Search | Preprints.org

Preprint CASE REPORT | doi:10.20944/preprints202008.0319.v1

M Mode Ultrasound and Tissue Doppler Imaging to Assess Diaphragm Function in Late Onset Pompe Disease

Paris Meng, Adam Ogna, Abdallah Fayssoil

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: LOPD, diaphragm, ultrasound

Online: 14 August 2020 (10:19:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0293.v1

PhotonLabeler: An Inter-disciplinary Platform for Visual Interpretation and Labeling of ICESat-2 Geolocated Photon Data

Lonesome Malambo, Sorin C. Popescu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: ICESat-2; photon-counting lidar; photon labeling; visualization; ATL03; ATL08; visual interpretation; solar-induced noise

Online: 13 August 2020 (08:08:40 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0241.v1

Technique of Gene Expression Profiles Extraction based on the Complex Use of Clustering and Classification Methods

Sergii Babichev, Jiří Škvor

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: gene expression profiles; lung cancer; clustering; classification; binary classifiers; SOTA clustering algorithm; clustering quality criteria; ROC analysis; fuzzy inference system

Online: 10 August 2020 (08:01:10 CEST)

Show abstract| Download PDF| Share

In this paper, we present the results of the research concerning extraction of informative gene expression profiles from high-dimensional array of gene expressions considering the state of patients' health using clustering method, ensemble of binary classifiers and fuzzy inference system. Applying of the proposed stepwise procedure can allow us to extract the most informative genes taking into account both the subtypes of disease or state of the patient's health for further reconstruction of gene regulatory networks based on the allocated genes and following simulation of the reconstructed models. We used the publicly available gene expressions data as the experimental ones which were obtained using DNA microarray experiments and contained two types of patients' gene expression profiles: the patients with lung cancer tumor and healthy patients. The stepwise procedure of the data processing assumes the following steps: in beginning, we reduce the number of genes by removing non-informative genes in terms of statistical criteria and Shannon entropy; then, we perform the stepwise hierarchical clustering of gene expression profiles at hierarchical levels from 1 to 10 using SOTA clustering algorithm with correlation distance metric. The quality of the obtained clustering was evaluated using complex clustering quality criterion which is considered both the gene expression profiles distribution relative to center of the clusters were these gene expression profiles are allocated and the centers of the clusters distribution. The result of this stage execution was selection of the optimal cluster at each of the hierarchical levels which corresponded to minimum value of the quality criterion. At the next step, we have implemented classification procedure of the examined objects using four well known binary classifiers: logistic regression, support-vector machine, decision trees and random forest classifier. The effectiveness of the appropriate technique was evaluated based on the use of ROC analysis using criteria included as the components the errors of both the first and the second kinds. The final decision concerning extraction of the most informative subset of gene expression profiles was taken based on the use of fuzzy inference system, the inputs of which are the results of the appropriate single classifiers operation and output is the final solution concerning state of the patient's health. To our mind, the implementation of the proposed stepwise procedure of the informative gene expression profiles extraction create the conditions for increasing effectiveness of the further procedure of gene regulatory networks reconstruction and the following simulation of the reconstructed models considering the subtypes of the disease and/or state of the patient’s health.

Preprint ARTICLE | doi:10.20944/preprints202008.0141.v1

Perception, Motivation and Satisfaction of Tourist Women on Their Visit to the City of Cordoba (Spain)

Alexandra Lenis Escobar, Ramón Rueda López, Manuel Pérez-Priego, María de los Baños García-Moreno García

Subject: Business, Economics And Management, Economics Keywords: tourist perception; tourist motivation; tourist satisfaction; gender; segmentation; Cordoba

Online: 6 August 2020 (09:33:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0109.v1

Legal Complexities of Entry, Rescue, Seizure and Disposal of Disaster Affected Companion Animals in New Zealand

Steve Glassey

Subject: Social Sciences, Law Keywords: animal; disaster; law

Online: 5 August 2020 (05:02:17 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Weather Conditions and COVID-19 Incidence in a Cold Climate: A Time-series Study in Finland

Behzad Heibati, Wenge Wang, Niilo Ryti, Francesca Dominici, Alan Ducatman, Zhijie Zhang, Jouni Jaakkola

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Cold Climate; Weather; Finland

Online: 4 August 2020 (15:59:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0074.v1

Clustering of Cardiovascular Disease Patients Using Data Mining Techniques with Principal Component Analysis and K-Medoids

Edy Irwansyah, Ebiet Salim Pratama, Margaretha Ohyver

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: data mining; cardiovascular diseases; cluster analysis; principle component analysis

Online: 4 August 2020 (03:56:19 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0060.v1

COVID-19: Knowledge, Perceptions and Attitudes of Residents in the Northern Region of Ghana, West Africa

Courage Kosi Setsoafia Saba, Joseph Nzeh, Francis Addy, Akosua Bonsu Karikari

Subject: Social Sciences, Area Studies Keywords: COVID-19; knowledge; perception; attitude; Northern Region; Ghana

Online: 3 August 2020 (00:53:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0052.v1

Preservation of Vitamin C and Phenolic Compounds from Umbu (Spondias Tuberosa Arr. Cam.) via Spray Drying

Thais Muniz, Hanndson Araujo, Eudeson G. Paiva Santos, Iara Bezerra de Oliveira, Maria Elita Duarte Martins, Mario Cavalcanti-Mata, Hugo Lisboa, Matheus A. Pasquali

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Spray Drying; Vitamin C; Phenolic Compounds; Preservation; Modeling; Optimization

Online: 2 August 2020 (18:22:59 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0036.v1

Climate Change and Alpine Screes: No Future for Glacial Relict Papaver occidentale (Papaveraceae) in Western Prealps

Yann Fragnière, Loïc Pittet, Benoît Clément, Sébastien Bétrisey, Emanuel Gerber, Michal Ronikier, Christian Parisod, Gregor Kozlowski

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Arctic-alpine flora; Extinction due to climate change; Narrow endemism; Papaver alpinum aggr; Scree species; Species distribution modelling

Online: 2 August 2020 (15:06:03 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Skymask Matching Aided Positioning Using Sky-Pointing Fisheye Camera and 3D City Models in Urban Canyons

Max Jwo Lem Lee, Shang Lee, Hoi-Fung Ng, Li-Ta Hsu

Subject: Engineering, Electrical And Electronic Engineering Keywords: GPS; GNSS; Localization; Navigation; Urban Canyon; Cameras; Image segmentation

Online: 2 August 2020 (12:19:53 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202007.0712.v1

Structures and Functions of Viral 5’ Non-Coding Genomic RNA Domain-I in Enterovirus-B Infections

Marie GLENET, Laetitia HENG, Domitille CALLON, Anne-Laure LEBREIL, Paul-Antoine GRETTEAU, Yohan NGUYEN, Fatma BERRI, Laurent ANDREOLETTI

Subject: Biology And Life Sciences, Virology Keywords: Group-B Enterovirus; RNA domain-I; viral ribonucleoprotein complexes; Enterovirus replication; 5’ terminally deleted viral forms; antiviral innate immune response; type I Interferon

Online: 30 July 2020 (10:00:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0694.v1

Modeling of Stochastic Temperature and Heat Stress directly underneath Agrivoltaic conditions with Orthosiphon Stamineus Crops Cultivation

Noor Fadzlinda Othman, Mohammad Effendy Yaacob, Ahmad Suhaizi Mat Su, Juju Nakasha Jaafar, Hashim Hizam, Mohd Fairuz Shahidan, Ahmad Hakiim Jamaluddin, Guangnan Chen, Adam Jalaludin

Subject: Engineering, Energy And Fuel Technology Keywords: Transpiration; PV Heat Conversion; Plant Heat Stress; Agrivoltaic system; Sustainable Integration; Thermal Analysis

Online: 29 July 2020 (11:20:25 CEST)

