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Preprint ARTICLE | doi:10.20944/preprints202002.0121.v1

The Effect of the Tool Rotational Speed, Plunging Speed and Tool Progressive Speed on the Defects During Friction Stir Processing on AZ91

Hoda Amini, Bani Arab, Hoseinpour Gollo, Bahram Nami

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Friction stir processing; Microhardness; creep; AZ91 alloy

Online: 10 February 2020 (09:17:00 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202001.0280.v1

Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to SMC Proliferation, Vascular Calcification, and Advanced Atherosclerosis

Yoko Kojima, Jianqin Ye, Vivek Nanda, Ying Wang, Alyssa M. Flores, Kai-Uwe Jarr, Pavlos Tsantilas, Liang Guo, Aloke V. Finn, Renu Virmani, Nicholas Leeper

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atherosclerosis; vascular biology; calcification; genetics; 9p21

Online: 24 January 2020 (11:17:21 CET)

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Background: Genome-wide association studies have identified the chromosome 9p21 locus as one of the most important genetic risk factors for cardiovascular disease. However, the mechanism by which this locus promotes disease remains unclear due to difficulty identifying the causal genes and lack of a suitable animal model. Methods and Results: A total of 180 coronary artery autopsy specimens were analyzed histopathologically. The genotype of 9p21 (rs1333049) was not associated with any coronary risk factors nor the vulnerable plaque phenotype, but carriers of 9p21 risk allele did demonstrate more lesional calcification. To extend these studies into an animal model, mice with a targeted deletion of the orthologous 70-kb non-coding interval on chromosome 4 (chr4^D70kb/^D70kb) were bred onto ApoE^-/- and fed with high fat diet. Targeted deletion of the 9p21 risk interval increased susceptibility to atherosclerotic plaque progression, but did not affect plaque rupture in the tandem stenosis model. Coronary risk factors such as body weight, blood pressure, lipid, and glucose levels did not differ between genotypes. Von Kossa staining revealed that chr4^D70kb/^D70kb, ApoE^-/- developed more calcification in the plaque compared with chr4^+/⁺, ApoE^-/- mice, and that this this change was accompanied by increased aortic mRNA expression of Runx2, a key osteogenic transcription factor. Primarily cultured smooth muscle cells from chr4^D70kb/^D70kb were hyperproliferative, and showed a calcification-prone phenotype after exposure to high-phosphate medium. Treatment with Palbociclib, a selective inhibitor of cyclin-dependent kinase 4/6, reduced mRNA expression of osteogenic genes in smooth muscle cells. Conclusion: Results from human and mouse studies indicate that the 9p21 non coding risk interval is associated with larger atherosclerotic plaque burden, but not with plaque rupture. 9p21 may promote lesion expansion by inducing the proliferation of de-differentiated and osteogenic smooth muscle cells.

Preprint ARTICLE | doi:10.20944/preprints202001.0270.v1

A Cost-minimization Analysis of Provider-to-provider Telemedicine Compared to Usual care in Catalonia: More Agile and Efficient, Especially for Users

Francesc López Seguí, Jordi Franch Parella, Xavier Gironès García, Jacobo Mendioroz Peña, Francesc García Cuyàs, Cristina Adroher Mas, Anna García-Altés, Josep Vidal Alaball

Subject: Business, Economics And Management, Economics Keywords: cost analysis; health technology assessment; provider-to-provider telemedicine; telehealth; economic analysis

Online: 23 January 2020 (16:19:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0173.v1

Description and Genome Analysis of Methylotetracoccus aquaticus sp. nov. , a Novel Tropical Wetland Methanotroph, with the Amended Description of Methylotetracoccus gen. nov.

Monali Rahalkar, Kumal Khatri, Jyoti Mohite, Pranitha Pandit, Rahul Bahulikar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: wetlands; methanotrophs; India; tropical; novel species; Type Ib; Methylotetracoccus

Online: 16 January 2020 (11:51:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0118.v1

Synthesis of ZnO-NPs Using Convolvulus Leaf Extract and Proving Its Efficiency as an Inhibitor for Carbon Steel Corrosion in 1M HCl

Ghadah Al-Senani

Subject: Chemistry And Materials Science, Electrochemistry Keywords: ZnO-NPs; corrosion; synthesis; carbon steel; convolvulus; leaf; extract

Online: 12 January 2020 (13:53:53 CET)

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Working Paper ARTICLE

High-frequency Near-infrared Diode Laser Irradiation Attenuates IL-1β-induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

Shuzo Sakata, Ryo Kunimatsu, Yuji Tsuka, Ayaka Nakatani, Tomoka Hiraki, Hidemi Gunji, Naoto Hirose, Makoto Yanoshita, Kotaro Tanimoto, Nurul Aisyah Rizky Putranti

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: high-frequency near-infrared diode laser; osteoarthritis; inflammation; matrix metalloproteinase; human chondrocyte

Online: 9 January 2020 (12:22:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0133.v1

Tatiana Leonova, Veronika Popova, Alexander Tsarev, Christian Henning, Kristina Antonova, Nadezhda Rogovskaya, Maria Vikhnina, Alena Soboleva, Ekaterina Dinastia, Mandy Dorn, Olga Shiroglasova, Tatiana Grishina, Gerd U. Balcke, Christian Ihling, Galina Smolikova, Sergei Medvedev, Vladimir A. Zhukov, Vladimir Babakov, Igor A. Tikhonovich, Marcus A. Glomb, Tatiana Bilova, Andrej Frolov

Subject: Biology And Life Sciences, Plant Sciences Keywords: advanced glycation end products (ages); drought; glycation; sh-sy5y human neuroblastoma cells; metabolomics; osmotic stress; pea (pisum sativum l.); pro-inflammatory; seeds; seed metabolism; signaling

Online: 10 December 2019 (14:53:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0029.v1

Evaluation of Oral Supplementation with a Casein Hydrolysate-based Formula to Favor the Clearance of HR-HPV Infections and their Derived Lesions

Carmen Pingarrón, Alfonso Duque, Ana Isabel López, Juan Ferragud

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: hpv; papilloma; lsil; hsil; hpv clearance; immunomodulation; nk cells; casein hydrolysate; ditriamino; hupavir

Online: 3 December 2019 (12:07:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0007.v1

Annual Projections of Future Built-Settlement Expansion Using Relative Changes in Projected Small Area Population and Short Time-Series of Built-Extents

Jeremiah J. Nieves, Maksym Bondarenko, Alessandro Sorichetta, Jessica E. Steele, David Kerr, Alessandra Carioli, Forrest R. Stevens, Andrea E. Gaughan, Andrew J. Tatem

Subject: Social Sciences, Geography, Planning And Development Keywords: urban; growth model; forecast; built; settlement; machine learning; time series

Online: 2 December 2019 (05:15:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0319.v1

Effects of Energy Consumption of Top 24 Polluted Countries on their GDP: New Evidence Based on Natural Resources and Production of Electricity

Rabnawaz Khan, YuSheng Kong

Subject: Business, Economics And Management, Economics Keywords: co2 emission; energy consumption; production of electricity; gdp

Online: 26 November 2019 (15:22:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0304.v1

Kaolinite-Magnesite Based Ceramics. Part I: Surface Charge and Rheological Properties Optimization of the Suspensions for the Processing of Cordierite-mullite Tapes

Aghiles Hammas, Gisèle Laure Lecomte-Nana, Nadjet Azril, Imane Daou, Claire Peyratout, Fatima Zibouche

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: Kaolinitic clay; magnesite; slurries; Na silicate; Na hexametaphosphate; rheology

Online: 26 November 2019 (03:37:00 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201911.0182.v1

Development of Populus alba L. and Populus tremula L. Species Specific Molecular Markers Based on the 5S rDNA Non-transcribed Spacer Polymorphism

Oleg S. Alexandrov, Gennady I. Karlov

Subject: Biology And Life Sciences, Forestry Keywords: poplars; molecular markers; non-transcribed spacers (ntss); 5s rdna; interspecies hybridization; species identification

Online: 15 November 2019 (16:50:27 CET)

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Working Paper ARTICLE

Perfect Combination of LBL with Sol-Gel Film to Enhance the Anticorrosion Performance on Al Alloy under Simulated and Accelerated Corrosive Environment

