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Preprint ARTICLE | doi:10.20944/preprints202306.2147.v1

Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer Cells

Rubén López-Cortés, Isabel Correa Pardo, Laura Muinelo-Romay, Almudena Fernández-Briera, Emilio Gil-Martín

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: FUT8 knockdown; core fucosylation; TRAIL-induced apoptosis; DR4; colorectal cancer

Online: 30 June 2023 (02:17:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1798.v1

Study on the Regulation Mechanism of Quality Deterioration During the Anhydrous Storage and Transportation of Chilling Stress and Dry Exposure for scallop (Patinopecten Yessoensis)

Peihong Jiang, Dongjie Chen, Xiangyang Chang, Changfeng Zhang, Xiuping Fan, Xiaoming Qin

Subject: Biology And Life Sciences, Life Sciences Keywords: Ecological ice temperature; chilling stress; anhydrous live preservation; regulation mechanism; Patinopecten yessoensis

Online: 26 June 2023 (10:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1757.v1

Characteristics and Establishment of Objective Identification Standard and Perdictor of Foehn Winds in Urumqi on the North Slope of Middle Tianshan Mountains of China

Maoling Ayitikan, Xia Li, Qing He, Yusufu Musha, Hao Tang, Shuting Li, Yuting Zhong, Gang Ren

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Foehn; Wind direction and speed; Potential temperature difference; Identification standard

Online: 26 June 2023 (07:18:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1720.v1

Finite Element Analysis (FEA) of the Stress and Strain Distribution in Cone-Morse Implant-Abutment Connection Implants Placed in an Equicrestal and Subcrestal Position

Natalia Di Pietro, Mario Ceddia, Tea Romasco, Nilton De Bortoli Junior, Bruno Freitas Mello, Margherita Tumedei, Alessandro Specchiulli, Adriano Piattelli, Bartolomeo Trentadue

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bacterial leakage; Cone-Morse connection; dental implants; equicrestal implant placement; Finite Element Analysis (FEA); implant-abutment junction; implant placement; subcrestal implant placement.

Online: 25 June 2023 (05:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1621.v1

The INOVMineral Project’s Contribution to Mineral Exploration – A WebGIS Integration and Visualization of Spectral and Geophysical Properties of the Aldeia LCT Pegmatite Spodumene Deposit

Joana Cardoso-Fernandes, Douglas Santos, Cátia Rodrigues de Almeida, Julia Tucker Vasques, Ariane Mendes, Ricardo Ribeiro, Antonio Azzalini, Lia Duarte, Alexandre Lima, Ana C. Teodoro

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: geological exploration; UAV; LiDAR; radiometry; geophysics; remote sensing; Landsat 9; GIS; lithium

Online: 22 June 2023 (12:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1271.v1

Assessment of Selenium, Iodine and Supplementary Blue Light Effects on the Growth Characteristics, Pigments, Trigonelline and Seed Yield of Fenugreek (Trigonella foenum-gracum L.)

Sadrollah Ramezani, Behnaz Yousefshahi, Yusuf Farrokhzad, Dariush Ramazan, Meisam Zargar, Elena Pakina

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Biofortification; Supplementary blue light; Growth; Health-preserving compounds; Trigonelline; Micronutrients

Online: 19 June 2023 (03:24:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0199.v1

Predicting the Effect of Mutations on Protein Stability and Binding: Assessment of Leading Algorithms Performance and Databases Content with Respect to Types of Mutations

Preeti Pandey, Shailesh Pandey, Prawin Rimal, Nicolas Ancona, Emil Alexov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mutations; folding free energy change; binding free energy change; single nucleotide variant

Online: 2 June 2023 (11:58:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0062.v1

Antimicrobial Action of Oregano (Origanum vulgare) and Rose-Mary (Rosmarinus officinalis) Essential Oils on Escherichia coli and Staphylococcus aureus Inoculated in “Minas Frescal” Cheese

Marco Cortez, Juliana Cruz, Maria Carmela Duarte, Aline Gomes, Evelyn Carvalho

Subject: Biology And Life Sciences, Food Science And Technology Keywords: inhibition; dairy products; cheese; essential oil; pathogens.

Online: 1 June 2023 (08:12:53 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1371.v1

Simple Preparation of a Unique Ionic Liquid/Deep Eutectic Solvent and β-Cyclodextrin Composite Discs and Its Use To Capture Hazardous Substances From Water

Yingying Guo, Na Liu, Hangping Chen, Ahmad Ali, Sara Toufouki, Shun Yao

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: ionic liquid; deep eutectic solvent; cyclodextrin; sorbent disc; water environment

Online: 19 May 2023 (04:04:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1073.v1

Continuous Glucose Monitoring (CGM) in Sports – a Comparison between a CGM Device and Lab-Based Glucose Analyser under Resting and Exercising Conditions in Athletes

Helen Bauhaus, Pinar Erdogan, Hans Braun, Mario Thevis

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: continuous glucose monitoring; application in sports; carbohydrate management; active subjects; validation

Online: 16 May 2023 (03:52:33 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202305.0554.v1

Development and Evaluation of Novel Apomorphine and Quetiapine Combinational Formulation for Parkinson’s Disease in Rat: New Era (Possibilities) for Pre – Clinical Protocol Concept Review

Minesh Patel

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Parkinson’s Disease; Pre-Clinical Protocol; Novel Combinational Formulation; In Vivo Model; In Vivo Study

Online: 9 May 2023 (03:49:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0027.v1

A Comparison of the Effect of Cellulose Nanocrystals (CNC) and Polyethylene Glycol (PEG) As Additives in Ultrafiltration Mem-Branes (PES-UF): Characterization and Performance

Amos Adeniyi, Gerald Okey Odo, Danae Gonzalez Ortiz, Celine Pochat-Bohatier, Sandrine Mbakop, Maurice S. Onyango

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: ultrafiltration; PEG; CNC; COD; turbidity; morphology

Online: 2 May 2023 (03:32:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0363.v2

Integrating Middle East and North Africa Unaccompanied Minors Refugees and Asylum Seekers through Mentoring: Exploring Eu-Based Research to Inform Future Applications in Portugal

Dora Carolo, Ricardo Carvalho, Carolina Batalha, Susana Gouveia, Paula Lebre

Subject: Social Sciences, Area Studies Keywords: migration; mentoring; unaccompanied minors; refugee; asylum seeker; integration

Online: 27 April 2023 (03:40:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0281.v1

The Effect of Ramadan Intermittent Fasting on Food Intake, Anthropometric Indices, and Metabolic Biomarkers among Pre-and Post-menopausal Women: A Cross-Sectional Study

Nada Alzunaidy, Abdulrahman Saleh Al-Khalifa, Maha Hussain Alhussain, Mohammed Awad alkareem Mohammed Ahmed, Hani A. Alfheeaid, MoezAlIslam E. Faris, Sami A. Althwab

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Intermittent fasting; Caloric restriction; Time-restricted eating; Menopausal; Women’s health

Online: 13 April 2023 (02:59:21 CEST)

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By shifting eating hours from daytime to nighttime, Ramadan intermittent fasting (RIF) illustrates how religious beliefs influence human dietary behavior and subsequent anthropometric and metabolic measures. This study aimed to investigate socioeconomic characteristics and examine how observing RIF affects dietary intake, anthropometric indices, and metabolic markers in healthy premenopausal (PRE-M) and post-menopausal (POST-M) Saudi women. Before starting the study, the authors hypothesized that the RIF improves some nutritional aspects and health in respondents, but not after breaking the fast.. The study includes 62 women (31 PRE-M, 21-43 years, and 31 POST-M, 44-68 years). A structured questionnaire was used to collect socioeconomic data. Physical activity, anthropometric, dietary, and biochemical assessments were undertaken before RIF and at the end of the third week of Ramadan fasting month. Socioeconomic data varied among respondents. Observing RIF was associated with significantly (at either p ≤ 0.01 or p ≤ 0.05) lower intake of calories, macronutrients, minerals (except for Na), and vitamins than before RIF for both groups. In terms of body mass index (BMI), and waist-to-height ratio (WHtR) for PRE-M, the percentage of overweight decreased significantly (p≤0.01) while obesity remained unchanged. In contrast, for POST-M, the percentage of overweight increased significantly (p≤0.05), but obesity decreased after RIF. Both groups' waist-to-hip ratio (WHR), body fat (BF), and fat mass (FM) decreased after RIF. High-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), triglycerides (TG), and blood pressure (SBP, DBP) were generally maintained at acceptable normal levels in most responders before and after RIF. However, low-density lipoprotein cholesterol (LDL-C) was significantly decreased during RIF than before, especially for POST-M. Age, occupation, and monthly income were the most important factors influencing women’s nutritional status and body fat. In conclusion, observing RIF by PRE- and POST-M Saudi women was associated with significant improvements in variable health indicators, with a few exceptions, particularly POST-M, and may help lower risk factors for chronic diseases.