Show abstract| Download PDF| Share

This paper shares some new information on the ambient temperature profile and the heat stress occurrences directly underneath ground-mounted Solar Photovoltaic (PV) Arrays (monocrystalline-based) focusing on different temperature levels. A common ground for this work lies on the fact that 10C increase of PV cell temperature results in reduction of 0.5% energy conversion efficiency thus any means of natural cooling mechanism would gain much benefit especially to the Solar Farm operators. Transpiration process plays an important role in the cooling of green plants where in average it could dissipate around 32.9% of the total solar energy absorbed by the leaf making it a good natural cooling mechanism. This condition is relatively applied for herbs specifically for this project, Orthosiphon Stamineus or generally known as Java Tea are used as the high value crops. The thermal process via convective heat and mass exchange of leaves with the environment is relevant for a better understanding of plant physiological processes in response to environmental conversion factors for a wide range of applications. An important fact for plant heat stress with respect to the Ambient temperature is that the range lies between 10 C to 15 C above the surrounding value. This heat stress condition is relatively important and should be modelled in crops-energy integration. Agrivoltaic concept is a system that combines commercial agriculture and photovoltaic electricity generation in the same space. The concept is in line with the Kyoto Protocol and the United Nation Sustainable Development Goals (UN-SDG) which highlights the clean energy and sustainable urban living. The integration of agrivoltaic systems would optimize the yield, improving clean system efficiency and solving the issue of land resource sustainability. The PV bottom surface temperature are the main source of dissipated heat as shown in the thermal images recorded at 5 minutes interval at 3 sampling time. Statistical analysis shows that the Thermal correlations for transpiration process and heat stress occurrences between PV bottom surface and plant height will be an important finding for large scale plant cultivation in agrivoltaic farms.

Preprint ARTICLE | doi:10.20944/preprints202007.0677.v1

Bacterivorous Nematodes Correlate with Soil Fertility and Improved Crop Production in an Organic Minimum Tillage System

Jan H. Schmidt, Johannes Hallmann, Maria R. Finckh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: conservation agriculture; compost; soil quality; bio-test; macro- and micronutrients; free-living nematodes; microbial respiration; microbial biomass

Online: 28 July 2020 (10:31:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0668.v1

Gut Microbiome in Children from Indigenous and Urban Communities in Mexico: Different Subsistence Models Different Microbiomes

Andres Sanchez-Quinto, Daniel Cerqueda-García, Luisa I. Falcón, Osiris Gaona, Santiago Martinez, Javier Nieto, Isaac González-Santoyo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Intestinal microbiome; infant microbiota; diet; westernized; non-westernized; lifestyle; microbial diversity; human health

Online: 28 July 2020 (08:37:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0599.v1

Crisis Self-Efficacy and Work Commitment of Education Workers among Public Schools during COVID-19 Pandemic

Erick Baloran, Jenny Hernan

Subject: Social Sciences, Education Keywords: crisis self-efficacy; work commitment; education workers; public schools; COVID-19 pandemic

Online: 24 July 2020 (14:47:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0577.v1

Mechanistic Modelling of Coronavirus Infections and the Impact of Confined Neighbourhoods on a Short Time Scale

Danish Ahmed, Ali Ansari, Mudassar Imran, Kamaludin Dingle, Naveed Ahmed, Michael Bonsall

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: COVID-19; Coronavirus; SARS-CoV2; Random walks; Population dispersal; Diffusion; Lockdown; Confinement; Movement restrictions; Disease spread; Kuwait

Online: 24 July 2020 (10:57:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0470.v1

Linear and Nonlinear Dynamic Methods towards Investigating Proprioception Impairment in Non-specific Low Back Pain Patients

Seyed Mohammadreza Shokouhyan, Mehrdad Davoudi, Maryam Hoviattalab, Mohsen Abedi, Soha Bervis, Mohamad Parnianpour, Simon Brumagne, Kinda Khalaf

Subject: Engineering, Bioengineering Keywords: Posture control; low back pain; COP; proprioception; Recurrence Quantification Analysis; Vibrator

Online: 20 July 2020 (11:39:23 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0343.v1

Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial

David C. Nieman, Kevin A. Zwetsloot, Andrew J. Simonson, Andrew T. Hoyle, Xintang Wang, Heather K. Nelson, Catherine Lefranc-Millot, Laetitia Guérin-Deremaux

Subject: Biology And Life Sciences, Food Science And Technology Keywords: protein; exercise; muscle damage; creatine kinase; myoglobin; inflammation

Online: 16 July 2020 (06:33:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0323.v1

Multiple Scattering Theory for Strong Scattering Heterogeneous Elastic Continua with Triaxial Inhomogeneities: Theoretical Fundamentals and Applications

Huijing He

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: scattering; heterogeneity; anisotropy; elastic waves; dispersion; attenuation; Mohorovičić discontinuity

Online: 15 July 2020 (09:01:02 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Preventing and Managing Urinary Tract Infections: Enhancing the Role of Community Pharmacists – A Mixed Methods Study

Nathan Peiffer-Smadja, Rosalie Allison, Leah F Jones, Alison H Holmes, Parvesh Patel, Donna M Lecky, Raheelah Ahmad, Cliodna AM McNulty

Subject: Public Health And Healthcare, Other Keywords: Pharmacist; Community; Urinary tract infections; Leaflet; Self-care; General Public; Antimicrobial stewardship

Online: 14 July 2020 (10:53:34 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Community pharmacists are involved in antimicrobial stewardship through self-care advice and delivering medications for uncomplicated infections. Objectives This mixed methods study aimed to identify opportunities to enhance the role of community pharmacists in the management of patients with suspected or confirmed urinary tract infection (UTI). Methods Data collection was through a service user survey (n=51) and pharmacist surveys and semi-structured interviews before (16 interviews, 22 questionnaires) and after (15 interviews, 16 questionnaires) trialling UTI leaflets designed to be shared with patients. Data were analysed inductively using thematic analysis and descriptive tabulation of quantitative data. Results Twenty-five percent (n=13/51) of service users with urinary symptoms sought help from a pharmacist first and 65% (n=33/51) were comfortable discussing their urinary symptoms with a pharmacist in a private space. Community pharmacists were confident as the first professional contact for service users with uncomplicated UTI (n=13/16, 81%), but indicated the lack of a specific patient referral pathway (n=16/16, 100%), the need for additional funding and staff (n=10/16, 62%), and the importance of developing prescription options for pharmacists (5/16, 31%). All community pharmacists reported playing a daily role in controlling antimicrobial resistance by educating service users about viral and bacterial infections and promoting a healthy lifestyle. Enhancing their role will need greater integrated working with general practices and more prescribers based in community pharmacy. Conclusion This study suggests that community pharmacists could play a greater role in the management of uncomplicated UTI. The current reconfiguration of primary care in England with primary care networks and integrated care systems could provide a real opportunity for this collaborative working with potential learning for international initiatives.