Xia Zhao, Zuquan Jin, Shuai Yuan, Binbin Zhang, Nazhen Liu, Shibo Chen, Shuan Liu, Xiaolin Sun, Jizhou Duan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: multilayer; corrosion; impedance; layer-by-layer

Online: 12 November 2019 (10:17:53 CET)

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Working Paper ARTICLE

Effect of Interlayer Cooling Time, Constraint and Tool Path Strategy on Deformation of Large Components made by Laser Metal Deposition with Wire

Yousub Lee, Yashwanth Bandari, Peeyush Nandwana, Brian Gibson, Brad Richardson, Srdjan Simunovic

Subject: Engineering, Mechanical Engineering Keywords: large-scale additive manufacturing; interlayer cooling time; tool path optimization; part deformation; Ti-6Al-4V

Online: 10 November 2019 (09:04:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0091.v1

Quality Criteria to Evaluate Performant and Scope of 2030 Agenda in Metropolitan Areas: Case Study on Strategic Planning of Environmental Municipality Management

María de Fátima Poza-Vilches, José Gutiérrez-Pérez, María Teresa Pozo-Llorente

Subject: Social Sciences, Urban Studies And Planning Keywords: 2030 Agenda; strategic planning; quality criteria

Online: 8 November 2019 (08:11:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0283.v1

Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge

Nayara Araújo dos Reis, Rosalina Aparecida Partezani Rodrigues, Darlene Mara dos Santos Tavares, Jack Roberto Silva Fhon, Jair Sindra Virtuoso Júnior

Subject: Medicine And Pharmacology, Hematology Keywords: chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health

Online: 25 October 2019 (04:16:43 CEST)

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Working Paper ARTICLE

Identiﬁcation of Hydrothermal Alteration Minerals for Exploring Gold Deposit Based on SVM and PCA Using ASTER Data: A Case Study of Gulong

Kai Xu, Xiaofeng Wang, Chunfang Kong, Ruyi Feng, Gang Liu, Chonglong Wu

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: gold deposit; alteration information; ASTER image; support vector machine (SVM); principal component analysis (PCA)

Online: 22 October 2019 (04:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0238.v1

Hybrid Machine Learning Model of Support Vector Machine and Fruit Fly Optimization Algorithm for Prediction of Remaining Service Life of Flexible Pavement

Nader Karballaeezadeh, Adrienn Dineva, Amir Mosavi, Narjes Nabipour, Shahaboddin Shamshirband, Danial Mohammadzadeh

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: hybrid machine learning model; transportation infrastructure; flexible pavement; remaining service life prediction; pavement condition index; support vector regression; fruit fly optimization algorithm (foa); gene expression programming (gep); svr-foa

Online: 20 October 2019 (17:11:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0230.v1

Quantification of Carotid Intraplaque Hemorrhage: Comparison between Manual Segmentation and Semi-Automatic Segmentation on Magnetization-Prepared Rapid Acquisition with Gradient-Echo Sequences

Young Ju Song, Hyo Sung Kwak, Gyung Ho Chung, Seongil Jo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: carotid intraplaque hemorrhage; carotid atherosclerosis; semi-automatic quantification; MPRAGE

Online: 20 October 2019 (01:39:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0323.v1

Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity

Se-Hee An, Chung-Young Lee, Seung-Min Hong, Chang-Seon Song, Jae-Hong Kim, Hyuk-Joon Kwon

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: clade 2.3.2.1c h5n1 virus; immunity evasion; ha trimer stability; thermostability; mammalian pathogenicity

Online: 29 September 2019 (05:21:52 CEST)

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Working Paper ARTICLE

Kinetics of Deformation and Recovery inQuasi-Stationary Deformation of Particle-Hardened Ultrafine-Grained Cu-Zr at 0.5 T_m Studied by Load Changes

Wolfgang Blum, Jiri Dvorak, Petr Kral, Philip Eisenlohr, Vaclav Sklenicka

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: cu-zr; ecap; ultrafine-grained; deformation; dynamic recovery; transient; load change tests

Online: 26 September 2019 (03:02:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0240.v1

Satisfaction Level of Tuberculosis Patients Regarding their Access to TB Care and Prevention Services, Delivered through Public Private Mix Model in Pakistan

Syed Mustafa Ali, Naveed Anjum, Farah Naureen, Aamna Rashid, Adeel Tahir, Muhammad Ishaq, Muhammad Usman

Subject: Public Health And Healthcare, Nursing Keywords: patient satisfaction; quality of care; private healthcare provider; public private mix model; tuberculosis control; health system

Online: 20 September 2019 (15:42:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0125.v1

Dietary Patterns Independent of Fast Food Are Associated with Obesity among Korean Adults: Korea National Health and Nutrition Examination Survey 2010–2014

Do-Yeon Kim, Ahleum Ahn, Hansongyi Lee, Jaekyung Choi, Hyunjung Lim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: adults; dietary pattern; fast food; KNHANES; obesity

Online: 11 September 2019 (14:59:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0272.v1

Benthic Habitat Morphodynamics- Using Remote Sensing to Quantify Storm-Induced Changes in Nearshore Bathymetry and Surface Sediment Texture at Assateague National Seashore

Arthur Trembanis, Alimjan Abla, Ken Haulsee, Carter DuVal

Subject: Environmental And Earth Sciences, Oceanography Keywords: side-scan sonar; swath bathymetry; habitat monitoring; hurricane Sandy; hurricane Joaquin; climate change; shoreline detection; remote sensing

Online: 26 August 2019 (15:47:04 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints201908.0232.v1

Preprint: Data from a Systematic Review of Crowdsourcing of Research Data from Wildlife Tourism Photographs and Comments Shared on Social Networking Sites

Greg D Simpson, Obelia Walker

Subject: Environmental And Earth Sciences, Environmental Science Keywords: citizen science; crowdsourced data; ecotourism; natural Resource management; social media; photo-elicitation; photovoice; wildlife conservation; wildlife tourism

Online: 22 August 2019 (11:32:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0141.v1

Post Synthetic Defect Engineering of UiO-66 Metal-Organic Framework with Iridium(III)-HEDTA Complex and Application in Catalysis for Water Oxydation

Ferdinando Costantino, Alceo Macchioni, Giordano Gatto, Roberto Bondi, Fabio Marmottini

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Metal-Organic Framework; Post-Synthetic Modification; Iridium Catalysis; Water Oxidation; Water Splitting

Online: 12 August 2019 (11:53:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0137.v1

Evaluation of The Antifungal Activity Of Mentha x piperita (Lamiaceae) Of Pancalieri (Turin, Italy) Essential Oil And Its Synergistic Interaction With Azoles

Vivian Tullio, Janira Roana, Daniela Scalas, Narcisa Mandras

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: essential oils; Mentha x piperita; “Mentha of Pancalieri”; azoles; antifungal activity; yeasts and dermatophytes; synergism

Online: 12 August 2019 (04:52:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0130.v1

You Can’t See the Woods for the Trees: Invasive Acer negundo L. In Urban Riparian Forests Harms Biodiversity and Limits Recreation Activity

Daria Sikorska, Piotr Sikorski, Piotr Archiciński, Jarosław Chormański, Richard Hopkins

Subject: Biology And Life Sciences, Forestry Keywords: blue-green infrastracture; nature-based solutions; urban green spaces; invasive trees; trampling

Online: 11 August 2019 (11:24:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0055.v1

Can Fetuin-A Level, CRP, and WBC be a Predictive Value in the Diagnosis of Acute Appendicitis in Children with Abdominal Pain?

