ARTICLE
|
doi:10.20944/preprints201711.0008.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
WNT pathway; porcupine inhibitor ETC-1922159; sensitivity analysis; colorectal cancer; unknown biological hypotheses; combinatorial search space; support vector ranking; DNA repair and genomic stability factor RAD51
Online: 1 November 2017 (05:08:04 CET)
REVIEW
|
doi:10.20944/preprints202309.1883.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
neutrophil extracellular traps (NETs); innate immunity; sepsis; lung disease; cardiovascular disease; liver disease; kidney disease; diabetes; COVID-19; coagulopathy and thrombotic microangiopathy; cancer; autoimmunity; preeclampsia; Kawasaki disease
Online: 28 September 2023 (04:00:59 CEST)
REVIEW
|
doi:10.20944/preprints202309.0633.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
metastatic hormone-sensitive prostate cancer; new hormonal agents; transcriptomic profiling; DNA damage repair genes; tumor suppressor genes; androgen receptor; immunotherapy; CDK4/6 inhibitors; PARP inhibitors; AKT inhibitors.
Online: 11 September 2023 (07:17:07 CEST)
ARTICLE
|
doi:10.20944/preprints202301.0454.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cell stress response; heat shock protein 90 (HSP90); SCAN domain-containing proteins (SCAND); MZF1; heat shock factors (HSF); co-expression correlation; Kaplan-Meyer analysis; cancer patients prognosis
Online: 25 January 2023 (10:18:20 CET)
REVIEW
|
doi:10.20944/preprints202201.0366.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cell-free DNA; liquid biopsy; cancer; next-generation sequencing (NGS); minimal residual disease; measurable residual disease; molecular residual disease (MRD); leukemia; lymphoma; myeloma; myeloproliferative neoplasms; myelodysplastic syndrome
Online: 25 January 2022 (08:13:24 CET)
COMMUNICATION
|
doi:10.20944/preprints202007.0709.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
intrinsic multi-drug resistance; acquired multi-drug resistance; circulating tumor cells; single cells; cell clusters; cell monolayer; multi-cellular spheroids; cytometry of reaction rate constant; ovarian cancer
Online: 30 July 2020 (09:01:50 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Neuroendocrine Neoplasms; NOTCH; cancer driven genes; mutational mechanism; germline mutations.; small cell lung carcinoma; pancreatic NET; small bowel NET; medullary thyroid carcinoma; malignant castration-resistant prostatic cells
Online: 23 July 2019 (10:34:50 CEST)
REVIEW
|
doi:10.3390/sci2030068
Subject:
Medicine And Pharmacology,
Tropical Medicine
Keywords:
COVID-19; pooling clinical trials; hyperinfection; steroids; treatment; targeted healthcare; population health management; cancer treatment; clinical research; clinical trials; developing vaccines; ranking and rating hospital quality; school closures; interventions for delirium; assessments of COVID-19 death inequities; regulatory safeguards; preventing child abuse and maltreatment; prevalence of health care worker burnout; nursing home ratings; challenging oncology practice; addressing racial; ethnic; social and economic divides; violence against sexual minority adolescents; primary tumors; metastasis; stages of cancer; reforming cancer clinical trials; supporting carers; protection and prevention; benign and malignant tumors; reforming cancer clinical trials; protection of healthcare personnel; comparing excess deaths in NYC; 1918 influenza pandemic; the possibility of full recovery from COVID-19; mental health impact of COVID-19 on young adults; ranking and rating nursing home quali
Online: 21 August 2020 (00:00:00 CEST)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
ARTICLE
|
doi:10.20944/preprints202309.0068.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
head and neck neoplasms; head and neck cancer; head and neck squamous cell carcinoma; radiotherapy; radiochemotherapy; salvage surgery; time interval; body composition; skeletal muscle; computed tomography scan; radiomics
Online: 4 September 2023 (02:41:55 CEST)
REVIEW
|
doi:10.20944/preprints202302.0123.v2
Subject:
Computer Science And Mathematics,
Mathematical And Computational Biology
Keywords:
WNT; NF-κ B, Ion Channels; Anthrax toxin recep- tors; Poliovirus receptors; Porcupine inhibitor ETC-1922159; Sensitivity analysis; Colorectal cancer; Unknown biological hypotheses; Combinatorial search space; Support vector ranking
Online: 20 September 2024 (11:03:20 CEST)
ARTICLE
|
doi:10.20944/preprints202107.0277.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Cervical cancer; Pap smear test; whole slide image (WSI); feature pyramid network (FPN); global context aware (GCA); region based convolutional neural networks (R-CNN); Region Proposal Network (RPN).
Online: 12 July 2021 (23:05:34 CEST)
REVIEW
|
doi:10.20944/preprints202010.0510.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
disease-associated mutation; IDR; intrinsically disordered region; LLPS; phase separation; PTM; Ahr; AhRR; SIM1; SIM2; Hif-2α; NPAS4; ARNT2; BMAL1; disorder prediction; LLPS prediction; cancer; HuVarBase; catGranule prediction
Online: 26 October 2020 (10:30:47 CET)
ARTICLE
|
doi:10.20944/preprints202009.0429.v1
Subject:
Biology And Life Sciences,
Ecology, Evolution, Behavior And Systematics
Keywords:
Microplastics; Polyethylene Ocean Water; Microplastics identification; Microorganisms identification; Ocean Water quality; Drinking water; Food quality; Cancer and microplastics; plastic and ocean; particle physics; particle accelerators in environmental studies.