Preprint ARTICLE | doi:10.20944/preprints202303.0519.v1

Spatial-Temporal Distribution Characteristics and Interrelationship of Sulfur and Iron Compounds in Sediments: A Model Study in the Closed-Section of Mikawa Bay, Japan

Mitsuyasu Waku, Ryota Sone, Tetsunori Inoue, Toshiro Ishida, Teruaki Suzuki

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: dissolved sulfide; iron; hypoxia; buffering capacity; environmental restoration; coastal waters; Mikawa Bay; dead zone

Online: 30 March 2023 (02:58:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0305.v1

Molecular Docking and ADMET Prediction of Modified and Derivative Forms of 2-Deoxy-D-glucose against COVID-19 Main Protease Complex: In silico Approach

Rashmi Rekha Samal, Suryasikha Samal, Choudhury Suryakant Mishra, Atala Bihari Jena, Asim K Duttaroy

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Covid-19; Deoxy-D-glucose; molecular docking; ADMET

Online: 17 January 2023 (09:32:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0250.v1

Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the Covid-19 Pandemic in Hong Kong and Korea

Yun Young Go, Maura Carrai, Yan Ru Choi, Christopher J. Brackman, Karina W.S. Tam, Pierra Y.T. Law, Fiona Woodhouse, Jane Gray, Ji Hun Kim, Joohyung Park, Chae Won Jeon, Hyomi Jang, Ioannis Magouras, Nicola Decaro, Samuel MS Cheng, Malik Peiris, Julia A. Beatty, Vanessa R. Barrs

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Feline; Canine; seroprevalence; zoonosis

Online: 13 January 2023 (10:21:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0510.v1

Unstable Behavioural Pattern of Teesta River and its Impact on Riverine Dwellers: A Case Study of Confluence Area of Teesta and Dharala River, India

Mantu Das, Mst Tania Parveen, Deep Ghosh, Abhisek Sarkar, Jiarul Alam, Snehasish Saha

Subject: Social Sciences, Geography, Planning And Development Keywords: channel migration; riverine landscape; riverine dwellers; livelihood vulnerability index (LVI); river confluence; RS-GIS

Online: 27 December 2022 (06:48:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0456.v1

Community-Based Approaches in the Construction, Ownership, and Management of Water Infrastructures and the Development of Socio-Political Complexity Among the Chagga, Kilimanjaro, Tanzania

Valence Meriki Silayo, Innocent Pikirayi

Subject: Arts And Humanities, Archaeology Keywords: Chagga; water infrastructures; water management; sustainable farming; social complexity; community collaboration

Online: 23 December 2022 (09:00:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0249.v1

The Genetic Mechanisms Underlying the Concerted Expression of the Yellow and Tan Genes in Complex Patterns on the Abdomen and Wings of Drosophila Guttifera

Komal K.B. Raja, Evan A Bachman, Catrina Fernholz, David Trine, Rebecca E. Hobmeier, Nathaniel Maki, Timothy Massoglia, Thomas Werner

Subject: Biology And Life Sciences, Insect Science Keywords: tan; Drosophila; Drosophila guttifera; CRM; cis-regulatory; evo-devo; yellow; transcription factor; cis-regulatory module; cis-regulatory element

Online: 14 December 2022 (06:48:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0122.v1

Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2

Marko Popovic

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Elemental composition; Gibbs energy of biosynthesis; Gibbs energy of binding; Variant of concern (VOC)

Online: 7 December 2022 (09:19:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0555.v1

Assessment of Nutritional Status and Risk of Malnutrition Using Adapted Standard Tools in Patients with Mental Illness and in Need of Intensive Psychiatric Treatment

Ladina Risch, Florian Hotzy, Stefan Vetter, Sascha Hiller, Kathrin Wallimann, Erich Seifritz, Sonja Mötteli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: nutritional risk screening; severe mental illness; psychiatric treatment; BMI; nutritional status; malnutrition; depression; schizophrenia; nutrition; diet

Online: 30 November 2022 (02:44:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0475.v1

The Local Coordination Effects on the Reactivity and Speciation of Active Sites in Graphene-Embedded Single-Atom Catalysts Over Wide pH and Potential Range

Milica S. Ritopečki, Ana S. Dobrota, Natalia V. Skorodumova, Igor A. Pašti

Subject: Chemistry And Materials Science, Nanotechnology Keywords: single-atom catalysts; graphene; activity; reactivity; stability; Pourbaix plots

Online: 25 November 2022 (10:06:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0336.v1

Combining Influenza and COVID-19 Booster Vaccination Strategy to Improve Vaccination Uptake Necessary for Managing the Health Pandemic: A Systematic Review and Meta-Analysis

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 Booster; Influenza and COVID-19; Vaccination Strategy; Combining Vaccination

Online: 17 November 2022 (10:31:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0269.v1

Occupational Stress and Burnout among Intensive Care Unit Nurses during the Pandemic: A Prospective Longitudinal Study of Nurses in COVID and non-COVID Units

Pratima Saravanan, Tariq Nisar, Qian Zhang, Faisal Masud, Farzan Sasangohar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: critical care; physiological measurement; nursing and nursing systems; naturalistic study; fatigue

Online: 15 November 2022 (03:18:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0250.v1

An Improved Retrieval of Snow and Ice Properties Using Spaceborne OLCI/S-3 Spectral Reflectance Measurements: Updated Atmospheric Correction and Snow Impurity Load Estimation

Alexander Kokhanovsky, Baptiste Vandecrux, Adrien Wehrlé, Olaf Danne, Carsten Brockmann, Jason Box

Subject: Environmental And Earth Sciences, Environmental Science Keywords: snow remote sensing; cloud screening; atmospheric correction; radiative transfer

Online: 14 November 2022 (09:38:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0105.v1

Commercial Topical Probiotics for the Skin Microbiome: The Majority Do Not Contain Live Microbes and May Not Satisfy Criteria for Safe and Effective Use

Christopher Wallen-Russell, Samuel Wallen-Russell

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: topical probiotics; skin microbiome; probiotics; biodiversity; microbiome; skin allergy; cosmetics

Online: 9 October 2022 (03:34:01 CEST)

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Preprint ESSAY | doi:10.20944/preprints202210.0085.v1

Using Directed Acyclic Graphs (Dags) to Represent the Data Generating Mechanisms of Disease and Healthcare Pathways: A Guide for Educators, Students, Practitioners and Researchers

George Ellison

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Directed Acyclic Graph; DAG; confounding; collider bias; epistemology; inferential statistics

Online: 8 October 2022 (02:59:34 CEST)

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Directed acyclic graphs (DAGs) are nonparametric causal path diagrams that have substantial utility as principled representations of disease and healthcare pathways, and of the underlying ‘data generating mechanisms’ these pathways involve. As such, DAGs provide a valuable bridge between: the aetiological knowledge, operational insight and professional experience on which clinical training and practice depend; and the more abstract epistemological and analytical considerations required to extract robust statistical insight from health and healthcare data. DAGs are nonetheless vulnerable to imperfect biomedical paradigms, partial clinical knowledge and limited empirical data. DAGs drawn under such circumstances offer limited scope for statistical insight free from cognitive, analytical or inferential bias if: they misrepresent the data generating mechanisms involved; or ignore the important role that omitted variables (whether measured, unmeasured or unacknowledged) might play therein. To address these weaknesses and broaden the appeal and application of DAGs, this chapter provides ten simple steps that educators can use to improve the analytical competence and statistical confidence of the healthcare students, qualified practitioners and experienced researchers they support. These steps use temporal logic to draw DAGs so as to: reduce reliance on uncertain knowledge, incomplete information, flawed assumptions or guesswork; and avoid, mitigate or acknowledge the errors and biases that each of these incur. The chapter comprises an accessible, non-technical overview of the perspective and thoughtfulness required to generate temporally coherent DAGs as objective representations of the probabilistic causal paths involved in context-specific data generating mechanisms. It encourages a focus on those variables operating as potential sources of analytical or inferential bias when estimating the plausible, probabilistic causal relationship between two pre-specified variables; and specifically addresses the challenges posed by: omitted; time-variant; non-asynchronous; and temporally obscure variables. The chapter includes a worked example based on a published clinical study to demonstrate how each of the steps required to generate temporally-informed DAGs can be applied to: critically appraise the analytical decisions made during applied healthcare research; and inform the decisions required when designing, undertaking and analysing primary and secondary, prospective and retrospective research. The appendices include a summary of ten recommendations for improving the reporting and interrogability of DAGs and DAG-informed analyses.