Abuzer Coskun, Cengiz Güney

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: emergency department; pediatric acute appendicitis; perforatio; fetuin-A level

Online: 5 August 2019 (08:00:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0028.v1

Hypoglycemic, Antiglycation and Cytoprotective Properties of A Phenol Rich Extract from Waste Peel of Punica Granatum L. Var. Dente Di Cavallo DC2

Antonella Di Sotto, Marcello Locatelli, Alberto Macone, Chiara Toniolo, Stefania Cesa, Simone Carradori, Margherita Eufemi, Gabriela Mazzanti, Silvia Di Giacomo

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: vegetable waste; phenolics; hyperglycemia-induced oxidative stress; antioxidant activity; AGE inhibition

Online: 2 August 2019 (10:36:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0009.v1

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Minxuan Yang, Yinglin Lu, Qizhao Zhu, Peng Gao, Xiaolei Xie, Debing Yu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: tea polyphenol; serum hormone; enzyme activity; immune function, enzyme-related genes

Online: 1 August 2019 (05:18:08 CEST)

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The present study was conducted to evaluate the effects of dietary supplementation of tea polyphenol （TP） on serum hormone, serum enzyme activity, antioxidant-related and immune-related gene expression of laying hens under heat stress. A total of 288 Chinese yellow chicken (186 days old) were randomly distributed among two treatments, each of which included 6 replicates of 24 hens. Dietary treatments were that the basal diet was supplemented with 200 mg / kg tea polyphenol. The study lasted for 7 weeks, including 1 week of adaptation and 6 weeks of the formal test. The content of high-density lipoprotein cholesterol (HDL-C) and total protein (TP) in serum significantly decreased by dietary supplementation with tea polyphenol. Dietary tea polyphenol supplementation improved serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activity and decreased serum malondialdehyde (MDA) content in treatments compared to the control. However, supplementation of tea polyphenol did not affect the activity of serum catalase (CAT). The results indicated that long-term feeding of tea polyphenols help to increase the amount of hormones (FSH, E2) associated with reproduction in laying hens and thus improve egg production. It also improved the immune function of laying hens in high temperature environments. Adding tea polyphenols to the diet can significantly increase the serum IgG, IgM content of the laying hens and can upregulate the IgA content. Dietary supplementation of tea polyphenols in the laying hens significantly increased the expression of antioxidant enzyme-related genes (SOD, CAT and GPX1) in the liver. Moreover, the addition of tea polyphenols significantly increased the expression of immune-related genes (Interferon-γ (INF-γ), Interleukin 2 (IL-2) and Interleukin 4 (IL-4)) in the spleen. It is concluded that addition of tea polyphenols has a positive effect on antioxidant activity and immune function of laying hens.

Preprint REVIEW | doi:10.20944/preprints201908.0002.v1

p53 Regulates Homeostasis in Irradiation-Injured Tissue in the Developing Brain and Mature Testis in the Small-Fish Model, Medaka (Oryzias latipes)

Takako Yasuda

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: p53; irradiation; medaka; developing brain; testis; apoptosis; embyogenesis; regeneration, mis-differentiation

Online: 1 August 2019 (03:46:42 CEST)

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Working Paper REVIEW

A New Perspective of Genetic Associations to the Cause of Multiple Sclerosis: The Role of Genes Expressed on Chromosomes 2 and 5

Robin Terese Montesano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress

Online: 22 July 2019 (04:37:27 CEST)

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The literature on the causation of multiple sclerosis (MS), both genetic and environmental, extends over hundreds of years, with no firm conclusions on the exact role of autoimmunity and lifestyle. The epidemiology of MS was the basis for this review, but with a new, extensive examination of genes pertaining to each disorder, and disease of first, and second, degree relatives of those with MS. The author’s motivation was to discover some relationship between MS, and notable familial conditions, as the heredity of MS is concluded to be 30%, and the disorders had a chronic and/or idiopathic nature. This investigation hoped to further understand the randomness of MS- who acquires it, and what symptoms develop- after the author’s decades of observing several incidences of multiple members developing MS in a single family. Online databases for the human genome were used to link genes to MS, and symptoms, including excessive depression, fatigue and suicide rates, in coordination with linking genes for specific familial conditions including seizures, stroke, mental illness, bowel disorders, and thyroid conditions. Interesting associations were found, notably a cluster of Th2 cytokines, known to cure the animal model of MS, important receptors for neurotransmitters and hormones, a gene specific to Epstein Barr Virus, and potential genes for mitochondrial dysfunction. The results surprised the author, showing polygenic regions of chromosome 2 and 5, especially a cluster at loci 5q31-q33, may be dysregulated. The conclusion agrees with past hypotheses MS results not from a single gene, but from various genes, including those expressed in glial cells. The individual theories to the causation of MS, starting with Charcot may be explained by multiple pathways converging into a single disease outcome. In coordination with a sunlight factor, chromosome 2 appears to mediate the immune system, and inflammation, through ultraviolet radiation producing vitamin D3 in the skin, but additionally through peptides formed in the melanocyte stimulating and concentrating hormone class. The impact of stress in MS could be primary, given the loci of several stress-related and stress-modulated genes on these chromosomes, and calls for more appreciation of, and greater care for, the MS patients’ state of mind.

Working Paper ARTICLE

Experimental Study on the Crystallinity of Different Density Polyethylenes on the Breakdown Characteristics and the Conductance Mechanism Transformation under High Electric Field

Liwei Zhou, Xuan Wang, Yongqi Zhang, Peng Zhang, Zhi Li

Subject: Physical Sciences, Particle And Field Physics Keywords: polyethylene; crystallinity; breakdown strength; conduction mechanism; SCLC; Field strength.

Online: 17 July 2019 (10:20:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0139.v1

Contributions of the Left- and the Right-Hemisphere on the Language-Induced Grip Force Modulation of the Left Hand in Unimanual Task

Ronaldo Luis da Silva, Francielly Ferreira Santos, Isabela Maria Gonçalves Mendes, Fátima Aparecida Caromano, Johanne Higgins, Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: grip force modulation; embodied language; left hand; right hemisphere; left hemisphere; unimanual task

Online: 10 July 2019 (07:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0195.v1

A Novel Hybrid Segmentation Method with Particle Swarm Optimization and Fuzzy C-Mean Based On Partitioning the Image for Detecting Lung Cancer

Kavitha P., Prabakaran S.

Subject: Computer Science And Mathematics, Information Systems Keywords: adaptive bilateral; marker watershed; PSO; fuzzy C-mean; GLCM; SVM

Online: 20 June 2019 (09:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0113.v1

Analysis of the Relationship Between Organizational Entrepreneurship and the Performance of Qom Telecom Center with the Role of Moderating Perceived Environmental Factors

Mohammad Karehvand

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: entrepreneurship; organizational entrepreneurship; organization performance; risk-taking; innovation; environmental factors

Online: 13 June 2019 (08:01:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0011.v1

Influence of the Rift Molango over the mineralization of platinum group elements and light rare earths into a sedimentary exhalative ore deposit

Edgar A. Cardenas-Reyes, Eleazar Salinas-Rodríguez, Juan Hernández-Ávila, Ventura Rodríguez-Lugo, Ma. Pilar Gutierrez-Amador, Edmundo Roldan-Contreras, Eduardo Cerecedo-Sáenz

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Platinum; Light Rare Earths Elements; Sedimentary ore deposit: SEDEX

Online: 3 June 2019 (09:12:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0292.v1

Is Perceived Exertion an Useful Indicator of Metabolic and Cardiovascular Response to Metabolic Conditioning of Functional-Fitness Session? A Randomized Controlled Trial

Ramires Alsamir Tibana, Nuno Manuel Frade de Sousa, Jonato Prestes, Dahan da Cunha Nascimento, Carlos Ernesto, Joao Henrique Falk Neto, Michael Kennedy, Fabrício Azevedo Voltarelli

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: CrossFit; high-intensity functional training; Extreme conditioning programs

Online: 24 May 2019 (11:36:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0265.v1

Modeling and Simulation of a Novel Piezo-Motor Based on Piezoelectric Properties of Pb(1-x)Srx(Ti0,48Zr0,52)(1-y)NbyO3 Ceramics

Lucian Pîslaru-Dănescu, Ion Fuiorea, Alina Dumitru, Lică Flore, Albert Arnau Cubillo, Ionel Popescu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: PZT; mixed-oxides techniques; dielectric properties; piezoelectricity; ultrasonic piezo-motor; piezoelectric cylinder; numerical simulation

Online: 22 May 2019 (08:41:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0170.v2

Moving Surface Boundary Layer Control Analysis and the Influence of the Magnus Effect on an Aerofoil with a Leading-Edge Rotating Cylinder

Md. Abdus Salam, Bhuiyan Shameem Mahmood Ebna Hai, M. A. Taher Ali, Debanan Bhadra, Nafiz Ahmed Khan

Subject: Engineering, Mechanical Engineering Keywords: Moving surface boundary layer control; symmetric aerofoil; asymmetric aerofoil; velocity ratio; Magnus effect; lift coefficient; drag coefficient

Online: 17 May 2019 (13:06:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0193.v1

Reconstruction of a Segment of the UNESCO World Heritage Hadrian’s Villa Tunnel Network by Integrated GPR, Magnetic-Paleomagnetic, and Electric Resistivity Prospections

Annalisa Ghezzi, Antonio Schettino, Pietro Paolo Pierantoni, Lawrence Conyers, Luca Tassi, Luigi Vigliotti, Erwin Schettino, Milena Melfi, Maria Elena Gorrini, Paolo Boila

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: archaeological geophysics; magnetic methods; ground penetrating radar; tunnel detection; data integration

Online: 15 May 2019 (11:14:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0186.v1

Colonization of Legionella spp. in Hot and Cold Water Networks of Residential Buildings in Pisa District (Tuscany, Italy): A Five-Years Survey

Michele Totaro, Anna Laura Costa, Lorenzo Frendo, Erica De Vita, Serena Giorgi, Beatrice Casini, Paola Valentini, Antonio Gallo, Gaetano Privitera, Angelo Baggiani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Legionella spp.; residential buildings; waterborne pathogens, water safety plan.