Preprint ARTICLE | doi:10.20944/preprints202007.0291.v1

A Dynamics Appraisal of Association among Food Insecurity, Women and Child Health: Evidence from Developing Countries

Shahzad Hameed, Wei Wei, Nazish Chaudhary

Subject: Business, Economics And Management, Economics Keywords: food availability; food access; food utilization; food stability; Asia

Online: 14 July 2020 (05:39:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0277.v1

Survival Outcomes of Metastatic Colorectal Cancer Patients in Brunei Darussalam and the Impact of KRAS Mutations

Datul Damit, Ravi Patnaik, Liling Chaw, Shir Kiong Lu, Telisinghe Pemasiri Upali, Zen Huat Lu, Kenneth Kok, Ya Chee Lim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; survival; KRAS; median; codon; metastasis; sided; tumour

Online: 13 July 2020 (03:03:23 CEST)

Show abstract| Download PDF| Share

Colorectal cancer (CRC) is the third most common cancer, with rising incidence due to lifestyle and diet. 40% of CRC cases are found to have KRAS mutations. In this study, we investigate the survival outcome of metastatic Colorectal cancer mCRC) patients in Brunei Darussalam restrospectively. Chi-squared test was used to compare the survival outcomes of mCRC patients, and Mann-Whitney U test was used to compare the median ages of both groups. Kaplan-Meier survival curves were drawn and logrank test was used to compare the survival outcome between two groups. There was a total of 105 patients with stage IV CRC being treated during the study period. 81.6% (n=62) of mCRC patients were found to have the primary tumours on the left side of the colon. 19 of these 26 (73.1%) mutant KRAS mCRC patients died, while 23 of 50 (46.0%) wild-type KRAS mCRC patients died at the end of the study period, contributing to death rates of 45.2% and 54.8%, correspondingly. 30.3% (n=23) of the study population had a single metastatic site detected (either liver, or lung or any other organs), while 69.7% (n=53) of the 76 mCRC patients had two (double) or more metastatic sites. 69.2% (n=18) and 30.8% (n=8) of the mutant KRAS mCRC patients had mutations within codons 12 and 13, respectively. To our knowledge, this is the first study in Brunei Darussalam to analyse both the survival outcomes of metastatic CRC patients and those of mutant KRAS mCRC patients. Chi-squared analysis showed a significant difference between the survival outcomes of wild-type KRAS and mutant KRAS mCRC patients (p-value = 0.024). There was a significant difference in the survival outcome between the mutant KRAS mCRC patients with RCC and mutant KRAS mCRC with LCC patients. There was no significant difference between the survival outcomes of mutant KRAS patients with mutations in either codon 12 or 13 of the KRAS gene (Table 3). However, there is a significant difference in the median survival periods between the mutant KRAS mCRC patients with mutations in codon 12 and those with mutation in codon 13 of the KRAS gene (p-value = 0.003). In conclusion, we found that mutant KRAS mCRC patients had a significantly poorer OS, which was shown to be worse when the primary tumours were found at the left side of the colon. Mutant KRAS mCRC patients with mutations in codon 12 were found to have shorter survival median periods than those with mutations within codon 13.

Preprint ARTICLE | doi:10.20944/preprints202007.0238.v1

Spatial Variability and Detection Levels for Chlorophyll-A Estimates in High Latitude Lakes Using Landsat Imagery

Filipe Lisboa, Vanda Brotas, Filipe Duarte Santos, Sakari Kuikka, Laura Kaikkonen, Eduardo Maeda

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Ocean colour; phytoplankton ecology; Earth Observation; Inland Waters; Lakes; phenology change

Online: 11 July 2020 (09:59:49 CEST)

Show abstract| Download PDF| Share

Monitoring lakes in high-latitude areas can provide a better understanding of freshwater systems sensitivity and accrete knowledge on climate change impacts. Phytoplankton are sensitive to various conditions: warmer temperatures, earlier ice-melt and changing nutrient sources. Satellite imagery can monitor algae biomass over large areas. The detection of chlorophyll a (chl-a) concentrations in small lakes is hindered by the low spatial resolution of conventional ocean colour satellites. The short time-series of the newest generation of space-borne sensors (e.g. Sentinel-2) is a bottleneck for assessing long-term trends. Although previous studies have evaluated the use of high-resolution sensors for assessing lakes' chl-a, it is still unclear how the spatial and temporal variability of chl-a concentration affect the performance of satellite estimates. We discuss the suitability of Landsat (LT) 30-m resolution imagery to assess lakes' chl-a concentrations under varying trophic conditions, across extensive high-latitude areas in Finland. We use in situ data obtained from field campaigns in 19 lakes and generate remote sensing estimates of chl-a, taking advantage of the long-time span of the LT 5 and 7 archives, from 1984 to 2017. Our results show that linear models based on LT data can explain approximately 50 % of the chl-a interannual variability. However, we demonstrate that the accuracy of the estimates is dependent on the lake's trophic state, with models performing in average twice as better in lakes with higher chl-a concentration (> 20 µg/l) in comparison with less eutrophic lakes. Finally, we demonstrate that linear models based on LT data can achieve high accuracy (R2 = 0.9; p-value < 0.05) in determining lakes' annual mean chl-a concentration, allowing the mapping of the trophic state of lakes across large regions. Given the long time-series and high spatial resolution, LT-based estimates of chl-a provide a tool for assessing the impacts of environmental change.

Preprint ARTICLE | doi:10.20944/preprints202007.0180.v1

Investigation of Cytotoxicity and Cell Uptake of Cationic Beta-Cyclodextrins as Valid Tools in Nasal Delivery

Giovanna Rassu, Silvia Fancello, Marta Roldo, Milo Malanga, Lajos Szente, Rossana Migheli, Elisabetta Gavini, Paolo Giunchedi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cationic cyclodextrin; cyclodextrin polymer; epichlorohydrin cross-linker; nasal delivery; cytotoxicity; cell uptake

Online: 9 July 2020 (08:05:35 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0177.v1

Evaluation of Shrimp Waste Valorization Combining Computer Aided Simulation and Numerical Descriptive Inherent Safety Technique (NuDIST)

Antonio Zuorro, Daylisney Cassiani-Cassiani, Demmy A. Meza-González, Kariana Andrea Moreno-Sader, Ángel Darío González-Delgado

Subject: Engineering, Bioengineering Keywords: Chitosan; Process safety; NuDIST; CAPE; Shrimp

Online: 9 July 2020 (07:49:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0167.v1

Renewable Energy Green Innovation, Fossil Energy Consumption and Air Pollution--- Spatial Empirical Analysis Based on China

Neng Shen, Hui Peng, Yifan Wang

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: renewable energy; energy consumption; air pollution; spatial dubin model; spatial analysis

Online: 9 July 2020 (06:00:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0161.v1

A Study on New Type of Degenerate Poly-Cauchy Polynomials and Numbers of the Second Kind

Waseem Khan

Subject: Computer Science And Mathematics, Mathematics Keywords: Degenerate polylogarithm functions; Degenerate poly-Cauchy polynomials; Degenerate unipoly-Cauchy polynomials

Online: 8 July 2020 (18:51:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0150.v1

A Novel Optimization Algorithm to Create Perennial Calendar System based on Gregorian and International Fixed Calendards

Claude El-Bayeh

Subject: Computer Science And Mathematics, Mathematics Keywords: Gregorian Calendar; weekly-based calendar; original calendar

Online: 8 July 2020 (11:25:27 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202007.0123.v1

The Status of Causality in Biological Databases for Logical Modeling: Data Resources and Data Retrieval Possibilities

Vasundra Touré, Åsmund Flobak, Anna Niarakis, Steven Vercruysse, Martin Kuiper

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: causal interactions; databases; interoperability; biological pathway; logical modeling; computational biology

Online: 7 July 2020 (09:50:40 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0036.v1

Development and Application of a Patient Group Engagement Prioritization Tool for Use in Medical Product Development

Brian Perry, Carrie Dombeck, Jaye Bea Smalley, Bennett Levitan, David Leventhal, Bray Patrick-Lake, Linda Brennan, Kevin McKenna, Zachary Hallinan, Amy Corneli

Subject: Medicine And Pharmacology, Other Keywords: patient engagement; stakeholder engagement; patient group engagement; prioritization tool; patient engagement activities

Online: 3 July 2020 (12:15:23 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0274.v1

Association between Bone Turnover Markers, Leptin and Nutritional Status in Girls with Adolescent Idiopathic Scoliosis (AIS)

Edyta Matusik, Jacek Durmala, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek, Pawel Matusik

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: adolescent idiopathic scoliosis; bone turnover markers; leptin; body composition

Online: 21 June 2020 (14:33:41 CEST)

