicles; Hybrid Electric Vehicles; Life Cycle Analysis; Thermal Cooling Fluids

Online: 17 June 2021 (10:46:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0370.v1

Incidence and Characteristics of Retinoblastoma in Poland: The First Nationwide Study 2010-2017

Michał Szymon Nowak, Bożena Romanowska-Dixon, Iwona Grabska-Liberek, Michał Żurek

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: retinoblastoma; eye surgery; chemotherapy; radiotherapy

Online: 14 June 2021 (15:00:47 CEST)

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Retinoblastoma is the most common intraocular paediatric eye cancer. It accounts for approximately 11% of primary cancers occurring in the first age of life, with 95% of diagnoses before 5 years of age [1-3]. Since retinoblastoma is very aggressive, early diagnosis and prompt treatment are vital for children to preserve their sight and life. In western countries in Europe and North America, retinoblastoma is diagnosed early so the chances of saving the patient’s life and preserving vision are good. However, in large regions of Africa and Asia, where the diagnosis of retinoblastoma is delayed, the deadly effect is observed [2-5]. In these regions, socioeconomic factors and poor recognition of the seriousness of the disease result in a high mortality rate of up to 70%. At the same time, the mortality rate in Europe and North America is 3-5 % [2]. Besides, the incidence of retinoblastoma also varies by race and region, from 40 to 60 per million live births, which corresponds to 1 per 16,000 - 24,000 live births, with the greatest disease burden recorded in the countries of Asia and Africa where the highest birth rates are recorded [2,3 However, the nationwide studies of the retinoblastoma epidemiology have been conducted in many countries, such as Sweden, Finland, Netherlands, Singapore, Great Britain, United States of America, Korea and Taiwan, there is a lack of data from Eastern European countries like Poland [1,3-11]. The management of retinoblastoma may also differ between developed and developing countries. The current strategy of retinoblastoma treatment aims to save the life, eye, vision and cosmetics of the child, in order of priority. Medical management of retinoblastoma includes surgical treatment (enucleation), external beam radiotherapy, systemic chemotherapy with or without focal therapies such as cryotherapy, laser photocoagulation and plaque radiotherapy. Recently, intra-arterial and intravitreal chemotherapies have been used to treat retinoblastoma with the ability to save globes that otherwise would have been enucleated [2,3]. The present study aimed to investigate the incidence and characteristics of retinoblastoma in the overall population of Poland in the years 2010-2017 and to report the changes that occurred during that period.

Preprint REVIEW | doi:10.20944/preprints202104.0665.v3

Maternal Supply of Both Arachidonic and Docosahexaenoic Acids is Required for Optimal Neurodevelopment

Sanjay Basak, Rahul Mallick, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Arachidonic acid, 20:4n-6; Brain; Docosahexaenoic acid, 22:6n-3; Fetus; Maternal diet; Cognitive; Infants; Neurodevelopment; Neurogenesis

Online: 14 June 2021 (14:54:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0344.v1

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway

Masaru Tanaka, Fanni Tóth, Helga Polyák, Ágnes Szabó, Yvette Mándi, László Vécsei

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic inflammation; low grade inflammation; immune tolerance; inflammatory factor; kynurenine; kynurenic acid; depression; bipolar disorder; substance use disorder; post-traumatic stress disorder; schizophrenia; autism spectrum disorder

Online: 14 June 2021 (10:06:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0340.v1

Axial Canal Regulates the Processes of Coral Branching and Calcareous Transportation in Acropora

Yixin Li, Tingyu Han, Chunpeng He, Zuhong Lu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Axial canal; reef-building coral; high resolution micro-computed tomography; Acropora muricata; calcareous transportation

Online: 14 June 2021 (09:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0283.v1

Development and Quality Analysis of Instant Soup Mix from Moringa oleifera Pod Powder

Faruk Ansari, Alpana Singh, Sanjay Patidar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Moringa; pods; instant soup mixes; proximate; sensory and storage study

Online: 10 June 2021 (09:08:44 CEST)

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Working Paper ARTICLE

Volatility Spillover between Developed and Developing Countries: The Global Foreign Exchange Market’s Channel