Online: 15 May 2019 (10:36:57 CEST)

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Working Paper ARTICLE

Effect of New Analogs of Hexyloxy Phenyl Imidazoline on Quorum Sensing in Chromobacterium violaceum and In Silico Analysis of Ligand-Receptor Interactions

José Luis Herrera-Arizmendi, Everardo Curiel-Quesada, José Correa-Basurto, Martiniano Bello, Alicia Reyes-Arellano

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: azolines synthesis; quorum sensing; Chromobacterium violaceum CV026; molecular docking; molecular dynamics

Online: 6 May 2019 (08:59:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0321.v1

Whole Genome Diversity, Population Structure and Linkage Disequilibrium Analysis of Chickpea (Cicer arietinum L.) Genotypes Using Genome-Wide DArTseq-Based SNP Markers

Somayeh Farahani, Mojdeh Maleki, Rahim Mehrabi, Homayoun Kanouni, Reza Talebi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chickpea; genetic diversity; linkage disequilibrium; DArTseq-SNP markers

Online: 29 April 2019 (07:56:52 CEST)

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Characterization of genetic diversity, population structure and linkage disequilibrium is prerequisite for proper management of breeding programs and conservation of genetic resources. In this study, 186 chickpea genotypes including advanced “Kabuli” breeding lines and Iranian landrace “Desi” chickpea genotypes were genotyped using DArTseq-Based SNP markers. Out of 3339 SNPs, 1152 markers with known chromosomal position were selected for genome diversity analysis. The number of mapped SNP markers varied from 52 (LG8) to 378 (LG4), with an average of 144 SNPs per linkage group. The chromosome size that covered by SNPs varied from 16236.36 kbp (LG8) to 67923.99 kbp (LG5), while LG4 showed higher number of SNPs, with an average of 6.56 SNPs per Mbp. Polymorphism information content (PIC) value of SNP markers ranged from 0.05 to 0.50, with an average of 0.32, while the markers on LG4, LG6 and LG8 showed higher mean PIC value than average. Un-weighted Neighbor Joining cluster analysis and Bayesian-based model population structure grouped chickpea genotypes into four distinct clusters. Principal component analysis (PCoA) and Discriminant Analysis of Principal Component (DAPC) results were consistent with that of the cluster and population structure analysis. Linkage disequilibrium (LD) was extensive and LD decay in chickpea germplasm was relatively low. A few markers showed r²≥0.8, while 2961 pairs of markers showed complete LD (r²=1) and a huge LD block was observed on LG4. High genetic diversity and low kinship value between pairs of genotypes suggesting the presence of a high genetic diversity among studied chickpea genotypes. This study also demonstrated the efficiency of DArTseq-based SNP genotyping for large scale genome analysis in chickpea. The genotypic markers provided in this study are useful for various association mapping studies when combined with phenotypic data of different traits such as seed yield, abiotic and biotic stresses and therefore can be efficiently used in breeding programs to improve chickpea.

Preprint ARTICLE | doi:10.20944/preprints201904.0238.v1

Assessment of Residual Feed Intake and Its Relevant Measurements in Two Varieties of Japanese Quail (Coturnix coturnix japonica) under High Environmental Temperature

Moataz M. Fathi, Ibrahim Al-Homidan, Tarek A. Ebeid, Ahmed Galal, Osama K. Abou-Emera

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: residual feed consumption; quail; high environmental temperature

Online: 22 April 2019 (11:22:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0177.v1

Enhanced Protection of Biological Membranes during Lipid Peroxidation. Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

Anja Sadžak, Lucija Mandić, Vida Strasser, Goran Baranović, Darija Domazet Jurašin, Maja Dutour Sikirić, Suzana Šegota

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: lipid peroxidation; membrane elasticity; mesoporous silica nanoparticles; myricetin; myricitrin; nanomechanics; protective effects of flavonoids; quercetin

Online: 16 April 2019 (09:54:03 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201904.0034.v2

Enhancing Food Safety through Adoption of Long-Term Technical Advisory, Financial and Storage Support Services in Maize Growing Areas of East Africa

Samuel Mutiga, Arnold Mushongi, Erastus Kang'ethe

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Maize, Food Safety, Community-based Support systems, Integrated Mycotoxin Control Strategies

Online: 8 April 2019 (13:21:53 CEST)

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Grain production and storage are major components in food security. In the ancient times, food security was achieved through gathering of fruits, grains, herbs, tubers, and roots from the forests by individual households. Advancements in human civilization led to domestication of crops and a need to save food for not only a household, but the nation. This extended need for food security led to establishment of national reservoirs for major produces and this practice varies greatly in different states. Each of the applied food production, handling and storage approaches has got its benefits and challenges. In sub-Saharan Africa, several countries have a public funded budget to subsidize production costs, to buy grains from farmers and to store the produce for a specific period and/or until the next harvests. During the times of famine, the stored grains are later given free to the citizens. If there is no famine, the grain is sold to retailers and/or processors (e.g., millers) who later sell it to the consumers. This approach works well if the produce (mainly grain) is stored under conditions that do not favor growth of molds, as some of these could contaminate the grain with toxic and carcinogenic metabolites called mycotoxins. Conditions that alleviate contamination of grains are required during production, handling and storage. Most of the grain is produced by smallholder farmers under sub-optimal conditions, which make vulnerable to colonization and contamination by toxigenic fungi. Further, the grain is stored in silos at large masses, where it is hard to monitor the conditions at different points of these facilities, and hence it becomes vulnerable to additional contamination. Production and storage of grain under conditions that favor mycotoxins poses major food health and safety risks to humans and livestock who consume the grain. This concept paper focuses on how establishment of local grain production and banking system (LGPBS) could enhance food security and safety in East Africa. The concept of LGPBS provides an extension of advisory and finance support within warehouse receipting system to enhance grain production under optimal conditions. The major practices at the LGPBS, and how each could contribute to food security and safety are discussed. While the concept paper gives more strength on maize production and safety, similar practices could be applied to enhance safety of other grains in the same LGPBS.

Working Paper ARTICLE

Effect of Three Different Physical Therapy Approaches on Function and Disability of the Knee Joint in Patients with Knee Osteoarthritis. Randomized Study.

Tareq F. Alkhudhir, Ahmed S. A. Youssef, Ayman A. Mohamed, Shimaa Emara, Min Lu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Disability, function, knee osteoarthritis, physical therapy.

