REVIEW
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Parkinson’s disease; precision medicine; personalized medicine; GBA; Glucocerebrosidase; GCase; LRRK2; Leucine-rich repeat kinase-2; Dopamine; PD drug trials; PD risk variants
Online: 14 September 2020 (00:22:59 CEST)
ARTICLE
|
doi:10.20944/preprints202312.0130.v1
Subject:
Engineering,
Control And Systems Engineering
Keywords:
UV water treatment; photovoltaic source; discharge lamp; electronic ballast; motor pump; motor speed; sliding mode control; state feedback; experimental results; bond graph approach
Online: 4 December 2023 (04:16:02 CET)
REVIEW
|
doi:10.20944/preprints202309.0407.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
human T-cell leukemia virus type 1; adult T-cell leukemia/lymphoma; viral genes; genetic alterations; immune response; host–pathogen interaction; pathogenesis; treatment
Online: 6 September 2023 (09:32:44 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0130.v1
Subject:
Medicine And Pharmacology,
Anesthesiology And Pain Medicine
Keywords:
Breast Cancer; Acute Postoperative Pain; Postoperative analgesia; Patient-Controlled Analgesia; Levobupivacaine; Diclofenac; Hand Grip Strength; Quality of life; Treatment Outcome; Long term survival.
Online: 2 August 2023 (04:37:34 CEST)
INTERESTING IMAGES
|
doi:10.20944/preprints202301.0439.v1
Subject:
Social Sciences,
Psychology
Keywords:
parental health literacy; necessary health education; understanding treatment guidelines; medication non-adherence; healthcare; avoidable medical costs; global health burden; COVID-19 vaccine negligence
Online: 25 January 2023 (03:43:57 CET)
ARTICLE
|
doi:10.20944/preprints202210.0160.v1
Subject:
Chemistry And Materials Science,
Metals, Alloys And Metallurgy
Keywords:
electron beam powder bed fusion (EBPBF); Inconel 625; microstructure and mechanical properties; layer-thickness effects; heat treatment; duplex grain structure; grain boundary carbides
Online: 12 October 2022 (02:09:35 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0288.v1
Subject:
Engineering,
Automotive Engineering
Keywords:
effect of temperature; exposure time; steel microstructure; residual mechanical properties; high-strength steel bolts; heat treatment of steel; phase transformation; fire; cooling method
Online: 13 May 2021 (12:53:32 CEST)
CASE REPORT
|
doi:10.20944/preprints202009.0009.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Lyme disease; Post-Treatment Lyme Disease Syndrome (PTLDS); dapsone combination therapy (DDS CT); double dose dapsone combination therapy (DDD CT); babesiosis; persistent infection
Online: 1 September 2020 (11:30:52 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0070.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer growth; tumor metastasis; cancer's Warburg effect; p53; p53 (re)activators; mitochondrial apoptosis; cytochrome c release; tumoricidal drug effect
Online: 4 January 2024 (09:34:19 CET)
ARTICLE
|
doi:10.20944/preprints202304.0534.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
micro injection molding; 3D printing; rapid tooling; digital light processing; implant; drug delivery system; dexamethasone; anti-inflammatory; TNF-α; biocompatibility; inner ear therapy
Online: 19 April 2023 (03:57:41 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0003.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture
Online: 3 February 2020 (03:16:54 CET)
ARTICLE
|
doi:10.20944/preprints202402.0312.v1
Subject:
Engineering,
Mechanical Engineering
Keywords:
steel hardenability; Bayesian optimization; k-fold cross-validation; hyperparameter tuning; neural networks regression; steel alloy; predictive model; heat treatment; hardenability band; Jominy end-quench
Online: 6 February 2024 (09:17:47 CET)
ARTICLE
|
doi:10.20944/preprints202309.1752.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Hepatocellular carcinoma; Transarterial radioembolization; Yttrium-90; Locoregional treatment; Portal vein tumor thrombosis; Overall survival; Progression-free survival; Skeletal muscle mass; Sarcopenia; Body mass index.
