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Preprint REVIEW | doi:10.20944/preprints202001.0030.v1

HDAC6 – An Emerging Target against Chronic Myeloid Leukemia?

Hélène Losson, Michael Schnekenburger, Mario Dicato, Marc Diederich

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: histone deacetylase 6 inhibitor; personalized treatment; heat shock protein 90α; leukemia stem cells; imatinib resistance; targeted therapy

Online: 4 January 2020 (06:18:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1455.v1

Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced severe respiratory failure: an exploratory proof of concept trial

Pratima Chowdary, Banwari Agarwal, Maria Rita Peralta, Sanjay Bhagani, Simon Lee, James Goldring, Marc Lipman, Emal Waqif, Mark Phillips, Helen Philippou, Jonathan H Foley, Nicola J Mutch, Robert Ariens, Kathleen A Stringer, Federico Ricciardi, Marie Watissée, Derralynn Hughes, Amit Nathwani, Anne Riddell, David Patch, Jim Buckley, Mark De Neef, Rahul Dimber, Cecilia Diaz-Garcia, Honey Patel, Aarti Nandani, Upuli Dissanayake, Nick Chadwick, Ahmed Alkhatip, Peter Watkinson, Eamon Raith, Suveer Singh, Tony Wolff, Rajeev Jha, Simon E Brill, Ameet Bakhai, Alison Evans, Farhat Gilani, Keith Gomez

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute respiratory illness; critical care; recombinant tissue plasminogen activator; nebulization, fibrinolytics, COVID-19 pandemic, inhaled medication, targeted therapy

Online: 20 June 2023 (14:59:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1677.v1

Latest Insights and Progress in the Clinical Management of Elderly Patients with Acute Myeloid Leukemia: From Genetic Advancements to Targeted Treatments

Pasquale NISCOLA, Nelida Ines Noguera, Valentina Gianfelici, Laura Cesini, Marco Giovannini, Daniela Piccioni, Gianfranco Catalano, Carla Mazzone, Paolo de Fabritiis

Subject: Medicine And Pharmacology, Hematology Keywords: Genomic profiling; Targeted therapies; Hypomethylating agents; Venetoclax-based combinations; Intensive chemotherapy; Transplantation; Clinical trials; Supportive care; Quality of life

Online: 24 June 2024 (12:04:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0053.v1

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Beata Paulina Rurarz, Małgorzata Bukowczyk, Natalia Gibka, Agnieszka Wanda Piastowska-Ciesielska, Urszula Karczmarczyk, Piotr Ulański

Subject: Chemistry And Materials Science, Nanotechnology Keywords: gastrin releasing peptide receptor; GRPR; bombesin receptor subtype 2; BB2; bombesin; targeted therapy; molecular imaging; theranostics; nanotechnology; nanoparticle; nanomedicine

Online: 4 January 2023 (03:19:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1989.v1

Cancer Treatments: Past, Present, and Future

Dmitriy Sonkin, Anish Thomas, Beverly Teicher

Subject: Biology And Life Sciences, Life Sciences Keywords: cancer; cancer treatment; cancer treatments history; cancer therapy; oncology; immunology; chemotherapy; radiation therapy; ADC; CART; BiTE; targeted therapy; cancer genetics

Online: 30 January 2024 (03:28:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0233.v1

Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives

Cedric Kier Lansangan, Menka Khoobchandani, Ruchit Jain, Serge Rudensky, Christopher C Perry, Rameshwar Patil

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Gold nanoparticle; nanomedicine; glioblastoma multiforme; blood-brain barrier; brain tumor treatment; targeted drug delivery; radiation treatment; boron neutron capture therapy

Online: 3 January 2024 (10:03:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0720.v2

Unlocking the Secrets of Androgen Receptors in the Susceptibility, Progression, and Treatment of Prostate Cancer

Suleiman Zakari, Christogonus C. Ekenwaneze, Emmanuel C. Amadi, Olubanke O. Ogunlana