Preprint ARTICLE | doi:10.20944/preprints202210.0048.v1

Phytomanagement of a Lead Polluted Shooting Range Using an Aromatic Plant Species and Its Effects on the Rhizosphere BacteRial Diversity and Essential Oil Production

Anabel Saran, Lucia Fernandez, Yanela Latini, Monica Bellozas Reinhard, Marisol Minig, Sofie Thijs, Jaco Vangronsveld, Luciano Merini

Subject: Biology And Life Sciences, Plant Sciences Keywords: Lead; Field trial; Phytostabilization; Phytomanagement; Aromatic plants; Bacterial community

Online: 5 October 2022 (17:51:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0039.v1

Evaluating the Increasing Trend of Strength and Severe Wind Hazard of Philippine Typhoons Using the Holland-B parameter and Regional Cyclonic Wind Field Modeling

Joshua Cunanan Agar

Subject: Engineering, Civil Engineering Keywords: Holland-B Parameter; Philippine typhoons; Regional wind; Wind hazard

Online: 2 September 2022 (10:39:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0507.v1

Evaluation of a Sleep Education Workshop for Trainee Psychologists Designed to Increase Knowledge and Practical Skills in Sleep and Insomnia Management: A Pilot Study

Hailey Meaklim, Imogen C Rehm, Moira F Junge, Melissa Monfries, Gerard A Kennedy, Romola S. Bucks, Lisa J Meltzer, Melinda L Jackson

Subject: Social Sciences, Psychology Keywords: sleep education; insomnia; training; circadian rhythms; behavioral sleep medicine, psychotherapy; dissemination; implementation science; mental health

Online: 30 August 2022 (05:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0364.v1

Telomerase Inhibitors TMPyP4 and Thymoquinone Decreased Cell Proliferation and Induced Cell Death in NSCLC Cell Line LC‐HK2, Modifying the Pattern of Focal Adhesion

A.M. Bernabe Garnique, P. Rezende‐Teixeira, G.M. Machado‐Santelli

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: TMPyP4 1; Thymoquinone 2; cell viability 3; cell adhesion 4; telomerase

Online: 19 August 2022 (10:46:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0403.v1

Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From the Liquid Biopsy to New Omics Technologies and Non-invasive Circulating Biomarkers

Carmela Balistreri

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endothelium; Endothelium dysfunction; Newer omics technologies; network medicine; biomarkers and therapeutic targets

Online: 29 June 2022 (09:48:20 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202206.0182.v1

Heat Transfer Equipment for Space Shuttle Orbiter, Its Main Engine (Aerojet Rocketdyne RS 25), Thermal (Passive and Active), Environmental Control and Life Support System

Muhammad Musaddique Ali Rafique

Subject: Engineering, Mechanical Engineering Keywords: heat transfer; thermodynamics; evaporation; condensation; regeneration

Online: 13 June 2022 (10:07:32 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202204.0299.v3

A Simplistic and Cost-Effective Design for Real-World Development of an Ambient Assisted Living System for Fall Detection and Indoor Localization: Proof of Concept

Nirmalya Thakur, Chia Y. Han

Subject: Computer Science And Mathematics, Information Systems Keywords: elderly; aging population; ambient intelligence; fall detection; indoor localization; real-world implementation; sensors; activities of daily living; assisted living

Online: 21 July 2022 (10:46:08 CEST)

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Falls, highly common in the constantly increasing global aging population, can have a variety of negative effects on their health, well-being, and quality of life, including restricting their capabilities to conduct Activities of Daily Living (ADLs), which are crucial for one’s sustenance. Timely assistance during falls is highly necessary, which involves tracking the indoor location of the elderly during their diverse navigational patterns associated with ADLs to detect the precise location of a fall. With the decreasing caregiver population on a global scale, it is important that the future of intelligent living environments can detect falls during ADL.s while being able to track the indoor location of the elderly in the real world. Prior works in these fields have several limitations, such as – the lack of functionalities to detect both falls and indoor locations, high cost of implementation, complicated design, the requirement of multiple hardware components for deployment, and the necessity to develop new hardware for implementation, which make the wide-scale deployment of such technologies challenging. To address these challenges, this work proposes a cost-effective and simplistic design paradigm for an Ambient Assisted Living system that can capture multimodal components of user behaviors during ADLs that are necessary for performing fall detection and indoor localization in a simultaneous manner in the real world. Proof of concept results from real-world experiments are presented to uphold the effective working of the system. The findings from two comparison studies with prior works in this field are also presented to uphold the novelty of this work. The first comparison study shows how the proposed system outperforms prior works in the areas of indoor localization and fall detection in terms of the effectiveness of its software design and hardware design. The second comparison study shows that the cost for the development of this system is the least as compared to prior works in these fields, which involved real-world development of the underlining systems, thereby upholding its cost-effective nature.

Preprint ARTICLE | doi:10.20944/preprints202205.0221.v1

Ascorbic Acid Effect on Frozen and Thawed on Sperm Motility, Plasma Membrane Integrity, Livability and Acrosome Integrity of Ring-Necked Pheasant (Phasianus colchicus) Semen

Umer Ali, Asif Bilal, Aasma Iqbal, Muhammad Sajjad Ansari, Bushra Allah Rakha, Shamim Akhter

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ring necked-pheasant; ascorbic acid; semen cryopreservation; semen quality

Online: 17 May 2022 (05:19:30 CEST)

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Ring necked-pheasant (Phasianus colchicus) is bird of order Galliformes. Ring necked-pheasant is also known as gallinaceous bird and game bird. It looks like chicken bird. It is national bird of South Dakota. It is mostly found in wild areas but in Pakistan it exists as Domestic bird. It has high proteins and low fat in its meat. The present study was conducted to check the effect of ascorbic acid on sperm Motility, sperm cytoplasmic membrane integrity, sperm livability and acrosome integrity of Ring-necked pheasant at different concentrations of ascorbic acid (0mM, 1mM, 2mM, 3mM and 4mM) were used. Semen was collected by abdominal massage technique. Motility of sperm was greater than 70%.Then it was processed further. The cryopreservation of semen was checked at various stages like Post Dilution, Post Cooling, Post Equilibration and Post Thawing. Semen was cooled from post-dilution stage (37⁰ C) to post-cooling (20⁰C).Then it further cooled gradually to get post-equilibration stage (4⁰ C) within 24 hours. After that 10% glycerol was added to the sample. Then it was transferred to liquid nitrogen (LN₂) cylinder for 24 hours. After thawing stage sample was removed from LN₂ cylinders and placed in water bath for 4 hours to achieve post-thawing. Then performed sperm quality assays at each stage of cryopreservation. Sperm motility was assessed by Neubauer Chamber Hemocytometer. Plasma Membrane Integrity was checked by using Hypo Osmotic Swelling Test with the help to 2% Eosin. Sperm livability was assessed by Lake’s glutamate solution and sperm Acrosome Integrity was checked by dual staining technique by using Formal citrate solution and Giemsa stain. The better results were seen at 3mM treatment of ascorbic acid. Sperm motility percentage was significantly different (P < 0.05) on 3mM treatment on all the stages of cryopreservation rather than other treatments. Plasma membrane integrity assay also showed good results at same concentration (P < 0.05) on all the stages of cryopreservation rather than other treatments. At the sperm livability stage 3mM treatment showed significantly difference (P < 0.05) on all the stages of cryopreservation rather than other treatments. The sperm acrosome integrity showed highest percentage on 3mM treatment (P < 0.05) on all stages of cryopreservation rather than other treatments. Effect of ascorbic acid on all the quality parameters (sperm motility, plasma membrane integrity, livability and acrosome integrity) was showed significant difference (P < 0.05) at 3mM treatment of ascorbic acid as compare to control as well as remaining treatments. It was seen that by increasing the concentration of ascorbic acid from 3mM concentration to onward it shows negative results on its cryopreservation. Now this cryopreserved semen can be transfer from one place to another place to obtain good varieties as well as better genetic characteristics of this species.

