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Preprint ARTICLE | doi:10.20944/preprints202106.0671.v1

Flexibility Versus Certainty in Planning: A Critical Review of Cross-Boundary Spatial Planning Systems and Practices

Anutosh Das, Mohammad Shahriyar Parvez

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Cross-Boundary Spatial Planning Systems and Practices

Online: 28 June 2021 (14:51:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0650.v1

Cellular and humoral immunogenicity of a candidate DNA Vaccine Expressing SARS-CoV-2 Spike Subunit 1

Khalid A. Alluhaybi, Rahaf H. Alharbi, Rowa Y. Alhabbab, Najwa D Aljehani, Sawsan S. Alamri, Mohammad Basabrain, Rehaf Alharbi, Wesam H. Abdulaal, Mohamed A. Alfaleh, Levi Tamming, Wanyue Zhang, Mazen Hassanain, Abdullah Algaissi, Adel M. Abuzenadah, Xuguang Li, Anwar M Hashem

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2 vaccine; cellular and humoral immunogenicity; DNA vaccine

Online: 28 June 2021 (13:40:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0619.v1

Natural Products From Madagascar, Socio-Cultural Usage, and Potential Applications in Advanced Biomedicine: A Concise Review

Camillo La Mesa, Oliarinony Ranalison, Lovasoa N. Randriantseheno, Gianfranco Risuleo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Natural products; Madagascan active principles; Nano-delivery.

Online: 25 June 2021 (12:02:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0601.v1

Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering

Saqib Rashid, Gian Marco Vita, Luca Persichetti, Giovanna Iucci, Chiara Battocchio, Rostislav Daniel, Daniela Visaggio, Martina Marsotto, Paolo Visca, Edoardo Bemporad, Paolo Ascenzi, Giovanni Capellini, Marco Sebastiani, Alessandra Di Masi

Subject: Chemistry And Materials Science, Biomaterials Keywords: bactericidal; biocompatibility; copper; human fibroblast; physical vapor deposition (PVD); silver; titanium; thin films

Online: 24 June 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0576.v1

Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction

Umar Farooq, Shahid Ali Shah, Taous Khan, Rahim Ullah, Naila Raziq, Muhammad Shahid, Ameer Khusro, Muhammad Umar Khayam Sahibzada, Veronique Seidel, Adel Alkhedaide, Gaber El-Saber Batiha, Niranjan Koirala

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Hypericum oblongifolium; Alzheimer’s disease; Folecitin; Memory impairment; Neurodegenerative disease; Neuroprotection

Online: 23 June 2021 (11:25:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0538.v1

Results of Pregnancy Control before and during the Covid-19 Pandemic: A Comparison of Two Cohorts

Javier Llorca, Carolina Lechosa-Muñiz, Pelayo Frank de Zulueta, Sonia Lopez-Gomez, Victoria Orallo, Jéssica Alonso-Molero, Barbara Arozamena-Llano, Yolanda Jubete, Maria Paz-Zulueta, Maria J Cabero

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID19; pregnant; cohort

Online: 22 June 2021 (10:22:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0534.v1

Bibliometric Analysis of SARS, MERS, and Covid-19 Studies from India with Focus on Sustainable Development

Raghu Raman, Ricardo Vinuesa, Prema Nedungadi

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: COVID-19; Coronavirus; pandemic; bibliometric analysis; MERS; SARS

Online: 22 June 2021 (08:33:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0608.v3

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

Iosif V. Gofman, Alexandra L. Nikolaeva, Albert K. Khripunov, Elena M. Ivan’kova, Anton S. Shabunin, Alexander V. Yakimansky, Dmitriy P. Romanov, Anton L. Popov, Artem M. Ermakov, Sergey O. Solomevich, Pavel M. Bychkovsky, Alexander E. Baranchikov, Vladimir K. Ivanov

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanocomposites; bacterial cellulose; ceria nanoparticles; thermal properties; swelling; mechanical behavior; biomedical applications; stem cells proliferation; gene expression

Online: 17 June 2021 (10:02:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0444.v1

Daily Stock Movements Through the Lens of Event and News: Evidence from the Pakistan Stock Exchange

Shahid Raza, Baiqing Sun, Pwint Kay Khine

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Stock Market; Financial Markets; News Model; KSE 100 Index; ARCH/GARCH; OLS

Online: 16 June 2021 (12:40:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0334.v1

Paradigm of Historical Science: Dealing with the Modern Juggernaut through across Time in Education and Government

Safin Karunia Rojuli, Moses Glorino Rumambo Pandin

Subject: Social Sciences, Anthropology Keywords: 21st century; Covid 19; education; the government system

Online: 14 June 2021 (08:46:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202106.0311.v1

A Case Report of Chronic Stress in Honey Bee Colonies Induced by Pathogens and Acaricide Residues

Elena Alonso-Prados, Amelia-Virginia González-Porto, José Luis Bernal, José Bernal, Raquel Martín-Hernández, Mariano Higes

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Honey bees; Apis mellifera; acaricides; pesticides; Toxic Unit; Varroa destructor; Nosema ceranae; bee viruses; tau-fluvalinate; coumaphos

Online: 11 June 2021 (09:55:42 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202106.0309.v1

Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-cell and In vitro Assays

Raef Shams, Yoshihiro Ito, Hideyuki Miyatake

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mTORC1; RHEB; G-Protein; Allosteric activation; Kinase domain; Binding kinetics

Online: 11 June 2021 (09:14:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0306.v1

Behaviour of Ternary Mixtures of Hydrogen Bond Acceptors and Donors in Terms of Band Gap Energies

Alberto Mannu, Francesca Cardano, Salvatore Baldino, Andrea Fin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: eutectic mixtures; hydrogen bond acceptor; hydrogen bond donor; design of experiments; Tauc plot; band gap energy

Online: 11 June 2021 (08:52:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0291.v1

Dynamic Connectedness and Portfolio Diversification during the Coronavirus Disease 2019 Pandemic: Evidence from the Cryptocurrency Market

Samia Nasreen, Aviral Kumar Tiwari, Seong-Min Yoon

Subject: Business, Economics And Management, Business And Management Keywords: Cryptocurrency; Coronavirus Disease 2019; Time-Varying Parameter Vector Autoregression; Portfolio Weight; Hedging Effectiveness

Online: 10 June 2021 (12:07:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0285.v1

Quantitative Fluorescent Polymerase Chain Reaction for Prenatal Diagnosis and Its Application in Vietnam: A Literature Review

Thuan Phan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: QF-PCR; cytogenetics; prenatal diagnosis; aneuploidy; chromosome abnormalities; screening test