Walid Abass Mohammed

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Foreign Exchange Market, Volatility Spillover, Return Spillover, VAR Framework, Variance Decomposition, Financial Crisis, Financial Interdependence

Online: 8 June 2021 (13:03:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0223.v1

Blockchain-Based Rice Supply Chain Traceability to Ensure Rice Quality and Food Safety

Qi Tao, Adnan Iftekhar, Zhenyu Cai, Xiaohui Cui

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Blockchain; Rice; Supply chain traceability; Quality control

Online: 8 June 2021 (12:34:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0203.v1

Analysis on Sustainability Reporting and Earnings Management Practices. Evidence from an Emerging Economy

Elena Nechita

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainability reporting; earnings management; European Directive 2014/95/EU; non-financial reporting; sustainable development goals (SDGs); empirical research

Online: 8 June 2021 (09:33:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0197.v1

The Symmetries of Quantum and Classical Information. The Ressurected “Ether" of Quantum Information

Vasil Penchev

Subject: Physical Sciences, Acoustics Keywords: confinement; discrete reference frame; still more general principle of relativity; quantum-information conservation; symmetries of information; the ether

Online: 8 June 2021 (08:55:31 CEST)

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The paper considers the symmetries of a bit of information corresponding to one, two or three qubits of quantum information and identifiable as the three basic symmetries of the Standard model, U(1), SU(2), and SU(3) accordingly. They refer to “empty qubits” (or the free variable of quantum information), i.e. those in which no point is chosen (recorded). The choice of a certain point violates those symmetries. It can be represented furthermore as the choice of a privileged reference frame (e.g. that of the Big Bang), which can be described exhaustively by means of 16 numbers (4 for position, 4 for velocity, and 8 for acceleration) independently of time, but in space-time continuum, and still one, 17th number is necessary for the mass of rest of the observer in it. The same 17 numbers describing exhaustively a privileged reference frame thus granted to be “zero”, respectively a certain violation of all the three symmetries of the Standard model or the “record” in a qubit in general, can be represented as 17 elementary wave functions (or classes of wave functions) after the bijection of natural and transfinite natural (ordinal) numbers in Hilbert arithmetic and further identified as those corresponding to the 17 elementary of particles of the Standard model. Two generalizations of the relevant concepts of general relativity are introduced: (1) “discrete reference frame” to the class of all arbitrarily accelerated reference frame constituting a smooth manifold; (2) a still more general principle of relativity to the general principle of relativity, and meaning the conservation of quantum information as to all discrete reference frames as to the smooth manifold of all reference frames of general relativity. Then, the bijective transition from an accelerated reference frame to the 17 elementary wave functions of the Standard model can be interpreted by the still more general principle of relativity as the equivalent redescription of a privileged reference frame: smooth into a discrete one. The conservation of quantum information related to the generalization of the concept of reference frame can be interpreted as restoring the concept of the ether, an absolutely immovable medium and reference frame in Newtonian mechanics, to which the relative motion can be interpreted as an absolute one, or logically: the relations, as properties. The new ether is to consist of qubits (or quantum information). One can track the conceptual pathway of the “ether” from Newtonian mechanics via special relativity, via general relativity, via quantum mechanics to the theory of quantum information (or “quantum mechanics and information”). The identification of entanglement and gravity can be considered also as a ‘byproduct” implied by the transition from the smooth “ether of special and general relativity’ to the “flat” ether of quantum mechanics and information. The qubit ether is out of the “temporal screen” in general and is depicted on it as both matter and energy, both dark and visible.

Preprint ARTICLE | doi:10.20944/preprints202106.0159.v1

Soil Hydrology Process and Sustainable Use of Soil Water Resources in Desert Regions

Zhongsheng Guo

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: run off; deep leakage; Soil water; plant growth; Soil Water Resource Use Limit by plants; Soil Water Carrying Capacity for Vegetation; key period of plant water relationship regulation; sustainable use of soil water resources

Online: 7 June 2021 (09:29:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0158.v1

Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations

Xiangbing Meng, Jason Z. Gao, Sean Michael T Gomendoza, John Li, Shujie Yang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: p53; Wee1; AZD1775; statins

Online: 7 June 2021 (09:29:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0154.v1

Eﬀects of Lorentz Symmetry Breaking and External Potential on a Relativistic Scalar Particle

Faizuddin Ahmed

Subject: Physical Sciences, Particle And Field Physics Keywords: Lorentz symmetry violation; Relativistic wave-equations; scalar potential; electric & magnetic ﬁeld; biconﬂuent Heun’s Eqiuation

Online: 7 June 2021 (08:47:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0126.v1

Attracting and Retaining School Leaders: A Case Study of Two Municipalities in Sweden.