Show abstract| Download PDF| Share

The link between scoliotic deformity and bone metabolism in adolescent idiopathic scoliosis (AIS) has not been well researched. Moreover, the data concerning the cross-talk between fat tissue content/hormonal activity and bone markers in this group of patients are lacking. The objective of this study was to correlate the extent of scoliotic-curve severity with the bone turnover vs. leptin level and nutritional status in girls with AIS. The study encompassed 77 AIS girls, aged 14.7 ± 2.17 years. Scoliotic curve severity assessed by Cobb’s angle was categorized as mild (10-19o) moderate (20-39º) or severe (≥40º). Corrected height, weight, waist and hip circumferences were measured and body mass index (BMI), corrected height Z-score, BMI Z-score and waist/height ratio (WHtR) were calculated for the entire group. Body composition parameters: fat mass (FAT), fat-free mass (FFM) and predicted muscle mass (PMM) were determined using a bioelectrical impedance analyzer. Bone turnover markers (osteocalcin (OC) and amino terminal of collagen cross-links NTx) and leptin levels were assessed in serum. Multiple regression analysis showed that, OC, NTx (negatively with p<0.05) and leptin (positively with p<0.01) were significantly associated with curve severity in AIS girls. Moreover, Cobb’s angle was positively correlated with W/HtR (p<0.01)and FAT (p<0.05). One-way analysis of variance (ANOVA) revealed significant differences in leptin (p<0.05 vs. mild only), OC (p<0.05 vs. mild and moderate)) and W/HtR (p<0.01 and p<0.05 vs. mild and moderate respectively) between the three AIS severity subgroups. OC was significantly lower in the severe AIS subgroup, while leptin and W/HtR were significantly higher. Significant correlations between leptin and anthropometrical parameters as BMI z-score and W/HtR were shown. Leptin level correlated also significantly with BMI z score (p<0.001), W/HtR (p<0.0001) and body composition parameters (p<0.000001). Moreover, there was a significant negative correlation between NTx and leptin level (p<0.05). Bone metabolism in AIS girls seems to be altered and significantly related to the scoliotic curve severity. Leptin may be a crucial link in the cross-talk between bone turnover and body composition in this group of patients. Further studies concerning this topic are needed.

Preprint ARTICLE | doi:10.20944/preprints202006.0271.v1

Vilfredo De Pascalis, Giuliana Cirillo, Arianna Vecchio, Joseph Ciorciari

Subject: Social Sciences, Behavior Sciences Keywords: ERPs; Autism Spectrum Quotient; face perception; emotion

Online: 21 June 2020 (14:04:53 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202006.0086.v2

An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies

Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies

Online: 14 June 2020 (16:49:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0129.v1

Impact of Lockdown due to COVID-19 Outbreak : Lifestyle Changes and Public Health Concerns in India

Latha Narayanan, Mansi Pandit, Subhro Basu, Arijeet Karmakar, Vanshika Bidhan, Hrithik Kumar, Kousheen Brar

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; Pandemic; Lockdown; Lifestyle changes; Public Health; Society

Online: 10 June 2020 (09:22:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0122.v1

Synergistic Hepatoprotective Interaction between α-Tocopherol and Ascorbic Acid on Paracetamol Induced Liver Damage in Rats

Saidul Islam Khan, Mahmuda Begum, Rama Chowdhury, Md. Mizanur Rahman, Muhammad Asaduzzaman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Hepatoprotective; ascorbic acid; α-tocopherol; paracetamol; ALT; MDA; Histology

Online: 9 June 2020 (11:40:38 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background and objectives: The hepatoprotective activity of vitamin E and C is evident due to their ability of modulating the antioxidant pathway. In this study, we have evaluated the effects of α-tocopherol and ascorbic acid on paracetamol induced liver damage with offsetting various levels of drug treatment following an in vivo experimental protocol on Wistar albino male rats. Materials and Methods: The level of lipid peroxidation as well as histological examination of liver tissues were observed among 50 Wistar albino male rats to evaluate hepatoprotective effect of α-tocopherol and ascorbic acid on hepatocytes. The experiment was divided into 5 groups (10 rats in each group)- Basal control group (Group-I, with propylene glycol), Paracetamol treated control group (Group –II), α-tocopherol pretreated & paracetamol treated group (Group –III), Ascorbic acid pretreated & paracetamol treated group (Group –IV) and Ascorbic acid pretreated & paracetamol treated group (Group –IV). Results: The mean (± SD) Malondialdehyde (MDA) concentration were significantly reduced in α-tocopherol pretreated and paracetamol treated group (P<0.001), Ascorbic acid pretreated and paracetamol treated group (P≤0.05) and combined α-tocopherol with ascorbic acid pretreated & paracetamol treated group (P<0.001). Statistically significant differences in histological findings of rat liver were observed in paracetamol treated control group (P<0.001), ascorbic acid pretreated and paracetamol treated group (P<0.001). The serum alanine aminotransferase (ALT) level was also significantly higher in paracetamol treated group (P<0.001), α-tocopherol pretreated plus paracetamol treated group (P≤0.05) and in ascorbic acid pretreated plus paracetamol treated group (P<0.001). Conclusion: The combined pretreatment of α-tocopherol & ascorbic acid have better hepatoprotective effects than α-tocopherol or ascorbic acid alone against paracetamol induced liver damage. The decrement of free radicals produced by vitamin E could be a better hepatoprotective antioxidant than vitamin C in paracetamol induced toxicity.

Working Paper ARTICLE

Further Results on a Matrix Equality and Matrix Set Inclusions for Generalized Inverses of Matrix Products

Yongge Tian

Subject: Computer Science And Mathematics, Mathematics Keywords: generalized inverse; matrix product; matrix equality; reverse order law; set inclusion; rank equality

Online: 5 June 2020 (14:41:12 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Novel Lockstep-based Approach with Roll-back and Roll-forward Recovery to Mitigate Radiation-Induced Soft Errors

Server Kasap, Eduardo Weber Wächter, Xiaojun Zhai, Shoaib Ehsan, Klaus McDonald-Maier

Subject: Engineering, Electrical And Electronic Engineering Keywords: Lockstep; Reliability; Fault Tolerance; Soft Error Mitigation; Zynq APSoC; ARM Cortex-A Processor; MicroBlaze Processor

Online: 8 August 2020 (04:57:57 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202006.0044.v1

Major Concerns on the Identification of Bat Coronavirus Strain RaTG13 and Quality of Related Nature Paper

xiaoxu lin, Shizhong Chen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Epidemiology; COVID-19; coronavirus; bat; RaTG13; BtCoV/4991; SARS-CoV-2; Pangolin Coronavirus; next generation sequencing

Online: 5 June 2020 (06:17:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0008.v1

Serum 25-Hydroxyvitamin D Concentrations Are Associated With Mental Health and Psychosocial Stress in Young Adults

Li Chen, Haidong Zhu, Gregory A. Harshfield, Frank A. Treiber, Jennifer S. Pollock, David Pollock, Olivia I. Okereke, Shaoyong Su, Yanbin Dong

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: 25-hydroxyvitamin D3; depression, anxiety; perceived stress; hostility

Online: 3 June 2020 (04:55:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0501.v1

Double-Edged Sword of Global Financial Crisis and COVID-19 Pandemic on Crude Oil Stock Returns

Monday Osagie Adenomon, Ngozi G. Emenogu

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Crude oil; Global financial crisis; COVID-19; Stock; Returns; Persistence

Online: 31 May 2020 (20:15:29 CEST)