Online: 10 June 2021 (09:17:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0249.v1

Do Mouthwashes Reduce Covid-19 Viral Load during Dental Procedures and Oropharyngeal Examinations? A Systematic Review

Simin Z. Mohebbi, Tayebe Ebrahimi, Ahmad Reza Shamshiri

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mouthwash; mouth rinse; oral rinse; covid19; SARS-COV-2; coronavirus

Online: 9 June 2021 (09:10:08 CEST)

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Working Paper ARTICLE

Occupational Health and Safety in Mining: Predictive Probabilities of Personal Protective Equipment (PPE) Use among Artisanal Goldminers in Ghana

Simon Appah Aram, Benjamin M. Saalidong, Augustine Appiah, Idongesit Bassey Utip

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Artisanal mining; PPE; Occupational factors; Occupational health and safety

Online: 13 September 2021 (08:43:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0183.v2

Structural Origin of Magnetotransport Properties in APCVD Deposited Single and Bi-Layer Tin Oxide Thin Films

Krunoslav Juraić, Matija Čulo, Željko Rapljenović, Jasper Rikkert Plaisier, Zdravko Siketić, Luka Pavić, Mario Bohač, Aden Hodzic, Davor Gracin

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: tin oxide; thin films; atmospheric pressure chemical vapour deposition transport properties; magnetoresistance; impedance spectroscopy; charge carrier mobility

Online: 8 June 2021 (13:55:21 CEST)

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Transparent conducting oxides (TCO) with high electrical conductivity and at the same time high transparency in the visible spectrum are an important class of materials widely used in many devices requiring a transparent contact such as light-emitting diodes, solar cells and display screens. Since the improvement of electrical conductivity usually leads to degradation of optical transparency, a fine-tuning sample preparation process and a better understanding of the correlation between structural and transport properties is necessary for optimizing the properties of TCO for use in such devices. Here we report a structural and magnetotransport study of tin oxide (SnO₂), a well-known and commonly used TCO, prepared by a simple and relatively cheap Atmospheric Pressure Chemical Vapour Deposition (APCVD) method in the form of thin films deposited on soda-lime glass substrates. The thin films were deposited at two different temperatures (which were previously found to be close to optimum for our setup), 590 °C and 610 °C, and with (doped) or without (undoped) the addition of fluorine dopants. Scanning Electron Microscopy (SEM) and Grazing Incidence X-ray Diffraction (GIXRD) revealed the presence of inhomogeneity in the samples, on a bigger scale in form of grains (80–200 nm), and on a smaller scale in form of crystallites (10–25 nm). Charge carrier density and mobility extracted from DC resistivity and Hall effect measurements were in the ranges 1–3 × 10²⁰ cm⁻³ and 10–20 cm²/Vs, which are typical values for SnO₂ films, and show a negligible temperature dependence from room temperature down to -269 °C. Such behaviour is ascribed to grain boundary scattering, with the interior of the grains degenerately doped (i.e., the Fermi level is situated well above the conduction band minimum) and with negligible electrostatic barriers at the grain boundaries (due to high dopant concentration). The observed difference for factor 2 in mobility among the thin-film SnO₂ samples most likely arises due to the difference in the preferred orientation of crystallites (texture coefficient).

Preprint ARTICLE | doi:10.20944/preprints202106.0201.v1

Cardiac Diagnostic Feature and Demographic Identification Models: A Futuristic Approach for Smart Healthcare Using Machine Learning

Deepak Kumar, Chaman Verma, Sanjay Dahiya, Pradeep Kumar Singh, Maria Simona Raboaca

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Serum Creatinine; Serum Sodium; Ejection Fraction; Creatinine Phosphokinase; Multicollinearity; Matthew Correlation coefficient.

Online: 8 June 2021 (09:19:02 CEST)

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Around the world, every year, about 17 million people death cause happen due to CardioVascular Diseases (CVD). As per clinical records, primarily sufferers exhibit myocardial infarctions and Heart Failures (HF). Creatinine is a Musculo - skeletal waste product. The kidneys filter creatinine from the blood and excrete it through the urine in a healthy body. High creatinine levels can suggest renal problems. Elevated Serum Creatinine (SC) has been well established in the HF. Patients’ electronic medical records can be used to quantify symptoms and other related clinical laboratory test values, which would then be utilized to direct biostatistics exploration to uncover patterns and associations that doctors would otherwise miss. The latest American Heart Association guidelines for 1500 mg/d sodium tend to be sufficiently relevant for patients with stage A and B with HF. In this article, we used a dataset of the year 2015 of heart patients records of 299 patients. The present paper used the data analytic and statistical tools to verify the significant differences between alive and dead patients’ SC and Serum Sodium (SS). It also demonstrates the impact of significant features on abnormal SC and SS on the Survival-Status levels. The Age-Group feature, which is derived from age attribute and, Ejection Fraction (EF), anemia, platelets, Creatinine Phosphokinase (CPK), Blood-Pressure (BP), gender, diabetes, and smoking-status were utilized to determine the potential contributing features to mortality with Cox regression model. The Kaplan Meier plot was used to investigate the overall pattern of survival concerning age-group. During pre-processing of the dataset, Age and SS were removed due to multicollinear features during performing machine learning algorithms experiments. This paper also predicted patients’ survival, age group, and gender using supervised machine learning classifiers. Detection of significant features would help in making informed decisions to balance the lifestyle of heart patients. The author revealed that the patient’s follow-up months, as well as SC, EF, CPK, and platelets, are sufficient key features to predict heart patient survival using Random Forest (RF) stratified 10-fold CV method with accuracy (96%) with 5% Standard Deviation (SD) from medical records dataset. We identified the age-group and gender of the patient, and the RF model outperformed others with the best accuracy 96% and 94% in both cases having 11% SD. Also, prominent features such as CPK, SC, follow-up month, platelets, and ejection were found to be significant factors in predicting the patient’s age-group. Smoking habits, CPK, platelets, follow-up month, and SC of each patient were discovered to be significant predictors of patient gender. The hypothetical study proved that SC and SS making substantial differences in the survival of patients (p < 0.05) and failed to reject that anemia, diabetes, and BP making a significant impact on the creatinine and sodium of each patient (p > 0.05). With χ2(1) = 8.565, the Kaplan Meier plot revealed that mortality was high in the extremely elder age-group. The finding has possible effects on clinical practice and becomes a new medical support system when predicting whether a patient can survive a heart attack or not. The doctor should primarily concentrate on follow-up month, SC and EF, CPK, and platelet count since the aim is to understand whether a patient survives after HF.

