Dynamic contrast-enhanced MRI (DCE-MRI) is increasingly used to quantify and map the spatial distribution of blood-brain barrier (BBB) leakage in neurodegenerative disease, including cerebral small vessel disease and dementia. However, the subtle nature of leakage and resulting small signal changes make quantification challenging. While simplified one-dimensional simulations have probed the impact of noise, scanner drift, and model assumptions, the impact of spatio-temporal effects such as gross motion, k-space sampling and motion artefacts on parametric leakage maps has been overlooked. Moreover, evidence on which to base the design of imaging protocols is lacking due to practical difficulties and the lack of a reference method. To address these problems, we present an open-source computational model of the DCE-MRI acquisition process for generating four-dimensional Digital Reference Objects (DROs), using a high-resolution brain atlas and incorporating realistic patient motion, extra-cerebral signals, noise and k-space sampling. Simulations using the DROs demonstrated a dominant influence of spatio-temporal effects on both the visual appearance of parameter maps and on measured tissue leakage rates. The computational model permits a greater understanding of the sensitivity and limitations of subtle BBB leakage measurement and provides a non-invasive means of testing and optimising imaging protocols for future studies.

Our study examines how dengue incidence is associated with spatial (demographic and socioeconomic) alongside temporal (environmental) factors at multiple scales. We used the incidence of dengue in Ibagué, Colombia, from 2013 to 2018, to examine the associations with climate, socioeconomic and demographic factors from the census and satellite imagery at various levels of local spatial aggregation, including Manzanas, Secciones, Sectores, and Comunas. Our findings show a significant effect of spatial variables at finer levels of aggregation, showing varying degrees of correlation with dengue incidence. Temporal variables such as temperature and precipitation displayed consistent patterns across all spatial levels, with notable variations in Relative Risk (RR). Our study employs Geographically Weighted Regression (GWR) to identify relevant socioeconomic and demographic predictors. Then, these predictors were integrated into hierarchical models implemented in Integrated Nested Laplace Approximation (INLA) at each spatial level to assess spatiotemporal interactions. We comprehensively analyzed the three distinct models developed for each level: spatial, temporal, and spatiotemporal. A comparative evaluation of the models reveals that while higher aggregation levels often yield a better overall model fit, finer levels offer more detailed insights into the localized impacts of socioeconomic and demographic variables on dengue incidence. Our results underscore the importance of considering macro and micro-level factors in epidemiological modeling and highlight the potential for targeted public health interventions based on localized risk factor analysis. Notably, the intermediate level Secciones emerged as the most informative, balancing spatial heterogeneity and case distribution density, thereby providing a robust framework for understanding the spatial determinants of dengue.

Hox gene clusters are crucial in Embryogenesis. It was observed that some Hox genes are located in order along the telomeric to centromeric direction of the DNA sequence: Hox1, Hox2, Hox3…. These genes are expressed in the same order in the ontogenetic units of the Drosophila embryo along the Anterior-Posterior axis. The two entities (genome and embryo) differ significantly in linear size and in-between distance. This strange phenomenon was named Spatial Collinearity (SP). Later, it was observed that, particularly in the Vertebrates, a Temporal Collinearity (TC) coexists: first is Hox1 expressed, later Hox2 and even later Hox3,…,. According to a Biophysical Model (BM), pulling forces act at the anterior end of the cluster while a cluster fastening applies at the posterior end. Hox clusters are irreversibly elongated along the force direction. During Evolution, the elongated Hox clusters are broken at variable lengths thus split clusters may be created. An Empirical Rule was formulated distinguishing development due to a complete Hox cluster from development due to split Hox clusters. BM can ‘explain’ this Empirical Rule. In a spontaneous mutation where the cluster fastening is dismantled, a minimal pulling force can automatically shift the cluster inside the Hox activation domain. This cluster translocation can probably explain the absence of Temporal Collinearity in Drosophila.

As an irreplaceable ecological barrier, the ecological conservation developing area (ECDA) is vital for the integrated construction of urban and rural areas, and optimization and adjustment of industrial structure. Developing green agriculture is the foundation and guarantee for improving the rural ecological environment and meeting the increasing needs of farmers′ income. Issued by the Chinese government, No. 1 Central Document stated the necessity of promoting agricultural green development (AGD) and the related technologies in dealing with ecological pressure and resource shortages, especially for large cities like Beijing. However, few empirical studies have conducted on spatiotemporal variations of AGD in ECDA of large cities. Based on the green agricultural traits of Beijing and the accessible data, we evaluate AGD and analyze its spatial and temporal heterogeneity of Beijing ECDA by constructiing a framework with 13 indicators. The weight coefficients of AGD indicators were calculated by the projection pursuit method, with the district panel data from 2006 to 2016. The results demonstrated that energy consumption is a vital factor of green agriculture production, and agricultural output value per unit of the arable land area is the key to the green agricultural revenue. From 2006 to 2016, the AGD index of ECDA had an increasing trend till 2012, followed by a decreasing tendency. The AGD index of the northern region is higher than the southern of ECDA. The obstacle degree model was used to verify AGD limiting factors. They were poor infrastructure, slow agritourism, low labor productivity, and low resource utilization efficiency that varied by districts in ECDA. Given these findings, our study is conducive to the AGD evaluation at the district (county) level for ECDA of large cities and also provides important policy implications.

