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Preprint REVIEW | doi:10.20944/preprints202109.0511.v1

Oxygen, pH, Lactate, and Metabolism- How Old Knowledge and New Insights Might be Combined for New Wound Treatment

Herbert Leopold Haller, Frank Sander, Sebastian Philipp Nischwitz, Daniel Popp, Matthias Rapp, Bernd Hartmann, Mehmet Demircan, Lars Peter Kamolz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Wound; chronic wound; hypoxia; Lactate; Acidosis; Alkalosis; neoangiogenesis; ECM; Polylactide; polylactide membranes

Online: 30 September 2021 (12:18:52 CEST)

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: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Preprint ARTICLE | doi:10.20944/preprints202109.0502.v1

Biomarkers of Angiogenesis in Hepatocellular Carcinoma: A Novel Sunshine Road

Krizia Pocino, Cecilia Napodano, Gabriele Ciasca, Mariapaola Marino, Nicoletta De Matthaeis, Luca Miele, Francesca Gulli, Raffaele Saporito, Gian Ludovico Rapaccini, Umberto Basile

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatocellular carcinoma; cirrhosis; neoangiogenesis factors

Online: 29 September 2021 (16:04:06 CEST)

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Working Paper REVIEW

Current Status and Perspectives on the Application of CRISPR/Cas9 Gene-Editing System to Develop a Low-Gluten, Non-Transgenic Wheat Variety

Anil K. Verma, Sayanti Mandal, Aadhya Tiwari, Chiara Monachesi, Giulia Naspi Catassi, Akash Srivastava, Simona Gatti, Elena Lionetti, Carlo Catassi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: CRISPR/Cas9; celiac disease; wheat; sgRNA; gluten; low-immunogenic wheat

Online: 29 September 2021 (15:39:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0495.v1

NUTM1-Rearranged Neoplasms: A Heterogeneous Group of Primitive Tumors with Expanding Spectrum of Histology and Molecular Alterations: An Updated Review

Wenyi Luo, Todd Stevens, Phillip Stafford, Markku Miettinen, Zoran Gatalica, Semir Vranic

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NUTM1 gene; NUT protein; Neoplasms; Pathogenesis; Therapy

Online: 29 September 2021 (12:17:31 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0492.v1

An Inherited Cancer Syndrome Due to a Germline Monoallelic EGFR Mutation with Loss of Heterozygosity in Lung and Breast Tumors

Hanifeh Mirtavoos-Mahyari, Farbod Bahreini, Hassan Vahidnezhad

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Adenocarcinoma of lung; Ductal carcinoma; Breast Neoplasms; ErbB receptors; Germ cells

Online: 29 September 2021 (11:41:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0404.v2

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 29 September 2021 (09:56:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0479.v1

Analysis of the Causes of Cerebral Palsy in Kazakhstan

Saule Issenova, Nagima Mamedalieva, Gani Bodykov, Ayat Assemov, Balzira Bishhekova

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cerebral palsy; perinatal risks; children; pregnancy; childbirth

Online: 28 September 2021 (21:54:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0464.v1

Systematic Review and Meta-Analysis of the Use of Hyaluronic Acid Injections to Restore Interproximal Papillae

Arturo Sanchez-Perez, Tania Rosa-Vela, Bibiana Mateos-Moreno, Alfonso Jornet-Garcia, Carlos Navarro-Cuellar

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: aesthetics; gingiva; hyaluronic acid; injections; surgical procedures; minimally invasive

Online: 28 September 2021 (11:08:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0441.v1

Genomic Risk Factors for Cervical Cancer

Dhanya Ramachandran, Thilo Dörk

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cervical cancer; cervical dysplasia, HPV, HLA, GWAS, genetic susceptibility, meta-analysis, SNP, eQTL, Papillomavirus

Online: 24 September 2021 (15:28:14 CEST)

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Working Paper REVIEW

A Generalizable One Health Framework for the Control of Zoonotic Diseases

Ria Ghai, Ryan Wallace, James Kile, Trevor Shoemaker, Antonio Vieira, Maria Negron, Sean Shadomy, Julie Sinclair, Grace Goryoka, Stephanie Salyer, Casey Barton Behravesh

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: One Health; zoonotic disease; zoonotic disease control; anthrax; brucellosis; rabies; rift valley fever; zoonotic influenza

Online: 24 September 2021 (14:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0436.v1

Incision and Prediction of Risk Factors Related to Surgical Site Infection Following Cesarean Section in Chinese Women

Qiuxiang Huang

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cesarean Section; surgical site infection; premature rupture of membrane

Online: 24 September 2021 (13:00:37 CEST)

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Working Paper ARTICLE

p53 Antibodies as a Diagnostic Marker for Cancer: a Metanalysis

Navid Sobhani, Giandomenico Roviello, Alberto D'Angelo, Raheleh Roudi, Praveen Kumar Neeli, Daniele Generali

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Meta-analysis; p53 wild type antibodies; p53 mutant antibodies; cancer survival prognostic factor.

Online: 24 September 2021 (12:46:26 CEST)

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Importance: p53 is an unequivocal tumor suppressor altered in half cancers. The immune system produces systemic p53 autoantibodies (p53 Abs) in many cancer patients. Objective: The focus of this systemic review and meta-analysis is on the prognostic value of p53 Abs expressed in the serum of patients with solid tumors. Data Sources: All the clinical investigations were searched on PubMed, MBase and Cochrane from 1993 reporting the first study until May 2021. Study Selection: Studies were included that met the following criteria: 1) participants with cancer; 2) outcome results expressed in relation to the presence of a p53 antibody; 3) a primary outcome (disease free survival, overall survival or progression free survival) expressed as hazard ratio (HR). The following exclusion criteria were used: 1) insufficient data available to evaluate outcomes; 2) animal studies; 3) studies with less than 10 participants. 1333 potentially relevant articles; studies as duplicates, non-patients studies or reviews were excluded. After viewing the titles and abstracts of the 52 remaining studies, the full texts of 34 studies were retrieved and 12 studies were included in the analysis. Data Extraction and Synthesis: PRISMA guidelines were used for abstracting and assessing data quality and validity by three independent observers. The summary estimates were generated using a fixed-effect model (Mantel–Haenszel method) or a random-effect model (DerSimonian–Laird-method) depending on the absence or presence of heterogeneity (I2). Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population size of patients with solid tumors, as determined before data collection. Results: In total 12 clinical studies and of which 2094 patients were included and it was determined that p53-wt Abs expression in the serum significantly correlated with a worse survival of cancer patients (95% CI 1.48 [1.24, 1.77]; p<0.00001). On the contrary, data from literature indicated that there was a potential association between p53-mut Abs antibodies with better survival. Conclusions and Relevance: This is the first meta-analysis proving the diagnostic utility of p53-Abs for cancer patients, predicting a worse outcome. The serum-p53 value (s-p53-value) could be useful for future theranostics.