Online: 22 March 2019 (10:10:19 CET)

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BACKGROUND: Knee osteoarthritis (OA) commonly causes increase in the patients’ disability and reduce their function because it causes pain, limitation in knee range of motion and decrease in muscle power.AIM: This study investigated the effect of three different physical therapy programs on knee range of motion , pain level, muscle strength and functional condition in patients with knee OA. DESIGN: Randomized comparative study.SETTING: Outpatient Rehabilitation clinic of Tongji Hospital (Wuhan, China).POPULATION: Seventy-two patients of Knee OA (aged 40-70) enrolled and randomly allocated into three groups. Group A (n=24) received physical agents and isometric quadriceps exercises, group B (n=24) received same physical agents as group A in addition to open kinetic chain exercises and group C (n=24) received physical agents as group A in addition to closed kinetic chain exercises.METHODS: knee range of motion (by electro goniometer), knee pain level (by VAS), quadriceps muscle strength (by isokinetic dynamometer) and functional condition (by WOMAC) were assessed before and after 5 weeks of treatment.RESULTS: In between group analysis, there were significant differences (P<0.05) between the three groups for all outcome measure. In within-group analysis, group C was the only group that showed significant differences (P<0.05) in all the outcomes. Group A and B showed significant differences (P<0.05) in quadriceps muscle strength and knee pain and no significant differences (P>0.05) in knee ROM and functional condition.CONCLUSIONS: After the study, our solid conclusion is that in physical therapy programs or protocols, closed kinematic chain exercise is very effective, it improves knee ROM, and help in reducing knee pain, muscle strength, function and disability for patients with knee osteoarthritis.CLINICAL REHABILITATION IMPACT: Comparison between different physical therapy programs provides the rehabilitation team with the best treatment intervention that is more effective in treating the problems associated with knee osteoarthritis.

Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0084.v1

Exploring the Influence of the Microstructure on the Passive Layer Chemistry and Breakdown for Some Titanium-Based Alloys in Normal Saline Solution

Nader El-Bagoury, Sameh Ibrahim, Ola Ahmed Abu Ali, Shimaa El-Hadad, Ahmed M. Fallatah, G.A.M. Mersal, Mohamed M. Ibrahim, Joanna Wysocka, Jacek Ryl, Rabah Boukherroub, Mohammed A. Amin

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: titanium-based alloys; microstructure; passivity breakdown; pitting corrosion

Online: 7 March 2019 (06:49:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0224.v1

Functional Fitness and Quality of Life among Women over 60 Years of Age Depending on their Level of Objectively Measured Physical Activity

Agnieszka Nawrocka, Jacek Polechoński, Wiesław Garbaciak, Władysław Mynarski

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: WHOQOL; Senior Fitness Test; exercises; actigraph; accelerometry; elderly; older adults; physical fitness

Online: 25 February 2019 (14:21:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0199.v1

Sleep Impairment at the Time of First Diagnosis in Patients with Seronegative Elderly-Onset Rheumatoid Arthritis and in Patients with Polymyalgia Rheumatica

Ciro Manzo, Alberto Castagna

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: polymyalgia rheumatica; elderly-onset rheumatoid arthritis; sleep impairment; seronegative rheumatoid arthritis; elderly patients

Online: 21 February 2019 (09:55:22 CET)

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Background: Differential diagnosis between polymyalgia rheumatica (PMR) and seronegative elderly-onset rheumatoid arthritis (SEORA) is not easy, to the point that in the past they were considered the same entity. In these patients, sleep disorders have been scarcely assessed, and considered as expression of mood disorders such as depression and anxiety. Methods: In 38 Caucasian elderly patients (median age: 73.9 ± 8.06 years) consecutively referred to two outpatient clinics from January to May 2018 with diagnosis of PMR and SEORA, sleep impairment was assessed using the Medical Outcomes Study-Sleep scale (MOS-SS). Depression and anxiety were assessed using the Neuropsychiatric Inventory (NPI) score, with point 0 for absent and point 3 for severe. Comorbidities were assessed using the Cumulative Illness Rating Scale (CIRS). Patients taking medications used to treat sleep disturbance or that could favor sleep disturbances were excluded. The study was approved by the local ethics committee and carried out in accordance with the Helsinki Declaration, revised 2013. Every patient signed an informed consent form at the time of the first visit. Results: MOS-SS total point in PMR patients was significantly higher than in SEORA patients (47.60 ± 8.4 vs 28.26 ± 12.4; P = 0.000). After six-month therapy with prednisone (12.5–15 mg/day, followed after 4 weeks by gradual tapering), MOS-SS total point improved in the two groups of patients, with no significant difference (17.0 ± 6.2 vs 17.8 ± 4.2; P = 0.644). No correlation was found between MOS-SS and comorbidities, and between MOS-SS, anxiety or depression. Conclusions: Our data suggest that the assessment of sleep impairment could be very useful in the differential diagnosis between PMR and SEORA. Up today, the reasons why patients with PMR have—at the time of diagnosis—a sleep impairment higher than SEORA are speculative. Further ad hoc complementary studies in multicenter cohorts are needed.

Preprint COMMUNICATION | doi:10.20944/preprints201902.0134.v1

Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Striking back on Treatments

Eloy Almenar-Pérez, Teresa Sánchez-Fito, Tamara Ovejero, Lubov Nathanson, Elisa Oltra

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Fibromyalgia (FM); Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); microRNA; miRNome; pharmacogenomics; pharmacoepigenomics; SM2miR; Pharmaco-miR; repoDB; ME/CFS Common Data Elements (CDEs)

Online: 14 February 2019 (11:04:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0016.v1

Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography–tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

Mohammad H. Semreen, Abdallah Shanableh, Lucy Semerjian, Hasan Alniss, Muath Mousa, Xuelian Bai, Kumud Acharya

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: liquid chromatography–tandem mass spectrometry; pharmaceuticals; wastewater analysis; solid phase extraction

Online: 2 February 2019 (03:21:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0299.v1

A Framework for Improving the Interpersonal Relationship of the Elderly with Mild Cognitive Impairment by Using Speaker Recognition and Social Network Platforms

Tan-Hsu Tan, Fu-Rong Jean, Chia-Jung Lin, Tsung-Yu Liu, Yung-Fa Huang

Subject: Engineering, Electrical And Electronic Engineering Keywords: mild cognitive impairment (MCI); speaker recognition; Gaussian Mixture Model (GMM); Universal Background Model (UBM)

Online: 30 January 2019 (05:11:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0232.v1

Computational Characterization of the mtORF of Pocilloporid Corals: Insights into Differences in Protein Structure and Function among Stylophora Lineages from Contrasting Environments

Eulalia Banguera-Hinestroza, Yvonne Sawall, Jean-François Flot

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein function, mtORF, Stylophora, thermal adaptation, disordered amino acids residues, pocilloporid corals, a transmembrane protein, pocilloporid corals.

Online: 23 January 2019 (08:58:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0096.v1

Interplay among calcium diet content, PTH(1-34) treatment and balance of bone homeostases in rat model: the trabecular bone as keystone

Marzia Ferretti, Francesco Cavani, Laura Roli, Marta Checchi, Maria Sara Magarò, Jessika Bertacchini, Carla Palumbo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: calcium diet content; mineral homeostasis; skeletal homeostasis; trabecular bone; PTH(1-34); rat

Online: 10 January 2019 (11:38:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0362.v1

An Update on Plant-Derived Compounds as Potential Inhibitors of the Bacterial Efflux Pumps: With Reference to Staphylococcus aureus and Escherichia coli

Saurav Das, Santosh Kumar, Pabitra Bhagowati, Ashish Kumar Singh

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Antibiotic resistance, efflux pump inhibitors, Escherichia coli, efflux pumps, multidrug resistance, Staphylococcus aureus

Online: 31 December 2018 (09:55:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0285.v1

Synergistic Effect of Mica, Glass Frit and Melamine Cyanurate for Improving Fire Resistance of Styrene-Butadiene Rubber Composites Destined for Ceramizable Coatings

Mateusz Imiela, Rafał Anyszka, Dariusz Bieliński, Magdalena Lipińska, Przemysław Rybiński, Bartłomiej Syrek

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: composite; ceramization; ceramification; styrene-butadiene rubber; melamine cyanurate; mica; flame retardancy; coating; glass frit

Online: 24 December 2018 (15:20:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0084.v1

Investigation of the Synergistic Toxicity of Binary Mixtures of Pesticides and Pharmaceuticals on Aliivibrio fischeri in Major River Basins in South Korea

In-hyuk Baek, Youngjun Kim, Seungyun Baik, Jongwoon Kim

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: mixture toxicity; concentration addition; pesticide; pharmaceuticals; Aliivibrio fischeri

Online: 6 December 2018 (11:08:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0043.v1

On the Volatility of Daily Stock Returns of Total Petroleum Company of Nigeria: Evidence from GARCH Models, Value-at-Risk and Backtesting