Preprint ARTICLE | doi:10.20944/preprints202106.0199.v1

Co-expression of candidate genes regulating growth performance and carcass traits of Barki lambs in Egypt

Nasser Ghanem, Mohamed Zayed, Ismail Mohamed, Mona Mohammady, M.F. Shehata

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: growth rate; carcass traits; gene expression.

Online: 8 June 2021 (09:15:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0179.v1

On the Importance of Gauge-Undercatch Correction Factors and Their Impacts on the Global Precipitation Estimates

Mohammad Reza Ehsani, Ali Behrangi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: gauge-undercatch; correction factors; global precipitation; GPCC; Legates correction factor; Fuchs correction factor;

Online: 7 June 2021 (12:59:50 CEST)

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Working Paper ARTICLE

Retrieving Surface Soil Moisture over Wheat-Covered Areas Using Data from Sentinel-1 and Sentinel-2

Yan Li, Chengcai Zhang, Weidong Heng

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Surface soil moisture; Sentinel-1 SAR; Sentinel-2; Vegetation water content; Water cloud model; Support vector regression

Online: 2 June 2021 (15:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0064.v1

Chemotherapy-Induced Nausea and Vomiting Breast Cancer Patients from a Chinese Multicenter Prospective Longitudinal Observational Study

Xin-Juan Huang, Xu-Ying Li, Lu Luo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: CINV; breast cancer; antiemetic guidelines; risk factors

Online: 2 June 2021 (10:06:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0034.v1

Local Muscle Endurance and Strength are the Best Predictors of Crossfit Open 2020 in Amateur Athletes

Ramires Alsamir Tibana, Ivo Vieira de Sousa Neto, Nuno Manuel Frade de Sousa, Caroline Romeiro, Adriana Hanai, Hiury Brandão, Fábio Hech Dominski, Fabricio Azevedo Voltarelli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Functional fitness training; athletic performance; exercise testing

Online: 1 June 2021 (12:32:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0747.v1

Tools for Edible Cities: A Review of Tools for Planning and Assessing Edible Nature-Based Solutions

Eric Mino, Josep Pueyo-Ros, Mateja Škerjanec, Joana A. Castellar, Andre Viljoen, Darja Istenič, Nataša Atanasova, Katrin Bohn, Joaquim Comas

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: nature-based solutions; productive urban landscapes; decision support systems; edible cities; urban agriculture; circular economy

Online: 31 May 2021 (11:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0729.v1

Prognostic Significance of CKS2 and CD47 Expression in Patients With Gastric Cancer Who Underwent Radical Gastrectomy

Yang zhou, Jing zeng, Haoran zhuang, wei zhou, keyan wu, weigan shen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gastric cancer; Cyclin-dependent protein kinase; Cluster of differentiation (CD) 47; Prognosis

Online: 31 May 2021 (10:13:20 CEST)

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Objective: To investigate the protein expression levels of cyclin‑dependent kinase subunit 2 (CKS2) and cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significances. Methods: A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumor, 42 patients with low-grade intraepithelial neoplasia (LGIEN), and 49 patients with high-grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analyzed the clinical significance of the expression of the two factors. Results: (1) The positivity rates for CKS2 in benign gastric tumor tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, i.e., 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumor diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r=0.625, P=0.000). (3) The median follow-up time of 126 patients was 46.5 months, and the overall survival rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (-) group, the overall survival rate for patients in the CKS2 (+) group was significantly worse (25.0% vs 64.0%, 2=15.67, P=0.000) and that compared with the CD47 (-) group, the CD47 (+) group had significantly worse overall survival (30.1% vs 60.5%, 2=15.67, P=0.000). (4) The overall survival rates of CKS2(+)CD47(+) group, CKS2(+)CD47(-) group, CKS2(-)CD47(+) group, and CKS2 (-)CD47 (-) group were 20.0%(13/65), 58.3%(7/12), 57.1%(8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2(+)CD47(+) group was significantly poor. Conclusion: High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.

Preprint ARTICLE | doi:10.20944/preprints202105.0715.v1

Raman and X-ray Photoelectron Spectroscopic Study of Aqueous Thiol-Capped Ag-Zn-Sn-S Nanocrystals

Volodymyr Dzhagan, Oleksandr Selyshchev, Yevhenii Havriliuk, Nazar Mazur, Oleksandra Raievska, Oleksandr Stroyuk, Serhiy Kondratenko, Alexander Litvinchuk, Mikhailo Valakh, Dietrich R.T. Zahn

Subject: Chemistry And Materials Science, Nanotechnology Keywords: colloidal nanocrystals; Ag2ZnSnS4; phonons; Ag-Zn-S; Ag-Sn-S; non-stoichiometry; secondary phase; XPS; FTIR

Online: 31 May 2021 (08:33:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0693.v1

Measuring and Evaluating the Quality of Urban Walkways from the Perspective of the Creative Urban Space

Ameneh Ekrasardashti, Hassan Sajadzadeh, Farshid Aram

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Urban walkways; Creative city, Urban Space

Online: 28 May 2021 (10:57:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0667.v1

Crushing of Double-Walled Corrugated Board and Its Influence on the Load Capacity of Various Boxes

Tomasz Gajewski, Tomasz Garbowski, Natalia Staszak, Małgorzata Kuca

Subject: Chemistry And Materials Science, Biomaterials Keywords: corrugated cardboard; converting; crushing; numerical homogenization; strain energy equivalence; finite element method; shell structures; transverse shear

Online: 27 May 2021 (13:13:08 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202105.0659.v1

Neural Timing Deficits Prevalent in Developmental Disorders, Aging, and Concussions Remediated Rapidly By Movement Discrimination Exercises

Teri Lawton, John Shelley-Tremblay, Ming-Xiong Huang

Subject: Social Sciences, Cognitive Science Keywords: Timing Deficits; Magnocellular Deficits; Remediating Cognitive Skills; Cortical Plasticity; Reading, Attention, Memory, and Executive Control Networks; Perceptual Learning

Online: 27 May 2021 (08:09:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0653.v1

High Survivorship of First-generation Monarch Butterfly Eggs and Larvae Associated with a Diverse Arthropod Community

Misty Stevenson, Kalynn L. Hudman, Alyx Scott, Kelsey Contreras, Jeffrey G. Kopachena

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: monarch butterfly; Danaus plexippus; Arthropods; community structure; survivorship

Online: 27 May 2021 (07:58:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0631.v1

On the Relationship between Circulation Patterns, the Southern Annular Mode, and Rainfall Variability in Western Cape

Chibuike Chiedozie Ibebuchi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Western Cape; Southern Annular Mode; Circulation type; Africa south of the equator; mid-latitude cyclone