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Prostate cancer; androgen receptor; AR signaling pathway; disease progression; therapeutic re-sistance; personalized treatment; androgen deprivation therapy; AR-targeted therapies

Online: 25 September 2023 (16:46:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0204.v2

DNA Aptamers for Functionalisation of DNA Origami Nanostructures

Yusuke Sakai, Md. Sirajul Islam, Martyna Adamiak, Simon Chi-Chin Shiu, Julian Alexander Tanner, Jonathan Gardiner Heddle

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: DNA origami; aptamer; DNA nanotechnology; protein nano array; biosensor; logic gate; enzyme cascade; drug delivery system; targeted therapy; molecular robotics

Online: 22 October 2018 (10:57:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0052.v1

Functional Metabolomics – a Useful Tool to Characterize Stress-Induced Metabolome Alterations Opening New Avenues Towards Tailoring Food Crop Quality

Corinna Dawid, Karina Hille

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Plant stress, abiotic stress, biotic stress, metabolomics, phytometabolomics, sensomics, phytohormonics, LC-MS/MS, NMR, targeted metabolomics, untargeted metabolomics, functional food.

Online: 3 July 2018 (14:18:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v2

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 14 September 2016 (08:30:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2222.v1

Microbiome: The Next Frontier in Psychedelic Renaissance

Robert B. Kargbo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Psychedelic renaissance; Mental health; Therapeutic potential; Gut microbiome; Psychedelic substances; Personalized medicine; Gut-brain axis; Mood regulation; Microbiome-targeted interventions; Psychopharmacology

Online: 31 May 2023 (10:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0144.v1

Surface Modification of Biodegradable Microparticles With the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies Against Encapsulated Protein Antigen in Young Naïve Mice After Respi

Jacob E. Parriott, Jason P. Stewart, Derek D. Smith, Stephen M. Curran, Christopher D. Bauer, Todd A. Wyatt, Joy A. Phillips, Elizabeth R. Lyden, Geoffrey M. Thiele, Joseph Anthoney Vetro

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: mucosal immunization; mucosal vaccine; vaccine delivery; administration volume; targeted vaccines; M cell targeting; dendritic cell targeting; C5aR1; C5a1R; CD88; EP54; EP67

Online: 8 August 2022 (10:17:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1816.v1

Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist-Antagonist Myoneural Interface

JIANPING HUANG, PING WANG, WEI WANG, JINGJING WEI, LIN YANG, ZHIYUAN LIU, GUANGLIN LI

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Agonist-antagonist myoneural interface; Electrical muscle stimulation; Muscle Reinnervation; Proprioception; Electromyograph; Targeted muscle reinnervation; Myoelectrical prosthesis; amputation; Peripheral nerve transfer; Compound action potential

Online: 23 July 2024 (18:00:18 CEST)

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The agonist-antagonist myoneural interface (AMI), a surgical method to reinnervate physiologically-relevant proprioceptive feedback for control of limb prostheses, has demonstrated the ability to provide natural afferent sensations for limb amputees when actuating their prostheses. Following an AMI surgery, one potential challenge is atrophy of the disused muscles, which would weaken the reinnervation efficacy of AMI. It is well known that electrical muscle stimulus (EMS) can reduce the muscle atrophy. In this study, we conducted an animal investigation to explore whether the EMS can significantly improve the electrophysiological performance of AMI. The AMI surgery was performed in 14 rats, in which the distal tendons of bilateral solei donors were connected and positioned on the surface of the left biceps femoris. Subsequently, the left tibial nerve and the common peroneus nerve were sutured onto the ends of the connected donor solei. Two stimulation electrodes were affixed onto the ends of the donor solei for EMS delivery. The AMI rats were randomly divided into two groups. One group regularly received the EMS treatment (designated as EMS_on) for eight weeks and another was no EMS (designated as EMS_off). Two physiological parameters, nerve conduction velocity (NCV) and motor unit number, were derived from the electrically evoked compound action potential (CAP) signals to assess the electrophysiological performance of AMI. Our experimental results demonstrated that the reinnervated muscles of the EMS_on group generated higher CAP signals in comparison to the EMS_off group. Both NCV and motor unit number were significantly elevated in the EMS_on group. Moreover, the EMS_on group displayed statistically higher CAP signals on the indirectly activated proprioceptive afferents than the EMS_off group. These findings may suggested that the EMS treatment would be promise in enhancing the electrophysiological performance and facilitating the reinnervation process of AMI.