Online: 18 September 2020 (11:03:59 CEST)
REVIEW
Subject:
Physical Sciences,
Condensed Matter Physics
Keywords:
Si micro- and nanoparticles; optically induced dynamic nuclear polarization; optical spin orientation; nuclear spin hyperpolarization; photosensitized generation of singlet oxygen; magnetic resonance imaging; diagnostics and therapy of cancer
Online: 21 June 2020 (10:37:30 CEST)
ARTICLE
|
doi:10.20944/preprints202310.1811.v1
Subject:
Medicine And Pharmacology,
Obstetrics And Gynaecology
Keywords:
Cervical cancer; HPV screening; Prevention strategies; Human Papillomavirus; HIV interaction; "Test and Treat" approach; Number Needed to Treat; Positive Predictive Value; Negative Predictive Value; Risk management; Global health challenges
Online: 27 October 2023 (13:21:23 CEST)
REVIEW
|
doi:10.20944/preprints202306.1113.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
Inflammatory bowel disease; Colitis-associated colorectal cancer; exogenous frees hemoglobin alpha chain; Fenton reaction; DNA damage; haptoglobin; deferoxamine; flavonoids; hydrogen peroxide; hygiene; iron; nanomedicine; oxidative stress; polyphenol; pharmaceutical therapy
Online: 16 June 2023 (07:11:38 CEST)
ARTICLE
|
doi:10.20944/preprints202211.0080.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Tumor initiation; Germ cell traits of tumors; Primordial germ cell-like tumor cells; Somatic to Pri-mordial germ cell-like transformation; Embryonic/germ cell hypothesis of tumor; Breast cancer
Online: 4 November 2022 (01:04:58 CET)
ARTICLE
|
doi:10.20944/preprints202301.0086.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
diffusion-weighted whole body imaging with background suppression(DWIBS); magnetic res-onance imaging (MRI); lung cancer; response evaluation criteria in solid tumors (RECIST); ap-parent diffusion coefficient (ADC); BD Score
Online: 5 January 2023 (01:43:25 CET)
HYPOTHESIS
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
environment; virus; pollutant; evolution; exaptation; stem cells; transposons; APOBEC; ADAR,; ORF2p; cancer; Eco-Evo-Devo; symbiosis; ecological genomics; environmental stress; genetic recombination; biological plasticity; hypermutation; epigenetics; fractal systems; natural selection
Online: 19 July 2020 (19:35:46 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1606.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Oral squamous cell carcinoma; OSCC; oral cancer; miRNA; miRNA expression; genes; gene expression; hyperplasia; dysplasia; early invasion; early stage OSCC; in situ carcinoma; precancerous lesions; animal model; early diagnosis; liquid biopsy
Online: 24 May 2024 (08:38:17 CEST)
REVIEW
|
doi:10.20944/preprints202311.0383.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
ACD; asymmetric cell division; AMF; amoebozoa; metazoa and fungi; DSCD; defective symmetric cell division; GRN; gene regulatory network; MGRS; multinucleated genome repair syncytium; NG; non-gametogenic germline; PGCC; polyploid giant cancer cell
Online: 7 November 2023 (11:39:43 CET)
ARTICLE
|
doi:10.20944/preprints202103.0658.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Pancreatic cancer; RNAseq; Humans; Weight loss; Prognosis; Rectus Abdominis; Carcinoma, Pancreatic Ductal; Adipose Tissue; Pancreatic Carcinoma; Pancreatic Neoplasms; Subcutaneous Fat; High-Throughput Nucleotide Sequencing; Body Composition; Muscles; Cachexia; Muscular Atrophy; Gene Expression
Online: 26 March 2021 (11:24:10 CET)
REVIEW
|
doi:10.20944/preprints202405.0500.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Gilbert’ s syndrome (GS), Genetic variations, Protective effects of Gilbert’ s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’ s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Online: 9 May 2024 (02:57:19 CEST)
REVIEW
|
doi:10.20944/preprints202203.0135.v1
Subject:
Biology And Life Sciences,
Food Science And Technology
Keywords:
Aspirin; COVID-19; Human blood platelets; Platelet hemostatic function; Angiogenesis; Fatty acids; Immunity; Inflammation; Non-hemostatic function; Atherosclerosis; Cancer; Diabetes; Obesity; Hypertension; Bioactive compound; Water-soluble tomato extract; Kiwi fruit; Fruitflow®; papaya leaf extract; Polyphenols; Evodiamine; Polyphenols
Online: 10 March 2022 (02:42:26 CET)
ARTICLE
|
doi:10.20944/preprints201810.0073.v1
Subject:
Medicine And Pharmacology,
Other
Keywords:
Classification; F-score; Gray-Level Co-occurrence Matrix (GLCM); Gray-Level Run-Length Matrix (GLRLM); Hepatocellular Carcinoma (HCC); Liver Cancer; Liver Abscess; Image Texture, Sequential Backward Selection (SBS); Sequential Forward Selection (SFS); Support Vector Machine (SVM); Ultrasound Image.
Online: 4 October 2018 (14:01:42 CEST)
REVIEW
|
doi:10.20944/preprints202407.1456.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
advanced therapy medicinal products (ATMPs); chimeric antigen receptors (CAR-T cells); B acute lymphoblastic leukaemia (B-ALL); food and drug administration (FDA); systemic lupus erythematosus (SLE); idiopathic inflammatory myositis (IIM); systemic sclerosis (SS); memorial sloan kettering cancer centre (MSKCC); hematopoietic stem cell transplantation [HSCT], non-Hodgkin’ s cell lymphoma (NHCL); multiple myeloma (MM); follicular lymphoma; (FL); large B cell-lymphoma (LBCL); mantle cell lymphoma (MCL); myeloid-derived suppressor cells (MDSCs); rheumatoid arthritis (RA); immune effector cell-associated neurotoxicity syndrome (ICANS); natural killer group member D ligands (NKG2DLs); acute myelogenous leukaemia (AML)
Online: 18 July 2024 (08:03:12 CEST)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)