Online: 26 May 2021 (11:04:08 CEST)

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Working Paper ARTICLE

The Effect of Acute Intense Exercise on Activity of Antioxidant Enzymes in Smokers and Non-smokers

Hadi Nobari, Hamzeh Abdi nejad, Mehdi Kargarfard, Soghra Mohseni, Katsuhiko Suzuki, Jose Carmelo Adsuar, Jorge Pérez-Gómez

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: exhaustive exercise; oxidative stress; regular physical activity; saliva; peroxidase; catalase; superoxide dismutase

Online: 24 May 2021 (10:27:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0555.v1

Technologies for the Development of New Value-Added Foods From Dates and Their Processing by-Products

Alex López-Córdoba

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Value addition; Functional Foods; Phoenix dactylifera; Innovation; Differentiation

Online: 24 May 2021 (10:25:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0483.v1

Calculation of the Flux Density Function for Protein Crystals from Small Scale Settling and Filtration Experiments

Benjamin Radel, Tu Hoang Nguyen, Hermann Nirschl

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Filtration; Flux density function; Protein crystals

Online: 20 May 2021 (11:07:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0424.v1

Four-Layer ConvNet to Facial Emotion Recognition with Minimal Epochs and the Significance of Data Diversity

Tanoy Debnath, Md. Mahfuz Reza, Anichur Rahman, Shahab Band, Hamid Alinejad Rokny

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Convolutional Neural Network (CNN); Emotion Recognition; Facial Expression; Classification; Accuracy

Online: 18 May 2021 (11:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0400.v1

Designing a Multi-Epitope Vaccine against Dracunculus medinensis by Employing Immuno-Informatics and In Silico Approaches

Mian Talha Sarfraz, Marvah Mehmood Rana

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Immuno-informatics; Multi-epitope; Dracunculiasis

Online: 18 May 2021 (09:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0610.v2

Fermentation of Soybean Seeds Using Rhizopus oligosporus for Tempeh Production and Standardization Based on Isoflavones Content

Yohanes Dwiatmaka, Endang Lukitaningsih, Nunung Yuniarti, Subagus Wahyuono

Subject: Biology And Life Sciences, Food Science And Technology Keywords: tempeh; soybean; fermentation; Rhizopus; isoflavones

Online: 17 May 2021 (17:03:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0367.v1

Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviours in the PI3K/mTOR Signalling Network

Milad Ghomlaghi, Anthony Hart, Sungyoung Shin, Lan K Nguyen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PI3K/mTOR signalling; feedback loop; crosstalk; nonlinear dynamics; cancer

Online: 17 May 2021 (07:54:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0357.v1

Impact of Rowing Training on Quality of Life and Perceived Health in Female Breast Cancer Survivors

Juan Gavala-González, Amanda Torres-Pérez, José Carlos Fernández-García

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: breast cancer; rowing; quality of life; perceived health; IPAQ-SF; SF-36.

Online: 14 May 2021 (17:14:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0287.v1

Forms and Dynamics of Soil Potassium in Acid Soil in the Wolaita Zone of Southern Ethiopia

Mesfin Kassa, Wassie Haile, fassile kebede

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Land use types; Quantity-intensity; Soil properties

Online: 13 May 2021 (12:49:40 CEST)

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Quantity-intensity characteristics are among conventional approaches for studying potassium dynamics and its availability; this was assessed to determine availability in four districts: namely, Sodo Zuria, Damot Gale, Damot Sore, and Boloso Sore at three different land use type viz., enset-coffee, crop land, and grazing land. There was water soluble, ammonium acetate, nitric acid extractable potassium, exchangeable potassium, and non-exchangeable potassium studied in soil samples, which were collected from 0-20 cm depth of each land type. The study revealed that water soluble and ammonium acetate extractable potassium concentrations ranged from 0.04 to 0.42 cmolKg-1 soils enset-coffee and grazing land use types, respectively. The study showed that exchangeable potassium constituted the highest proportion of available potassium, while the proportion of water soluble potassium was found to be the lowest. In this study, non-exchangeable potassium concentrations varied from 0.10 to 0.04cmolKg-1soils for enset-coffee, and crop and grazing land use type. Furthermore, available potassium and exchangeable potassium concentrations were positively correlated with OC(r=0.95***), cation exchange capacity, and sand and clay(r=0.98***). In addition, the K dynamics as impacted by land use types found that the highest change in exchangeable potassium (0.31cmolkg-1soils) and potential buffering capacity (1.79cmolkg-1soils) were noted in crop land use types, whereas the lowest change(1.26cmolkg-1 soils) was observed in the enset-coffee system, The varying properties, potassium status, dynamic and land use type of soils identified in the study areas provided adequate information to design soil potassium management options and further research about the soil in each site. Therefore, application of site specific soil fertility management practices and research can improve soil potassium status and quantity intensity parameters to sustain crop productive soils.

Preprint REVIEW | doi:10.20944/preprints202105.0264.v1

Applying Philosophy, Logic, and Rational Argumentation to the Severe Acute Respiratory Syndrome Coronavirus-2 Pandemic Response

Ari Joffe, David Redman

Subject: Social Sciences, Anthropology Keywords: COVID-19; critical scrutiny; logic; pandemic; response; SARS-CoV-2

Online: 12 May 2021 (10:48:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0141.v2

Effectiveness of Health Education Given To Prevent Back Pain In Women: Pre- And Post-Test Study

Elizabeth Olubunmi Babalola

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: low back pain; women; exercise; physical activity; health education; Oswestry Disability Index; Back Pain Functional Scale; ergonomics

Online: 10 May 2021 (14:07:50 CEST)

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Working Paper ARTICLE

What Is the Environmental Impact of Different Strategies for the Use of Medical and Community Masks?

Alexandre Bouchet, Julien Boucher, Kevin schutzbach, Nicolas Senn, blaise genton, david vernez

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Facemask; community mask; medical mask; recycling; reuse; carbon footprint; COVID-19

Online: 26 April 2021 (20:04:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0642.v1

Keratin5-BMP4 Mechanosignaling Network Regulates Cell Cytoskeletal Reorganization and Chromatin Accessibility during Revascularization-Based Blastema Regeneration

Xuelong Wang, Huiping Guo, Feifei Yu, Hui Zhang, Ying Peng, Chenghui Wang, Gang Wei, Jizhou Yan

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: blastema regeneration: epigenetic reprogramming; keratin; BMP signaling; myocardium resalvage; zebrafish

Online: 23 April 2021 (13:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0492.v1

Monetary Health Co-benefits and GHG Emissions Reduction Benefits: Contribution from Private on-the-road Transport

Je-Liang Liou, Pei-Ing Wu

Subject: Business, Economics And Management, Economics Keywords: Benefit matrix; Benefit transfer method; Benefit per ton; Health; Social cost of carbon; Value of statistical life

Online: 19 April 2021 (13:42:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0491.v1

Productive Capacities, Economic Growth and Economic Growth Volatility in Developing Countries: Does Structural Economic Vulnerability Matter?