Online: 26 September 2023 (08:22:48 CEST)
REVIEW
|
doi:10.20944/preprints202003.0235.v2
Subject:
Medicine And Pharmacology,
Dietetics And Nutrition
Keywords:
acute respiratory distress syndrome (ARDS); ascorbic acid; cathelicidin; coronavirus; COVID-19; cytokine storm; influenza; observational; pneumonia, prevention; respiratory tract infection; solar radiation; treatment; UVB; vitamin C; vitamin D
Online: 30 March 2020 (05:48:43 CEST)
ARTICLE
|
doi:10.20944/preprints201706.0116.v1
Subject:
Computer Science And Mathematics,
Computer Networks And Communications
Keywords:
big data; body area network;body sensor network;edge computing;Fog Computing; Medical Cyberphysical Systems; medical internet-of-things;telecare; tele-treatment;wearable devices
Online: 26 June 2017 (06:24:07 CEST)
REVIEW
|
doi:10.20944/preprints202309.0459.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
migraine disorders; headache disorders; nociceptive pain; analgesics; calcitonin gene-related peptide; pituitary adenylate cyclase-activating polypeptide (PACAP); vasoactive intestinal peptide; adrenomedullin; neuropeptides; drug development
Online: 17 October 2023 (10:50:15 CEST)
ARTICLE
|
doi:10.20944/preprints202308.1050.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
transungual; antifungal nail lacquer; Itraconazole Nail Medication; Nail Drug Uptake; Nail penetration; Nail Plate Application; itraconazole hydrochloride; Topical Nail Polish; nail clipping; Nail Diffusion
Online: 15 August 2023 (07:06:34 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0046.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Cancer; tumor homing peptide; in silico drug discovery; complex network; chemical space network; centrality measure; similarity searching, group fusion; motif discovery; starPep toolbox software
Online: 3 February 2022 (10:14:05 CET)
REVIEW
|
doi:10.20944/preprints202005.0234.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
SIRD; Twitter; GHSI; Pre-symptomatic; EHR; Contact tracing; On-line survey; qRT-PCR; X-ray; CT/HRCT; CNN; Autoencoder; Drug affinity; CPI; and Inflation.
Online: 14 May 2020 (11:25:57 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0092.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Nano-pulse treatment (NPT); in situ vaccination; breast cancer; tumor microenvironment; immunosuppression; apoptosis; memory T cells; regulatory T cells; myeloid-derived suppressor cells; tumor-associated macrophages
Online: 2 May 2024 (12:04:27 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
ARTICLE
|
doi:10.20944/preprints202308.1047.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related Macular Degeneration (AMD); Cornea; docosahexaenoic acid (DHA); drug delivery; non-invasive ocular delivery platform (NIODP); ocular disease; omega-3; retina; retinal delivery; retinal dis
Online: 14 August 2023 (15:18:22 CEST)
ARTICLE
|
doi:10.20944/preprints202406.1799.v1
Subject:
Engineering,
Civil Engineering
Keywords:
concrete; construction; sustainable; waster waste; coconut fiber reinforced concrete(CFRC); Crumb rubber concrete (CRC); Water treatment sludge concrete (WTSC); Mining concrete (MC); Oyster Shells waste concrete (OSWC)
Online: 26 June 2024 (03:01:27 CEST)
CASE REPORT
|
doi:10.20944/preprints202406.1511.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
ibrutinib; 17p deletion; kidney biopsy; renal lymphomatous infiltration; monoclonal b cell lymphocytosis (mbl); complications of cll; venetoclax; chronic lymphocytic leukemia (cll); cll treatment; renal involvement in cll
Online: 24 June 2024 (07:41:28 CEST)
ARTICLE
|
doi:10.20944/preprints202310.1387.v3
Subject:
Biology And Life Sciences,
Aging
Keywords:
ageing, age-related disease, antagonistic pleiotropy, biological mechanisms, Blueprint Maps, evolutionary biology, hyperactivity, new ageing theory, patho-pathway, patho-pathway cascades, prediction, prevention, network constraint, treatment, triggers
Online: 14 May 2024 (09:11:20 CEST)
ARTICLE
|
doi:10.20944/preprints202309.0641.v1
Subject:
Environmental And Earth Sciences,
Water Science And Technology
Keywords:
potential of wastewater fertigated/irrigated Short Rotation Coppice/Plantation (SRC; SRP) in India; nature-based wastewater treatment & reuse systems; phytofiltration; sustainable biomass (willow; poplar; bamboo) production systems
Online: 11 September 2023 (10:09:57 CEST)
REVIEW
|
doi:10.20944/preprints201912.0386.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology
Online: 29 December 2019 (13:46:21 CET)
REVIEW
|
doi:10.20944/preprints201911.0331.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