Preprint REVIEW | doi:10.20944/preprints202109.0432.v1

Cancer: More Than a Geneticist’s Pandora’s Box

Kritika Saxena, Ayalur Raghu Subbalakshmi, Prakash Kulkarni, Mohit Kumar Jolly

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Non-genetic heterogeneity; multistability; drug-tolerant persisters; phenotypic plasticity; biological noise; epithelial-mesenchymal plasticity; PAGE4

Online: 24 September 2021 (12:44:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0431.v1

mRNA Transcriptomic Profiling of Human Hepatocellular Carcinoma Cells HepG2 Treated with Catharanthus roseus-Silver Nanoparticles

Nur Asna Azhar, Siti Aishah Abu Bakar, Marimuthu Citartan, Nor Hazwani Ahmad

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: C. roseus; HepG2; silver nanoparticles; AgNPs; mRNA; transcriptomic; gene expression; oxidative stress; apoptosis; cell cycle.

Online: 24 September 2021 (12:44:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0429.v1

Hepatic Arterial Infusion Chemotherapy with Cisplatin Versus Sorafenib for Intrahepatic Advanced Hepatocellular Carcinoma: A Propensity Score-Matched Analysis

Yuki Zaizen, Masahito Nakano, Kazuta Fukumori, Yoichi Yano, Kota Takaki, Takashi Niizeki, Kotaro Kuwaki, Masaru Fukahori, Takahiko Sakaue, Sohei Yoshimura, Mika Nakazaki, Ryoko Kuromatsu, Shusuke Okamura, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Yu Noda, Naoki Kamachi, Hironori Koga, Takuji Torimura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; hepatic arterial infusion chemotherapy; cisplatin; sorafenib; multikinase inhibitors; risk factors; propensity score-matched analysis

Online: 24 September 2021 (12:38:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0424.v1

Microfluidic Lab-On-a-Chip based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells

Elisa Lambert, Rémi Manczak, Elodie Barthout, Sofiane Saada, Elena Porcù, Francesca Maule, Barbara BESSETTE, Giampietro Viola, Luca Persano, Claire DALMAY, Fabrice Lalloué, Arnaud POTHIER

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: high frequency dielectrophoresis; glioblastoma cells; single cell manipulation; microfluidic point-of-care device; cancer stem cells

Online: 24 September 2021 (11:11:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0418.v1

Disposal Practices of Unused Medication Among Pharmacists in Libya

Ahmed Atia

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Take-back Program; Prescription Disposal; Pharmacist Awareness

Online: 24 September 2021 (08:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0417.v1

Prevalence, Causes and Associated Factors for Postpartum Haemorrhage (Pph) At St. Joseph Referral Hospital Peramiho-Songea, Tanzania; A Hospital-Based Retrospective Cross-Sectional Study.

Samson Mvandal, Coletha Kindimba

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Haemorrhage; Prevalence; postpartum; Postpartum haemorrhage; Peramiho; Songea.

Online: 24 September 2021 (08:20:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0530.v2

Persistence of Anti-SARS-CoV-2 Antibodies Six Months After Infection in an Outbreak With Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study

Salvador Domènech-Montoliu, Joan Puig-Barberà, Maria Rosario Pac-Sa, Paula Vidal-Utrillas, Marta Latorre-Poveda, Alba Del Rio-González, Sara Ferrando-Rubert, Gema Ferrer-Abad, Manuel Sánchez-Urbano, Laura Aparisi-Esteve, Gema Badenes-Marques, Belen Cervera-Ferrer, Ursula Clerig-Arnau, Claudia Dols-Bernad, Maria Fontal-Carcel, Lorna Gomez-Lanas, David Jovani-Sales, Maria Carmen Leòn-Domingo, Maria Dolores Llopico-Vilanova, Mercedes Moros-Blanco, Cristina Notari-Rodríguez, Raquel Ruíz-Puig, Sonia Valls-López, Alberto Arnedo-Pena

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; antibodies; cohort; population-based; body mass index; ECLIA

Online: 23 September 2021 (11:10:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0397.v1

The Story of Life’s Quality of Patients with Hypertentions and Its Complication

Amelia Rumi, Rudi Safarudin, Ririen Hardani, Dwi She Dewi Melinency, Nur Indah Sari, Khildayanti S, Lilies Handayani, Nurulhuda Rahman, Ismail Setyopranoto, Sitti Rahmawati

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Hypertension management; Complications of cardiovascular; Quality of Life

Online: 23 September 2021 (09:03:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0366.v1

Genetic Predisposition and Chemotherapeutic Approaches Including Oncolytic Virus for the Treatment of Prostatic Adenocarcinoma

Faiza Naseer, Tahir Ahmad, Kousain Kousar, Salik Kakar, Rabia Gul

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Docetaxel; Paclitaxel; Oncolytic Poliovirus; PVSRIPO; Sipuleucel

Online: 21 September 2021 (14:21:19 CEST)