With increasing power and speed of laser welding, in-process monitoring has become even more crucial to ensure process stability and weld quality. Due to its low cost and installation flexibility, acoustic process monitoring is a promising method and has demonstrated its effectiveness. Since its feasibility has been the focus of existing studies, the temporal resolution of acoustic emissions (AE) has not yet been addressed despite its utmost importance for realizing real-time systems. Aiming to provide a benchmark for further development, this study investigates the relationship between duration and informativeness of AE signals during high power (3.5kW) and high speed (12m/min) laser beam butt welding. Specifically, the informativeness of AE signals is evaluated based on the accuracy of detecting and quantifying joint gaps for various time windows of signals, yielding numerical comparison. The obtained results show that signals can be shortened up to a certain point without sacrificing their informativeness, encouraging to optimize the signal duration. Our results also suggest that large gaps (> 0.3mm) induce unique signal characteristics in AE, which are clearly identifiable from 1 ms signal segments, equivalent to 0.2mm weld seam.

Information is commonly considered as a mathematical quantity that forms the basis of computing. In mathematics, information can propagate instantly, so its transfer speed is not the subject of information science. In all kinds of implementations of computing, whether technological or biological, some material carrier for the information exists, so the information’s propagation speed cannot exceed the speed of the carrier. Because of this limitation, for any implementation, one must consider the transfer time between computing units. We need a different mathematical method to take this limitation into account: classic mathematics can only describe infinitely fast and infinitely small computing system implementations. The difference between the mathematical handling methods leads to different descriptions of the behavior of the systems. The correct handling also explains why biological implementations can have lifelong learning and technological ones cannot. The conclusion about learning evidences matches others’ experimental evidence, both in technological and biological computing.

To ensure the security of spatial-temporal Top-k query in two-tiered wireless sensor networks, many schemes have been proposed in the literature in the past decade. However, most of them only consider the scenario where sensor nodes are static, and cannot achieve the security goal for spatial-temporal Top-k query in mobile sensor networks, because the mobility of the sensor nodes will affect the spatial-temporal relationships of the sensory data items generated by the sensor nodes. Although we have proposed some schemes for two-tiered mobile wireless sensor networks (TMWSNs) in our previous work, there is still large room to improve their performances. In this paper, we proposed a novel scheme named STQ-TMWSN for secure fine-grained spatial-temporal Top-k query in TMWSNs based on the virtual-grid construction and the size-order encryption binding. Theoretic analysis shows that STQ-TMWSN can achieve low computation complexity and high security performance. Simulation results indicate that STQ-TMWSN brings much lower communication cost than the state-of-the-art schemes on securing Top-k query in TMWSNs.

How, if at all, consciousness can be part of the physical universe remains a baffling problem. This article outlines a new, developing philosophical theory of how it could do so, and offers a preliminary mathematical formulation of a physical grounding for key aspects of the theory. Because the philosophical side has radical elements, so does the physical-theory side. The philosophical side is radical, first, in proposing that the productivity or dynamism in the universe that many believe to be responsible for its systematic regularities is actually itself a physical constituent of the universe, along with more familiar entities. Indeed, it proposes that instances of dynamism can themselves take part in physical interactions with other entities, this interaction then being “meta-dynamism” (a type of meta-causation). Secondly, the theory is radical, and unique, in arguing that consciousness is necessarily partly constituted of meta-dynamic auto-sensitivity, in other words it must react via meta-dynamism to its own dynamism, and also in conjecturing that some specific form of this sensitivity is sufficient for and indeed constitutive of consciousness. The article proposes a way for physical laws to be modified to accommodate meta-dynamism, via the radical step of including elements that explicitly refer to dynamism itself. Additionally, laws become, explicitly, temporally non-local in referring directly to quantity values holding at times prior to a given instant of application of the law. The approach therefore implicitly brings in considerations about what information determines states. Because of the temporal non-locality, and also because of the deep connections between dynamism and time-flow, the approach also implicitly connects to the topic of entropy insofar as this is related to time.