pH and breast cancer; breast cancer etiology; breast cancer etiopathogenesis; breast cancer treatment; pH-centric anticancer paradigm; hydrogen ion dynamics of cancer; cancer proton reversal; MDR integral approach
Online: 27 November 2019 (04:57:00 CET)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
REVIEW
|
doi:10.20944/preprints202305.1078.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
bacterial resistance; methicillin-resistant S. aureus (MRSA); multi drug resistant (MDR) bacteria; Cannabis sativa; phytocannabinoids (PCs); endocannabinois (ECs); synthetic cannabinoids (SCs); synthetic procedures; cannabichromene (CBC); cannabigerol (CBG); cannabidiol (CBC)
Online: 16 May 2023 (04:29:36 CEST)
REVIEW
|
doi:10.20944/preprints202305.0658.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nanotechnology application; nano-suspension techniques; nano-emulsion techniques; bioactive constituents of plant; phytochemicals (PHYs); poor water solubility; drug delivery systems (DDSs); toxicological risks of NPs; clinical application of NPs
Online: 9 May 2023 (12:50:27 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0625.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adverse drug reaction; cisplatin liposomes; circulating tumor cells; enhanced permeability and retention effect; nephrotoxicity; pulmonary metastasis of pancreatic cancer; quality of life; recurrent liver metastases from primary nasal cancer
Online: 20 April 2023 (07:52:10 CEST)
REVIEW
|
doi:10.20944/preprints202111.0090.v2
Subject:
Medicine And Pharmacology,
Orthopedics And Sports Medicine
Keywords:
adipose-derived regenerative cells; ADRCs; adipose-derived stem cells; ADSCs; bone regeneration, cartilage regeneration; efficacy; point of care treatment; stem cell; tendon healing without scar formation; tendon regeneration; vaPS cells
Online: 12 November 2021 (11:44:31 CET)
REVIEW
|
doi:10.20944/preprints202407.1534.v1
Subject:
Hematology,
Medicine And Pharmacology
Keywords:
lymphoma; B‐cell; hematologic neoplasms; bruton tyrosine kinase; protein kinase inhibitors; drug resistance; neoplasm; ibrutinib; pirtobrutinib; molecular targeted therapy; chronic lymphocytic leukemia; hematopoietic stem cell transplantation; covalent inhibitors; protein degradation
Online: 18 July 2024 (17:24:05 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0344.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
Deep phenotyping; AI; 2D and 3D facial scans; Genetic diseases; Early treatment; Big data; 2D and 3D facial scans; Facial traits; Healthcare; Citizen privacy; Ethical concerns; EU legal framework; Forensic medicine; Orwellian ramifications
Online: 14 April 2023 (03:56:59 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0102.v1
Subject:
Medicine And Pharmacology,
Dietetics And Nutrition
Keywords:
acute malnutrition; combined protocol; community-based management of acute malnutrition; ef-fectiveness; Mali; mid-upper-arm circumference; moderate acute malnutrition; ready-to-use ther-apeutic food; treatment; severe acute malnutrition; simplified protocol; wasting
Online: 7 September 2022 (05:21:16 CEST)
CASE REPORT
|
doi:10.20944/preprints202308.1373.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Large B-cell lymphoma (LBCL); Immunohistochemical (IHC) staining; Glucoseregulated protein 94 (GRP94); CYP3A4; Multidrug resistance protein 1 (MDR1); Aldo-keto reductase family 1 member C3 (AKR1C3); Multi-drug resistance-associated protein 1 (MRP1); P53
Online: 18 August 2023 (11:42:22 CEST)
REVIEW
|
doi:10.20944/preprints202405.0500.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Gilbert’ s syndrome (GS), Genetic variations, Protective effects of Gilbert’ s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’ s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Online: 9 May 2024 (02:57:19 CEST)
REVIEW
|
doi:10.20944/preprints202406.0911.v1
Subject:
Engineering,
Transportation Science And Technology
Keywords:
RPAS (Remotely Piloted Aircraft Systems); Drones; Regulations; Medication Transport; INVIMA (National Institute for Food and Drug Surveillance); UAEAC (Special Administrative Unit of Civil Aeronautics); Safe and Quick Delivery; Cold Chain; Drone Delivery; Flight and Maintenance Log; Operations Manual; Manufacturer's Manual
Online: 13 June 2024 (09:55:59 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0122.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Tissue agnostic drug development; Pembrolizumab; Microsatellite instability-high (MSI-H); Tumor mutational burden-high (TMB-H); Dostarlimab-gxly; Larotrectinib; Entrectinib; Neurotrophic tyrosine kinase (NTRK); Dabrafenib and trametinib; V-Raf Murine Sarcoma Viral Oncogene Homolog B V600E (BRAFV600E); Selpercatinib; Rearranged during transfection (RET); Precision oncology.