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Among the leading causes of cancer mortality, prostatic adenocarcinoma (PaC) is at second to lung carcinoma, but it is the most commonly happening non-cutaneous malignancy in elderly men in the world. Therapeutic options for PaC depend on age, growth & stage of malignancy, the desired outcomes and shortcomings of available treatment, estimated cost and patient compliance. Patients older than 60 years with a sluggish localized tumor may be placed on active surveillance, otherwise go with transurethral resection of the prostate (TURP), prostate artery embolization (PAE) and pelvic lymphadenectomy with/without radiation therapy. For metastatic PC androgen-deprivation therapy is an option with or without surgery. These agents decline the body’s testosterone production or block its activity by gonadotropin- releasing hormone (GnRH) analogues including leuprolide acetate and goserelin acetate implant. The hormone’s activity can be stopped by androgens antagonist such as flutamide, bicalutamide and nilutamide along with chemotherapeutic agents, such as taxanes (e.g., docetaxel, paclitaxel) but after all the disease relapses in 20-30% of patients. So, new immunological or vaccine-based therapeutic moieties have been investigated to meet the objective of providing selectivity to cancerous cells and desired therapeutic outcomes with less/no harmful effects to normal cells. The chimeric version, oncolytic poliovirus and human rhinovirus i.e. PVSRIPO is most promising feature in cancer therapeutics and activate innate immunity by neutrophils infiltration via PAMP & DAMP pathways while Sipuleucel-T expresses major histocompatibility complex (MHC) which can stimulate CD4+ helper T-cells and CD8+ cytotoxic T-cells and ultimately activate the acquired immunity against cancer cells. In this article, we have discussed the role of genetic predisposition and chemotherapeutic approaches including oncolytic poliovirus for the treatment of PaC in order to better understanding of tumor biology and mechanisms involved in chemotherapeutic drugs based resistance.

Preprint HYPOTHESIS | doi:10.20944/preprints202109.0360.v1

Geometric Basis of Action Potential of Skeletal Muscle Cells

Qing Li

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: action potential; skeletal muscle cells; synaptic connection of neurons; space curved manifolds; time curved manifolds

Online: 21 September 2021 (12:04:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0359.v1

Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature

James Clark, Simona Piccirella, Rakez Kayed, Giulia Abate, Daniela Uberti, Paul Kinnon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: p53; post-translational modifications; alzheimer's disease

Online: 21 September 2021 (12:01:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0355.v1

Neonatal Pneumothorax- Five Years of Experience in a Tertiary Care Center

Miljana Z Jovandaric, Svetlana J Milenkovic, Ivana R Babovic

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; therapy; pneumothorax

Online: 21 September 2021 (11:09:28 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0349.v1

The Colon Transcriptome Explorer (CoTrEx) 2.0: a Reference Web-Based Resource for Exploring Population-Based Normal Colon Gene Expression

Virginia Díez-Obrero, Ferran Moratalla-Navarro, Christopher Dampier, Matthew Devall, Robert Carreras-Torres, Graham Casey, Victor Moreno

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: RNA-Seq; bioinformatics; web application; gene expression; alternative splicing; visualization; molecular epidemiology

Online: 20 September 2021 (16:56:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0346.v1

A Predictive Test of Outflow Enhancement by Ab Interno Trabeculectomy

Raoul Verma-Fuehring, Mohamad Dakroub, Hong Han, Jost Hillenkamp, Nils A. Loewen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: goniopuncture; ab interno trabeculectomy; porcine eyes; glaucoma; predictive test

Online: 20 September 2021 (16:34:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0345.v1

Exploring the Societal Burden of Endometriosis on Women: a Metaethnography

Olivia C. Nwankudu, Israel Oluwaseyidayo Idris, Francis Ifeanyi Ayomoh, Uju Onyes

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometriosis; qualitative research; gynaecology; infertility; illness experience; health service

Online: 20 September 2021 (16:14:24 CEST)

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Working Paper REVIEW

Microbiota-Immune Interactions in Ulcerative Colitis and Colitis-Associated Cancer, and Emerging Microbiota-Based Therapies

Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ulcerative colitis; inflammatory bowel disease; pediatrics; FMT; probiotics; synbiotics; antibiotics; prebiotics; fecal microbiota transplant; colitis-associated cancer; colorectal cancer; CAC; CRC; dysbiosis

Online: 20 September 2021 (14:20:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0349.v2

Cost Implications of Menstrual Hygiene Management in Nigeria and Its Associated Impacts

Esther Ajari, Temidayo Abass, Esther Ilesanmi, Yusuff Adebisi

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Menstrual Hygiene Management; Menstrual pads; Menstruation; Nigeria; Period poverty; Sustainable Development Goals

Online: 20 September 2021 (10:37:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0314.v1

Prevalence of Multidrug Resistance Mycobacterium Tuberculosis (MDR-TB) Using GeneXpert Assay in Northern Sudan, How Serious is the Situation?

Sufian Khalid Noor, Mohamed Osman Elamin, Ziryab Imad Mahmoud, Mohammed Salah, Taqwa Anwar, Ahmed A. Osman, Hatim Abdullah Natto

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: GeneXpert; MDR-TB; Prevalence; River Nile State; Sudan

Online: 17 September 2021 (12:41:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0296.v1

Comparative Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii in vitro and in Pregnant Mice Infected with T. gondii Oocysts

Jessica Ramseier, Dennis Imhof, Nicoleta Anghel, Kai Hänggeli, Richard Betteck, Vreni Balmer, Luis-Miguel Ortega-Mora, Roberto Sánchez-Sánchez, Ignacio Ferre, Richard K Haynes, Andrew Hemphill

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: quinolone; decoquinate; Toxoplasma gondii; tachyzoites; bradyzoites; oocysts; vertical transmission; proliferation; resistance

Online: 16 September 2021 (16:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0295.v1

Eating Disorder Symptoms and Body Image in Adolescents from Public Schools in Brazil

Roges Ghidini Dias, Ricardo Rodrigo Rech, Ricardo Halpern

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Obesity; Eating Disorder; Body Image; Adolescents.