There has been a growing interest in incorporating psychological and neuroscientific knowledge about the development of cognitive functions in educational policies and academic practices. In this paper, we argue that the current knowledge about the interactions between these functions and their neurodevelopmental characteristics should also be considered in order to develop practices that could be better suited to pupils depending on their age. To facilitate this, we review current neuroscientific knowledge on the competitive interactions between two neural circuitry underlying distinct learning functions, their developmental trajectories and how they are linked to other functions such as cognitive control. The incorporation of this knowledge in education could help improve academic outcomes.

The nature of contemporary Spatial Data Infrastructures lies in the provision of geospatial information in an on-demand fashion. Though recent applications identified the need to react to real-time information in a time-critical way. In particular, research efforts in the field of geospatial Internet of Things have identified substantial gaps in this context, ranging from a lack of standardization for event-based architectures to the meaningful handling of real-time information as ''events''. This manuscript presents work in the field of Event-driven Spatial Data Infrastructures with a particular focus on sensor networks and the devices capturing in-situ measurements. The current landscape of Spatial Data Infrastructures is outlined and used as the basis for identifying existing gaps that retain certain geospatial applications from using real-time information. We present a selection of approaches - developed in different research projects - to overcome these gaps. Being designed for specific application domains, these approaches share commonalities as well as orthogonal solutions and can build the foundation of an overall Event-driven Spatial Data Infrastructure.

Hox gene clusters are crucial in Embryogenesis. It was observed that some Hox genes are located in order along the telomeric to centromeric direction of the DNA sequence: Hox1, Hox2, Hox3…. These genes are expressed in the same order in the ontogenetic units of the Drosophila embryo along the Anterior-Posterior axis. The two entities (genome and embryo) differ significantly in linear size and in-between distance. This strange phenomenon was named Spatial Collinearity (SP). Later, it was observed that, particularly in the Vertebrates, a Temporal Collinearity (TC) coexists: first is Hox1 expressed, later Hox2 and even later Hox3,…,. According to a Biophysical Model (BM), pulling forces act at the anterior end of the cluster while a cluster fastening applies at the posterior end. Hox clusters are irreversibly elongated along the force direction. During Evolution, the elongated Hox clusters are broken at variable lengths thus split clusters may be created. An Empirical Rule was formulated distinguishing development due to a complete Hox cluster from development due to split Hox clusters. BM can ‘explain’ this Empirical Rule. In a spontaneous mutation where the cluster fastening is dismantled, a weak pulling force automatically shifts the cluster inside the Hox activation domain. This cluster translocation can probably explain the absence of Temporal Collinearity in Drosophila.

The water resources carrying capacity (WRCC) system comprises multiple complex and nonlinear interactions related to society, economy, water resources and the water environment. A full understanding of its internal mechanism is conducive to the further improvement of the regional WRCC. This article focuses on the temporal and spatial variability of WRCC to explore a method of dynamic successive assessment. Firstly, the Pressure-State-Response (PSR)framework is used to develop a systematic and causal indicator system. Then, The Variable Fuzzy Pattern Recognition (VFPR) model and an analytic hierarchy process-entropy (AHP-E) model are combined to successively and dynamically assess WRCC. The proposed method is applied to the dynamic successive assessment of WRCC in Hebei Province, and it is obtained that the poor water resources carrying capacity in Hebei Province is mainly due to the basic attribute of the decision of the water resources shortage, but Hebei Province actively adopts a variety of measures to save water and pressurize mining, which makes the province's water resources carrying capacity have a tendency to become better gradually. At the same time, the system dynamics model (SD) of water resources carrying capacity based on the analysis of the model structure was established. Moreover, three scenarios were designed, including existing continuation, high-efficiency water-saving, cross-regional water transfer and coordinated development, each scenario divided into high and low-speed economic development and population growth schemes, then total 6 schemes between 2023 and 2030 were simulated and predicted respectively. The results indicate that if the current development model is adopted, the water resource carrying capacity will continue to maintain low levels. It was concluded that the high-speed development of economy and population, the efficient water conservation and inter-basin transfer scenario (scenario 2 with high-speed) is the best choice for sustainable development of water resources and social economy in Hebei.

Malaria is a prevalent disease in several tropical and subtropical regions, including Brazil, where remains a significant public health concern. Despite control efforts, reintroduction of endemics in areas without cases for decades poses a challenge. To assess factors influencing ma-laria risk, regional outbreak cluster analysis and a spatio-temporal models were developed for the Brazilian Amazon, incorporating climate, land use/cover interactions, endemic bird, and amphibian richness. Results showed that amphibian, bird richness and endemism correlated with a reduction in malaria risk. Presence of forest had a positive effect on risk, but it depended on its juxtaposition with anthropic land uses. Biodiversity and landscape composition, rather than forest formation presence alone, modulated malaria risk in the period. Areas with low en-demic species diversity and high human activity, predominantly anthropogenic landscapes posed high malaria risk. This study underscores the importance of considering the broader eco-logical context in malaria control efforts.