Cresantus Biamba, Signhild Olsson

Subject: Business, Economics And Management, Accounting And Taxation Keywords: municipality; profession; school leaders; retention and working conditions

Online: 4 June 2021 (08:23:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0096.v1

Comparison of Direct Intersection and Sonogram Methods for Acoustic Indoor Localization of Persons

Dominik Schott, Addythia Saphala, Georg Fischer, Wenxin Xiong, Andrea Gabbrielli, Joan Bordoy, Fabian Höflinger, Kai Fischer, Christian Schindelhauer, Stefan Johann Rupitsch

Subject: Engineering, Automotive Engineering Keywords: Presence detection; passive localization; room impulse response; acoustic localization; indoor localization

Online: 3 June 2021 (09:57:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0037.v1

Implementation of NAO Robot Maze Navigation Based on Computer Vision and Collaborative Learning

Daniela Magallán-Ramirez, Areli Rodriguez-Tirado, Jorge David Martínez-Aguilar, Carlos Francisco Moreno-García, David Balderas, Edgar Omar López-Caudana

Subject: Computer Science And Mathematics, Robotics Keywords: robot navigation; computer vision; camera calibration; mapping; path planning; communication; NAO robot; educational innovation; higher education

Online: 1 June 2021 (14:49:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0008.v1

Multiscale Modeling in Smart Cities: A Survey on applications, Current Trends, and Challenges

Asif Khan, Khursheed Aurangzeb, Sheraz Aslam, Musaed Alhussein

Subject: Computer Science And Mathematics, Computer Science Keywords: Multiscale modeling; Multiscale Systems; Megacities; Smart Cities; Multiscale Modeling Applications;

Online: 1 June 2021 (09:39:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0691.v1

Uganda Mountain Community Health System Perspectives and Capacities Towards Emerging Infectious Disease Surveillance

Aggrey Siya, Richardson Mafigiri, Richard Migisha, Rebekah C. Kading

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Alerts; Village Health Teams; Community Based Surveillance; Integrated Disease Surveillance and Reporting; Elgon; Climate Change; One Health

Online: 28 May 2021 (10:20:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0620.v1

The Paradox between Health and Work of the Metallurgical Complex in La Oroya

Israel Mallma Perez, Lita Salazar Vásquez

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Doe Run Peru; socioeconomic policy; public health; systemic freedom; La Oroya

Online: 26 May 2021 (08:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0472.v1

Effect of Storage Conditions on Storability and Antioxidant Potential Of Pears CV. ‘Conference’

Grzegorz P. Łysiak, Krzysztof Rutkowski, Dorota Walkowiak-Tomczak

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rootstock; 1-MCP; cost-effectiveness of technology, controlled atmosphere, cold storage, ORAC, TSS, acidity, firmness

Online: 20 May 2021 (10:12:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0439.v1

Design and Optimization of Microring Resonators Integrated with Graphene Oxide Films for FWM

David Moss

Subject: Physical Sciences, Acoustics Keywords: Four-wave mixing; 2D materials; microring resonator; graphene oxide

Online: 19 May 2021 (10:21:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0324.v1

Brain Morphology and Physical Symptoms: A Population-Neuroimaging Study in 13,250 Pre-Adolescents

Fernando Estévez-López, Hannah H. Kim, Mónica López-Vicente, Jeroen S. Legerstee, Manon H. J. Hillegers, Henning Tiemeier, Ryan Muetzel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cohort studies; Epidemiology; Gray matter; Neuroimaging; Paediatrics; Psychiatric symptoms; QDECR; Vertex-wise analysis.