Preprint ARTICLE | doi:10.20944/preprints202205.0105.v1

Calibration of PurpleAir PA-I and PA-II monitors using daily mean PM2.5 concentrations measured in California, Washington, and Oregon from 2017 to 2021

Lance Arthur Wallace, Tongke Zhao, Neil Klepeis

Subject: Environmental And Earth Sciences, Environmental Science Keywords: low-cost particle monitors; calibration factor; PurpleAir; particles; PM2.5; ALT-CF3; algorithm; PMS1003; PMS5003

Online: 9 May 2022 (06:05:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0201.v1

Compliance with Standard Precaution and Its Relationship With Views on Infection Control and Prevention Policy Among Chinese University Students During the COVID-19 Pandemic

Winnie Cheng, Enid Kwong, Regina Lee, Anson Tang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; emotion-focused coping; infection control practices; perceived stress; relation-ship-focused coping

Online: 21 April 2022 (10:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0199.v1

Nano-Structured Na2CaP2O7: a New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

Redouane Achagar, Abdelhakim Elmakssoudi, Abderrahmane Thoume, Mohamed Dakir, Abdelaziz Elamrani, Yassine Zouheir, Mohamed Zahouily, Zouhair Ait-Touchente, Jamal Jamaleddine, Mohamed M. M. Chehimi

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Catalyst; antibacterial activity; solvent-free conditions; heterogeneous catalysis; Synthesis; cyanopyridines; pyrimidines; nano-structured Na2CaP2O7; catalyst recovery

Online: 21 April 2022 (09:26:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0283.v1

Exploring the Association between Misinformation Endorsement, Opinions on the Government Response, Risk Perception, and COVID-19 Vaccine Hesitancy in the US, Canada, and Italy

Elena Savoia, Nigel Walsh Harriman, Rachael Piltch-Loeb, Marco Bonetti, Veronica Toffolutti, Marcia A. Testa

Subject: Social Sciences, Government Keywords: COVID-19 Vaccine Hesitancy; Misinformation; Government Actions; Communication

Online: 21 March 2022 (10:29:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0277.v1

Collaborative Research for Long COVID Haulers in Greece (Characteristics, Clinical Assessment and Rehabilitation). Non-hospitalized and Hospitalized Long COVID Patients Share Similar Symptom Patterns

Martha Spyridoula Katsarou, Eleni Iasonidou, Alexander Osarogue, Efthymios Kalafatis, Stylianos Gatzonis, Sofia Pappa, Athanasia Verentzioti, Maria Stefanatou, Pantelis Gounopoulos, Christos Demponeras, Eleni Konstantinidou, Nikolaos Drakoulis, Andreas Asimakos, Archontoula Antonoglou, Aspasia Mavronasou, Stavroula Spetsioti, Anastasia Kotanidou, Paraskevi Katsaounou

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Long Covid; post Covid; Post-acute COVID

Online: 21 March 2022 (08:25:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0205.v1

Modelling the Origin, Fate, and Ecological and Health Impacts of Heavy Metals from an Abandoned Mercury Mine in a Paradise Island in the Philippines

Reymar R. Diwa, Custer C. Deocaris, Lhevy D. Geraldo, Lawrence P. Belo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: heavy metals; abandoned mine; soil pollution; potential ecological risk; multivariate analysis; health index; soil; sediments

Online: 15 March 2022 (10:58:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0007.v1

Natural Language Processing Of Helpline Chat Data Before And During The Pandemic Revealed Significant Decrease In Self-image Appreciation And Changes In Other Traits

Maria Paz Raveau, Julian Goñi, José Rodriguez, Isidora Paiva, Fernanda Barriga, Maria Paz Hermosilla, Claudio Fuentes, Susana Eyheramendy

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: mental health; natural language processing; interdisciplinary research; mental health helpline

Online: 1 February 2022 (12:03:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0390.v1

Analytic and clinical validation of a pan-cancer NGS liquid biopsy test for the detection of copy number amplifications, fusions and exon skipping variants.

Audrey Audetat, Cherie Tschida, Sarah Kreston, Adam Stephen, Brittany D'Alessio, Brittany D’Alessio, Leisa Jackson, John Williamson, Hestia Mellert, Niki Givens, Ubaradka G. Sathyanarayana, Gary A. Pestano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-small cell lung cancer (NSCLC); liquid biopsy; cell-free nucleic acid (cfNA); next generation sequencing (NGS); CNA (copy number amplifications); fusions, exon-skipping.

Online: 26 January 2022 (03:21:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0513.v1

Antiparasitic Activity of Single Solanum ferox Extract and Concoction with Zingiber zerumbet and Boesenbergia pandurata Extracts to Control Argulus sp. on Goldfish (Cyprinus carpio)

Esti Handayani Hardi, Rudy Agung Nugroho, Irawan wijaya kusuma, gina Saptiani, agustina agustina, Abinawanto Abinawanto, Yushinta Fujaya, Bambang Murtiyoso, Tjahjo Winanto, Nurhidayat Nurhidayat

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Argulus sp.; anti parasitic; natural product; fish diseases; solasodine; Solanum ferox

Online: 31 December 2021 (11:28:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0337.v1

Gypsum Supplies Calcium to Ultisol Soil and Its Effect on Pineapple Growth, Yield and Fruit Quality in Lower Single Bed under Climate Change Issue

Supriyono Loekito, Afandi Afandi, Auliana Afandi, Nasomasa Nishimura, Hiroyuki Koyama, Masateru Senge

Subject: Biology And Life Sciences, Horticulture Keywords: Lower bed single row; plant weight; fruit texture; crop growth

Online: 18 November 2021 (17:31:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0306.v1

Lifestyle Variations During and After the COVID-19 Pandemic: A Cross-Sectional Study of Dietary, Physical Activities and Weight Gain Among the Adult Population

Hanan Hammouri, Fidaa Almomani, Ruwa Abdel Muhsen, Aysha Abughazzi, Rawand Daghmash, Alaa Abudayah, Inas Hasan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: COVID-19 Pandemic; Dietary patterns; BMI; Nutrition; Vitamins; Healthy Food; Dietary Supplements; Factor analyses; Internal Consistency; weight gain

Online: 17 November 2021 (12:09:58 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202111.0284.v1

Orientia tsutsugamushi and Epstein-Barr Virus in a Young Adult with Acalculous Cholecystitis: A Case Report and Epidemiology of Scrub Typhus in the Maldives

Hisham Ahmed Imad, Aishath Azna Ali, Mariyam Nahuza, Rajan Gurung, Abdulla Ubaid, Aishath Maeesha, Sariu Ali Didi, Rajib Kumar Dey, Abdullah Isneen Hilmy, Aishath Hareera, Ibrahim Afzal, Wasin Matsee, Wang Nguitragool, Emi E. Nakayama, Tatsuo Shioda

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: acute acalculous cholecystitis; Orientia tsutsgugamushi; scrub typhus; eschar; Epstein-Barr virus; re-activation; clinical manifestation; Maldives

Online: 16 November 2021 (09:34:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0206.v1

The Residual Efficacy of SumiShield™ 50WG and K-Othrine® WG250 IRS Formulations Applied to Different Building Materials Against Anopheles and Aedes Mosquitoes

Rosemary Susan Lees, Giorgio Praulins, Natalie Lissenden, Andy South, Jessica Carson, Faye Brown, John Lucas, David Malone

Subject: Biology And Life Sciences, Insect Science Keywords: Indoor residual spray (IRS); Vector control; Anopheles; Aedes aegypti; Culex quinquefasciatus; Neonicotinoids; Pyrethroid; Insecticide resistance; SumiShield; K-Othrine.

Online: 10 November 2021 (14:24:24 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202111.0118.v1

Validating the Effects of Disruptive Technologies using Operational Breakeven Theory, Relative Solvency Ratio and Altman’s Z-score on Selected Firms in Nigeria and India

Enyi Patrick Enyi, Ayodeji Kofi Ajibade

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Disruptive Technologies; Operational Breakeven; Altman’s Z-score; Enyi’s RSR; Going Concern; Market Induced Survival Ratio; Disruptive Technology Gains Index

Online: 5 November 2021 (11:31:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202111.0055.v1

The Effect of Natural Falling and Dipping of House Fly (Musca domestica) on the Microbial Contamination of Water and Milk: A Short Communication Report

Nabih Abdulrahman Baeshen, Nagwa Thabet Elsharawy, Naseebh Nabih Baeshen, Mohammed Nabih Baeshen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: hosue fly,; falling,; dipping,; antimicrobial,; milk,; water

Online: 2 November 2021 (22:48:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0288.v1

Sex Differences in the Associations of Nutrient Patterns with Total and Regional Adiposity: A Study of Middle-Aged Black South African Men and Women

Tshifhiwa Ratshikombo, Julia H. Goedecke, Melikhaya Soboyisi, Clement Kufe, Maphoko Masemola, Lisa K Micklesfield, Tinashe Chikowore

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Nutrient patterns; Obesity; Sex differences; Total and regional adiposity; South Africa

Online: 20 October 2021 (10:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0034.v1

An Advax-adjuvanted Inactivated Cell-culture Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-flavivirus Antibodies and T-cell Immunity and Provides Single Dose Protection