(1) Aim of the study was to investigate the spatial and temporal characteristics of the airflow created by two commercially available non-contact tonometers, the CorvisST and the Ocular Re-sponse Analyser. (2) The airflow pressure was measured using a MEMS pressure sensor to inves-tigate the spatial and temporal distribution. The airflow from the CorvisST and Ocular Response Analyser were mapped to a 600µm and a 1mm resolution grid, respectively. (3) Central airflow pressure of the CorvisST (96.4 ± 1.4)mmHg was higher than the Ocular Response Analyser (91.7 ± 0.7)mmHg. The duration of the air-puffs also differed, with the CorvisST showing a shorter du-ration (21.483 ± 0.2881)ms than the ORA (23.061 ± 0.1872)ms. The rising edge of the CorvisST airflow pressure profile demonstrated a lower gradient (+8.94mmHg/ms) compared to the Oc-ular Response Analyser (+11.00mmHg/ms). Both had similar decay response edges; CorvisST -11.18mmHg/ms, Ocular Response Analyser -11.65mmHg/ms. (4) The study presents a valid method to investigate physical dimensions of the airflow pressure of non-contact tonometers. Novel findings relating to the magnitude, duration and spatial characteristics of the respective airflow pressures are reported. It is anticipated that this information will better inform clinical studies and theoretical models relating to ocular biomechanics.

This pioneering study explores the geospatial and temporal patterns of natural and human-induced disasters from 1900 to 2024, providing essential insights into their global distribution and impacts. Utilizing the comprehensive international EM-DAT database, our analysis reveals significant trends and disparities in disaster occurrences and their widespread consequences. Results showed a dramatic escalation in both natural and man-made (technological) disasters over the decades, with notable surges in the 1991-2000 and 2001-2010 periods. A total of 25,836 disasters were recorded worldwide, of which 69.41% were natural disasters (16,567) and 30.59% were man-made (technological) disasters (9,269). The most significant increase in natural disasters occurred from 1961-1970, while man-made (technological) disasters surged substantially from 1981-1990. Seasonal trends reveal that floods peak in January and July, while storms are most frequent in June and October. Droughts and floods are the most devastating in terms of human lives, while storms and earthquakes cause the highest economic losses. The most substantial economic losses were reported during the 2001-2010 period, driven by catastrophic natural disasters in Asia and North America. Our research highlights Asia as the most disaster-prone continent, accounting for 41.75% of global events, with natural disasters making up 61.89% of these events. Oceania, despite experiencing fewer total disasters, shows a remarkable 91.51% of these as natural disasters. Africa is notable for its high incidence of man-made (technological) disasters, which constitute 43.79% of the continent's disaster events. Europe, representing 11.96% of total disasters, exhibits a balanced distribution but tends towards natural disasters at 64.54%. Examining specific countries, China, India, and the United States emerged as the most frequently affected by both natural and man-made (technological) disasters. The impact of these disasters has been immense, with economic losses reaching their highest during the decade of 2010-2020, largely due to natural disasters. The human toll has been equally significant, with Asia recording the most fatalities and Africa the most injuries. Particularly, the decade from 2001 to 2010 experienced the greatest economic losses, primarily driven by natural disasters in Asia and North America. These insights highlight the urgent need for tailored disaster risk management strategies that address the distinct challenges and impacts in various regions. By understanding historical disaster patterns, policymakers and stakeholders can better anticipate and manage future risks, ultimately safeguarding lives and economies.

Speech recognition, also known as automatic speech recognition (ASR), is a technology that enables software to transcribe spoken language into text. However, existing Amharic ASR methods require multiple separate blocks, such as language, acoustic, and pronunciation models with dictionaries, which can be time-consuming and influence performance. This study proposes an approach that replaces much of the speech pipeline with a single recurrent neural network (RNN) architecture. Our proposed architecture is based on a hybrid approach that combines a convolutional neural network (CNN) with a recurrent neural network (RNN) and a connectionist temporal classification (CTC) loss function. We conducted several experiments with noisy audio data that contain 20,000 valid sentences. The model was evaluated using the word error rate (WER) metric, achieving impressive results of 7% WER on noisy data. This approach has significant implications for the field of speech recognition, as it reduces the human effort required to create dictionaries and improves the efficiency and accuracy of ASR systems, making them more practical for real-world applications.