Show abstract| Download PDF| Share

This study investigates the impact of global financial crisis and the present COVID-19 pandemic on daily and weekly Crude oil futures using four variants of ARMA-GARCH models: ARMA-sGARCH, ARMA-eGARCH, ARMA-TGARCH and ARMA- aPARCH with dummy variables We also investigated the persistence, half-life and backtesting of the models. This study therefore seeks to contribute to the body of literature on the impact of global financial crisis and the present COVID-19 pandemic on crude oil futures market. This investigation of the impact of global financial crisis and the COVID-19 on crude oil futures has not been much studied at present. We obtained and analyzed the daily and weekly crude oil futures from secondary sources. Daily crude oil futures used in this study covers the period from the 4th January 2000 to 27th April 2020 while the weekly crude oil futures covered from 2ndJanuary 2000 to 26th April 2020 . The global financial crisis period covered from 2nd July 2007 to 31st March 2009 and the current COVID-19 pandemic covered from 1st January 2020 to 27th April, 2020. The study used both student t and skewed student t innovations with AIC, goodness-of-test fit and backtesting to select the best model. Most of the estimated ARMA-GARCH models are supported by skewed student t distribution while most of the ARMA-GARCH models exhibited high persistence values in the presence of global financial crisis and the COVID-19 pandemic. In the overall, the estimated ARMA(1,0)-eGARCH(2,1) and ARMA(1,0)-eGARCH(2,2) model for daily crude oil futures and weekly crude oil futures respectively have been significantly impacted by the global financial crisis and the Present COVID-19 pandemic while the preferred estimated models also passed the goodness-of-test fit and backtesting.This study recommends shareholders and investors should think outside the box as crude oil futures tend to be affected by global financial crisis and COVID-19 pandemic while countries also that depend mostly on crude oil are encouraged to diversify their economy in other to survive and be sustained during financial and health crisis.

Preprint ARTICLE | doi:10.20944/preprints202005.0443.v1

Inactivated Platelet Lysate Supports Proliferation and Immunomodulant Characteristics Of Mesenchymal Stromal Cells in GMP Culture Condition

Katia Mareschi, Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Elena Marini, Alessia Giovanna Santa Banche Niclot, Massimiliano Bergallo, Luciana Labanca, Ivana Ferrero, Franca Fagioli

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mesenchymal Stromal Cells; Good Manufacturing Practice; Inactivated Platelet Lysate

Online: 27 May 2020 (08:15:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0412.v1

Τhe February – March 2019 Seismic Swarm Offshore North Lefkada Island, Greece: Microseismicity Analysis and Geodynamic Implications

Anastasios Kostoglou, Vassilios Karakostas, Polyzois Bountzis, Eleftheria Papadimitriou

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: seismic swarm; relocated aftershocks; transition zone; b-value temporal variation; central Ionian Islands (Greece)

Online: 25 May 2020 (16:47:35 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0302.v1

Oxidized and Non-Oxidized Multiwalled Carbon Nanotubes as Materials for Adsorption of Lanthanum(III) Aqueous Solutions

Francisco J. Alguacil, Irene García-Díaz, Esther Escudero Baquero, Olga Rodríguez Largo, Félix Antonio López

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: lanthanum; multiwalled carbon nanotubes; adsorption; recovery

Online: 18 May 2020 (12:35:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0269.v1

Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria

Maria-Lauretta Orji, Nnamdi Onyire, Uche Unigwe, Nnennaya Ajayi, Demian Nwidi, Elizabeth Odey, Joseph Agboeze, Chiedozie Ojide, Fortune Ujunwa, Emeka Onwe, Robinson Onoh, Precious Madume

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: case fatality; Lassa virus; pattern; positivity rate; outcome; ribavirin

Online: 16 May 2020 (16:41:27 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint CASE REPORT | doi:10.20944/preprints202005.0190.v1

Deteriorating Atrioventricular Block in COVID-19 Suspected Patient after Receiving Initial Dose of Azythromycin and Hydroxychloroquine

Billy Aditya Pratama, Afik Maulana Rachman, Vita Yanti Anggraeni, Erika Maharani, Ika Trisnawati, Bambang Sigit Riyanto, Anggoro Budi Hartopo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; azythromycin; hydroxychloroquine; atrioventricular block

Online: 11 May 2020 (10:10:42 CEST)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0162.v1

Joint Space Redundancy Resolution of Serial Link Manipulator: An Inverse Kinematics and Continuum Structure Numerical Approach

Toshit Jain, Jinesh Kumar Jain, Debanik Roy

Subject: Engineering, Mechanical Engineering Keywords: inverse kinematics; DLS system; redundancy resolution; redundant manipulator; continuum structure; manipulator positioning

Online: 9 May 2020 (10:12:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0133.v1

Analysis of Lower-hand Wrist Flexion and Twist of the Mallet Head in a Croquet Shot

Jenny Clarke

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Wrist injury; motion capture; croquet; technique analysis; overuse

Online: 7 May 2020 (15:16:48 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

When COVID-19 Will Decline in India? Prediction by Combination of Recovery and Case Load Rate

Atanu Bhattacharjee, Mukesh Kumar, Kamalesh Kumar Patel

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: COVID-19; recovery rate; case load rate; India

Online: 4 May 2020 (02:17:29 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0510.v1

A Structural View at SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

Maria Romano, Alessia Ruggiero, Flavia Squeglia, Giovanni Maga, Rita Berisio

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID19; RNA replication; protein structure; infectious disease

Online: 29 April 2020 (12:52:18 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202004.0479.v1

Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes

Mujib Ullah

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Stem cells banks; Cancer; Cytosine deaminase; Tumor; Gene therapy

Online: 27 April 2020 (04:49:54 CEST)

Show abstract| Download PDF| Share

Working Paper HYPOTHESIS

The First, Comprehensive Immunological Model of COVID-19: Implications for Prevention, Diagnosis, and Public Health Measures

Paolo Matricardi, Roberto Dal Negro, Roberto Nisini

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antibodies; COVID-19; glycans; immunoglobulin M; SARS-CoV-2; pneumonia; prediction; protection

Online: 24 April 2020 (10:25:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0425.v1

Non-Coding RNAs and Innovative Therapeutic Strategies to Target the 5’UTR of SARS-CoV-2

Antonella Baldassarre, Alessandro Paolini, Stefania Paola Bruno, Cristina Felli, Alberto Eugenio Tozzi, Andrea Masotti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; 5’UTR; miRNAs; RNAi; GapmeRs

Online: 24 April 2020 (04:16:20 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0398.v1

Psychosocial, and Socio-Economic Crisis in Bangladesh due to COVID-19 Pandemic: A Perception-Based Assessment

Mashura Shammi, Md. Bodrud-Doza, Abu Reza Md. Towfiqul Islam, Md. Mostafizur Rahman

Subject: Social Sciences, Cognitive Science Keywords: COVID-19; Perception-based questionnaire; principal component analysis (PCA); Linear regression model; social panic; social conflict

Online: 22 April 2020 (09:55:38 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202004.0377.v1

The Dynamics of Humoral Immune Responses Following SARS-CoV-2 Infection and the Potential for Reinfection

Paul Kellam, Wendy Barclay

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; immune response; antibodies

Online: 21 April 2020 (06:56:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0336.v1

Role of Socially-Equitable Economic Development in Creating Resilient and Sustainable Systems: COVID-19-Related Reflections

Adjo Amekudzi-Kennedy, Samuel Labi, Brian Woodall, Greg Marsden, Emily Grubert

Subject: Engineering, Civil Engineering Keywords: COVID-19; pandemic; economic development; equity; socially-equitable development; resilient and sustainable infrastructure; resilient and sustainable communities; disaster management

Online: 19 April 2020 (07:09:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0322.v1

Food Supplements in the Treatment of Male Infertility: A Critical Review on Their Formulations and Use

Andrea Garolla, Gabriel Cosmin Petre, Francesco Francini-Pesenti, Luca De Toni, Amerigo Vitagliano, Andrea Di Nisio, Carlo Foresta

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fertility; male reproduction; semen parameters; supplements; ingredients

Online: 19 April 2020 (04:18:39 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0313.v1

Estimating the Beginning and End Dates of Covid-19 for Several Countries Using the Logistic Model

Ademir Xavier Jr

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: covid-19; forecast; epidemic; logistic model; pandemic

Online: 19 April 2020 (02:21:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0306.v1

Dealing Hybrid Model Appling in the Selection and Prioritization of Software Requirements Using Verbal Decision Analysis