Tomoyoshi Komiya, Yoshikazu Honda-Okubo, Jeremy Baldwin, Nikolai Petrovsky

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Japanese encephalitis; Vaccine, Flavivirus; Antibody-dependent enhancement; Advax; Adjuvant

Online: 4 October 2021 (09:05:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0258.v1

Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

Alexander Panossian, Sara Abdelfatah, Thomas Efferth

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Red Ginseng; HRG80TM; Ginsenoside Rg5; Gene expression; IPA pathways; Network pharmacology,; Transcriptomics

Online: 15 September 2021 (12:36:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0171.v1

Scapular Retraction Under Adduction Load: an Alternative to Overhead Exercises to Activate Infraspinatus, Upper and Lower Trapezius in Subjects With and Without Shoulder Pain

Jefferson James dos Santos, Rebeca Orozco Nagy, Matheus Almeida Souza, Leonardo Intelangelo, Michelle Almeida Barbosa, Gabriela Silveira-Nunes, Alexandre Carvalho Barbosa

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Shoulder impingement syndrome; Scapula; Exercise therapy; Exercise movement techniques; Musculoskeletal pain

Online: 6 August 2021 (17:21:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0116.v1

Pharmacological, Biochemical and Molecular Investigations in 6-OHDA Induced Parkinson’s Disease Rats on the Protection Benefits of Mangiferin in Behavioral, Inflammatory and Oxidative Biomarkers

Prafulla Chandra Tiwari, Mayank Jain, Shipra Kartik, Rajendra Nath, Rishi Pal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: 6-OHDA, NF-κB, Mangiferin, Inflammation, Cox, Caspases

Online: 4 August 2021 (13:22:51 CEST)

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Background: Persistent up regulation of NF-κB leads to chronic inflammation and subsequent microglial activation and takes neurons towards death by activating death receptor domains and the p53 pathway. Thus, inhibition of NF-κB may lead to more effective treatment for Parkinson’s disease. Therefore, we have used mangiferin, specific inhibitor of NF-κB in this study. Method: The study utilized male Wistar rats weighing 200-250 gm (n=8 in each group). Stereotactic surgery of rats was done to induce 6-OHDA lesioning in rats. On day 42, rats were subjected to behavioural studies to evaluate effect of mangiferin and their brains were taken out after euthanasia to perform biochemical and molecular studies. Results: Mangiferin significantly increases locomotor parameters in 6-OHDA lesioned rats. It also decreases activity of Cyclooxygenase enzyme which then leads to decrease concentration of inflammatory cytokines. Microglial inflammation was also substantially reduced by reducing MPO concentration. Oxidative stress burden was also reduced after treatment with mangiferin as indicated by increase in Total Antioxidant Capacity, SOD and Catalase and reduction in concentration of MDA. Treatment with mangiferin also reduces burden of oxidative stress by increasing the activity of NRF2/ARE pathway. Activity of Caspase 3 and 9 was also significantly reduced after treatment with mangiferin. Significant decrease in activity of both Cox1 and Cox 2 was also observed. Maximum improvement in all parameters was observed in rats treated with grouping of mangiferin 45mg.kg-1 and levodopa 10mg.kg-1. Treatment with levodopa alone has no significant effect on biochemical and molecular parameters though it significantly improves behavioural parameters. Conclusion and Implications: Results of this study suggest that mangiferin has protective effect in hemi-parkinsonian rats by inhibiting NF-κB. Current treatment of Parkinson’s disease does not target the underlying problem of the disease. Therefore, combination therapy of mangiferin and levodopa can be helpful in better management of Parkison’s.

Preprint ARTICLE | doi:10.20944/preprints202107.0580.v1

Physical Activity, Mental Health and Wellbeing of Irish Adolescents during Covid-19 Restrictions. A Re-Issue of the Physical Activity and Wellbeing Study (PAWS)

John Murphy, Bronagh McGrane, Mary Rose Sweeney

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Exercise; Sport; Team Sport; Resilience; Identity; Health; School

Online: 26 July 2021 (14:24:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0563.v1

Five Years Prospective Study on Implant Failure and Marginal Bone Remodeling Expected Using Bone Level Implants with Sandblasted/Acid-Etched Surface and Conical Connection

Marco Tallarico, Aurea Immacolata Lumbau, Silvio Mario Meloni, Irene Ieria, Chang-Joo Park, Łukasz Zadrożny, Erta Xhanari, Milena Pisano

Subject: Chemistry And Materials Science, Biomaterials Keywords: sandblasted implants; acid-etched implants; taper connection; marginal bone remodeling; marginal bone loss

Online: 26 July 2021 (10:25:54 CEST)

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Aim: the purpose of the present prospective, case series study were to report implant survival rate and marginal bone remodeling expected five years after loading using dental implants placed in in the daily practice. Material and Methods: this research was designed as an open-cohort, prospective case series study. Any completely or partially edentulous patients scheduled to receive at least one bone leve were considered eligible for this study. Primary outcomes were: cumulative implant (ISR) and prosthetic (PSR) survival rates, and any complications experienced up the five years follow-up. Secondary outcomes were: marginal bone remodeling, implant insertion torque, implant stability quotient (ISQ), and thickness of gingival biotype. Results: ninety consecutive patients (34 males and 56 females; mean age 53.2±15.4 years; range of 24–81 years), 243 implants were placed and followed for at least five years after loading (mean of 65.4±3.1 months; range of 60–72 months). The mean implant insertion torque was 42.9±4.8 Ncm (range from 15 to 45 Ncm). Overall, 83.5% of the implants (n=203) were placed with an insertion torque between 35 and 45 Ncm. At the one year follow-up, no drop-outs were recorded, but 17 patients (18.9%) with 18 restorations (12.6%) delivered on 34 implants (14%) were lost at the five years examination. At the five-year examination, six implants failed in six patients, resulting in a cumulative ISR of 97.5%. At the five-year follow-up, four prostheses failed (2.8%) resulting in a cumulative PSR of 97.2%. At the five-year examination, five complications were reported by five different patients, resulting in a prosthetic success rate of 96.5%, measured at patient level. Five years after loading, mean MBL was 0.41 ± 0.30 mm (95% CI: 0.26–0.34). Difference from the one year data was 0.04 ± 0.19 mm (95% CI: 0.01–0.07). The mean ISQ value at implant placement was 71.6 ± 5.5 (range of 45–88). Six months later, the mean ISQ was 76.7 ± 4.4 (range of 66–89). The difference was statistically significant (P=0.0001). Statistically significant higher MBL was found for smokers, and patient with thin gingival biotype. Conclusions: High implant survival and success rates could be expected with stable marginal bone remodeling up to five years after loading. Smoking and thin tissue biotype were the most important variabilities associated with higher MBL. Further research are needed to confirm these results.

Preprint REVIEW | doi:10.20944/preprints202107.0471.v1

Identification of Novel Simulants for Toxic Industrial Chemicals and Chemical Warfare Agents for Human Decontamination Studies: A Systematic Review and Categorisation of Physicochemical Characteristics

Thomas James, Samuel Collins, Tim Marczylo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Human volunteer; mass decontamination; simulants; CWA; TIC

Online: 21 July 2021 (08:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0115.v1

Effect of Controlled Drainage on the Migration of Water, Nutrients, and Salts in Soil and the Yield of Oilseed Sunflower in Hetao Irrigation District

Xu Dou, Haibin Shi, Ruiping Li, Qingfeng Miao, Feng Tian, Dandan Yu, Liying Zhou, Bo Wang

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Controlled drainage; Water content; Salinity (EC); Mineral nitrogen; Nitrogen loss; Yield of oilseed sunflower

Online: 5 July 2021 (16:06:58 CEST)

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Controlled drainage (CD) is an important agricultural measure for maintaining soil moisture and nutrients, controlling groundwater level, and increasing crop yield. In arid regions, CD can be used to improve the water supply in agriculture and reduce environmental pollution. In this study, we investigated the effect of CD, including a drainage depth of 40 cm (CWT1) and 70 cm (CWT2) during the plant growth period, free drainage (FD), and open ditch drainage (OD) on the migration of water, nutrients, and salts in the soil; the dynamics of groundwater level; the loss of soil nitrogen; and the growth of oilseed sunflower plants. Compared with FD, CD increased the water and nutrient content in the soil, reduced nitrogen loss, and enhanced the ability of the soil to continuously supply nitrogen to the oilseed sunflower plants, which benefited plant growth at later growth stages and reduced environmental pollution. During the period between irrigation at the budding stage and harvest stage, the average soil water content in the 0–20 cm soil layer in CWT1 increased by 3.67%, 4.78%, and 0.55%, respectively, compared with that in CWT2, FD, and OD. The soil mineral content in CWT1 was 25.17%, 35.05%, and 17.78% higher than that in CWT2, FD, and OD, respectively, indicating that higher soil salinity occurred at the later stage of plant growth in CWT1, which actually had little effect on the plants due to their enhanced salt tolerance and increased need for water and nutrients at that stage. In addition, CD delayed the decline in groundwater level, which allowed the plants to use groundwater at later growth stages, and as a result the yield and water use efficiency were improved. CWT1 significantly increased oilseed sunflower yield by 4.52–11.14% and increased water use efficiency by 1.16–10.8%. Moreover, CWT1 also increased the survival rate of the oilseed sunflower plants by 2.62–2.92%, and the plants demonstrated good growth. Therefore, under CD conditions, plants used soil water and nitrogen more efficiently and, as a result, their productivity was increased, and the water quality was improved.