Sena Kimm Gnangnon

Subject: Business, Economics And Management, Economics Keywords: Productive capacities; Economic growth; Economic growth volatility; Structural Economic Vulnerability.

Online: 19 April 2021 (13:30:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202104.0398.v1

A Two-Stage Polynomial and Nonlinear Growth Approach for Modeling the COVID-19 Outbreak in Mexico

Rafael Perez Abreu, Samantha Estrada, Héctor de-la-Torre-Gutiérrez

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: COVID-19; epidemic modeling; time series forecasting; nonlinear growth models; Prais-Winsten estimation

Online: 15 April 2021 (07:44:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0197.v2

Stability and Stabilization of Ecosystem for Epidemic Virus Transmission Under Neumann Boundary Value Via Impulse Control

Ruofeng Rao

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Neumann boundary value; Laplacian semigroup; Poincare inequality lemma; impulse control; Lyapunov-Razumikhin method

Online: 14 April 2021 (16:10:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0342.v1

Energy Scenarios towards Achieving SDG7 and the Interlinkages with Other Sustainable Development Goals: A Systematic Review

Fatma S. Hafez, Da’u Abba Umar, Y.H. Taufiq Yap, Saad Mekhilef

Subject: Engineering, Automotive Engineering Keywords: Energy; Sustainable Development Goal 7; Sustainable Development Goals; Paris Agreement; 2030 agenda.

Online: 13 April 2021 (10:50:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0328.v1

Eye-tracking in Immersive Virtual Reality for Education: A Review of the Current Progress and Applications

Maria Mikhailenko, Mikhail Kurushkin

Subject: Business, Economics And Management, Accounting And Taxation Keywords: eye-tracking; virtual reality; education and VR; education and eye-tracking

Online: 13 April 2021 (09:11:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0326.v1

PET and SPECT Imaging of Tumor Micro-Environment: A Systematic Review of the Last 20 Years

Valeria Stati, Chiara Lauri, Michela Varani, Martina Conserva, Alberto Signore

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: microenvironment; radiopharmaceuticals; treatment response; personalised medicine; Nuclear Medicine

Online: 13 April 2021 (08:29:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0566.v2

4D Einstein - Gauss - Bonnet Gravity with Nonlinear Electrodynamics: Entropy, Energy Emission, Quasinormal Modes and Deflection Angle

Sergey Kruglov

Subject: Physical Sciences, Acoustics Keywords: Einstein - Gauss - Bonnet gravity; nonlinear electrodynamics; entropy; energy emission; quasinormal modes; deflection angle

Online: 12 April 2021 (12:11:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0269.v1

Application of Long Short Term Memory Networks for Long- and Short-term Bus Travel Time Prediction

Osama Osman, Hesham Rakha, Archak Mittal

Subject: Engineering, Transportation Science And Technology Keywords: Travel Time Prediction; Deep Learning; Long Short Term Memory Networks; transit; temporal correlation

Online: 9 April 2021 (15:04:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0251.v1

Effects of Least Cost Homemade Ration on Growth Performance of Sasso and Indigenous Breeds of Chicks

Lemma Gulilat, Firew Tegegne, Solomon Demeke

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Breed; Diet; Growth; Indigenous; Intake; Sasso

Online: 9 April 2021 (09:48:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0224.v1

Electrical Transport and Magnetic Properties of Metal/Metal Oxide/Metal Junctions Based on Anodized Metal Oxides

Arkadiusz Zarzycki, Juliusz Chojenka, Marcin Perzanowski, Marta Marszalek

Subject: Chemistry And Materials Science, Biomaterials Keywords: magnetic junction; magnetoelectric properties; metal-oxides; porous; anodization, thin film

Online: 8 April 2021 (09:13:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0218.v1

The Role of Advance Care Planning in Cancer Patient and Caregiver Grief Resolution: Helpful or Harmful?

Francesca B Falzarano, Holly Gwen Prigerson, Paul Kevin Maciejewski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Grief; Advance Care Planning; Advanced Cancer, Family Caregivers

Online: 7 April 2021 (17:51:17 CEST)

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Working Paper ARTICLE

Is Ride-sourcing Service really Sustainable : Operational efficiency and Social Welfare Analysis through an equilibrium model

zipeng zhang, 宁张

Subject: Social Sciences, Psychology Keywords: Vacant trip; Cruising Taxis service; ride sourcing service

Online: 6 April 2021 (13:25:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0144.v1

Biofilm Inhibition and Antimicrobial Properties of Silver Ion-Exchanged Zeolite a against Vibrio spp Marine Pathogens

Zarina Amin, SAZMAL EFFENDI ARSHAD, NUR ARIFAH WALY

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Biofilms; Zeolite A; Vibrio sp; Antimicrobials

Online: 5 April 2021 (14:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0138.v1

Comparison of Forecasting Ability for Energy Consumption in BRICS: ARIMA (1,1,1) and FGM (1, 1) Models

Atif Maqbool Khan, Magdalena Osinska

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Energy consumption; BRICS; GM (1, 1); Fractional-order; GREY; Forecasting accuracy

Online: 5 April 2021 (13:51:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0121.v1

Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America

Janvier Gasana, Boubakari Ibrahimou, Ahmed N. Albatineh, Mustafa Al-Zoughool, Dina Zein

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Allergy; Asthma; Wheeze; Rhinitis; Home Allergens; Household Dust; Mildew; Cockroach; Dust mites; Pets; Endotoxin; Population Study; Prevalence Study; NHANES

Online: 5 April 2021 (12:23:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0101.v1

Generation and Activity Evaluation of a Mouse-Human Immunoglobulin G1 Chimeric Antibody to Histoplasma capsulatum HSP60

Ágata Nogueira D'Áurea Moura, Scott J. Garforth, Leandro Buffoni Roque da Silva, Darien Woodley, Filipe Vieira Barbalho, Jose A. Quiroz, Steven C. Almo, Jonathan R. Lai, Joshua Daniel Nosanchuk, Carlos Pelleschi Taborda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mouse-Human Chimeric Antibody; Immunotherapy; Infectious diseases; Histoplasmosis; Paracoccidioidomycosis; Histoplasma capsulatum; Paracoccidioides lutzii