Online: 16 September 2021 (16:34:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0290.v1

Changes in Alienation in Physical Education Classes, School Happiness, and Future Healthy Life Expectancy After the COVID-19 Pandemic in Korean Adolescents

Seung-Man Lee, Jung-In Yoo, Hyun-Su Youn

Subject: Medicine And Pharmacology, Other Keywords: adolescents; alienation in PE class; school happiness; future healthy life expectancy; COVID-19 pandemic

Online: 16 September 2021 (13:55:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0289.v1

BRD9 Expression, Alteration, Survival And Pathway Analysis In 11 Independent Prostate Cancer Cohorts

Nafisa Barma, Timothy C Stone, Lina Maria Carmona Echeverria, Susan Heavey

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: BRD9; Prostate Cancer; SWI/SNF; Survival; pathways; signal transduction; human cohorts; targeted therapy

Online: 16 September 2021 (13:51:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0288.v1

Role of Diet in Modification of Gut Microbiota in Obesity: Review of Recent Literature

Umama Khan, S M Niazur Rahman, Nazmun Nahar Alam

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diet; Obesity; Gut microbes; High-fiber diet; High fat diet

Online: 16 September 2021 (13:50:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0287.v1

Anti-Cancer Drug Screening with Microfluidic Technology

Mojdeh Monjezi, Milad Rismanian, Hamidreza Jamaati, Navid Kashaninejad

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: drug screening; monodrug or combinatorial drug screening; anti-cancer

Online: 16 September 2021 (13:46:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0281.v1

Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations

Alexander Panossian, Sara Abdelfatah, Thomas Efferth

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Red Ginseng; Ginsenoside Rg5; Gene expression; IPA pathways; Network pharmacology; Transcriptomics

Online: 16 September 2021 (11:47:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0275.v1

Big Data Approach to Large Scale Molecular Dynamics Simulations: Necessity and Inevitability for Drug Design

Dheeraj Chitara, Sanjeev B. S.

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cloud infrastructure; Spark; Molecular Dynamics simulations; Drug design.

Online: 16 September 2021 (11:02:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0267.v1

Analysis of Management of Newborns With Critical CHD at Preoperative Stage

Berkin Turkulov, Altyn Aringazina, Kairat Kuatbekov, Vitalii Pak, Ayat Assemov

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: CHD; newborn; management; organization; cardiac surgery

Online: 15 September 2021 (14:55:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0263.v1

The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia After Laparoscopic and Open Gastrectomy in Gastric Cancer Patients

Tomaz Jagric

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: serum leptin; nutritional status; laparoscopic gastrectomy

Online: 15 September 2021 (14:15:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0261.v1

Essential Oil of Lippia origanoides H.B.K.: A Promising Compound Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Aldenora Maria Ximenes Rodrigues, Brenda Nayranne Gomes dos Santos, Ranyelison Silva Machado, Rubens Renato de Sousa Carmo, Matheus Pedrosa de Oliveira, Antônia Maria das Graças Lopes Citó, Maria das Graças Freire de Medeiros Carvalho, Paulo Tércio dos Santos Leite

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Acetylcholinesterase; Dementia; Essencial oil

Online: 15 September 2021 (13:14:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0258.v1

Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

Alexander Panossian, Sara Abdelfatah, Thomas Efferth

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Red Ginseng; HRG80TM; Ginsenoside Rg5; Gene expression; IPA pathways; Network pharmacology,; Transcriptomics

Online: 15 September 2021 (12:36:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0335.v2

Gender Differences in Urothelial Bladder Cancer. Effects of Natural Killer Lymphocyte Immunity

Charles T. Lutz, Lydia Livas, Steven R Presnell, Morgan Sexton, Peng Wang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urothelial bladder cancer; Natural Killer Cells; Androgens; Immunosuppression; X Chromosome

Online: 15 September 2021 (12:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0248.v1

Task-fMRI Group and Functional Connectivity Analysis of the Brain During Faradarmani Consciousness Field Connection

Mohammad Ali Taheri, Sara Torabi, Noushin Nabavi, Fatemeh Modarresi-Asem, Majid Abbasi Sisara, Ali Rezaei, Parisa Maftoun, Farid Semsarha

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Consciousness Field; functional connectivity; task fMRI

Online: 14 September 2021 (15:54:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0235.v1

Coarsened Exact Matching of Excisional to Plasma-Ablative Ab Interno Trabeculectomy

Mohamad Dakroub, Raoul Verma-Fuehring, Alicja Strzalkowska, Jost Hillenkamp, Yousef Al Yousef, Nils A. Loewen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; TrabEx; Trabectome; ab-interno trabeculectomy; prognosis; intraocular pressure

Online: 14 September 2021 (11:01:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0229.v1

Rapid Intraoperative Detection of Residual Glioma Cell in Resection Cavity Walls Using a Compact Fluorescence Microscope

Jiro Akimoto, shinjiro Fukami, Megumi Ichikawa, Kenta nagai, Michihiro Kohno

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: intraoperative photodiagnosis; malignant glioma; fluorescence-guided surgery; intraoperative cytology; fluorescence microscope

Online: 14 September 2021 (10:02:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0228.v1

Faecal Microbial Transplantation in Critically Ill Patients – Structured Review and Perspectives

Ivana Cibulková, Veronika Řehořová, Jan Hajer, Frantisek Duska

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: gut microbiota; critically ill; faecal microbial transplantation; multiorgan

Online: 14 September 2021 (09:52:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0221.v1

Three-Dimensional Finite Element Investigation Into Effects of Implant Thread Design and Loading Rate on Stress Distribution in Dental Implants and Anisotropic Bone

Dawit Bogale Alemayehu, Yeau Ren Jeng

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: quasi-static load; abutment screw; dental implant; finite element method; dynamic load; mesiodistal

Online: 13 September 2021 (15:55:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0197.v1

Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in E. Coli and K. Pneumoniae, A. Baumanii and P. Aeruginosa: A Global Ecological Analysis

Chris Kenyon

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: One-health; food-animals; E. coli; K. pneumoniae; Acinetobacter; P. aeruginosa; fluoroquinolones; antimicrobial resistance; antibiotic consumption

Online: 13 September 2021 (09:55:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0192.v1

Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: an Integrated Analysis of Preclinical and Clinical Data

Roberto Giugliani, Ana Maria Martins, Torayuki Okuyama, Yoshikatsu Eto, Norio Sakai, Kimitoshi Nakamura, Hideto Morimoto, Kohtaro Minami, Tatsuyoshi Yamamoto, Mariko Yamaoka, Toshiaki Ikeda, Sairei So, Kazunori Tanizawa, Hiroyuki Sonoda, Mathias Schmidt, Yuji Sato

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: neuronopathic mucopolysaccharidosis; Hunter syndrome; mucopolysaccharidosis II; idu-ronate-2-sulfatase; enzyme replacement therapy; neurodegeneration; neurocognitive impairment; pabinafusp afa; blood brain barrier

Online: 10 September 2021 (15:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0187.v1