Preprint ARTICLE | doi:10.20944/preprints202106.0379.v1

Design of Experimental Approach Biosensor for the Development and Validation of UV Spectrophotometry Method for Determination of Thiamine in Biological Samples and Tablet Formulation

Hemraj Sharma, Hari Prasad Sapkota, Sushant Aryal, Nim Bahadur Dangi, Gaber El-Saber BATIHA, Niranjan Koirala

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: thiamine; PDAB reagent; UV Spectrophotometry; Design of experiment; pharmaceutical samples

Online: 14 June 2021 (16:04:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0345.v1

The Effects of Temperature and Salinity Stressors on the Survival, Condition, and Valve Closure of the Manila Clam, Venerupis philippinarum in a Holding Facility

Hyeonmi Bae, Jibin Im, Soobin Joo, Boongho Cho, Taewon Kim

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: warming; freshening; salinity fluctuation; multiple stressors; stock holding

Online: 14 June 2021 (10:28:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0122.v1

Supporting Restoration Decisions through Integration of Tree-Ring and Modeling Data: Reconstructing Flow and Salinity in the San Francisco Estuary over the Past Millennium

Paul H Hutton, David M Meko, Sujoy B Roy

Subject: Environmental And Earth Sciences, Environmental Science Keywords: tree-ring; flow reconstruction; pre-development; estuarine salinity; salinity intrusion

Online: 4 June 2021 (08:11:27 CEST)

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This work presents updated reconstructions of watershed runoff to San Francisco Estuary from tree-ring data to AD 903, coupled with models relating runoff to freshwater flow to the estuary and salinity intrusion. We characterize pre-development freshwater flow and salinity conditions in the estuary over the past millennium and compare this characterization with contemporary conditions to better understand the magnitude and seasonality of changes over this time. This work shows that the instrumented flow record spans the range of runoff patterns over the past millennium (averaged over five, ten, twenty and one hundred years), and thus serves as a reasonable basis for planning-level evaluations of historical hydrologic conditions in the estuary. Over annual timescales we show that, although median freshwater flow to the estuary has not changed significantly, it has been more variable over the past century compared to pre-development flow conditions. We further show that the contemporary period is generally associated with greater spring salinity intrusion and lesser summer-fall salinity intrusion relative to the pre-development period. Thus, salinity intrusion in summer and fall months was a common occurrence under pre-development conditions and has been moderated in the contemporary period due to the operations of upstream reservoirs, which were designed to hold winter and spring runoff for release in summer and fall. This work also confirms a dramatic decadal-scale hydrologic shift in the watershed from very wet to very dry conditions during the late 19th and early 20th centuries; while not unprecedented, these shifts have been seen only a few times in the past millennium. This shift resulted in an increase in salinity intrusion in the first three decades of the 20th century, as documented through early records. Population growth and extensive watershed modification during this period exacerbated this underlying hydrologic shift. Putting this shift in the context of other anthropogenic drivers is important in understanding the historical response of the estuary and in setting salinity targets for estuarine restoration. By characterizing the long-term behavior of San Francisco Estuary, this work supports decision-making in the State of California related to flow and salinity management for restoration of the estuarine ecosystem.

Preprint ARTICLE | doi:10.20944/preprints202105.0615.v1

Evaluating the Economic and Environmental Impacts of Smart Management Systems for Cooling and Heating Systems in Building: Case study of Office Building in Tehran

Gholamreza Heravi, Milad Rostami, Maryam Shekari

Subject: Engineering, Architecture, Building And Construction Keywords: Building management system; Smart building; Energy consumption management; Demand response management; Energy consumption optimization

Online: 25 May 2021 (14:19:32 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202105.0239.v2

Hypothesis of Quantum Gravity - Resulting from a Static, Topological Universe Resulting from the Positives and Negatives of the Steady State and Big Bang Theories

Rodney Bartlett

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Gravitation, Electromagnetic-gravitational union, Dark energy, Dark matter, Cosmology, Geometry, Topology

Online: 24 May 2021 (11:58:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0748.v1

Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes

Mercedes Lachén-Montes, Ignacio Iñigo-Marco, Paz Cartas-Cejudo, Joaquín Fernández-Irigoyen, Enrique Santamaría

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mixed dementia; Alzheimer´s disease; vascular dementia; olfactory bulb; proteomics

Online: 28 April 2021 (11:03:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0294.v1

P^N bridged Cu(I) Dimers Featuring both TADF and Phosphorescence. From Overview Towards Detailed Case Study of the Excited Singlet and Triplet States.

Thomas Hofbeck, Thomas A. Niehaus, Michel Fleck, Uwe Monkowius, Hartmut Yersin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Dimeric copper(I) complexes; PN phosphine ligands; X-ray structures; Combined thermally activated delayed fluorescence (TADF) and phosphorescence; Combined singlet and triplet harvesting; High emission quantum yields; Tunability of photophysical properties; Zero-field splitting (ZFS), Spin-lattice relaxation (SLR); Triplet substate decay components.

Online: 12 April 2021 (12:41:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0652.v1

Influence of Chitosan-Based Edible Coating on the Shelf Life and Nutritional Quality of Guava (Psidium guajava L.) Fruit in Room and Refrigerated Temperatures

Areeqa Shamshad, shahzad Zafar Iqbal, Ahmad Faizal Abdull Razis, Sunusi Usman, Nada Basheir Ali, Amna Mumtaz, Muhammad Rafique Asi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chitosan coating; edible coating; guava fruit; shelf-life; HPLC; flavonoids

Online: 26 March 2021 (10:12:24 CET)

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Working Paper ARTICLE

Introducing a New Comprehensive Model for Fault Detection and Condition Monitoring of Rotor Bars of Large Induction Motors Based on MCSA and ZCT Methods

Abolfazl Attar

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: condition monitoring; faulty rotor bar detection; large induction motor; neural network; classification; MCSA; ZCT

Online: 18 March 2021 (11:01:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0242.v2

"Domains of Deprivation Framework" for Mapping Slums, Informal Settlements, and Other Deprived Areas in LMICs to Improve Urban Planning and Policy: A Scoping Review

Ángela Abascal, Natalie Rothwell, Adenike Shonowo, Dana R. Thomson, Peter Elias, Helen Elsey, Godwin Yeboah, Monika Kuffer

Subject: Business, Economics And Management, Accounting And Taxation Keywords: global south; indicators; urban; city; poverty; neighborhood-level

Online: 3 March 2021 (10:16:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0074.v1

Uptake of Human Papillomavirus Vaccine and Intention to Vaccinate Among Healthy Pregnant Women in Serbia: A Cross-Sectional Study on Awareness, Knowledge, and Attitudes

Ljiljana Markovic-Denic, Srboljub Milicevic, Jovana Todorovic, Vladimir Nikolic, Olivera Djuric, Vuk Marusic, Stefan Dugalic, Brankica Vasiljevic, Miroslava Gojnic-Dugalic

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Human papillomavirus; vaccine; pregnancy; attitudes; knowledge

Online: 2 March 2021 (10:47:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0053.v1

The Trend of Scientific Productivity of Chinese, European Union and United States Universities and Private Companies: Does the Future Belong to E-Technology Companies?