Preprint REVIEW | doi:10.20944/preprints202406.0155.v1

The Future Directions of CAR-T Cell Therapy: Unlocking the Potential of Immunotherapy in Cancer Treatment

Angel A Justiz-Vaillant, Sachin Soodeen, Darren Gopaul, Rodolfo Arozarena-Fundora, Patrick Eberechi Akpaka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: CAR-T cell therapy; Hematologic malignancies; Cytokine release syndrome; Antigen mutation; γ δ CAR-T cells; Multi-targeted CAR-T cells; Precision medicine

Online: 4 June 2024 (16:12:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2434.v1

Navigating Change and Driving Innovation: Leveraging Big Data for Enhanced User Behavior Analysis and Strategic Decision-Making

Daniel Spadacini

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: User Behavior Analysis; Big Data; Machine Learning; Natural Language Processing; Livestreaming E-Commerce; Text-Mining; Targeted Marketing; Strategic Decision-Making; Ethical AI; Sentiment Analysis

Online: 30 July 2024 (09:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0380.v1

Circulating Tumor Cell Assay to Non-Invasively Evaluate PD-L1 and Other Therapeutic Targets in Multiple Cancers

Raymond Page, Darshana Patil, Dadasaheb Akolkar, Sudha S Murthy, Kiran Bendale, Revati Patil, Pradeep Fulmali, Pooja Fulmali, Archana Adhav, Sneha Puranik, Sachin Apurwa, Vineet Datta, Chirantan Bose, Stefan Schuster, Jinumary John, Ajay Srinivasan, Rajan Datar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Therapeutic biomarkers; circulating tumor cells; Immunocytochemistry; targeted therapy; Fluorescence in situ hybridization (FISH); Immune Checkpoint Inhibitors; Liquid Biopsy; Hormonal Treatments; Breast Cancer; Lung Cancer

Online: 25 January 2022 (11:31:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1050.v1

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Patricia Segura-Medina, Ahmed M Agiba, Jose Luis Arreola-Ramirez, Veronica Carbajal

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: smart nanocarriers; light-responsive liposomes; dual-targeted stimuli-responsive liposomes; phototriggered targeting strategies; light-triggering mechanisms; nir-responsive nanocarriers; nano carriers current challenges; future perspectives

Online: 14 December 2023 (05:55:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0500.v1

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Jessica Panes, Thi Kim Oanh Nguyen, Huanyao Gao, Trace A Christensen, Andrea Stojakovic, Sergey Trushin, Jeffrey L Salisbury, Jorge Fuentealba, Eugenia Trushina

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s Disease (AD) mitochondria; endoplasmic reticulum (ER); serial block-face scanning electron microscopy (SBFSEM); three-dimensional electron microscopy (3D EM); small molecule mitochondria targeted therapeutics

Online: 27 January 2023 (10:08:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0542.v2

Safety of Combined Targeted and Helixor® Viscum album L.Therapy in Breast and Gynecological Patients, a Real-World Data Study

Friedemann Schad, Anja Thronicke

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: safety analysis; targeted therapy; monoclonal antibody therapy; immune checkpoint inhibibitors; tyrosine kinase inhibitors; breast cancer; gynecological cancer; Helixor; Viscum album L.; PARP inhibitors; CDK 4/6 inhibitors