Paratemporal methods based on tree expansion have proven to be effective in efficiently generating trajectories of stochastic systems. However, combinatorial explosion of branching arising from multiple choice points presents a major hurdle that must be overcome to implement such techniques. In this paper we tackle this scalability problem by developing a systems theory-based framework covering both conventional and proposed tree expansion algorithms for speeding up discrete event system stochastic simulations while preserving desired accuracy. An example is discussed to illustrate the tree expansion framework in which a discrete event system specification (DEVS) Markov stochastic model takes the form of a tree isomorphic to a free monoid over the branching alphabet. We derive the computation times for baseline, non-merging, and merging tree expansion algorithms to compute the distribution of output values at any given depth. The results show the remarkable reduction from exponential to polynomial dependence on depth effectuated by node merging. We relate these results to the similarly reduced computation time of binomial coefficients underlying Pascal’s triangle. Finally, we discuss application of tree expansion to estimating temporal distributions in stochastic simulations involving serial and parallel compositions with potential real world use cases.

The sources of dark matter and its spatial distribution is not in the typical standard model. The study thought to induct the physical causalities with empirical evidence on the theory of black hole and white hole juxtapose. The research applied a mixed method of data analysis and observational cosmology. With the cosmological observations on the traces of white holes, the research finds that the accretion phenomenon of black holes is largely contributed by its thermonuclear binding with the white hole. The antimatter saturated plasma of cold fusion and hot fission are key to the phenomenon of black hole and white hole juxtapose. The force between the black hole and the white hole is stronger than the strong force, and sheds new directions on cosmological and gravitation studies. The research concludes that black holes are white hole entropy. The higher order of the universe in matter forms can exist beyond the observed force. The thermal arrow of time is critical to future general relativity dependent instrumentation discoveries.

Segment Anything Model 2 (SAM 2) is a state-of-the-art development by Meta AI Research, designed to address the limitations of its predecessor, SAM, particularly in the realm of video segmentation. SAM 2 employs a transformer-based architecture enhanced with streaming memory, enabling real-time processing for both images and videos. This advancement is important given the exponential growth of multimedia content and the subsequent demand for efficient video analysis. Utilizing the SA-V dataset, SAM 2 excels in handling the intricate spatio-temporal dynamics inherent in video data, ensuring accurate and efficient segmentation. Key features of SAM 2 include its ability to provide real-time segmentation with minimal user interaction, maintaining robust performance even in dynamic and cluttered visual environments. This study provides a comprehensive overview of SAM 2, detailing its architecture, functionality, and diverse applications. It further explores the model's potential in improving practical implementations across various domains, emphasizing its significance in advancing real-time video analysis.

The salt marshes, lying at the land-sea temperate interface, furnish a plethora of ecosystems services such as biodiversity niche support, ocean-climate change regulation, ornithology recreo-tourism or plant gathering by hand. They undergo significant worldwide losses due to their conversion into crop fields and to their spatial compression between the rising sea-level and the armoring shoreline. Their monitoring however requires to use a suite of remote sensing sensors to embrace the regional scale while capturing the plant details. This research innovatively adopts a multiscale approach using a cascading spaceborne and airborne process, from the 10-m Sentinel-2, through the 3-m Dove, to the 0.03-m unmanned airborne vehicle (UAV) imageries. The high to very high temporal resolution of the Sentinel-2 and Dove enabled to cover twenties and tens of km2 over five and four years, respectively, in the form of normalized difference vegetation index (NDVI) classes, associated with microphytobenthos, low, medium and high salt marsh vegetation, including the opportunistic Elyma genus. The NDVI was then modelled at the UAV scale (a few km2) using a three-layered NN prediction, providing the final near-infrared (NIR), and the intermediate red, green and blue reflectance imageries, calibrated/validated/tested with the Dove reflectance imageries (R2NIR=0.98, R2red=0.88, R2green=0.84, and R2blue=0.90). The 100fold increase in pixel size allowed to detect the decimeter-scale objects of the tidal flats and salt marshes, to enlarge the NDVI class ranges, and hold great promise to model other spectral bands at the UAV scale for further deeply enhancing the salt marsh mapping.

An effective process monitoring strategy is a requirement for meeting the challenges posed by increasingly complex products and manufacturing processes. To address these needs, this study investigates a comprehensive scheme based on classical machine learning methods, deep learning algorithms, and feature extraction and selection techniques. In a first step, a novel deep learning architecture based on convolutional neural networks (CNN) and gated recurrent units (GRU) is introduced to predict the local weld quality based on mid-wave infrared (MWIR) and near-infrared (NIR) image data. The developed technology is used to discover critical welding defects including lack of fusion (false friends), sagging and lack of penetration, and geometric deviations of the weld seam. Additional work is conducted to investigate the significance of various geometrical, statistical, and spatio-temporal features extracted from the keyhole and weld pool regions. Furthermore, the performance of the proposed deep learning architecture is compared to that of classical supervised machine learning algorithms, such as multi-layer perceptron (MLP), logistic regression (LogReg), support vector machines (SVM), decision trees (DT), random forest (RF) and k-Nearest Neighbors (kNN). Optimal hyperparameters for each algorithm are determined by an extensive grid search. Ultimately, the three best classification models are combined into an ensemble classifier that yields the highest detection rates and achieves the most robust estimation of welding defects among all classifiers studied, which is validated on previously unknown welding trials.