Ngozi G. Emenogu, Monday Osagie Adenomon, Nweze Nwaze Obinna

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: volatility; returns; stocks; total petroleum; akaike information criterion (AIC), GARCH; value-at-risk (VaR), backtesting

Online: 4 December 2018 (03:16:48 CET)

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Total Nigeria Plc is a Marketing and Services subsidiary of Total; a multinational energy company operating in more than 130 countries and committed to providing sustainable products and services for its customers. For over 50 years, Total Nigeria Plc has remained the leader in the downstream sector of the Nigerian oil and gas industry. This study investigated the volatility of the stock price of Total Petroleum Nigeria plc using nine (9) GARCH models namely sGARCH, gjrGARCH, eGARCH, iGARCH, aPARCH, TGARCH, NGARCH, NAGARCH and AVGARCH. We also investigated the Value-at-Risk (VaR) and Backtesting of the Models. The aim actually of this study is to boost the confidence of the shareholders and investors of the Total Nigeria plc. To achieve this, daily stock price for Total petroleum Nigeria plc from secondary was collected from January 2^nd 2001 to May 8^th 2017. . The study used both normal and student t innovations, using Akaike Information Criterion (AIC) to select the best model, for normal innovations for log returns and cleansed log returns of Total plc, the eGARCH and sGARCH models performed best respectively, while NGARCH model performed best for student t innovation for both log returns and cleansed returns of Total plc. The persistence of the models are stable except in few cases where iGARCH, eGARCH where not stable. Also for student t innovation, the sGARCH and gjrGARCH fails to converge. The mean-reverting number of day for the returns of Total Nigeria plc differs from model to model. Evidence from the VaR Analysis revealed from the selected models revealed that the Risk of VaR losses is high at 99% confidence level, slightly high at 95% confidence level and better at 90% confidence level. Although The Duration-Based Tests of independence conducted revealed that the models are correctly specified since in all cases the null hypotheses were accepted. This means that the probability of an exception on any day did not depends on the outcome of the previous day. Finally, both the unconditional (Kupiec) and conditional (Christoffersen) coverage tests for the correct number of exceedances for both Total stock returns and cleansed returns. The tests revealed rejection of the models at 1% level of significance. This confirms that unconditional (Kupiec) and conditional (Christoffersen) coverage tests for the correct number of exceedances are reliable compared to the Duration-Based Tests of independence. Therefore we recommend that shareholders and investors in Total Nigeria plc are to remain and continue to investment in Total Nigeria plc because if there is any form of losses, the price of the stock has the potentials to improve in the future. Again, though the risk is high at 99% confidence level, this in line with the financial theory that states that an asset with high expected risk would pay higher return on the average.

Preprint ARTICLE | doi:10.20944/preprints201812.0020.v1

Steric Effects of Alkyl Substituents at N-Donor Bidentate Amines Direct the Nuclearity, Bonding and Bridging Modes in Thiocyanato-Copper(II) Complexes

Franz A. Mautner, Roland C. Fischer, Ana Torvisco, Maher M. Henary, Andrew Milner, Hunter DeVillier, Tolga N. V. Karsili, Febee R. Louka, Salah S. Massoud

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: coordination compounds; coordination polymers; copper; thiocyanate; crystal Structure; DFT calculations

Online: 3 December 2018 (10:02:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0493.v1

Automated Recognition of Epileptic EEG States Using a Combination of Symlet Wavelet Processing, a Gradient Boosting Machine, and a Grid Search Optimizer

Xiashuang Wang, Guanghong Gong, Ni Li

Subject: Social Sciences, Behavior Sciences Keywords: recognition of epilepsy EEG; Symlet wavelet; gradient boosting machine; grid search optimizer; multiple-index evaluation

Online: 20 November 2018 (09:31:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0288.v1

Valuation, assessment and mapping of Ecosystems Services of the Site of Community Importance “Dunas de Mira, Gândara e Gafanhas” (Portugal); Methodological Approach

Luís Carlos Leitão, José Gomes Santos, Alexandra Aragão

Subject: Environmental And Earth Sciences, Environmental Science Keywords: ecosystem services; valuation; monetization; assessment; mapping, biodiversity; geographic information technologies

Online: 12 November 2018 (11:51:07 CET)

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Putting value to ecosystem services is something that society still refuses or simply ignores because it is not aware of the benefits that ecosystems provide us. In fact, people should be aware that a good understanding of ecosystem services can lead to win-win situations. Being aware of the importance of preserving the ecosystem and attaching value to its services will enable the development of self-sustaining strategies and appropriate policies for better ecological governance. Decades of over exploitation of natural resources, introduction and spread of alien species and, also, climate change, forest fires among other threats, have fostered biodiversity loss. The European Union Biodiversity Strategy has as one of its main goals to stop biodiversity loss and the degradation of ecosystem services; if possible, to recover the most threatened and degraded ecosystems, based on 20 Actions divided into 6 Targets. The present work falls within the scope of Action 5 of Target 2 – Improve knowledge of ecosystems and their services in the EU. The specific focus of this study is the Site of Community importance “Dunas de Mira, Gândara and Gafanhas” (Portugal) and the assessment of its ecosystem services, in accordance with the methodology proposed by the MAES (Mapping and Assessment of Ecosystems and their Services) Working Group. The work currently under way, a small segment of which is presented here, aims to identify, map and, when possible, assign value to the ecosystem services. For this purpose, modern GIS technologies will be used. This approach was implemented using a combination of data and tasks, including the photo-interpretation of Sentinel 2 (COPERNICUS Program) satellite imagery. The data geoprocessing tasks and image segmentation were developed using QGIS software and IMPACT Toolbox software (developed by the Joint Research Center – JRC, of the European Union), respectively. The analysis of Land Use and Burned Areas maps for the SCI "Dunas de Mira, Gândara and Gafanhas" led us to conclude that Forests ecosystems, the most affected by the fire of October 2017, continue to have the greatest expression in the area under study even though they have lost more than 50% of the area, and their services were also the ones most affected by the fire.

Preprint ARTICLE | doi:10.20944/preprints201811.0150.v2

The Inhibitory Effects and Positive Contributions of Live Foods on Protease Activities of Meagre, Argyrosomus regius (Asso 1801) Larvae in vitro Assay

Gürkan Diken, Orhan Demir, Mehmet Naz

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: meagre; Argyrosomus regius; protease activity; inhibitions; live foods; in vitro

Online: 9 November 2018 (10:43:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0091.v1

The Synthesis and Characterisations of Porous Thioamide-Sulfonated-Modified Poly (Acrylonitrile-Co-Divinylbenzene-80) as a Potential Sorbent to Capture Polar Analytes

Farhana Syakirah Ismail, Siti Nurul Ain Md. Jamil, Peter A. G. Cormack, Luqman Chuah Abdullah, Sazlinda Kamaruzaman, Rusli Daik

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: polyacrylonitrile; chemical modification; thiourea; polar pharmaceuticals; sulphonation; dispersion-solid phase extraction

Online: 5 November 2018 (08:48:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0025.v1

Effect of SLM Process Parameters on the Quality of Al Alloy Parts; Part I: Powder Characterization, Density, Surface Roughness, and Dimensional Accuracy

Ahmed H. Maamoun, Yi F. Xue, Mohamed A. Elbestawi, Stephen C. Veldhuis

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: additive manufacturing; selective laser melting; AlSi10Mg; Al6061; SLM process parameters; powder characterization; density, surface topology; dimensional accuracy

Online: 2 November 2018 (06:19:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0606.v1

Synthesis and Characterization of Cu Decorated Zeolite A@void@Et-PMO Nanocomposites for Removal of Methylene Blue by a Heterogeneous Fenton Reaction

Xiayu Li, Shangjing Zeng, Xuejian Qu, Jinyu Dai, Xiaofang Liu, Runwei Wang, Zongtao Zhang, Shilun Qiu

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: Fenton reaction; yolk-shell structure; zeolite A; PMO

Online: 25 October 2018 (12:38:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0456.v1

The salt-stress response of the transgenic plum line J8-1 and its interaction with the salicylic acid biosynthetic pathway from mandelonitrile