Online: 3 June 2024 (16:08:38 CEST)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)
COMMUNICATION
|
doi:10.20944/preprints202402.0604.v2
Subject:
Physical Sciences,
Mathematical Physics
Keywords:
Dissipative Hydrodynamics, Schwinger-Keldysh Field Theory, Navier-Stokes Equations, Long-Range Massless Modes, Fluid Dynamics, Volume-Preserving Diffeomorphisms, Closed-Time-Path Formalism, Hydrodynamic Correlation Functions, Effective Field Theory, Non-Relativistic Fluid Dynamics, Systematic Treatment, Second Order in Derivatives, Energy-Momentum Balance Equation, Hydrodynamic Transport, Gravitational Anomaly, Quasinormal Modes, Holography, Entropy Production, Conformal Invariance
Online: 21 February 2024 (09:20:45 CET)
REVIEW
|
doi:10.3390/sci2030068
Subject:
Medicine And Pharmacology,
Tropical Medicine
Keywords:
COVID-19; pooling clinical trials; hyperinfection; steroids; treatment; targeted healthcare; population health management; cancer treatment; clinical research; clinical trials; developing vaccines; ranking and rating hospital quality; school closures; interventions for delirium; assessments of COVID-19 death inequities; regulatory safeguards; preventing child abuse and maltreatment; prevalence of health care worker burnout; nursing home ratings; challenging oncology practice; addressing racial; ethnic; social and economic divides; violence against sexual minority adolescents; primary tumors; metastasis; stages of cancer; reforming cancer clinical trials; supporting carers; protection and prevention; benign and malignant tumors; reforming cancer clinical trials; protection of healthcare personnel; comparing excess deaths in NYC; 1918 influenza pandemic; the possibility of full recovery from COVID-19; mental health impact of COVID-19 on young adults; ranking and rating nursing home quali
Online: 21 August 2020 (00:00:00 CEST)
REVIEW
|
doi:10.20944/preprints202404.1817.v1
Subject:
Environmental And Earth Sciences,
Water Science And Technology
Keywords:
Produced Water Treatment; Membrane Technology; Automated Control Systems; RTU (Remote Terminal Unit); PLC (Programmable Logic Control); SCADA (Supervisory Control And Data Acquisition); Process Dynamic Control; PID (Proportional Integral Derivative); Feedback And Feedforward Controls; Control Loops; Pressure Drop Ratio; Real-Time Optimization (RTO); Dynamic Real-Time Optimization (DRTO); Analytical Instrumentation Process Monitoring; Manual Monitoring; Inline Probe; Side Stream; Model Predictive Control
Online: 28 April 2024 (10:58:00 CEST)
REVIEW
|
doi:10.20944/preprints202407.1456.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
advanced therapy medicinal products (ATMPs); chimeric antigen receptors (CAR-T cells); B acute lymphoblastic leukaemia (B-ALL); food and drug administration (FDA); systemic lupus erythematosus (SLE); idiopathic inflammatory myositis (IIM); systemic sclerosis (SS); memorial sloan kettering cancer centre (MSKCC); hematopoietic stem cell transplantation [HSCT], non-Hodgkin’ s cell lymphoma (NHCL); multiple myeloma (MM); follicular lymphoma; (FL); large B cell-lymphoma (LBCL); mantle cell lymphoma (MCL); myeloid-derived suppressor cells (MDSCs); rheumatoid arthritis (RA); immune effector cell-associated neurotoxicity syndrome (ICANS); natural killer group member D ligands (NKG2DLs); acute myelogenous leukaemia (AML)
Online: 18 July 2024 (08:03:12 CEST)
REVIEW
|
doi:10.20944/preprints202402.0879.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity
Online: 16 February 2024 (05:40:14 CET)