Paulo A. M. Barbosa, Plácido R. Pinheiro, Francisca R. V. Silveira, Marum S. Filho

Subject: Computer Science And Mathematics, Information Systems Keywords: requirements planning; search-based software engineering; verbal decision analysis

Online: 17 April 2020 (17:10:16 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0249.v1

Introducing Fractal Dimension for Interlaminar Shear and Tensile Strength Assessment of Mechanically Interlocked Polymer-Metal-Interfaces

Erik Saborowski, Philipp Steinert, Axel Dittes, Thomas Lindner, Andreas Schubert, Thomas Lampke

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymer-metal-hybrid; surface pretreatment; mechanical interlocking; roughness evaluation; interlaminar shear strength; interlaminar tensile strength; fractal geometry; laser structuring

Online: 15 April 2020 (14:21:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0229.v1

Design and Test of a Student Hybrid Rocket Engine with an External Carbon Fiber Composite Structure

Francesca Heeg

Subject: Engineering, Mechanical Engineering Keywords: hybrid rocket engine; sounding rocket; carbon fiber composite; engine test; total impulse; lightweight design

Online: 15 April 2020 (05:10:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0123.v1

Dynamic Modeling and Adaptive Controlling in GPS-Intelligent Buoy (GIB) Systems Based on Neural-Fuzzy Networks

Dangquan Zhang, Muhammad Aqeel Ashraf, Zhenling Liu, Wan-Xi Peng, Mohammad Javad Golkar, Amir Mosavi

Subject: Computer Science And Mathematics, Computer Science Keywords: positioning system; neural-fuzzy network; adaptive control; buoys

Online: 8 April 2020 (08:51:47 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Volume Variations of Small Inland Water Bodies from a Combination of Satellite Altimetry and Optical Imagery

Christian Schwatke, Denise Dettmering, Florian Seitz

Subject: Environmental And Earth Sciences, Environmental Science Keywords: water levels; surface areas; volume variations; hypsometry; bathymetry; lakes; reservoirs; remote sensing

Online: 8 April 2020 (06:41:59 CEST)

Show abstract| Download PDF| Share

In this study, a new approach for estimating volume variations of lakes and reservoirs using water levels from satellite altimetry and surface areas from optical imagery is presented. Both input data sets, namely water level time series and surface area time series, are provided by DGFI-TUM‘s Database of Hydrological Time Series of Inland Waters (DAHITI). The approach is divided into three parts. In the first part, a hypsometry model based on the new modified Strahler approach is computed by combining water levels and surface areas. The hypsometry model describes the dependency between water levels and surface areas of lakes and reservoirs. In the second part, a bathymetry between minimum and maximum surface area is computed. For this purpose, DAHITI land-water masks are stacked using water levels derived from the hypsometry model. Finally, water levels and surface areas are intersected with the bathymetry to estimate a time series of volume variations in relation to the minimum observed surface area. The results are validated with volume time series derived from in-situ water levels in combination with bathymetric surveys. In this study, 28 lakes and reservoirs located in Texas are investigated. The absolute volumes of the investigated lakes and reservoirs vary between 0.099 km³ and 6.448 km³. The correlation coefficients of the resulting volume variation time series with validation data vary between 0.80 and 0.99. Overall, the relative errors with respect to volume variations vary between 2.8% and 14.9% with an average of 8.3% for all 28 investigated lakes and reservoirs. When comparing the resulting RMSE with absolute volumes, the absolute errors vary between 1.5% and 6.4% with an average of 3.1%. This study shows that volume variations can be calculated with a high accuracy which depends essentially on the quality of the used water levels and surface areas. In addition, this study provides a hypsometry model, high-resolution bathymetry and water level time series derived from surface areas based on the hypsometry model. All data sets are publicly available on the Database of Hydrological Time Series of Inland Waters (DAHITI, https://dahiti.dgfi.tum.de).

Preprint ARTICLE | doi:10.20944/preprints202003.0467.v1

Which Are the Effects of Hard and Soft Equality Constraints on the Iterative Outlier Elimination Procedure?

Vinicius Francisco Rofatto, Marcelo Tomio Matsuoka, Ivandro Klein, Mauricio Roberto Veronez, Luiz Gonzaga Da Silveira, Jr.

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: constraints; hypothesis testing; outlier detection; Monte Carlo; quality control; geodesy

Online: 31 March 2020 (22:59:14 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202003.0423.v1

Variable Structural Networks at the Active Site of the SARS-CoV and SARS-CoV2 Main Proteases

Navaneethakrishnan Krishnamoorthy

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; SARS-CoV2; SARS-CoV; variable residues; main protease; structural analysis

Online: 29 March 2020 (06:22:06 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Badging for Sustainable Development: Applying EdTech Micro-Credentials for Advancing SDGs amongst Mountain and Pastoralist Societies

Randall Gwin, Marc Foggin

Subject: Social Sciences, Education Keywords: education; skills development; online distance learning; credentials; open badges; blockchain; sustainable livelihoods; sustainable mountain development; traditional knowledge; culture; Kyrgyzstan; Central Asia

Online: 27 March 2020 (03:07:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0317.v1

Analysis of Eddy Formation and Heat Transfer Process in Weld Pool during Plasma Keyhole Arc Welding

Nguyen Van Anh, Ngo Huu Manhh, Tam Thanh, Dang Tran, Hai T. Nguyen

Subject: Engineering, Mechanical Engineering Keywords: Plasma keyhole arc welding; X-ray observation; Heat transportation; Eddy; Convective pattern

Online: 20 March 2020 (13:03:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0294.v1

Evaluation of Open Access Precipitation and Temperature Products Using SWAT in Shiyang River Basin, Northwest China

Gengxi Zhang, Xiaoling Su, Olusola O. Ayantobo, Kai Feng, Jing Guo

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: remote sensing; precipitation; temperature; GSMaP_Gauge; CHIRPS; CFSR; SWAT

Online: 19 March 2020 (02:37:37 CET)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202003.0221.v1

Binding Epitopes of 2019-nCoV Proteins for Perspective Diagnostic and Therapeutic Applications: Insights from Computational Approaches

Ilda D'Annessa, Filippo Marchetti, Giorgio Colombo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; 2019-nCoV; diagnostics; antibodies; structural vaccinology

Online: 12 March 2020 (15:02:49 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202003.0220.v1

3D Printing for Ecology and Evolution: A Hands-on Guide to Turn an Idea into Reality

Nicolas Schtickzelle, Estelle Laurent, Thibaut Morel-Journel

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: 3D printing; 3D scanning; customized ecological objects; methods; stereolithography; open-source lab

Online: 12 March 2020 (14:46:07 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

The Cytosolic Phospholipase A2α N-Terminal C2 Domain Binds and Oligomerizes on Membranes with Positive Curvature

Katherine E. Ward, Ranjan Sengupta, James P. Ropa, Robert V. Stahelin

Subject: Biology And Life Sciences, Biophysics Keywords: cytosolic phospholipase A2; electron microscopy; C2 domain; Golgi; membrane bending; membrane curvature; oligomerization

Online: 12 March 2020 (04:10:52 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0179.v1

Multi-Physical Design and Resonant Controller Based Trajectory Tracking of the Electromagnetically Driven Fast Tool Servo

Imran Hussain, Wei Xia, Dongpo Zhao, Peng Huang, Zhiwei Zhu

Subject: Engineering, Mechanical Engineering Keywords: fast tool servo; voice coil motor; flexure mechanism; resonant controller

Online: 11 March 2020 (04:04:49 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0127.v1

Combining Experimental Evolution and Genomics to Understand How Seed Beetles Adapt to a Marginal Host Plant

Alex Rêgo, Samridhi Chaturvedi, Amy Springer, Alexandra M. Lish, Caroline L. Barton, Karen M. Kapheim, Frank J. Messina, Zachariah Gompert