Online: 5 April 2021 (11:33:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0094.v1

Recent Survey for Delphinids at Tristao Islands, Guinea, Reinforces Concern for Bycatches and Marine Bushmeat Use

Idrissa Bamy, Abdoulaye Djiba, Koen Van Waerebeek

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: West Africa ; Atlantic humpback dolphin ; bottlenose dolphin ; bycatch ; marine bushmeat ; aquatic wild meat ; conservation

Online: 5 April 2021 (10:38:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0089.v1

High Concentration of Heavy Metal and Metalloid Levels in Edible Campomanesia adamantium Pulp from Anthropic Areas

David Johane Machate, Elaine S. Pádua Melo, Daniela G. Arakaki, Rita de Cássia Avellaneda Guimarães, Priscila Aiko Hiane, Danielle Bogo, Arnildo Pott, Valter Aragão de Nascimento

Subject: Chemistry And Materials Science, Biomaterials Keywords: Cerrado; Myrtaceae; edible fruit; farm-margin; roadside; macro- and microelements; health risk.

Online: 5 April 2021 (10:21:30 CEST)

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Working Paper ARTICLE

Depression in Bolivian Adults During COVID 19 Social Confinement: Moderating Effects of Resilience and Self-Efficacy

Eric Roth, Gustavo Choque, M. Fernanda García, Andrés Villalobos

Subject: Social Sciences, Psychology Keywords: Depression by confinement; COVID 19; Bolivia; perceived loneliness; anxiety; moderation effects

Online: 2 April 2021 (18:47:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0013.v1

Application of Analytical Hierarchy Process for Structural Health Monitoring and Prioritizing of Concrete Bridges in Iran

Saeid Darban, Hosein Ghasemzadeh Tehrani, Nader Karballaeezadeh, Amir Mosavi

Subject: Engineering, Civil Engineering Keywords: transportation infrastructure; concrete bridges; structural health monitoring; bridge condition index; analytical hierarchy process; prioritizing

Online: 1 April 2021 (11:14:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0769.v1

Towards a Pluralistic and Experiential Teaching of Economics for the Agenda 2030. the SDSN France Textbook

Thomas Lagoarde-Segot, Laurence Le Poder

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Economics education; Sustainability

Online: 31 March 2021 (14:40:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0752.v1

Assessing Combined Effects for Mixtures of Similar and Dissimilar Acting Neuroactive Substances on Zebrafish Embryo Movement

Afolarin Olaposi Ogungbemi, Riccardo Massei, Rolf Altenburger, Stefan Scholz, Eberhard Küster

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Mixture toxicity; Neurotoxicity; Antagonism; Organophosphate; Acetylcholinesterase inhibitors; GABA; Behavior; Risk assessment; Spontaneous movement activity

Online: 31 March 2021 (07:52:05 CEST)

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Risk assessment of chemicals is usually conducted for individual chemicals whereas mixtures of chemical are occurring in the environment. Considering that neuroactive chemicals are a group of contaminants that dominate in the environment, it is then imperative to understand the combined effects from mixtures. The commonly used models to predict mixture effects, namely concentration addition (CA) and independent action (IA), are thought suitable for mixtures of similarly or dissimilarly acting components, respectively. For mixture toxicity prediction, one important challenge is to clarify whether to group neuroactive substances based on similar mechanisms of action, e.g. same molecular target or rather similar toxicological response, e.g. hyper- or hypoactivity (effect direction). We addressed this by using the spontaneous tail coiling (STC) of zebrafish embryos, which represents the earliest observable motor activity in the developing neural network, as a model to elucidate the link between mechanism of action and toxicological response. Two questions were asked: 1.) Can the mixture models CA or IA be used to predict combined effects for neuroactive chemical mixtures when the components share a similar mode of action (i.e. hyper- or hypoativity) but show different mechanism of action? 2.) Will a mixture of chemicals where the components show opposing effect directions result in an antagonistic combined effect? Results indicate that mixture toxicity of chemicals such as propafenone and abamectin as well as chlorpyrifos and hexaconazole that are known to show different mechanisms of action but similar effect directions were predictable using CA and IA models. This could be interpreted with the convergence of effects on the neural level leading to either a collective activation or inhibition of synapses. We also found antagonistic effects for mixtures containing substances with opposing effect direction. Finally, we discuss how the STC may be used to amend risk assessment.

Preprint ARTICLE | doi:10.20944/preprints202103.0634.v1

GEM-Based Detectors for Direct Detection of Low-Mass WIMP, Solar Axions and Narrow Resonances (Quarks)

Victor Parusov, Boris Ovchinnikov

Subject: Physical Sciences, Acoustics Keywords: MGEM; pin-anodes; Low-Mass WIMP; Axions; Quarks; TPC; SD-interactions; H2; CF4; CH4; TMAE

Online: 25 March 2021 (15:21:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0602.v2

Symptoms and Underlying Diseases Associated with the Hospitalization Period of 3480 Covid-19 Patients in Hormozgan, Iran

Hesamuddin Kamalzadeh Takhti, Mahdieh Ardaneh, Shahram Zare, Maryam Rezaei Sarkhaei, Ehsan Amiri-Ardekani

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; hospitalization period; respiratory disease; Hormozgan

Online: 10 May 2021 (12:34:09 CEST)

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Abstract Introduction: COVID-19 has a relationship with patients’ demographic characteristics as well as their underlying diseases. This research has been conducted to evaluate factors' effect on Covid-19 patient's hospitalization rate and period in Hormozgan, Iran. Materials and Methods: The inclusion criteria of this retrospective study included all patients diagnosed as COVID-19 Patients after PCR who were referred to Covid-19 hospitals from February 2020 to June 2020 in Hormozgan province, Iran. After the completion of the consent form and observing ethical principles, 3480 patients' information was collected through the interview by Medical care monitoring center unit experts. The checklist was designed according to COVID-19 guidelines and approved by the World Health Organization and Iran Ministry of Health and Medical Education. The studied variables included gender, age, patients’ residence place, smoking history and medications use history, pregnancy, referral type to hospital, contact history with COVID-19 patients, early symptoms, gastrointestinal symptoms, intubation, Po2 level, history of cancer, chronic liver diseases, diabetes, chronic blood diseases, HIV/AIDS, acquired or congenital immunodeficiency, cardiovascular diseases, chronic kidney diseases, dialysis status, asthma and other chronic lung diseases, and chronic neurological disorders. These data were analyzed using descriptive (average-standard deviation-percentage) and analytical (including Chi-square, t-test, and regression tests) statistics with SPSS Ver.23 software. Results: In this study, 3480 COVID-19 patients including 1852 male patients (53.20%) with a median age of 43.11±21.72 and 1628 female patients (46/80%) with a median age of 44.86±22.40. The median age of men was significantly lower than the women's median age (P= 0.02). The duration of hospitalization of male and female patients was reported 2.64±4.14 and 2.76±4.297, respectively which was not statistically significant. The death rate of patients in our study was 6.6%. Conclusion: The results of this study also showed that the hospitalization period of HIV-positive patients and patients with cardiovascular and pulmonary diseases is much longer than other people, which imposes many human and financial costs on the country's health care system. Therefore, to maintain individual health and help improve the critical condition of the virus, it is better to develop and apply stricter protocols to prevent further outbreaks of the disease and check underlying diseases of people suspected to have Covid-19. These results can improve health care system planning and improving medical services presented to covid-19 patients.