Online: 30 December 2022 (12:00:35 CET)

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Preprint REVIEW | doi:10.20944/preprints201912.0135.v1

Systemically Administered, Target-specific, Multi-functional Therapeutic Recombinant Proteins in Regenerative Medicine

Tero Järvinen, Toini Pemmari

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: vascular homing peptide; cell penetrating peptide; angiogenesis; vascular heterogeneity; fibrosis; targeted delivery; decorin; transforming growth factor-β (tgf-β), bystander effect, cendr peptide; tissue regeneration; regenerative medicine

Online: 10 December 2019 (15:02:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202407.1534.v1

Advances in Targeted Therapy: Addressing Resistance to BTK Inhibition in B‐Cell Lymphoid Malignancies

Andres Bravo-Gonzalez, Maryam Alasfour, Deborah Soong, Jose Noy, Georgios Pongas

Subject: Medicine And Pharmacology, Hematology Keywords: lymphoma; B‐cell; hematologic neoplasms; bruton tyrosine kinase; protein kinase inhibitors; drug resistance; neoplasm; ibrutinib; pirtobrutinib; molecular targeted therapy; chronic lymphocytic leukemia; hematopoietic stem cell transplantation; covalent inhibitors; protein degradation

Online: 18 July 2024 (17:24:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0518.v1

Avogadro Number’s-oriented HyperGeometric and ChebyshevT Functions for Black Hole Paradox Generalizations and Turing Machine Ruled Quantum Homeopathy Water Memory Entanglements for the Translation of COVID19 Homeopathy Remedies into the Neprilysin and ACE2/AT1R receptors targeted DRVYIHPFX- ligands.

Ioannis George Grigoriadis

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: COVID19; ; Chern-Simons Topological; QED (Quantum Electrodynamics); Homeopathic medicine; Water Memory; AI-Quantum computing; Quantum-Inspired Evolutionary Algorithm Predictive Toxicology; QSAR Quantum gates; CS Supergravity Quantum Foam; Cheminformatics artificial intelligence; Phase Data Mining; Machine Learning; Euclid Chemical space exploration; (bosonic) Quantum fields Theory (QFT); Angiotensin Receptor Neprilysin targeted DRVYIHPFX mimetic Holomorphic Ligands; Hidden Entanglement Negativity Translations; Uncertainty Quantum Relationships; Quantum fields theory; Quantum information; HyperGeometric Functions; Chemical Block Systems; Black Hole Paradox Generalizations; SphericalHarmonicY-Supersymmetry breaking foundations; WhittakerM Functions; Hypergeometric1F1 Functions; Turing Machine Learning Ruled Calculations; Avogadro Number’ s oriented Quantum Homeopathy Hidden Entanglement Negativities; Quantum foam; non-commutative geometry; small molecule ligand engineering; prot

Online: 11 March 2024 (03:52:07 CET)

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Preprint REVIEW | doi:10.3390/sci2030068

Perspectives on Topical Medical Research in the COVID-19 Era

Michael McAleer

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: COVID-19; pooling clinical trials; hyperinfection; steroids; treatment; targeted healthcare; population health management; cancer treatment; clinical research; clinical trials; developing vaccines; ranking and rating hospital quality; school closures; interventions for delirium; assessments of COVID-19 death inequities; regulatory safeguards; preventing child abuse and maltreatment; prevalence of health care worker burnout; nursing home ratings; challenging oncology practice; addressing racial; ethnic; social and economic divides; violence against sexual minority adolescents; primary tumors; metastasis; stages of cancer; reforming cancer clinical trials; supporting carers; protection and prevention; benign and malignant tumors; reforming cancer clinical trials; protection of healthcare personnel; comparing excess deaths in NYC; 1918 influenza pandemic; the possibility of full recovery from COVID-19; mental health impact of COVID-19 on young adults; ranking and rating nursing home quali

Online: 21 August 2020 (00:00:00 CEST)

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