Agustina Bernal-Vicente, Daniel Cantabella, Cesar Petri, Jose Antonio Hernández, Pedro Díaz-Vivancos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chlorophyll fluorescence; J8-1 plum line; mandelonitrile; Prunus domestica; redox signalling; salicylic acid; salt-stress; soluble nutrients

Online: 19 October 2018 (14:57:02 CEST)

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Salinity is considered as one of the most important abiotic challenges that affect crop productivity. Plant hormones, including salicylic acid (SA), are key factors in the defence signalling output triggered during plant responses against environmental stresses. We have previously reported in peach a new SA biosynthetic pathway from mandelonitrile (MD), the molecule at the hub of the cyanogenic glucoside turnover in Prunus sp. In this work, we have studied whether this new SA biosynthetic pathway is also present in plum and the possible role this pathway plays in plant plasticity under salinity, focusing on the transgenic plum line J8-1, which displays stress tolerance via an enhanced antioxidant capacity. The SA biosynthesis from MD in non-transgenic and J8-1 micropropagated plum shoots was studied by metabolomics. Then the response of J8-1 to salt stress in presence of MD or Phe (MD precursor) was assayed by measuring: chlorophyll content and fluorescence parameters, stress related hormones, levels of non-enzymatic antioxidants, the expression of two genes coding redox-related proteins, and the content of soluble nutrients. The results from in vitro assays suggest that the SA synthesis from the MD pathway demonstrated in peach is not clearly present in plum, at least under in vitro conditions. Nevertheless, in J8-1 NaCl-stressed seedlings, an increase in SA was recorded as a result of the MD treatment, suggesting that MD could be involved in the SA biosynthesis under NaCl stress conditions in plum plants. We have also shown that the plum line J8-1 was tolerant to NaCl under greenhouse conditions, and this response was somewhat different in MD-treated plants. In that regards, the MD treatment produced an increase in SA, jasmonic acid (JA) and reduced ascorbate (ASC) contents as well as in the coefficient of non-photochemical quenching (qN) and the gene expression of Non-Expressor of Pathogenesis-Related 1 (NPR1) and thioredoxin H (TrxH) under salinity conditions, suggesting a crosstalk between different signalling pathways (NPR1/Trx and SA/JA) leading to salinity tolerance in the transgenic plum line J8-1.

Preprint ARTICLE | doi:10.20944/preprints201810.0414.v1

In Schizophrenia, Increased Plasma Igm/Iga Responses to Gut Commensal Bacteria are Associated with Negative Symptoms, Neurocognitive Impairments and the Deficit Phenotype

Michael Maes, Buranee Kanchanatawan, Sunee Sirivichayakul, Andre F. Carvalho

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: immune, inflammation, natural IgM, B1 cells, oxidative stress, TRYCATs, schizophrenia, psychosis, psychiatry

Online: 18 October 2018 (10:55:52 CEST)

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Increased gut permeability (leaky gut) with increased translocation of Gram-negative bacteria plays a role in the gut-brain axis through effects on systemic immune-inflammatory processes. Deficit schizophrenia is characterized by an immune-inflammatory response combined with a deficit in natural IgM antibodies to oxidative specific epitopes (OSEs), which are a first line defense against bacterial infections. This study measured plasma IgA/IgM responses to 5 Gram-negative bacteria in association with IgM responses to malondialdehyde (MDA) and azelaic acid in 80 schizophrenia patients (40 with the deficit syndrome and 40 without) and in 38 healthy controls.Deficit schizophrenia was characterized by significantly increased IgA responses to Hafnei alvei, Pseudomonas aeruginosa, Morganella morganii and Klebsiella pneumoniae as compared with non-deficit schizophrenia. The presence of deficit schizophrenia was highly predicted by increased IgA responses to Pseudomonas putida and IgM responses to all 5 Gram-negative bacteria and lowered natural IgM to MDA and azelaic acid with a bootstrap area under the ROC curve of 0.960 (2000 random curves). A large proportion of the variance (41.5%) in the PANSS negative score was explained by the regression on IgA responses to K. pneumoniae and IgM responses to the 5 enterobacteria coupled with lowered IgM antibodies to azelaic acid. There were significant associations between IgA levels to Gram-negative bacteria and Mini Mental State Examination, Boston naming test, Verbal Fluency and Word List Memory test scores.These findings provide further evidence that deficit schizophrenia is a distinct phenotype of schizophrenia, which is characterized by an increased impact of Gram-negative commensal bacteria coupled with a deficit in natural IgM, pointing to aberrations in B1 cells. It is concluded that increased bacterial translocation and deficits in the compensatory immune-regulatory system (CIRS) may drive negative symptoms and neurocognitive impairments, which are hallmarks of deficit schizophrenia.

Preprint ARTICLE | doi:10.20944/preprints201810.0351.v1

Ionic Liquid-Promoted Three-Component Domino Reaction of Propargyl Alcohols, Carbon Dioxide and 2-Aminoethanols: A Thermodynamically Favorable Synthesis of 2-Oxazolidinones

Shu-Mei Xia, Yu Song, Xue-Dong Li, Hong-Ru Li, Liang-Nian He

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Ionic liquid; synergistic activation; aminoethanol; 2-oxazolidinone; atmospheric CO2; sustainable catalysis

Online: 16 October 2018 (10:48:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0288.v1

Differential Effects of Red Yeast Rice, Berberis Aristata and Morus Alba Extracts, Active Components of LopiGLIK®, on PCSK9 in HepG2 Cells

Maria Giovanna Lupo, Chiara Macchi, Silvia Marchianò, Haixia Chen, Cesare Sirtori, Alberto Corsini, Massimiliano Ruscica, Nicola Ferri

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: red yeast rice; berberis aristate; morus alba; PCSK9

Online: 15 October 2018 (07:49:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0041.v1

Milk Other than Breast Milk and the Development of Asthma in Children 3 Years of Age. A Birth Cohort Study (2006-2011)

Asmaa Elheneidy, Manar Abdel-Rahman , Gabor Mihala, Lynda J. Ross, Tracy Comans

Subject: Biology And Life Sciences, Food Science And Technology Keywords: asthma; breastfeeding; milk other than breast milk

Online: 3 October 2018 (11:32:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0002.v1

Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis

Pedro Gutierrez-Castrellon, Zvi Weizman, Silvia Cruchet, Ener Cagri Dinleyci, Carlos Jimenez-Gutierrez, Gabriel Lopez-Velazquez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Probiotics, Upper Respiratory Infections, Network Meta-Analysis

Online: 1 October 2018 (10:22:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0550.v1

A Multi-mode SAR Imaging Chip based on a Dynamically Reconfigurable SoC Architecture Consisting of Dual-operation Engines and Multilayer Switching Network

Teng Long, Zhu Yang, Bingyi Li, Liang Chen, Zegang Ding, He Chen, Yizhuang Xie

Subject: Engineering, Electrical And Electronic Engineering Keywords: synthetic aperture radar (SAR); real-time processing; single FPGA node imaging processing; multi-node parallel accelerating technique

Online: 27 September 2018 (15:14:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0495.v1

A Cooperation of Multileader Fruit Fly and the Probabilistic Random Walk with Adaptive Normalization for Solving Solution of the Unconstrained Optimization Problems

Wirote Apinantanakon, Khamron Sunat, Sirapat Chiewchanwattana

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: nature-inspired optimization algorithm; fruit fly optimization algorithm; multileader strategy; random walk; cooperative algorithm

Online: 26 September 2018 (04:16:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0275.v1

Exploring the Cornerstone Factors that Cause Water Scarcity in Some Parts of Africa, Possible Adaptation Strategies and a Quest in Food Security

Sharmaarke A. Musse

Subject: Environmental And Earth Sciences, Environmental Science Keywords: water scarcity; water withdrawal; food security; water management; climate change; adaptation

Online: 16 September 2018 (07:38:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0457.v1

Sensor-Based Sleep Quality Index (SB-SQI): A New Metric to Examine the Association of Office Workstation Type on Stress and Sleep

Hyoki Lee, Javad Razjouyan, hung nguyen, Casey Lindburg, Karthik Srinivasan, Brian Gilligan, Kelli Canada, Amir Sharafkhaneh, Matthias Mehl, Faiz Currim, Sudh Ram, Melissa Lunden, Judith Heerwagen, Kevin Kampschroer, Esther Sternberg, Bijan Najafi