I introduce now for the first time the neutrosophic modal logic. The Neutrosophic Modal Logic includes the neutrosophic operators that express the modalities. It is an extension of neutrosophic predicate logic, and of neutrosophic propositional logic. In order for the paper to be self-contained, I also recall the etymology and definition of neutrosophy and of neutrosophic logic. Several examples are presented as well.

An event occurring within a stationary environment, in the direction toward which an observer self-rotates, is perceived to precede a simultaneous event, in the direction away from which she moves. When self-rotation results from angular acceleration in the dark, perception of space is also distorted, such that the subjective straight-ahead shifts in the opposite direction to motion and temporal event promotion. A reference frameshift theory, based on the special theory of relativity, is proposed to explain these findings. Here, a hyperbolic tangent transformation of objective angular velocity constrains subjective self-rotation velocity within finite bounds, consistent with it being a limited perceptual resource. Identifying this subjective variable with vestibular nystagmus slow-phase angular velocity, the asymptotic perceived self-rotation velocity is estimated at ~200 °⁄s. When included in the Lorentz transformations of the new formalism, this value predicts experimental simultaneity distortion. Hypothetically, the hyperbolic tangent objective-to-subjective transfer function would maximize the differential entropy of the percept, and thereby also the stimulus/percept mutual information, if angular velocities of body rotation encountered in naturalistic environmental interaction have a logistic probability density distribution of scale 100 °⁄s, a proposed experimental test of the scheme.

In light of the critical and emerging global challenge posed by the increasing frequency and severity of heatwaves in recent decades, this study demonstrates a practical and robust workflow that bridges the gap in understanding how the effective integration of remote sensing data with ground-based observations can facilitate a comprehensive assessment of spatiotemporal heatwave patterns and trends in the central region of Thailand. This research transcends traditional methods, utilizing air temperature (Tair) and satellite-derived land surface temperature (LST) data from 1981 to 2019. Results exhibit that an analysis of Tair indicates increasing daytime heatwaves in peri-urban areas, with significant trends in heatwave number (HWN), heatwave frequency (HWF), and heatwave duration (HWD), heatwave amplitude (HWA) rises in urban settings while nighttime heatwaves significantly intensify in rural locales. Notably, LST trends reveal varied patterns, with peri-urban areas showing marked daytime increases in heatwave magnitude (HWM), HWA, and HWF. Correlation analysis (p=0.05) highlights strong daytime associations between Tair and LST in rural (HWN, HWF, HWD, r>0.90) and peri-urban (HWM, HWA, r>0.65) regions. Overall, this study advances approaches to the adaptable measurement and spatial-temporal pattern of heatwave-related risk areas, providing insights for decision-makers to develop sustainable practices and strategies for climate change adaptation.

Nowadays, power sector is an area that gather great scientific interest, due to events such as the increase in electricity prices in the wholesale energy market and new investments due to technological development in various sectors. These new challenges have in turn created new needs, such as the accurate prediction of the electrical load of the end users. On the occasion of the new challenges, Artificial Neural Networks approaches have become increasingly popular due to their ability to adopt efficiently to time-series predictions. In this paper, it is presented the development of a model which, through an automated process, will provide an accurate prediction of electrical load for the island of Thira in Greece. Through an automated application, deep learning load forecasting models have been created, such as Multilayer Perceptron, Long Short-Term Memory (LSTM), Convolutional Neural Network One Dimensional (CNN-1D), CNN-LSTM, Temporal Convolutional Network (TCN) and a proposed hybrid model called Convolutional LSTM Encoder-Decoder. The results in terms of prediction accuracy show satisfactory performances for all models, with the proposed hybrid model achieving the best accuracy.