Mauro Giovanni Carta, Matthias Angermeyer, Silvano Tagliagambe

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Scientific Productivity; Universities; Private Companies; USA; European Union; China; Innivation; Reseach; Societal

Online: 2 March 2021 (09:24:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0079.v1

Effects of NPS and Bio-organic Fertilizers on Yield and Yield Components of Faba bean (Vicia faba L.) in Gozamin District, East Gojjam, Ethiopia

Addisu Ebbisa, Tadele Amdemariam

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Faba Bean; Farmyard Manure (FYM); Nodulation; NPS Fertilizers; Rhizobium; Yield

Online: 2 February 2021 (09:40:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0357.v1

Using GRACE/GRACE-FO, Data-Driven, and Modeling to Assess the Twentieth and Twenty-first Century Water Storage Changes in the Nile River Basin

Emad Hasan, Aondover Tarhule, Pierre-Emmanuel Kirstetter

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: GRACE; GRACE-FO; TWS; hydroclimatic; drought; flooding; Nile River Basin; Africa

Online: 18 January 2021 (15:14:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0341.v1

Prevalence and Factors Associated with Mental and Emotional Health Outcomes among Africans during the COVID-19 Lockdown Period - A Web-Based Cross-Sectional Study

Raymond Langsi, Uchechukwu Levi Osuagwu, Piwuna Christopher Goson, Emmanuel Kwasi Abu, Khathutshelo Percy Mashige, Bernadine Ekpenyong, Godwin O Ovenseri-Ogbomo, Timothy G Chikasirimobi, Chundung Asabe Miner, Tanko Ishaya, Richard Oloruntoba, Obinna Nwaeze, Deborah Donald Charwe, Kingsley Agho

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; sub-Saharan Africa; mental health; feeling anxious; worried; frustrated; psychological problem; bored and angry

Online: 18 January 2021 (13:56:06 CET)

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Mental health and emotional responses to the effects of COVID-19 lockdown in sub-Saharan Africa (SSA) are of serious public health concern and may negatively affect the mental health status of people. Hence, this study assessed the prevalence of mental health symptoms as well as emotional reactions among sub-Saharan Africans (SSAs) and associated factors among SSAs during the COVID-19 lockdown period. This was a web-based cross-sectional, a study on mental health and emotional features from 2005 respondents in seven SSA countries. This study was conducted between April 27 and May 17, 2020 corresponding to the lockdown period in most SSA countries. Respondents aged 18 years and above and the self-reported symptoms were feeling anxious, being worried, angry, bored and frustrated. These were the main outcomes and were treated as dichotomous variables. Univariate and multivariate logistic regression analyses were used to identify the factors associated with these symptoms. We found that over half (52.2%) of the participants reported any of the mental health symptoms in SSA and the prevalence of feeling bored was 70.5% followed by feeling anxious (59.1%), being worried (57.5%), frustrated (51.5%) and angry (22.3%) during the COVID-19 pandemic. Multivariate analysis revealed that males, those aged >28 years, Central and Southern Africans, those who were not married, the unemployed, those living with more than six persons in a household, had higher odds of mental health and emotional symptoms. Similarly, people who perceived low risk of contracting the infection, and those who thought the pandemic would not continue after the lockdown had higher odds of mental health and emotional symptoms. Health care workers had lower odds for feeling angry than non-healthcare workers. During COVID-19 lockdown periods in SSA, about one in two participants reported mental health and emotional symptoms. Public health measures can be effectively used to identify target groups for prevention and treatment of mental health and emotional symptoms. Such interventions should be an integral component of SSA governments’ response and recovery strategies of any future pandemic.

Preprint ARTICLE | doi:10.20944/preprints202101.0040.v1

Knowledge, Attitude and Practice on Antibiotics and Its Resistance: Two Phases Mixed-Methods Online Study Among Pakistani Community Pharmacists to Promote Rational Antibiotics Use

Faiz Ullah Khan, Farman Ullah Khan, Khezar Hayat, Tawseef Ahmad, Amjad Khan, Jie Chang, Usman Rashid Malik, Zakir Khan, Krizzia Lambojon, Yu Fang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Antibiotics; antibiotic resistance; rational drug use; community pharmacist

Online: 4 January 2021 (12:58:43 CET)

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Antibiotic resistance (ABR) is an emerging global threat to public health. Substantial evidence has indicated that community pharmacists (CPs) can play a critical role in managing the ever-increasing threat of antibiotic resistance. The study aimed to determine the knowledge, attitude, and practices of CPs (n=180) towards antibiotics and antibiotic resistance as well as to improve the rational use of antibiotics. Two phases of mixed methods (quantitative and qualitative) online study were conducted in Pakistan from August 2019 to March 2020 by using validated questionnaires and semi-structured interview data. Different statistical methods were used to tabulate the quantitative data whereas inductive thematic analysis was conducted to categorize themes from the qualitative data and draw conclusions. Approximately 64.4% were male (mean: 29-33 years old). Overall, CPs had good knowledge of and were familiar with superbugs and their roles in ABR (65.6%, Median=1, IQR=1) although they were poor in differentiating some antibiotic groups with their respective ABR patterns (31.1%, Median=1, IQR=1). Most CPs have a positive attitude towards antibiotics with most (90.0%) having identified ABR as a critical issue in public health (Median=1, IQR=0). Overall, CPs' practices towards antibiotics were reasonable where they tend to educate patients about the rational use of antibiotics (52.8%, Median=1, IQR=1). Two main themes (antibiotics and counseling of patients) were related to self-medication with while educational interventions are the sub-theme. ABR is multifactorial where the subthemes related to budget, time constraints incompetent staff, the absence of CPs, the lack of training, enforcement of laws and regulations are the need of the hour in Pakistan. Effective antibiotic stewardship programs, patient education, and awareness campaigns about antibiotics and ABR along with training of the CPs are important factors that have to be addressed in a timely manner.

Preprint ARTICLE | doi:10.20944/preprints202012.0503.v1

Corynebacterium Glutamicum Regulation beyond Transcription: Organizing Principles and Reconstruction of an Extended Regulatory Network Incorporating Regulations Mediated by Small Rna and Protein-Protein Interactions

Juan M. Escorcia-Rodríguez, Andreas Tauch, Julio A. Freyre-González

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Corynebacterium glutamicum; regulatory interactions; regulatory network; curation; network inference; systems; modules; NDA; regulogs

Online: 21 December 2020 (10:52:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0164.v1

Multi-Fading Factor and Update Monitoring Strategy Adaptive Kalman Filter Based Variational Bayesian with Inaccurate Time-Varying Process and Measure-Ment Noise Covariance Matrices

Chenghao Shan, Weidong Zhou, Yefeng Yang, Zihao Jiang

Subject: Engineering, Automotive Engineering Keywords: variational Bayesian; multiple-fading factors; time-varying noise covariance matrices; inaccurate noise; target tracking; update monitoring strategy

Online: 7 December 2020 (14:54:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0598.v1

The Effects of Caffeinated Beverage Consumption on the Sleep Habits and Lifestyle of Medical Students in Public and Private Medical Universities in Karachi, Pakistan

Maham Noor Afroz, ayesha Asghar, Shaheera Kamal, Saneea Ishfaque, Shueeta Chandar bhan, anum kamal, hira tariq

Subject: Social Sciences, Behavior Sciences Keywords: caffeine; sleep habits; lifestyle; medical students; universities

Online: 23 November 2020 (20:15:40 CET)

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Working Paper DATASET

Beyond History and “on a Roll”: The List of the most Well-Studied Human Protein Structures and Overall Trends in the Protein Data Bank

Zhenlu Li, Matthias Buck

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mostly studied human protein structure; human diseases; biophysics

Online: 16 October 2020 (12:11:04 CEST)

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Working Paper ARTICLE

Histomorphometric, Immunohistochemical, Ultrastructural and Statistic Biomaterial Evaluation: Comparison between Synthetic Nano-Hydroxyapatite /Beta-Tricalcium Phosphate and Hydroxyapatite in No Critic Defects in Rat Calvaria

Igor da Silva Brum, Lucio Frigo, Renan Lana Devita, Jorge Luís da Silva Pires, Victor Hugo Vieira de Oliveira, Ana Lucia Rosa Nascimento, Jorge José de Carvalho

Subject: Chemistry And Materials Science, Biomaterials Keywords: synthetic; xenogenous; nano-hydroxyapatita; beta-tricalcium phosphate

Online: 6 October 2020 (13:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0193.v1

The Questions of Who, What, and How in the Science - Policy Dialogue: Experiences from the Pan - Canadian Framework on Clean Growth and Climate Change

Ha Pham

Subject: Social Sciences, Decision Sciences Keywords: Science and policy - making; Environmental communication; Pan - Canadian Framework on Clean Growth and Climate Change

Online: 9 September 2020 (03:13:14 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202008.0659.v1

Noisy Genome Data and Faulty Clade Statistics Undermine Conclusions on SARS-CoV-2 Evolution and Strain Typing in the Brazilian Epidemy: A Technical Note

Marcelo R. S. Briones, Fernando Antoneli, Renata C. Ferreira, Isabel M. V. G. Carvalho, Luiz M. R. Janini