Preprint ARTICLE | doi:10.20944/preprints202103.0545.v1

Is Ride-sourcing Service Really Sustainable : Operational Efficiency and Social Welfare Analysis Through an Equilibrium Model

zipeng zhang, Ning Zhang

Subject: Engineering, Automotive Engineering Keywords: Vacant trip; Cruising Taxis service; ride sourcing service

Online: 22 March 2021 (15:43:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0360.v1

ClefNet: Recurrent Autoencoders with Dynamic Time Warping for Near-Lossless Music Compression and Minimal-Latency Transmission

Vignav Ramesh, Mason Wang

Subject: Computer Science And Mathematics, Computer Science Keywords: music production, latent space, live system, recurrent autoencoder, dynamic time warping, compression

Online: 15 March 2021 (08:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0352.v1

Entomological Remote Dark Field Signal Extraction by Maximum Noise Fraction and Unsupervised Clustering for Species Identification

Kouakou Benoit, Eliane Koko Assoi, Adolphe Yatana Gbogbo, Jeremie Zoueu

Subject: Physical Sciences, Acoustics Keywords: remote sensing; spectroscopy; blind source separation; unsupervised clustering; insects

Online: 12 March 2021 (20:16:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0351.v1

Strategies to Increase Uptake of Parent Education Programs in Preschool and School Settings: A Delphi Study

Wan Hua Sim, John W Toumbourou, Elizabeth M Clancy, Elizabeth M Westrupp, Michelle L Benstead, Marie BH Yap

Subject: Social Sciences, Psychology Keywords: family-school; home-school; parent engagement; family engagement; parent involvement; recruitment; prevention; intervention; mental health; partnership

Online: 12 March 2021 (20:10:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0346.v1

New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect

Anca Roxana Petrovici, Natalia Simionescu, Andreea Isabela Sandu, Vasile Paraschiv, Mihaela Silion, Mariana Pinteala

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cannabidiol; hemp oil; soft decarboxylation; antioxidant properties; reactive oxygen species; apoptosis; osteosarcoma

Online: 12 March 2021 (16:28:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0288.v1

COVID-19 and Health Information Seeking Behavior: Digital Health Literacy Survey Amongst University Students in Pakistan

Rubeena Zakar, Sarosh Iqbal, Muhammad Zakria Zakar, Florian Fischer

Subject: Business, Economics And Management, Accounting And Taxation Keywords: eHealth Literacy; digital health literacy; sense of coherence; COVID-19; COVID-HL-Q; Pakistan.

Online: 10 March 2021 (15:07:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0279.v1

Resolution of the Faint Young Sun Paradox via the Expanding Earth and Radiation Balance Equilibrium Hypothesis

Golden Gadzirayi Nyambuya

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Expanding Earth; Exolife; Faint Young Sun Paradox; Radiation Balance Equation.

Online: 10 March 2021 (13:07:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0239.v1

EU Green Deal and Opportunity Cost: A Comparison Between the Viability of Different Wastewater Treatment Project

José María Vindel, Estrella Trincado, Antonio Sánchez-Bayón

Subject: Business, Economics And Management, Accounting And Taxation Keywords: EU Green Deal; Horizon 2030; clean energy production; High-rate algal ponds (HRAP); activated sludge system (AS); photovoltaic power (PV)

Online: 9 March 2021 (07:23:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0287.v2

The Impact of the COVID-19 Pandemic on Quality of Life and Well-Being in Morocco

Zouhour Samlani, Yassine Lemfadli, Adil Ait Errami, Sofia Oubaha, Khadija Krati

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Covid-19; quality of life; mental health; physical health

Online: 8 March 2021 (09:51:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0206.v1

Predicting Electrokinetic Coupling and Electrical Conductivity in Fractured Media Using a Bundle of Tortuous Capillary Fractures

Luong Duy Thanh, Damien Jougnot, Phan Van Do, Dang Thi Minh Hue, Tran Thi Chung Thuy, Vu Phi Tuyen

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Fractured media; Streaming potential; Electrical conductivity; Fractal

Online: 5 March 2021 (21:51:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0154.v1

Bioactive Components in Oat and Barley Grain as a Promising Breeding Trend for Functional Food Production

Nataliia Shvachko, Igor Loskutov, Tatyana Semilet, Vitaly Popov, Olga Kovaleva, Alexey Konarev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: β-glucans; polysaccharides; flavonoids; anthocyanins; antioxidants; biological role of pigments; gene families

Online: 4 March 2021 (11:19:12 CET)

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Working Paper ARTICLE

XEN Glaucoma Implant for Refractory Glaucoma Management: Results and Complications during a 2-year Follow-up

Katarzyna Lewczuk, Joanna Konopińska, Joanna Joablonska, Zofia Mariak, Marek Rękas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: refractory glaucoma; XEN implant; management; retrospective study, MIGS, glaucoma surgery, bleb, subconjunctival stent

Online: 2 March 2021 (14:25:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0069.v1

Influence of Traditional and Solar Reflective Coatings on the Heat Transfer of Building Roofs in Mexico

Iván Hernández-Pérez

Subject: Engineering, Automotive Engineering Keywords: Solar reflective coatings; Heat transfer; Heat gains; Building roofs

Online: 2 March 2021 (10:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0042.v1

Determination of the modulus of elasticity using a Smartphone and mode of unsupport beam Euler-Bernoulli

Newton Huamaní Castro

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Modulus of elasticity; frequency spectrum; mic; Euler-Bernoulli equation

Online: 1 March 2021 (18:31:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0023.v1

Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated with Maternal Undernutrition

Polyxeni-Maria Sarli, Antigoni Manousopoulou, Elias Efthymiou, Andreas Zouridis, Anastasios Potiris, Panagiota Pervanidou, Konstantinos Panoulis, Nikolaos Vlahos, Efthimios K. Deligeoroglou, Spiros D. Garbis, Makarios Eleftheriades