Monitoring crown closure evolution using multi-temporal Light Detection and Ranging (LiDAR) surveys is a method that we expect to be increasingly adopted given the availability of LiDAR sensors and the accumulating survey archives. However, little attention was devoted to comparing crown closure estimates from independent surveys. Although survey parameters cannot be modified after the data collection, we speculate that the error associated to crown closure estimates comparison can be reduced by selecting optimal post-survey parameters. In this study, we compared crown closure estimates of three airborne LiDAR surveys from 2018 (40 pt/m²) used as a reference, and two lower-density surveys from 2016 (4.5 pt/m²) and 2018 (2 pt/m²). We studied the effect of the height threshold used to separate canopy points and the grid resolution, using skewness and variance of lagged difference of crown closure. Crown closure estimates using low height thresholds were more different across surveys, resulting in higher root mean squared error (RMSE), bias and more different variograms. Results show that optimal height threshold was 3 m and grid resolution was 25 m, although there was room for decision (RMSE of 7% and 5%, and bias of 4% and 0% for 2016 and 2018 low-density surveys).

Apraxia of speech is a persistent speech motor disorder that affects speech intelligibility. Studies on speech motor disorders with transcranial Direct Current Stimulation (tDCS) have been mostly directed to post-stroke aphasia. Only a few tDCS studies have focused on apraxia of speech or childhood apraxia of speech (CAS), and no study has investigated individuals with CAS and people with trisomy 21 (T21, Down Syndrome). This study examined the effects of tDCS combined with a motor learning task in developmental apraxia of speech co-existing with T21 (ReBEC RBR-5435x9). The accuracy of speech sound production of nonsense words (NSWs) during Rapid Syllable Transition Training (ReST) under 10 sessions of anodal tDCS (1.5 mA, 25 cm) over the Broca’s area with cathode over the contralateral region was compared to 10 sessions of sham-tDCS and 4 control sessions in a 20-year-old male individual with T21 presenting moderate-severe childhood apraxia of speech (CAS). The accuracy for NSWs production progressively improved (gain 40%) under tDCS only (sham-tDCS and control sessions showed <20% gain). A decrease in speech severity from moderate-severe to mild-moderate indicated transfer effects in speech production. The speech accuracy under tDCS was correlated with Wernicke’s area activation (P3 current source density), which in turn, was correlated with the activation of the left supramarginal gyrus and the Sylvian Parietal Temporal Junction. Repetitive bihemispheric tDCS paired with ReST may have facilitated the speech sound acquisition in a young adult with T21 and CAS, possibly by recruiting brain regions required for the phonological working memory.

There are rich proper noun derivative semantic relationships in geographic entity vector data. The identification of traditional proper noun derivative semantic relationships usually requires toponym researchers to examine the source of derived toponyms by consulting a large number of toponym documents. This method cannot adapt to the mining of proper noun derivative semantic relationships for large-scale geographical entity. In this regard, this paper proposes a method of identifying the proper noun derivative semantic relationships for geographical entity by combining prompt learning and XGBoost model. This method transforms the extraction problem of proper noun derivative semantic relationships into a binary classification problem by analyzing the characteristics of the derivation relationship of toponyms in the form of toponyms and the spatial and temporal distribution of geography. Firstly, prompt learning and gaussian mixture model are used to extract and cluster the derivation words of toponyms, so as to realize the recognition of derived toponyms collections. Then, enumerate the possible proper noun derivations in the toponym set, and then the XGBoost model is used to identify the semantic relations derived from the proper noun of geographical entities. In the experiment, the recognition method of proper noun derivative semantic relationships based on prompt learning and XGBoost proposed in this paper has achieved good relationship recognition effect in the experiment. This method has certain practical value in the fields of toponym management and toponym translation.

Predicting change from multivariate time series has relevant applications ranging from medical to engineering fields. Multisensory stimulation therapy in patients with dementia aims to change the patient’s behavioral state. For example, patients who exhibit a baseline of agitation may be paced to change their behavioral state to relaxed. This study aims to predict changes in behavioral state from the analysis of the physiological and neurovegetative parameters to support the therapist during the stimulation session. In order to extract valuable indicators for predicting changes, both handcrafted and learned features were evaluated and compared. The handcrafted features were defined starting from the CATCH22 feature collection, while the learned ones were extracted using a Temporal Convolutional Network, and the behavioral state was predicted through Bidirectional Long Short-Term Memory Auto-Encoder, operating jointly. From the comparison with the state-of-the-art, the learned features-based approach exhibits superior performance with accuracy rates of up to 99.42% with a time window of 70 seconds and up to 98.44% with a time window of 10 seconds.