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Viral Evolution

Online: 30 August 2020 (11:22:12 CEST)

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Preprint ESSAY | doi:10.20944/preprints202004.0447.v2

China Neighborhood and Village Committee confront the COVID-19 Pandemic；Cultural History and Tracking back Review of Relevant Public Health Events in Last Century

Huibing Tan, Yunge Jia, Yinhua Li, Wei Hou

Subject: Social Sciences, Sociology Keywords: neighborhood committee; collective responsibility; Baojia system; COVID-19 pandemic; Wu Lien-teh; China

Online: 27 April 2020 (03:07:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0071.v1

Covid-19: Immunological Lessons from Bats, Pangolins and Old Coronaviruses; And How We Can Apply Them in a Timely Way for a Better Outcome

Devika Dua, Madhur Yadav, Pranav Jetley, Radhika Dua

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS CoV; macrophage activation syndrome; cytokine storm; immunology

Online: 6 April 2020 (16:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0186.v1

Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels

Michael Maes, Joao Nani, Cristiano Noto, Lucas Rizzo, Mirian Hayashi, Elisa Brietzke

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: bipolar depression; inflammation; neuroimmunomodulation; cytokines; psychoneuroimmunology; staging

Online: 11 March 2020 (10:45:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0095.v1

Comparative Antimicrobial Susceptibility Profiles of Uropathogenic Extended-Spectrum ß-Lactamase Producing Strains of Klebsiella pneumonia and Escherichia coli by the CLSI and EUCAST Methodologies

Doğan Akdoğan, Mustafa Güzel, Orhan Akpınar, Altan Aksoy, Yasemin Genç Bahçe

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: CLSI; EUCAST; ESBL Urinary tract infections; Escherichia coli; Klebsiella pneumoniae; Kappa coefficient

Online: 5 March 2020 (14:58:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0260.v1

El Niño Southern Oscillation and Its Impact on Rainfall Distribution and Productivity of Major Agricultural Crops: The Case of Kemabata Tembaro Zone, Southern Ethiopia

Bereket Tesfaye Haile, Kassahun Ture Bekitie, Gudina Legesse Feyissa, Tadesse Terefe Zeleke

Subject: Environmental And Earth Sciences, Environmental Science Keywords: ENSO; El Nino; La Nina; Crop Yield; Climate change

Online: 22 January 2020 (09:44:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0347.v1

Combining Direct and Indirect Measurements to Assess Patients’ Satisfaction with the Quality of Public Health Services in Romania: Uncovering Structural Mechanisms and Their Implications

Viorel Mihaila

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: patients’ satisfaction; health services quality; PLS–PM modeling; mediation analysis

Online: 25 December 2019 (10:38:06 CET)

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Introduction: Patients’ satisfaction was extensively researched over the last decades, given its role in building loyalty, compliance to treatment, prevention, and eventually higher levels of wellbeing and improved health status. Patients’ feedback on the perceived quality of health services can be incorporated into practice; therefore, understanding factors and mechanisms responsible for patients’ satisfaction allows providers to tailor targeted interventions. Method: A questionnaire assessing patients’ perception of the quality of health services was administered to a country-representative sample of 1500 Romanian patients. Using a partial least squares—path modeling approach (PLS-PM), with cross-sectional data, we developed a variance-based structural model, emphasizing the mediating role of trust and satisfaction with various categories of health services. Results: We confirmed the mediating role of trust in shaping the relationship between the procedural accuracy of health professionals, along with the perceived intensity of their interaction with patients, and patients’ experienced quality of the health services. We confirmed the mediating role of satisfaction by the categories of services in the relationship between waiting time on the premises, attention received, and the perceived reliability of the information received, as predictors, and the experienced quality of the health services. In addition, indirect assessment of patients’ satisfaction is a good predictor for direct assessment, thereby affirming the idea that the results of the two types of evaluations converge. Discussions: One of the most efficient solutions to increase both patients’ satisfaction and their compliance is to empower the communication dimension between patients and health practitioners. Given the non-linear relationships among variables, we advocate that, unless the nature of the relationships between satisfaction and its predictors is understood, practical interventions could fail. The most relevant variable for intervention is the degree of attention patients perceive they received. We suggest three methods to turn waiting time into attention given to patients.

Preprint ARTICLE | doi:10.20944/preprints201911.0233.v1

Water and Climate Change, Two Key Objectives in Agenda 2030: Assessment of Climate Literacy Levels and Social Representations in Academics from Three Climate Contexts

Amor Escoz-Roldán, José Gutiérrez-Pérez, Pablo A. Meira-Cartea

Subject: Social Sciences, Education Keywords: water; climate change; territorial context; sustainable development goals; Agenda 2030; university students; climate literacy; social representation

Online: 20 November 2019 (03:38:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0355.v1

Cognitive Fusion Mediates the Relationship between Dispositional Mindfulness and Anxiety and Other Negative Emotions: A Study in a Sample of Spanish Primary-School Students

María García-Gómez, Joan Guerra, Victor M. López-Ramos, José M. Mestre

Subject: Social Sciences, Psychology Keywords: dispositional mindfulness; cognitive defusion; anxiety; mindfulness based on interventions; mental health; experiential avoidance; children and adolescents

Online: 30 October 2019 (10:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0037.v1

Exploring the Vital Worker Over Time – A Week-Level Study on How Positive and Negative Work Events Contribute to Affect and Sustain Work Engagement

Oliver Weigelt, Antje Schmitt, Christine J. Syrek, Sandra Ohly

Subject: Social Sciences, Psychology Keywords: affective events; work engagement; sensitization-satiation effects; job demands-resources model; experience sampling; growth curve modeling

Online: 3 October 2019 (04:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0123.v1

Are Tropical Reptiles Really Declining? A Six-year Survey of Snakes in Drake Bay, Costa Rica, and the Role of Temperature, Rain and Light

José Pablo Barquero-González, Tracie L. Stice, Gianfranco Gómez, Julian Monge-Najera

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: snake demography; moonlight; rain; temperature; climate change in Osa

Online: 11 August 2019 (05:35:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0013.v1

Evolutionary Analysis of Rett Syndrome-Causing Proteins and Their Pathogenic Missense Point Mutations: Structural Order–Disorder, Post-Translational Modifications, Evolutionary Rates, and Interacting Proteins

Muhamad Fahmi, Gen Yasui, Kaito Seki, Syouichi Katayama, Takako Kaneko-Kawano, Tetsuya Inazu, Yukihiko Kubota, Masahiro Ito

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Rett Syndrome; intrinsically disordered region; phylogenetic profile analysis; post-transcriptional modification; methyl-CpG-binding protein 2; cyclin-dependent kinase-like 5; forkhead box protein G1

Online: 1 July 2019 (11:59:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0258.v1

The Effectiveness of Progressive and Traditional Coaching Strategies to Improve Sprint and Jump Performance across Varying Levels of Maturation within a General Youth Population

Regan Standing, Peter Maulder

Subject: Social Sciences, Behavior Sciences Keywords: PHV; sprint; jump; coaching; adolescent

Online: 26 June 2019 (05:17:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0227.v2

Foliar Application of Y-Aminobutyric Acid (GABA) Improves Vegetative Growth, and the Physiological and Antioxidative Potential of Daucus Carota L. under Water Deficit Conditions

Rohina Bashir, Hafiza Naila Riaz, Muhammad Shafiq, Nusrat Parveen, Mekhled Mutiran Alenazi, Sumera Anwar, Abdullah Issa Alebidi

Subject: Biology And Life Sciences, Horticulture Keywords: oxidative stress; enzymatic antioxidants; malondialdehyde; membrane permeability; chlorophyll

Online: 28 March 2019 (11:15:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0002.v1

Combining Blockchain Technology and the Physical Internet to Achieve Triple Bottom Line Sustainability: A Comprehensive Research Agenda for Modern Logistics and Supply Chain Management

Horst Treiblmaier

Subject: Computer Science And Mathematics, Computer Science Keywords: blockchain; distributed ledger technology; physical internet; logistics; supply chain management; research framework; innovation; information technology; triple bottom line; sustainability

Online: 1 February 2019 (04:00:54 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201810.0773.v2

A Comparative Study of the AHP and TOPSIS Techniques for Dam Site Selection Using GIS: A Case Study of Sistan and Baluchestan Province, Iran

Ali Jozaghi, Babak Alizadeh, Mohsen Hatami, Ian Flood, Mohammad Khorrami, Nastaran Khodaei, Erfan Ghasemi Tousi

Subject: Engineering, Civil Engineering Keywords: multi-criteria decision-making; TOPSIS; AHP; water resources; dam site selection

Online: 18 December 2018 (12:04:57 CET)

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