Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with photon irradiation or chemotherapeutic drugs in the management of breast cancer. Studies on combination of HDACi and particle type of radiation remain limited. CUDC-101 is a multitarget inhibitor of Histone deacetylases (HDACs), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2(HER-2). In this paper, the effectiveness of CUDC-101 in enhancing radiation response to protons irradiation was studied in MCF-7, MDA-MB-231 and MCF-10A cell lines, using X-rays as reference radiation. γ-H2AX foci assays showed increased sensitivity to CUDC-101 in MDA-MB-231 cell line compared to the MCF-7 cell line. In both cell lines, induction of apoptosis was enhanced in CUDC-101 pre-treated cells compared to radiation (protons or X-rays) alone. Increased apoptosis was also noted in CUDC-101 pre-treated cells in the MCF-10A cell line. Cell cycle analysis showed increased G2/M arrest by CUDC-101 mono-treatment as well as combination of CUDC-101 and X-irradiation in the MDA-MB-231 cell line. Collectively, the findings indicate that CUDC-101 effectively enhances response to both X-radiation and proton irradiation, in the triple negative MDA-MB-231 cell line. The study highlights that CUDC-101 holds potential in the management of triple negative breast cancer as monotherapy or in combination with X-irradiation.

In order to maintain the best conditions of the building from the first day of opening, explorations of office buildings in the world investigated the approaches of optimizing the building operation and property facilities, whereas building managers often have trouble prioritizing improvements toward their sustainable objectives. The challenge is due to numerous equipment types in the building, which has various durability in years and represents users’ different feelings of importance and satisfaction. When faced with multiple improvement projects, building managers are often unable to determine the order of implementation.Hence, this research applies the Analytic Hierarchy Process (AHP) using TAIPEI 101 Tower as a case study to explore the key factors affecting tenants’ willingness to lease office buildings by distributing questionnaires to real estate experts. By filtering out key indicators related to property facilities that users care about, this study used Importance and Satisfaction Analysis (IS Analysis) to identify items that need urgent improvement. The research revealed that air conditioning is the top priority for improvement through empirical evaluation and weight ranking. This study hopes to establish an evaluation model for facility improvements to help clarify the prioritization and defeat limited resources to projects effectively, which is helpful for sustainable property management.

The electronic structural evolution of LLM-105 crystal and the (101) plane of LLM-105 crystal under different pressures is investigated by the density functional theory (DFT) calculations and the surface properties of seven low-Miller-index planes of LLM-105 crystal were investigated in this study. The result demonstrates that the surface energy of (101) plane of LLM-105 is much smaller when compared with other low-Miller-index planes of LLM-105.In order to further investigate the stability of crystal structure and (101) plane of LLM-105 under different pressures, a series of pressures ranged from 0 GPa to 55 GPa were applied during the DFT calculation, and the result shows that the electronic structures of LLM-105 crystal and the (101) plane changed with the increase of external pressure and the evolution process of (101) plane is different from that of LLM-105 crystal structure.

This study presents a novel Fe-CNs-P/S carbon composite material, synthesized by doping elements P and S into NH2-MIL-101 (Fe) using carbonization method. The material's application in sustainable water treatment was evaluated, focusing on its effectiveness in activating persulfate for pollutant degradation. The research thoroughly investigates the synthesis process, structural characteristics, and performance in degrading pollutants. Results indicate that Fe-CNs-P/S-5 with 50% P and S co-doping is higher than that of other samples, where the degradation rate of TC in 30min is as high as 98.11% under the optimum conditions, that is temperature at 25 ℃, 0.05 g/L of catalyst concentration, and 0.2 g/L of PMS concentration. The composite material demonstrates robust versatility and stability, maintaining high degradation efficiency across multiple organic pollutants, with no significant reduction in catalytic performance after four cycles. Furthermore, the free radical quenching experiments displays that the singlet oxygen 1O2 is the main active species. It is demonstrated that the doping of P and S play a role in the enhancement of PMS activation over the Fe-CNs-P/S catalyst. This material demonstrates remarkable efficacy in treating a range of organic contaminants and exhibits excellent reusability, presenting a promising approach for enhancing sustainability in water treatment applications.

Peroxydisulfate activation has garnered a lot of interest due to its benefits of broad adaptability, strong anti-interference ability, and powerful oxidation capacity. Due to their low cost and potent action, carbon materials are new green catalysts that have garnered interest. In order to effectively degrade organic contaminants in water by activating peroxydisulfate, carbon compounds are currently commonly used. Better metal ions for activating peroxydisulfate include Fe2+ and Co2+, and these metal ions can be encapsulated in carbon compounds made by calcinating metal organic framework（MOFs ）as precursors. The synthesis of carbon compounds from MOF precursors as well as their effectiveness and mechanism in reducing organic pollutants in peroxydisulfate systems. The following are the specific research contents: NH2-MIL-101 (Fe/Co) bimetallic MOFs material was synthesized by hydrothermally altering the Fe3+ to Co2+ ratio, followed by the carbonization of Fe/Co-CNs. XRD, SEM, TEM, FT-IR, and XPS were used to analyze the materials' morphology, structure, and chemical make-up. The results demonstrate that Fe/Co-CNs-2 (Co2+ doping concentration approaches 20%) has a stable three-dimensional carbon structure and effectively incorporated Co ions into the carbon material. The simultaneous encapsulation of both Fe and Co metals by the three-dimensional carbon skeleton ensures material stability and reaction activity. Tetracycline hydrochloride was reported to degrade more quickly in Fe/Co-CNs-2 than in other Co2+ doping concentrations within 30 minutes of peroxymonosulfate（PMS） activation. The degradation rate of Fe/Co-CNs-2 for 20 mg/L TC was determined to be 93.34% within 30 minutes under the following conditions: Fe/Co-CNs-2 concentration of 0.1 g/L, PMS concentration of 0.2 g/L, and pH of 7.33. The catalyst also demonstrates good stability. Last but not least, the Fe/Co-CNs-2 free radical quenching experiment revealed that singlet oxygen (1O2) is the primary active species in the reaction system, and a potential mechanism was examined by combining degradation and XPS analysis.

Probiotics, as defined by the World Health Organization, are live microorganisms that, when consumed in sufficient quantities, provide health benefits to the host. Although some countries have approved specific probiotic species for use in food, safety concerns may still arise with individual strains. Lacticaseibacillus paracasei subsp. paracasei NTU 101 (NTU 101), isolated from the gut of healthy infants, has demonstrated various probiotic effects and shown safety in prior 28-day animal feeding study. To further verify its safety and mitigate potential risks, we performed a comprehensive genotypic and phenotypic safety evaluation in accordance with European Food Safety Authority guidelines for safety assessment through whole genome sequencing and related literature. In this research, minimum inhibitory concentration testing identified NTU 101's resistance to chloramphenicol; however, subsequent gene analysis confirmed no associated risk of resistance. Assessments of safety, including biogenic amine content, hemolytic activity, mucin degradation, and D-lactic acid production, indicated a low level of risk. Additionally, a repeated dose 90-day oral toxicity study in Sprague-Dawley rats revealed no toxicity at a dose of 2000 mg/kg body weight, further supporting the strain's safety for consumption. Based on these comprehensive analyses, NTU 101 is considered safe for regular consumption as a health supplement.