Subject: Engineering, Bioengineering Keywords: Sleep, Office workers, office workstation, wellbeing, stress, physical activity, wearables, digital health, sleep quality index, tracking sleep quality, workstation types, accelerometry, heart rate variability

Online: 27 August 2018 (11:33:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0322.v1

Effects of Different Techniques of Malolactic Fermentation Induction on Diacetyl Metabolism and Biosynthesis of Selected Aromatic Esters in Cool-Climate Grape Wines

Małgorzata Lasik-Kurdyś, Małgorzata Majcher, Jacek Nowak

Subject: Chemistry And Materials Science, Food Chemistry Keywords: malolactic fermentation; coinoculation; diacetyl; esters; aromatic compounds; grape wine

Online: 18 August 2018 (06:00:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0610.v1

A Comparison of the Dinosaur Communities from the Middle Jurassic of the Cleveland (Yorkshire) and Hebrides (Skye) Basins, Based on Their Ichnites

Mike Romano, Neil D. L. Clark, Stephen L. Brusatte

Subject: Environmental And Earth Sciences, Paleontology Keywords: ichnite; Skye; Yorkshire; footprints; dinosaur; sauropod; theropod; ornithopod

Online: 31 July 2018 (06:40:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0456.v1

Micromorphological and Chemical Features of Soils as Evidence of Bronze Age Ancient Anthropogenic Impact (Late Bronze Age Muradymovo Settlement, Ural Region, Russia)

Alexandra Golyeva, Olga Khokhlova, Marina Lebedeva, Nikolay Shcherbakov, Iia Shuteleva

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Bronze Age settlement; modern soil; micromorphology; chemical properties; gypsum; anthropogenic impact

Online: 24 July 2018 (12:00:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0356.v1

Numerical Simulation and FRAP Experiments Show that the Plasma Membrane Binding Protein PH-EFA6 does not Exhibit Anomalous Sub-Diffusion in Cells.

Cyril Favard

Subject: Physical Sciences, Biophysics Keywords: Anomalous diffusion; FRAP; Numerical Simulations; PH -domain, Membrane Binding

Online: 19 July 2018 (11:17:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0349.v1

A Reflection on Development of Indigenous Languages for Knowledge Creation and Sharing in a Globalising World: A Case of Esan Language, Nigeria

Gabriel Aine Obinyan, Mabel Ejoghoye Aziegbe

Subject: Social Sciences, Language And Linguistics Keywords: humanity; culture; development and language; globalization; indigenous capabilities; knowledge creation and technological development

Online: 19 July 2018 (06:34:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0417.v1

Generation-common and -specific factors in intention to leave among female hospital nurses: A cross-sectional study using a large Japanese sample

Maki Tei-tominaga, Kyoko Asakura, Takashi Asakura

Subject: Public Health And Healthcare, Nursing Keywords: female, generation, hospital, intention to leave, nurse

Online: 26 June 2018 (12:34:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0239.v1

ApoB-100 Lipoproteins Complex Formation with Intima Proteoglycans as Cause of Atherosclerosis and Its Possible Ex vivo Evaluation as a Disease Biomarker

Eva Hurt-Camejo, Germán Camejo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ApoB-100 lipoproteins-Proteoglycans-Interactions-Arterial intima Atherosclerosis-LDL modifications

Online: 14 June 2018 (16:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0173.v1

Comparison between Different Fiber Coatings and Adhesives on Steel Surfaces for Distributed Optical Strain Measurements based on Rayleigh Backscattering in Concrete Structures

Martin Weisbrich, Klaus Holschemacher

Subject: Engineering, Civil Engineering Keywords: optical fiber; flat steel; bending test; fiber coating; adhesives; Rayleigh backscatter; distributed optical strain measurement

Online: 12 June 2018 (08:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0150.v1

Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Michael Brunsteiner, Johannes Khinast, Amrit Paudel

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: molecular dynamics simulation; amorphous; physical stability; hydrogen-bond; molecular mobility; mixing energy; molecular interactions

Online: 11 June 2018 (10:24:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0123.v1

Who is more Food Secure among Rural, Peri-urban and Urban Households in Pakistan? Results from a field survey in Punjab province

Ali Sher, Saman Mazhar, Azhar Abbas, Muhammad Amjed Iqbal, Li Xiangmei

Subject: Business, Economics And Management, Economics Keywords: sustainable; livelihood; policy; vulnerability; choice; quality

Online: 7 June 2018 (12:39:47 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201806.0117.v1

Comprehensive Study of Soil-Plant and Surface Water Chemistry Relationships in Highly S Contaminated Environment on Reforested Former Sulfur Borehole Mine Sites

Marcin Pietrzykowski, Justyna Likus-Cieślik

Subject: Environmental And Earth Sciences, Environmental Science Keywords: sulfur; reclamation; acid mine drainage; salinity; soil contamination

Online: 7 June 2018 (11:21:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0082.v1

Computing the Real Impact of Wind Turbine Power Curve Upgrades: A SCADA-Based Multivariate Linear Method and a Vortex Generator Test Case

Davide Astolfi, Francesco Castellani, Mario Luca Fravolini, Silvia Cascianelli, Ludovico Terzi

Subject: Engineering, Energy And Fuel Technology Keywords: wind energy; wind turbines; supervisory control and data acquisition; retrofitting; performance evaluation

Online: 6 June 2018 (10:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0013.v1

Trust and Distress Prediction in Modal Shift Potential of Long-Distance Road Freight in Containers: Modelling Approach in Transport Services for Sustainability

Elżbieta Szaruga, Elżbieta Skąpska, Elżbieta Załoga, Wiesław Matwiejczuk

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: sustainability; trust; distress; transport services; road freight transport; modal shift potential; shift paradigm; modelling; prediction; General Discriminant Analysis

Online: 1 June 2018 (10:44:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0006.v1

Radar Data Analyses for a Single Rainfall Event and Their Application for Flow Simulation in an Urban Catchment Using the SWMM Model

Mariusz Barszcz

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: urban catchment; radar reflectivity; rainfall rate; Z-R relationship; SWMM model; flow simulation

Online: 1 June 2018 (07:46:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0433.v1

Association Between the General Practitioner Workforce Crisis and Premature Mortality in Hungary: Nationwide Evaluation of Health Insurance Data from 2006 to 2014

János Sándor, Anita Pálinkás, Ferenc Vincze, Valéria Sipos, Nóra Kovács, Tibor Jenei, Zsófia Falusi, László Pál, László Kőrösi, Magor Papp, Róza Ádány

Subject: Biology And Life Sciences, Other Keywords: primary health care; workforce crisis; general practitioner vacancy; aging of general practitioners; premature mortality

Online: 30 May 2018 (05:47:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0244.v1

Evolutionary History of the GH3 Family Based on 48 Sequenced Plants and Identification of Jasmonic Acid-Relate GH3 Genes in Solanum tuberosum

Chao Zhang, Leilei Zhang, Dongdong Wang, Haoli Ma, Bailin Liu, Zheng Shi, Xiaohui Ma, Yue Chen, Qin Chen

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: GH3 family; sequencing plants; potato; jasmonic acids; tissues; biotic

Online: 17 May 2018 (12:01:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0179.v1

Assessment of Green Solvents and Extraction Methods for Biopesticide Preparation from Neem Azadirachta indica Leaves against Oriental Fruit Fly Bactrocera dorsalis (Hendel)

Danila S. Paragas, Kathlia Cruz, Elaida R. Fiegalan

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: rice wash; vinegar; rice wine; Soxhlet; fermentation

Online: 11 May 2018 (09:04:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0167.v1

Spatio-temporal Features of Urban Heat Island and its Relationship with Land Use/Cover in Mountainous City: A Case Study in Chongqing

Chunxia Liu, Yuechen Li

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: spatio-temporal pattern; land cover; mountainous city; Chongqing

Online: 10 May 2018 (14:59:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0120.v1

The Improved Least Square Support Vector Machine Based on Wolf Pack Algorithm and Data Inconsistency Rate for Cost Prediction of Substation Projects

Haichao Wang, Dongxiao Niu, Si Li, Fenghua Wang, Yi Liang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: cost prediction of substation projects; improved least square support vector machine; wolf pack algorithm; data inconsistency rate

Online: 8 May 2018 (05:01:45 CEST)

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