Subject: Biology And Life Sciences, Insect Science Keywords: plant-insect interaction; host shift; parallel evolution; detoxification; experimental evolution; population genomics; genome-wide association mapping; gene expression; Callosobruchus maculatus

Online: 8 March 2020 (01:52:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0126.v1

Evaluating the Pricing Strategy for Change Orders between General Contractors and Subcontractors Using ET-SD Model

Chien-Liang Lin, Yu Che Lai

Subject: Engineering, Architecture, Building And Construction Keywords: change order; pricing; game theory; evolutionary stable strategy (ESS); system dynamics

Online: 8 March 2020 (01:19:49 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202003.0084.v1

Single-diode Models of PV Modules: A Comparison of Conventional Approaches and Propose a Novel Model

Tuyen Nguyen-Duc, Huy Nguyen-Duc, Thinh Le-Viet, Hirotaka Takano

Subject: Engineering, Electrical And Electronic Engineering Keywords: Single-diode model; Five-parameter model; Photovoltaic panels; Analytics method

Online: 5 March 2020 (11:41:58 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0075.v1

Identification of Metabolite and Lipid Profile in a Segregating Peach Population Associated with Mealiness in Peach

Victoria Lillo-Carmona, Alonso Espinoza, Karin Rothkegel, Miguel Rubilar, Ricardo Nilo-Poyanco, Romina Pedreschi, Reinaldo Campos-Vargas, Claudio Meneses

Subject: Biology And Life Sciences, Plant Sciences Keywords: chilling injury; mealiness; metabolomics; lipidomics; biomarker

Online: 5 March 2020 (02:42:26 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0056.v1

A Chemically Safe Way to Produce Insect Biomass for Possible Application in Feed and Food Production

Truzzi Cristina, Anna Annibaldi, Federico Girolametti, Leonardo Giovannini, Paola Riolo, Sara Ruschioni, Ike Olivotto, Silvia Illuminati

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Hermetia illucens prepupae; Black soldier fly; coffee silverskin; microalgae; toxic metals; bioaccumulation; chemical hazard

Online: 4 March 2020 (09:48:16 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0023.v1

Carbon and Biodiversity Outcomes under Divergent Management Scenarios in Shifting Cultivation Landscapes in the Upland Philippines

Sharif A. Mukul, John Herbohn, Jennifer Firn, Nestor Gregorio

Subject: Environmental And Earth Sciences, Environmental Science Keywords: shifting cultivation; Philippines; biodiversity; carbon; REDD+

Online: 2 March 2020 (02:27:00 CET)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202002.0242.v2

Potential Therapeutic Agents for COVID-19 Based on the Analysis of Protease and RNA Polymerase Docking

Yu-Chuan Chang, Yi-An Tung, Ko-Han Lee, Ting-Fu Chen, Yu-Chun Hsiao, Hung-Ching Chang, Tsung-Ting Hsieh, Chan-Hung Su, Su-Shia Wang, Jheng-Ying Yu, Shang-shung Shih, Yu-Hsiang Lin, Yin-Hung Lin, Yi-Chin Ethan Tu, Chun-Hua Hsu, Hsueh-Fen Juan, Chun-Wei Tung, Chien-Yu Chen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; molecular docking; HIV protease inhibitor; nucleotide analogues

Online: 29 February 2020 (12:43:40 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0216.v2

In-Stream Energy by Tidal and Wind-Driven Currents: An Analysis for the Gulf of California

Vanesa Magar, Victor M. Godínez, Markus S. Gross, Manuel López-Mariscal, Anahí Bermúdez-Romero, Julio Candela, Luis Zamudio

Subject: Environmental And Earth Sciences, Oceanography Keywords: tidal power density; in-stream renewable energy; peak spring tide flow; annual energy production; Gulf of California

Online: 24 February 2020 (03:14:28 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202002.0283.v1

Emerging Understanding of Etiology and Epidemiology of the Novel Coronavirus (COVID-19) infection in Wuhan, China

Daibing Zhou, Peng Zhang, Chen Bao, Youzhi Zhang, Ning Zhu

Subject: Biology And Life Sciences, Virology Keywords: Etiology; Epidemiology; COVID-19; Wuhan

Online: 19 February 2020 (11:58:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0268.v1

Stratosphere–Troposphere Exchange and O₃ Decline in the Lower Stratosphere over Irene SHADOZ Site, South Africa

Thumeka Mkololo, Nkanyiso Mbatha, Sivakumar Venkataraman, Nelson Begue, Gerrie Coetzee, Casper Labuschagne

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: ozone enhancement; Irene; ozone decline; potential vorticity; ozonesondes

Online: 18 February 2020 (11:25:41 CET)

Show abstract| Download PDF| Share

This study aims to investigate the Stratosphere-Troposphere Exchange (STE) events and ozone trends over Irene (25.5°S, 28.1°E). Twelve years of ozonesondes data (2000–2007, 2012–2015) from Irene station operating in the framework of the Southern Hemisphere Additional Ozonesodes (SHADOZ) was used to study the troposphere (0–16 km) and stratosphere (17– 28 km) ozone (O₃) vertical profiles. Ozone profiles were grouped into three categories (2000–2003, 2004–2007 and 2012–2015) and average composites were calculated for each category. Fifteen O₃ enhancement events were identified over the study period. These events were observed in all seasons (one event in summer, four events in autumn, five events in winter and five events in spring), however, they predominantly occur in winter and spring. The STE events presented here are observed to be influenced by the Southern Hemisphere polar vortex. During the STE events, the advected potential vorticity maps assimilated using Modélisation Isentrope du transport Méso–échelle de l’Ozone Stratosphérique par Advection (MIMOSA) model for the 350 K (~12–13 km) isentropic level indicated a transport of high latitude air masses which seems to be responsible for the reduction of the O₃ mole fractions at the lower stratosphere over Irene which takes place at the same time with the enhancement of ozone in the upper troposphere. In general, the stratosphere is dominated by higher Modern Retrospective Analysis for Research Application (MERRA-2) potential vorticity (PV) values compared to the troposphere. However, during the STE events, higher PV values from the stratosphere were observed to intrude the troposphere. Ozone decline was observed from 12 km to 24 km with highest decline occurring from 14 km to 18 km. An average decrease of 6.0 and 9.1% was calculated from 12 to 24 km in 2004–2007 and 2012–2015 respectively. The observed decline occurred in the upper troposphere and lower stratosphere with winter and spring showing more decline compared with summer and autumn.

Working Paper ARTICLE

Characterization of Essential Fatty Acid Semicarbazide (EFASC) from Linum usitatissium as a Safe and Effective Adjuvant

Mayyada Darweesh, Ahmad Hady, Hayat salman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: essential fatty acid semi carbazide; ID50; IL-4; IL-12

Online: 18 February 2020 (11:15:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0238.v1

Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons

Magdalena Meyer, Kerstin Kuffner, Julia Winter, Inga D. Neumann, Christian H. Wetzel, Benjamin Jurek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: oxytocin; cellular morphology; neurite outgrowth; neurite retraction; autism; MEF2A; CRISPR-Cas; hyperconnectivity

Online: 17 February 2020 (03:44:01 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0233.v1

Wind Speed Prediction Using a Hybrid Model of the Multi-Layer Perceptron and Whale Optimization Algorithm

Saeed Samadianfard, Sajjad Hashemi, Katayoun Kargar, Mojtaba Izadyar, Ali Mostafaeipour, Amir Mosavi, Narjes Nabipour

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: wind power; machine learning; hybrid model; prediction; whale optimization algorithm

Online: 17 February 2020 (02:22:05 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0202.v1

Forage Performance and Detection of Marker Trait Associations with Potential for Napier Grass (Cenchrus Purpureus) Improvement

Ermias Habte, Meki S. Muktar, Asebe Abdena, Jean Hanson, Alieu M. Sartie, Alemayehu Teressa Negawo, Juarez Machado, Franscisco ledo, Chris S. Jones