Effect of Smoking on Contralateral Suppression of Distortion Product Oto Acoustic Emissions (DPOAEs)

Sindhuja Nadella

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Smoking; DPOAEs; Contralateral supression; OAE; Non-smokers; auditory system; ill-effects on efferent system

Online: 10 September 2021 (11:29:00 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202106.0125.v2

Cell Fusion as a Link between the SARS-CoV-2 Spike Protein, COVID-19 Complications, and Vaccine Side Effects

Yuri Lazebnik

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cell fusion; syncytia; cell hybrids; viruses; coronaviruses; SARS-CoV-2; COVID-19; fusogens; blood coagulation cascade; thrombosis, cancer; vaccines; neurological complications

Online: 9 September 2021 (10:54:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0170.v1

Effects of Molecular Iodine/Chemotherapy in the Immune Component of Breast Cancer Tumoral Microenvironment

Olga Cuenca-Micó, Evangelina Delgado-González, Brenda Anguiano, Felipe Vaca-Paniagua, Alejandra Medina-Rivera, Mauricio Rodríguez-Dorantes, Carmen Aceves

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: molecular iodine; immune response; breast cancer

Online: 9 September 2021 (10:45:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Working Paper ARTICLE

Could Strengthening the Gut and Skin Microbiome Help with the Adverse Effects after Stopping Long Term Topical Steroid Use?

Christopher Wallen-Russell, Anja Gijsberts-Veens, Samuel Wallen-Russell

Subject: Medicine And Pharmacology, Dermatology Keywords: topical steroid withdrawal; topical steroids; eczema; atopic dermatitis; skin microbiome; gut mi-crobiome; microbiome; biodiversity; skin allergy epidemic;

Online: 8 September 2021 (20:19:35 CEST)

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We set up this preliminary study to evaluate one main question: could strengthening the microbiome have potential benefits for patients suffering with adverse effects after stopping long term topical steroid use? We aim to turn it into a much larger study if the results show promise. After commonly being prescribed for eczema, cessation of topical steroid use, especially after long periods of inappropriate use, can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). Furthermore, the subsequent withdrawal the body experiences when coming off the drug can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). This preliminary study involved seven human participants suffering with skin problems associated with TSW who approached Dr. Anja Gijsberts-Veens of their own volition because they were interested in more natural recovery methods. Five completed the study in full. Progress in skin condition was tracked by self-assessed symptom severity questionnaires filled out at the beginning and end of the study. The skin microbiome was addressed by using a 100% natural product shown in previous work to significantly increase skin microbiome biodiversity. Three participants implemented dietary changes and supplementation in response to guidance after fecal sample analysis to improve their gut health and biodiversity. The average improvement in skin symptoms for all participants was 40% and average symptom improvement ranged from 14% for Patient 5 to 92% for Patient 1. On average, the participants saw an improvement in 85% of their symptoms and a stagnation or regression in 11% and 4% respectively. We believe these results show enough promise to warrant expansion of this research to use a larger sample size, preferably 50+ participants, in future work. We also aim to swab the skin of participants to assess the effect on the skin microbiome from skin and gut treatments, as well as including more in-depth analysis of skin and gut microbiomes.

Preprint REVIEW | doi:10.20944/preprints202109.0159.v1

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; neuro-immune; inflammation; oxidative and nitrosative stress; depression; mood disorders; schizophrenia; psychiatry

Online: 8 September 2021 (20:03:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0156.v1

Dynamics of Serum Thymidine Kinase 1 at the First Cycle of Neoadjuvant Chemotherapy Predicts Outcome of Disease in Estrogen-receptor-positive Breast Cancer

Bernhard Tribukait

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating thymidine kinase 1; cell loss; biomarker; early treatment response; breast cancer

Online: 8 September 2021 (16:25:39 CEST)

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Working Paper REVIEW

Purinergic Signaling in Neutrophils During Inflammatory Diseases

Hui Sun

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: purinergic signaling; regulatory role; neutrophils; inflammation

Online: 8 September 2021 (13:16:11 CEST)

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Working Paper ARTICLE

Dual Effects of Vericiguat on Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways

Kaiqiang Sun, Fanqi Kong, Feng Lin, Fudong Li, Jingchuan Sun, Changzhen Ren, Bing Zheng, Jiangang Shi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Vericiguat; osteoclast (OCs), MAPK, NF-κB; RANKL; AKT, molecular mechanism

Online: 8 September 2021 (13:02:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0149.v1

New Perspectives in Imaging of Uveal Melanoma

Malgorzata Solnik, Natalia Paduszynska, Anna M. Czarnecka, Kamil J. Synoradzki, Yacoub A. Yousef, Tomasz Choragiewicz, Robert Rejdak, Mario Damiano Toro, Katarzyna Dyndor, Michal Fiedorowicz

Subject: Medicine And Pharmacology, Ophthalmology Keywords: uveal melanoma; diagnosis; imaging; MRI; PET; CT; SPECT; OCT; ultrasonography

Online: 8 September 2021 (12:38:40 CEST)

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Working Paper REVIEW

M2 Macrophage in Fibrosis and Kidney Graft Rejection

Reza Jafari, Motahareh Dargahi, Niloufar Taheri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: M2 macrophages; Fibrosis; kidney; Graft rejection

Online: 8 September 2021 (11:24:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0138.v1

In-silico study of Agaricus Bisporus on DNA damaging protein

Sanket Shelke, Pravin Badhe

Subject: Medicine And Pharmacology, Pharmacy Keywords: Agaricus Bisporus; Button Mushroom; Molecular docking; PyRx software; BIOVIA Discovery studio

Online: 8 September 2021 (10:14:03 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0127.v1

Is 6-Shogaol a Beneficial Phytochemical for Patients with Lower-Risk Myelodysplastic Syndrome? A Narrative Review

Soo Liang Ooi, Ron Campbell, Sok Cheon Pak, Terry Golombick, Arumugam Manoharan, Raj Ramakrishna, Vladimir Badmaev, Janet Schloss

Subject: Medicine And Pharmacology, Hematology Keywords: Zingiber officinale; 6-Shogaol; 6-gingerol; hematopoiesis; hepcidin; anaemia

Online: 7 September 2021 (12:08:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0123.v1

Genistein Mediated Molecular Pharmacology, Cell-Specific Anti-Breast Cancer Mechanism with Synergistic Effect and in silico Safety Measurement

Md Sohel, Partha Biswas, Md. Al Amin, Dipta Dey, Habiba Sultana, Suraiya Aktar, Md. Sharif Khan, Md. Arju Hossain, Priyanka Paul, Islam Md. Nurul, Md. Ataur Rahman, Bonglee Kim, Abdullah Al Mamun

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Genistein; Estrogen receptor; BRCA-1; Cell cycle; Tumor suppressor gene; Molecular pharmacology; Synergistic activity.