Advanced methods of treatment are needed to fight the threats of virus-transmitted deseases and pandemics. Often they are based on an improved biophysical understanding of virus replication strategies and processes in their host cells. For instance, an essential component of the replication of the Hepatitis C virus (HCV) proceeds under the influence of non-structural HCV proteins (NSPs) that are anchored to the endoplasmatic reticulum (ER), such as the NS5a protein. The diffusion of NSPs has been studied by in-vitro fluorescence recovery after photobleaching (FRAP) experiments. The diffusive evolution of the concentration field of NSPs on the ER can be described by means of surface partial differential equations (sufPDE). Knodel et al, Viruses 2018, 10, 28 estimated the diffusion coefficient of the NS5a protein by minimizing the discrepancy of an extended set of sufPDE simulations and experimental FRAP time series data. Here, we provide a scaling analysis of the sufPDEs that describe the diffusive evolution of the concentration field of NSPs on the ER. This analysis provides an estimate of the diffusion coefficient that is based only on the ratio of the membrane surface area in the FRAP region and its contour length. The quality of this estimate is explored by comparison to numerical solutions of the sufPDE for a flat geometry and for ten different 3D embedded 2D ER grids that are derived from fluorescence z-stack data of the ER. Finally, we apply the new data analysis to the experimental FRAP time-series data analyzed in our previous paper, and we discuss the opportunities of the new approach.

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca2+) homeostasis after stimuli, thus exerting crucial neuroprotection for cerebellar ataxias and corticospinal motor neuron degeneration. Our Atxn2-CAG100-Knock-In mouse faithfully models features observed in patients at pre-onset, early and terminal stages. Here, its cerebellar global RNA profiling revealed downregulation of signaling cascades to precede motor deficits. Validation work at mRNA/protein level defined alterations that were independent of constant physiological ATXN2 functions, but specific for RNA/aggregation toxicity, and progressive across the short lifespan. Earliest changes were detected at 3 months among Ca2+ channels/transporters (Itpr1, Ryr3, Atp2a2, Atp2a3, Trpc3), IP3 metabolism (Plcg1, Inpp5a, Itpka), and Ca2+-Calmodulin dependent kinases (Camk2a, Camk4). CaMKIV–Sam68 control over alternative splicing of Nrxn1, an adhesion component of glutamatergic synapses between granule and Purkinje neurons, was found affected. Systematic screening of pre/post-synapse components, with dendrite morphology assessment, suggested early impairment of CamKIIα abundance together with weakening of parallel fiber connectivity. These data reveal molecular changes due to ATXN2 pathology, impacting communication and excitability of cerebellar neurons. Discovery of such risk versus progression markers improves the assessment of pre-symptomatic treatments in SCA2 and related disorders.

While paresthesia-based spinal cord stimulation (SCS) has been proven effective to treat chronic neuropathic pain, initial benefits may lead to the development of “Failed SCS Syndrome’ (FSCSS) defined as decrease over time related to Loss of Efficacy (LoE) with or without Loss of Coverage (LoC). Development of technologies associating new paresthesia-free stimulation waveforms and implanted pulse generator adapters provide opportunities to manage patients with LoE. The main goal of our study was to investigate salvage procedures, through neu-rostimulation adapters, in patients already implanted with SCS and experienced LoE. We retro-spectively analyzed a cohort of patients who were offered new SCS programs/waveforms through an implanted adapter between 2018 and 2021. Patients were evaluated before, and at 1, 3, 6 and 12-month follow-up. Outcomes included pain intensity rating with Visual Analog Scale (VAS), pain/coverage mappings and stimulation preferences. Last follow-up evaluations (N=27) showed significant improvement in VAS (p = 0.0001), ODI (p = 0.021) and Quality of Life (p=0.023). In the 11/27 patients with LoC, SCS efficacy on pain intensity (36.89%) was accompa-nied by paresthesia coverage recovery (55.57%) and pain surface decrease (47.01%). At 12-month follow-up, 81.3% preferred to keep tonic stimulation in their waveform portfolio. SCS conver-sion using adapters appears promising as a salvage solution, with an emphasis on paresthesia recapturing enabled by spatial retargeting. In light of these results, adapters could be integrated to SCS rescue algorithms or should be considered in SCS rescue.

This paper delves into the intricate nature of the different essence interactions that shape our perceived reality, leveraging a blend of existing empirical data and original experiments. Through a multidisciplinary approach encompassing quantum mechanics, general physics, metaphysics, philosophy, and spiritualism, it seeks to elucidate the fundamental interplays governing phenomena such as gravity, mass, electromagnetism, force, motion, and quantum mechanics. This exploration promises a reexamination and unification of these principles, offering novel perspectives on the extraordinary phenomena that underpin our reality. By comprehending and manipulating these interactions, the potential arises to orchestrate reality towards desired ends. This study not only unveils compelling avenues for scientific advancement but also proposes transformative technologies and concepts, including light-speed transportation, remote viewing, communication with the deceased, alchemy, and the realization of what is commonly perceived as magic. These visionary notions not only push the boundaries of current understanding but also provide a captivating glimpse into the future possibilities that may await humanity.