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Napier grass; elephant grass; EMBRAPA; forage yield; feed quality; marker trait association

Online: 15 February 2020 (15:01:37 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0163.v1

The Observation Path Problems and the Formation Conditions of the Elevated Layer of Black Carbon Aerosol

Lianji Jin, Liang Lin, Deping Ding, Delong Zhao, Bin Zhu, Qingfei Zhai, Zheng Liu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: black carbon aerosol; aerosol layer; vertical distribution; numerical simulation; WRF-Chem

Online: 13 February 2020 (10:13:31 CET)

Show abstract| Download PDF| Share

Studies on the detection of layers with elevated black carbon aerosol (BC) concentrations and the formation conditions of these layers help understand the vertical distribution of BC concentrations, which will provide a basis for the assessment of climate effects and early BC pollution warnings. By using the Weather Research and Forecasting with Chemistry (WRF-Chem) numerical model, we performed a numerical simulation analysis on the authenticity of strong elevated BC concentration layers that were detected by an aircraft in the mixing layer over Harbin, China, which is a high-emission area, on a clear sunny afternoon in the early heating period of 2016. We then discuss possible problems and solutions when non-vertical paths are used to detect the vertical distribution of BC concentrations. Finally, we discuss the favorable conditions for the formation of elevated BC concentration layers by weak vertical flow. The results show that the horizontal variability of BC concentration in the mixing layer in the observation area in Harbin was sufficiently large during the measurement. This produced a false elevated layer, as detected by the aircraft during one round of spiral flight in the mixing layer. The root mean square of the horizontal distribution of BC concentration did not change with height in the mixing layer during the daytime, but it decreased with the thickness of the mixing layer and was higher in the mixing layer than in the free atmosphere. Therefore, the thinner the mixing layer, in which the vertical distribution of the BC concentration is detected in an inclined path, the stronger interference of the horizontal variability on the detected results. When a spiral flight detection path is used, the aircraft should fly at least two rounds in the mixing layer. In the daytime, due to strong turbulence in the mixing layer, weak vertical uplift is not favorable for the occurrence of elevated BC concentration layers in the mixing layer. In the nighttime, if weak vertical uplift is well matched with the BC concentration or its vertical gradient, elevated BC concentration layers can be formed in the atmosphere. Compared with upper layers far from the ground, nighttime elevated layers are easier to form in lower layers near the ground because high BC concentrations or large vertical gradients are more likely to occur in the lower layers. Both cases facilitate the occurrence of large vertical upward transport rates of BC.

Preprint ARTICLE | doi:10.20944/preprints202002.0083.v1

Adherence to Mediterranean Diet Related with Physical Fitness and Physical Activity in Schoolchildren Aged 6-13

José Francisco López-Gil, Javier Brazo-Sayavera, Antonio García-Hermoso, Juan Luis Yuste-Lucas

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Cardiorespiratory Fitness; Muscle Strength; Feeding Patterns; Life Style; Children

Online: 6 February 2020 (10:27:07 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0082.v1

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

Joanna Szopinska-Tokov, Sarita Dam, Jilly Naaijen, Prokopis Konstanti, Nanda Rommelse, Clara Belzer, Jan Buitelaar, Barbara Franke, Esther Aarts, Alejandro Arias Vasquez

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: gut microbiota; ADHD; 16S rRNA gene; Inattention

Online: 6 February 2020 (10:25:29 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0062.v1

Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors

Darren Isaacs, Sello Given Mikasi, Adetayo Emmanuel Obasa, George Mondinde Ikomey, Ruben Cloete, Graeme Brandon Jacobs

Subject: Biology And Life Sciences, Virology Keywords: Integrase; HIV-1; Naturally occurring polymorphism; diversity; Molecular Modelling; Molecular Docking

Online: 5 February 2020 (11:02:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201909.0043.v3

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Daniel Missailidis, Sarah Annesley, Claire Allan, Oana Sanislav, Brett Lidbury, Donald Lewis, Paul Fisher

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry

Online: 3 February 2020 (09:34:29 CET)

Show abstract| Download PDF| Share

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic condition characterized by exacerbation of symptoms after exertion (post-exertional malaise or “PEM”), and by fatigue whose severity and associated requirement for rest are excessive and disproportionate to the fatigue-inducing activity. There is no definitive molecular marker or known underlying pathological mechanism for the condition. Increasing evidence for aberrant energy metabolism suggests a role for mitochondrial dysfunction in ME/CFS. Our objective was therefore to measure mitochondrial function and cellular stress sensing in actively metabolising patient blood cells. We immortalized lymphoblasts isolated from 51 ME/CFS patients diagnosed according to the Canadian Consensus Criteria and an age- and gender-matched control group. Parameters of mitochondrial function and energy stress sensing were assessed by Seahorse extracellular flux analysis, proteomics, and an array of additional biochemical assays. As a proportion of the basal oxygen consumption rate (OCR), the rate of ATP synthesis by Complex V was significantly reduced in ME/CFS lymphoblasts, while significant elevations were observed in Complex I OCR, maximum OCR, spare respiratory capacity, nonmitochondrial OCR and “proton leak” as a proportion of the basal OCR. This was accompanied by a reduction of mitochondrial membrane potential, chronically hyperactivated TOR Complex I stress signalling and upregulated expression of mitochondrial respiratory complexes, fatty acid transporters and enzymes of the β-oxidation and TCA cycles. By contrast, mitochondrial mass and genome copy number, as well as glycolytic rates and steady state ATP levels were unchanged. Our results suggest a model in which ME/CFS lymphoblasts have a Complex V defect accompanied by compensatory upregulation of their respiratory capacity that includes the mitochondrial respiratory complexes, membrane transporters and enzymes involved in fatty acid β-oxidation. This homeostatically returns ATP synthesis and steady state levels to “normal” in the resting cells, but may leave them unable to adequately respond to acute increases in energy demand as the relevant homeostatic pathways are already activated.

Preprint ARTICLE | doi:10.20944/preprints202002.0021.v1

PbMoO₄Synthesis from Ancient Lead and Its Single Crystal Growth for Neutrinoless Double Beta Decay Search

Archad Khan, Pabitra Aryal, Hongjoo Kim, Moo Hyun Lee, Yeongduk Kim

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: ancient Pb; synthesis; single crystal growth; scintillation; thermally stimulated luminescence

Online: 3 February 2020 (06:06:07 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202001.0370.v1

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

Mariya Ivanovska, Zakee Abdi, Marianna Murdjeva, Danielle Macedo, Annabel Maes, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: eotaxin; immune marker; neuroinflammation; ageing; neuro-psychiatric disorder

Online: 30 January 2020 (14:42:45 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint TECHNICAL NOTE | doi:10.20944/preprints202001.0311.v1

Assessment of the Atmosphere Composition after Washing, Gas-Freeing and Aerating Processes in Vessel Cargo Tanks

Jerzy Herdzik

Subject: Engineering, Marine Engineering Keywords: vessel cargo holds; tank washing; gas-freeing; aerating; atmosphere composition; assessment of safe atmosphere

Online: 26 January 2020 (07:43:21 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202001.0284.v1

Religious Beliefs and Public Pro-Environmental Behavior in China: the Mediating Role of Environmental Risk Perception

Sheng Zeng, Lin Wu, Tianyuan Liu

Subject: Social Sciences, Religion Keywords: Religious beliefs; Public pro-environmental behavior; Environmental risk perception; China

Online: 24 January 2020 (14:35:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202001.0244.v1

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice

Dolors Puigoriol-Illamola, Mirna Martínez-Damas, Christian Griñán-Ferré, Mercè Pallàs

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Stress; epigenetics; senescence; cognition; age-related cognitive decline; Alzheimer’s disease; SAMP8; SAMR1; oxidative stress; inflammation; autophagy

Online: 21 January 2020 (11:44:35 CET)

Show abstract| Download PDF| Share

Search Results

39808 articles found