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: FGR; fetal programming; food restriction; metabolic disorders; liver proteomics

Online: 1 March 2021 (13:54:56 CET)

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Working Paper ARTICLE

Increased Excitability of Serotoninergic Neurons and Reduced Concentrations of Circulating Corticosteroids Two Weeks After Chronic Stress in Rats: Mechanisms Involved

Eliyahu Dremencov, Daniil Grinchii, Katarína Buzgoova, Maxim Lapshin, Maria Komelkova, Jan Graban, Olga Tseilikman, Vadim Tseilikman, Daniela Jezova

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: predator scent; aldosterone; corticosterone; adrenal gland; dorsal raphe nucleus (DRN); serotonin (5-HT); electrophysiology

Online: 15 July 2021 (10:40:31 CEST)

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Working Paper ARTICLE

New Insights Into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel a-Ring Reduced Metabolites

Steffen Loke, Lingyu Liu, Maxi Wenzel, Heike Scheffler, Michele Iannone, Xavier de la Torre, Nils Schloerer, Francesco Botrè, Annekathrin Martina Keiler, Matthias Bureik, Maria Kristina Parr

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: 17α-methyl steroids; long-term metabolites; gas chromatography-mass spectrometry; 17-hydroxymethyl-17-methyl-18-nor; D-ring alteration; doping control; metabolism

Online: 1 March 2021 (13:19:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0584.v1

Occurrence of Physiological Browning Disorders in Stored ‘Braeburn’ Apples as Influenced by Orchard and Weather Conditions

Roy McCormick, Konni Biegert, Josef Streif

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: controlled atmosphere (CA) storage; crop load; internal browning disorders; receiver operating characteristic (ROC)

Online: 25 February 2021 (13:45:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0525.v1

Exploring New Scaffolds for the Dual Inhibition of HIV-1 Rt Polymerase and Ribonuclease Associated Functions

Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Peter Matyus, Elias Maccioni

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: HIV-RT; ribonuclease H; dual inhibitors; docking; putative binding

Online: 23 February 2021 (15:51:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0521.v1

Evaluating the Accuracy of Gridded Population Estimates in Slums: A Case Study in Nigeria and Kenya

Dana R. Thomson, Andrea E. Gaughan, Forrest R. Stevens, Gregory Yetman, Peter Elias, Robert Chen

Subject: Business, Economics And Management, Accounting And Taxation Keywords: SDG11; urban; deprivation; informal settlement; poverty; mapping

Online: 23 February 2021 (14:31:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0513.v1

Development of Tools for Coastal Management in Google Earth Engine: Uncertainty Bathtub Model and Bruun Rule

Lucas Terres de Lima, Sandra Fernández-Fernández, João Francisco Gonçalves, Luiz Magalhães Filho, Cristina Bernardes

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Sea-Level Rise; GIS; Open-Source Software; Modeling

Online: 23 February 2021 (12:39:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0510.v1

Descriptive Analysis Of Clinical Presentation And Management Of Pancreatic Trauma At A Level I Trauma Centre

Hassan Al-Thani, Ahmed Faidh Ramzee, Ammar Al-Hassani, Gustav Strandvik, Ayman El-Menyar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: trauma; pancreas; abdominal injury; head injury; polytrauma

Online: 23 February 2021 (11:03:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0440.v1

Effect of Different Types of Warm-up on Strength and Skin Temperature of Paralympic Powerlifting Athletes

Marcelo de Aquino Resende, Felipe J. Aidar, Roberta Barreto Vasconcelos Resende, Gracielle Costa Reis, Layanne de Oliveira Barros, Dihogo Gama de Matos, Anderson Carlos Marçal, Paulo Francisco de Almeida-Neto, Alfonso López Díaz de Durana, María Merino Fernández, José Vilaça-Alves, Breno Guilherme de Araújo Tinoco Cabral, Eduardo Borba Neves, Victor Machado Reis, Nuno Domingos Garrido

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: warm up; muscle force; performance; resistance training; thermal imaging; physiology

Online: 19 February 2021 (14:15:20 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202102.0434.v1

Phenotypic Divergence of P Proteins of Australian Bat Lyssavirus Lineages Circulating in Microbats and Flying Foxes

Celine Deffrasnes, Meng-Xiao Luo, Linda Wiltzer, Cassandra T David, Kim G Lieu, Lin-Fa Wang, David A. Jans, Glenn A. Marsh, Gregory Moseley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Australian bat lyssavirus; lyssavirus; rabies virus; immune evasion; nuclear trafficking; interferon; STAT1; bats; virus reservoirs; adaptation

Online: 19 February 2021 (10:06:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0432.v1

Biomedical Research During the COVID-19 Pandemic: Success in Sars-Cov-2 and Other Infectious Diseases

Nuno S. Osório, Maria Isabel Veiga

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; SARS-CoV-2; Infectious disease; Pandemics; Epidemics; Biomedical Research

Online: 19 February 2021 (10:03:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0421.v1

Development of Tools for Coastal Management in Google Earth Engine: Uncertainty Bathtub Model and Bruun Rule

Lucas Terres de Lima, Sandra Fernández-Fernández, João Francisco Gonçalves, Luiz Magalhães Filho, Cristina Bernardes

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Sea-Level Rise; GIS; Open-Source Software; Modeling

Online: 18 February 2021 (13:52:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0411.v1

Loneliness and Its Associated Factors Nine Months After the COVID-19 Outbreak: A Cross-National Study

Tore Bonsaksen, Mariyana Schoultz, Hilde Thygesen, Mary Ruffolo, Daicia Price, Janni Leung, Amy Østertun Geirdal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: concerns; coronavirus; cross-national study; pandemic; social distancing; social media

Online: 18 February 2021 (11:02:48 CET)

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Working Paper ARTICLE

Predicting the Curvature of the Cosmos, and Point of Volume Contraction in a Big Bounce Scenario

Christopher Pilot

Subject: Physical Sciences, Acoustics Keywords: Big Bounce Model, Closed Universe, Cosmological Curvature, Big Crunch, Cyclic Universe, Heat Engine Model for Universe

Online: 16 February 2021 (13:41:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0313.v1

The Impact of New Ways of Working on Organizations and Employees: A Systematic Review of Literature

Karine Renard, Frederic Cornu, Yves Emery, David Giauque

Subject: Business, Economics And Management, Accounting And Taxation Keywords: New Ways of Working, Flexible Work Arrangements, Activity-Based Offices, Flexitime, Telework, Knowledge Workers

Online: 12 February 2021 (16:29:21 CET)

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