Online: 7 September 2021 (11:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0116.v1

Study on the Value of C1q in the Diagnosis of Esophageal Cancer

Xin Cai, Huan Li, Juanjuan Chen, Dongling Tang, Pingan Zhang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: C1q; Biomarker; Esophageal cancer; Diagnosis; Tumor

Online: 7 September 2021 (10:03:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0115.v1

Prevalence of Health Problems Targeted by the National School-based Screening Program among Primary School Students in Saudi Arabia, 2019

Manal Matar Al Daajani, Dina Mohammed Al-Habib, Mona Hamed Ibrahim, Nora Abdulrhman Al Shewear, Yahya Mohammad Fagihi, Abrar Abdulazeem Alzaher, Amjad Alfaleh, Khaled Ibrahim Alabdulkareem

Subject: Medicine And Pharmacology, Other Keywords: Health Status; National Survey; KSA; School Health; Students

Online: 7 September 2021 (09:59:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0111.v1

The Utilization and Benefits of Telehealth Services by Health Care Professionals Managing Breast Cancer Patients During the COVID-19 Pandemic

Donovan A. McGrowder, Fabian Miller, Kurt Vaz, Melisa Anderson Cross, Lennox Anderson-Jackson, Sophia Bryan, Lyndon Latore, Rory Thompson, Dwight Lowe, Shelly R. McFarlane, Lowell Dilworth

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: telehealth; teleoncology; telerehabilitation; telemedicine; coronavirus disease; management; video conferencing; web-based platforms; breast cancer patients

Online: 6 September 2021 (17:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0106.v1

Impact of the Pre-transplant Circulatory Supportive Strategy on Post-transplant Outcome: Double Bridge May Work

Nai-Kuan Chou, Heng-Wen Chou, Chuan-I Tsao, Chih-Hsien Wang, Shu-Chien Huang, Kevin Po-Hsun Chen, Nai-Hsin Chi, Hsi-Yu Yu, Yih-Sharng Chen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mechanical circulatory support; heart transplantation; survival curve; ventricular assist device; extracorporeal membrane oxygenation

Online: 6 September 2021 (14:39:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0105.v1

The Role of Wnt/Beta-Catenin Pathway, SATB1 and SATB2 in Endometrial Cancer Patients

Paweł Sadłecki, Magdalena Bodnar, Andrzej Marszalek, Malgorzata Walentowicz-Sadlecka

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometrial cancer; tumor microenvironment; Wnt/β-catenin pathway; SATB1; SATB2

Online: 6 September 2021 (14:29:35 CEST)

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Wnt/β-catenin signaling pathway plays an established role in various diseases and is considered a hallmark of endometrial cancer (EC). Special AT-rich sequence-binding protein 1 and 2 (SATB1 and SATB2) are nuclear matrix-associated proteins involved in chromatin remodeling and regulation of gene expression. SATB1 promotes the progression of numerous types of cancers, whereas SATB2 acts as a tumor suppressor. Despite a recent progress in our knowledge about EC, the exact mechanisms that control their proliferation and metastatic potential still remain unknown. The aim of our study was to investigate the association between Wnt3A, β-catenin, SATB1 and SATB2 protein level and the clinicopathological features of EC patients. 92 EC patients, aged 37-84, were enrolled to our study. The immunoexpression of WNT3A was found in specimens from all EC patients, β-catenin was expressed in 97% of the cases, SATB1 in 87%. The significant association between Wnt3a expression and tumor grade was found; moreover mean IRS for Wnt3a turned out to be significantly lower in high-grade tumors than in low-grade malignancies (p=0.038). In turn, immunoexpression of β-catenin varied significantly across FIGO stages and was associated with the presence of lymph node metastases. Mean IRS for β-catenin in patients with lymph node metastases was significantly lower than in those without (p = 0.028). The Kaplan-Meier analyses demonstrated a stepwise impairment of cancer overall survival with increasing SATB1 expression. In conclusion, both Wnt/β-catenin signaling pathway and SATB1 contribute to progression of EC. Downregulation of β-catenin may predispose to lymphatic spread of EC. In turn, downregulation of Wnt3a seems to be characteristic for high-grade tumors, but probably does not play a role in formation of lymph node metastases. The important role of SATB1 as a predictor of poor survival and could be helpful in establishing a more accurate prognosis in endometrial cancer patients.

Preprint REVIEW | doi:10.20944/preprints202109.0104.v1

Hydrogel-Based Delivery for Antineoplastic Drugs and Vascular Scaffolding

Adelaide Iervolino, Camilla Chello, Massimo Chello, Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hyrogel; cardiotoxicity; regenerative medicine; antineoplastic drugs; polydioxanone; pulmonary autograft

Online: 6 September 2021 (14:01:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0103.v1

Keypoints to a Successful Newborn Hearing Screening. Thirty Years of Experience and Innovations

Jose Miguel Sequi Canet, Juan Brines Solanes

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neonatal hearing screening; Otoacoustic emissions; Deafness; Newborn screening.