Online: 14 May 2021 (11:31:23 CEST)

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Physical symptoms are defined as symptoms for which adequate examination does not reveal a sufficient underlying root cause, e.g., pain and fatigue. The extant literature of the neurobiological underpinnings of physical symptoms has been largely inconsistent and primarily consists of (clinical) case-control studies with relatively small samples sizes. Therefore, we studied the association of brain morphology with physical symptoms in pre-adolescents from two independent and population-based cohorts. This study included 2,683 individuals from the Generation R Study (51% girls, 10.1 ± 0.6 years old) and 10,567 pre-adolescents from the ABCD Study (48% girls, 9.9 ± 0.6 years old). High- resolution structural magnetic resonance imaging (MRI) was collected using 3-Tesla MRI systems. Physical symptoms were evaluated using the somatic complaints syndrome scale from the parent-reported school-age version of the Child Behavior Checklist. Linear regression models were fitted for global brain metrics (i.e., cortical and subcortical grey matter volume and total white matter volume) as well as surface-based vertex-wise measures (surface area and cortical thickness). Analyses were initially conducted separately in each cohort and later meta-analysed. No associations were observed in either cohort separately. In the combined vertex-wise meta-analysis of both cohorts; the right hemisphere surface area, most notably the rostral middle frontal gyrus, superior frontal gyrus and anterior cingulate cortex, were related to physical symptoms after correcting for multiple comparisons (cluster area = 1,882 mm2). The present study, which is the most representative and well-powered to date, suggests that surface area, but not other measures of brain morphology, are modestly related to physical symptoms in pre- adolescents. While these effects are subtle, future longitudinal research is warranted to elucidate whether such associations indicate a cause or a consequence of the physical symptoms.

Preprint ARTICLE | doi:10.20944/preprints202105.0243.v1

Action and Entropy in Heat Engines: An Action Revision of the Carnot Cycle

Ivan Robert Kennedy, Migdat Hodzic

Subject: Physical Sciences, Quantum Science And Technology Keywords: Carnot cycle; Caloric; specific heat; entropy; Gibbs potential; vortical entropy; reversible cycle; working fluid, quantum field, relative action, heat engine

Online: 11 May 2021 (11:18:39 CEST)

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Despite the remarkable success of Carnot’s heat engine cycle in founding the discipline of thermodynamics two centuries ago, false viewpoints of his use of the caloric theory in the cycle still linger, limiting his legacy. An action revision of the Carnot cycle can correct this, showing that the heat flow powering external mechanical work is compensated internally with configurational changes in the thermodynamic or Gibbs potential of the working fluid, differing in each stage of the cycle quantified by Carnot as caloric. Action (@) is a property of state having the same physical dimensions as angular momentum (mrv=mr2ω). However, this property is scalar rather than vectorial, including a dimensionless phase angle (@=mr2ωδφ). We have recently confirmed with atmospheric gases that their entropy is a logarithmic function of the relative vibrational, rotational and translational action ratios with Planck’s quantum of action ħ. The Carnot principle shows that the maximum rate of work (puissance motrice) possible from the reversible cycle is controlled by the difference in temperature of the hot source and the cold sink, the colder the better. This temperature difference between the source and the sink also controls the isothermal variations of the Gibbs potential of the working fluid, that Carnot identified as reversible temperature-dependent but unequal exchanges in caloric. Importantly, the engine’s inertia ensures that heat from work performed adiabatically in the expansion phase is all restored to the working fluid during the adiabatic recompression, less the net work performed. This allows both the energy and the thermodynamic potential to return to the same values at the beginning of each cycle, a point strongly emphasized by Carnot. Our action revision equates Carnot’s calorique, or the non-sensible heat later described by Clausius as ‘work-heat’ exclusively to negative Gibbs energy (-G) or quantum field energy. This action field complements the sensible energy or vis-viva heat as molecular kinetic motion and its recognition should have significance for designing more efficient heat engines or better understanding of the heat engine powering the Earth’s climates.

Preprint ARTICLE | doi:10.20944/preprints202105.0192.v1

Table in Gradshteyn and Ryzhik: Derivation of definite integrals of a Hyperbolic Function

Robert Reynolds, Allan Stauffer

Subject: Computer Science And Mathematics, Mathematics Keywords: entries in Gradshteyn and Rhyzik, Lerch function, Logarithm function, Contour Integral, Cauchy, Infinite Integral

Online: 10 May 2021 (13:51:04 CEST)

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