Online: 6 September 2021 (13:57:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0134.v2

Same Brain, Different Look? – the Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters

Ronja Thieleking, Rui Zhang, Maria Paerisch, Kerstin Wirkner, Alfred Anwander, Frauke Beyer, Arno Villringer, A. Veronica Witte

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Diffusion Magnetic Resonance Imaging; White Matter; Fractional anisotropy; Multi-centre; Reproducibility; Imaging artefacts; Ageing

Online: 6 September 2021 (13:20:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0085.v1

Chick Embryo Experimental Platform for 3D Tissue Engineering Modelling of Cancer Micrometastases for Tumor Biology, Drug Development and Nanomaterials Testing

Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei Zvyagin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chick embryo; 3D culture; tumor models in vitro; tissue engineering; metastasis; triple-negative breast cancer; liver; mesoporous silica nanoparticles; doxorubicin; micrometastasis

Online: 6 September 2021 (11:46:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0078.v1

Time Course of Recovery Following Crossfit® Karen Benchmark Workout in Trained Men

Ramires Alsamir Tibana, Ivo Vieira de Sousa Neto, Nuno Manuel Frade de Sousa, Arthur M. Zecchin-Oliveira, Frederico Ribeiro Neto, João Henrique Falk Neto

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Functional Fitness; High intensity Functional training; Periodization; Overreaching; Muscle recovery.

Online: 6 September 2021 (07:19:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0071.v1

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Saïda Azhar, Raphaël Thuillet, Marc Humbert, Vincent Richard, Christophe Guignabert, Jérémy Bellien

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: lysophospholipids; lysophosphatidic acids; cardiovascular diseases; HPLC-MS/MS; rodent models; pulmonary hypertension; chronic heart failure; hypertension

Online: 3 September 2021 (15:19:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0070.v1

New Drug Targets to Prevent Death due to Stroke: Results of Protein-Protein Interaction Network, Enrichment and Annotation Analyses.

Michael Maes, Nikita Nikiforov, Kitiporn Plaimas, Apichat Suratanee, Edna Maria Reiche

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: stroke; inflammation; neuro-immune; cytokines; hemostasis; coagulation; protein-protein interactions

Online: 3 September 2021 (15:11:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0069.v1

Variability in the Control of Type 2 Diabetes in Primary Care and Its Association with Hospital Admissions for Vascular Events. The APNA Study.

Sara Guillen-Aguinaga, Luis Forga, Antonio Brugos-Larumbe, Francisco Guillen-Grima, Laura Guillen-Aguinaga, Ines Aguinaga-Ontoso

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Healthcare Disparities; Diabetes Mellitus, Type 2; Vascular Diseases; Primary Health Care; Cohort

Online: 3 September 2021 (14:58:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0066.v1

In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels

Maegan E. Boutot, Brian W. Whitcomb, Nadia Abdelouahab, Andrea A. Baccarelli, Amélie Boivin, Artuela Caku, Virginie Gillet, Guillaume Martinez, Jean-Charles Pasquier, Jiping Zhu, Larissa Takser, Lindsay St-Cyr, Alexander Suvorov

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dyslipidemia; fetal programing; lipid metabolism; NAFLD; persistent organic pollutants

Online: 3 September 2021 (13:56:53 CEST)

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Working Paper ARTICLE

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-analysis and Meta-regression

Elke van Westering-Kroon, Maurice J Huizing, Eduardo Villamor-Martínez, Eduardo Villamor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: preterm birth; oxidative stress; sex differences; male disadvantage; female advantage; bronchopulmonary dysplasia; retinopathy of prematurity; necrotizing enterocolitis; intraventricular hemorrhage; periventricular leukomalacia; mortality.

Online: 3 September 2021 (11:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0043.v1

Aphasia After Acute Ischemic Stroke in Romania: Epidemiology and Impact on Tertiary Care Resources

Adina Stan, Stefan Strilciuc, Nicoleta Gherghel, Angela Cozma, Cristian Alexander, Silvina Ilut, Alina Blesneag, Vitalie Vacaras, Delia Stanca, Horatiu Stan, Dafin Fior Muresanu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: aphasia; acute ischemic stroke; length of stay; mRS; NIHSS

Online: 2 September 2021 (14:39:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0037.v1

Hygiene Behavior in Face of the Corona Pandemic: Compliance Rates and Associations With Fear, SARS-COV-2 risk, Mental Health and Disability

Sonia Lippke, Franziska M. Keller, Christina Derksen, Lukas Kötting, Alina Dahmen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; disability; risk factors; communication; medical rehabilitation; psychosomatic patients; general public; infection; physical health; psychological health

Online: 2 September 2021 (12:08:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0031.v1

The Added Value of Subcutaneous Peripheral Nerve Field Stimulation Combined with SCS, as Salvage Therapy, for Refractory Low Back Pain Component in Persistent Spinal Pain Syndrome Implanted Patients: A Randomized Controlled Study (CUMPNS Study) Based on 3D-Mapping Composite Pain Assessment

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Benedicte Bouche, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Elodie Charrier, Delphine Rannou, Laure Poupin, Chantal Wood, Romain David, Dylan Héraud, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: spinal cord stimulation (SCS); peripheral nerve field stimulation (PNfS); SubQ-stimulation; hybrid stimulation; multidimensional pain assessment; pain mapping; pain software; persistent spinal pain syndrome - T2 (PSPS-T2); failed back surgery syndrome; failed spinal cord stimulation syndrome (FSCSS); salvage therapy; salvage algorithm

Online: 1 September 2021 (18:16:10 CEST)

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Working Paper REVIEW

Obesity – An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Erind Gjermeni, Anna Kirstein, Florentien Kolbig, Michael Kirchhof, Linnaeus Bundalian, Julius L. Katzmann, Ulrich Laufs, Matthias Blüher, Antje Garten, Diana Le Duc

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: obesity; diabetes mellitus; anti-obesity drugs; obesity metabolism; energy balance

Online: 1 September 2021 (17:29:05 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0015.v1

HIV Prevalence and Risk Factors for Infants Born to Mothers on Arv Treatment at CHUB/Rwanda

Bernard Nsengimana, Francois Nkurunziza, Wivine Mudahigwa Ntaganira, Ruth Uzayisenga, Gad Rutayisire

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rwanda; Risk associated MTCT; HIV-exposed infants

Online: 1 September 2021 (12:18:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0010.v1

Machine Learning Algorithms Provide Greater Prediction of Response to Scs Than Lead Screening Trial: A Predictive AI-Based Multicenter Study

Amine Ounajim, Maxime Billot, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Nihel Adjali, Kevin Nivole, Nicolas Naiditch, Chantal Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: spinal cord stimulation; screening trial; infection; supervised learning; machine learning; predictive modeling; patient outcome

Online: 1 September 2021 (12:05:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0565.v1

Comparable Efficacy in Ischemic and Non-Ischemic ICD Recipients for the Primary Prevention of Sudden Cardiac Death

Andreea Maria Ursaru, Irina Iuliana Costache, Antoniu-Octavian Petris, Nicolae Dan Tesloianu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: primary prevention of sudden cardiac death; non-ischemic cardiomyopathy; ischemic cardiomyopathy; appropriate ICD therapy; mortality rate comparison

Online: 31 August 2021 (11:26:43 CEST)

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(1) Background: In patients suffering from heart failure, the main causes of death are either he-modynamic failure, or ventricular arrhythmias. The only tool to significantly reduce arrhythmic sudden death is the implantable cardioverter defibrillator (ICD), but not all patients benefit to the same extend of these devices. (2) Methods: The primary outcome of this single center study was defined as cardiovascular death in patients with ischemic and non-ischemic heart failure who have benefited from ICD therapy. The secondary outcomes were death from any cause, sudden cardiac death, ICD-related therapies (appropriate antitachycardia pacing or shock therapy for ventricular tachycardia or fi-brillation) and recurrences of ventricular tachyarrhythmias. (3) Results: A total of 403 consecutive ICD recipients – symptomatic heart failure patients with ICD for the primary prevention of sudden cardiac death – were included retrospectively: 59% is-chemic cardiomyopathy (ICMP) and 41% non-ischemic cardiomyopathy (NICMP). Within a median follow-up period of 36 months, the incidence of cardiovascular mortality was not signif-icantly different in patients with NICMP and ICMP: the primary outcome had occurred in 9 pa-tients (5.4%) in the NICMP group and in 14 patients (5.9%) in the ICMP group (hazard ratio 1; 95%confidence interval [CI] 0.45 to 2.28; p =0.97). All-cause mortality occurred in 14 of 166 pa-tients (8.4%) in NICMP group and 18 of 237 patients (7.6%) in ICMP group. Sudden cardiac death occurred in 2 patients (1.2%) in the NICMP group and in 4 patients (1.7%) in the ICMP group (hazard ratio 0.71; 95% CI, 0.13 to 3.88; P=0.69). The rate of appropriate device therapies was comparable in both groups. (4) Conclusion: In this study, ICD implantation for primary prevention of sudden cardiac death in patients with symptomatic systolic heart failure was associated with similar rates of cardiovas-cular and all-cause mortality in patients with ischemic heart disease, and in patients with heart failure from other causes. NICMP and ICMP showed comparable rates of recurrent ventricular tachyarrhythmias and appropriate ICD therapies.

Preprint ARTICLE | doi:10.20944/preprints202108.0562.v1

In vitro 3D Model of Female Reproductive Tract: An Overview and Future Aspect

Arnaud Martino Capuzzo

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: female reproductive tract; organoid; co-culture; crosstalk; blastocyst

Online: 31 August 2021 (11:19:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0556.v1

Osteoarthritis Induces Gender Related Changes in the Knee Range of Motion

Carmen Stătescu, Doru Stoica, Bogdan Ion Gavrilă, Magdalena Rodica Trăistaru, Tudor Adrian Bălșeanu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: angles app; goniometry; range of motion; assessment; telemedicine; joint examination

Online: 31 August 2021 (10:26:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0550.v1

Interdisciplinary Co-design Framework in Healthcare Design for Older Adult Patients with Chronic Low-back Pain

Muhammad Tufail, HaeBin Lee, Hwang Kim, KwanMyung Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Interdisciplinary co-design; healthcare design; exercise; low-back pain; older adult patients; rehabilitation

Online: 30 August 2021 (15:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0545.v1

A Novel Multi-dimensional Clinical Response Index Dedicated to Improving Global Assessment of Pain in Patients with Persistent Spinal Pain Syndrome After Spinal Surgery, Based on a Real-life Prospective Multicentric Study (PREDIBACK) and Machine Learning

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Nicolas Naiditch, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Nelly Grimaud, Nihel Adjali, Kevin Nivole, Mathilde Many, Romain David, Chantal H. Wood, Raphael Rigoard, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Composite score; Machine learning; PSPS; Failed Back Surgery Syndrome (FBSS); Chronic pain; Pain Intensity; Quality of Life; Pain Mapping; Pain Surface; Functional Capacity; Psychological Distress; Anxiety and Depression

Online: 30 August 2021 (13:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0533.v1

Inter-Eye Correlation Analysis of 24-hour IOPs and Glaucoma Progression

Mohamad Dakroub, Raoul Verma-Fuehring, Vaia Agorastou, Julian Schön, Jost Hillenkamp, Frank Puppe, Nils A. Loewen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: glaucoma progression; nycthemeral intraocular pressure; right-left comparison; laterality

Online: 30 August 2021 (09:52:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0529.v1

Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations

Marie Sabatier, Emeline Boet, Sonia Zaghdoudi, Nathan Guiraud, Alexis Hucteau, Nathaniel Polley, Guillaume Cognet, Estelle Saland, Laura Lauture, Thomas Farge, Ambrine Sahal, Vera Pancaldi, Emeline Chu-Van, Florence Castelli, Sarah Bertoli, Pierre Bories, Christian Récher, Héléna Boutzen, Véronique Mansat-De Mas, Lucille Stuani, Jean-Emmanuel Sarry

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: AML; IDH; Vitamin D; VDR; ATRA; CEBPa; Differentiation

Online: 27 August 2021 (16:32:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0520.v1

Distinct Exosomal miRNA Profiles from BALF and Lung Tissue from COPD and IPF Patients

Gagandeep Kaur, Krishna Maremanda, Michael Campos, Hitendra Singh Chand, Feng Li, Nikhil Hirani, M A Haseeb, Irfan Rahman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Exosomes; COPD; smokers; IPF; BALF; lung

Online: 27 August 2021 (11:33:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0513.v1

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Jordan H. Whitlock, Tabea M. Soelter, Avery S. Williams, Andrew A. Hardigan, Brittany N. Lasseigne

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: liquid biopsy; epilepsy; circulating biomarkers; cfDNA; lncRNA; tRNA; miRNA; diagnosis; prognosis; therapeutics

Online: 26 August 2021 (16:40:54 CEST)

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