Previous studies demonstrate the critical importance of non-coding RNAs interfacing with chromatin-modifying machinery resulting in promoter-enhancer-based gene regulation and raise the possibility that many other enhancer-like RNAs may operate via similar mechanisms. Critically, more than 80% of the disease-linked variations identified in genome-wide studies are located in the non-coding regions of genomes, especially non-coding RNA, suggesting non-coding RNAs are relevant to disease. Thus, a critical path forward for understanding non-coding RNAs' role, especially long non-coding RNAs, is to understand the genomic regions' transcriptional regulation, especially non-coding regions. Here, we developed a user-friendly R package called SomaGene for studying and identifying enhancer-like non-coding RNAs with enriched somatic mutations in the cancer genome. SomaGene accepts different genomic variants (whole genome/exome somatic point mutations, structural variations, copy number variations) to identify those RNAs that significantly mutated in diseases (e.g., cancer). It then uses multiple publicly available genomics and epigenetics datasets including ENCODE epigenomics annotations, FANTOM5 tissue-specific expression profiles, disease-associated genome-wide association SNPs, and tissue-specific eQTL pairs to identify those RNAs with potentially enhancer function. SomaGene, as a powerful R package, can provide the opportunity to cancer scientists to study the roles of non-coding RNAs in different cancer genomes.

This work communicates cavity ring-down spectroscopy (CRDS) of methylidyne (CH) in a chemiluminescent plasma that is produced in a microwave cavity. Of interest are the rotational lines of the 0-0 vibrational transition for the A-X band and the 1-0 vibrational transition for the B-X band. The reported investigations originate from CH-radical research in 1996 that constituted the first case of applying CRDS to the CH radical. The report also includes recent analysis that shows excellent agreement of measured and computed data, and it communicates CH line strength data.

Real-world evidence (RWE) is increasingly involved in the early benefit assessment of medicinal drugs. It is expected that RWE will help to speed up approval processes comparable to RWE developments in vaccine research during the COVID-19 pandemic. Definitions of RWE are diverse marking the highly fluid status in this field. So far, RWE comprises information produced from data routinely collected on patient’s health status and/or delivery of health care from various sources other than traditional clinical trials. These sources can include electronic health records, claims, patient-generated data including in home-use settings, data from mobile devices as well as patient, product and disease registries. The aim of the present update was to review the current RWE developments and guidelines mainly in the U.S., the UK, Europe and Germany field during the last decade. RWE has already been included in various approval procedures of regulatory authorities reflecting its actual acceptance and growing importance in evaluating and accelerating new therapies. However, since the RWE research is still in a transition process and since a number of gaps in this field have been explored, more guidance and a consented definition are necessary to increase the implementation of real-world data.

Context: Anomaly detection in a data center is a challenging task, having to consider different services on various resources. Current literature shows the application of artificial intelligence techniques to either log files or monitoring data: the former created by services at run time, while the latter produced by specific sensors directly on the physical or virtual machine. Objectives: We propose a model that exploits information both in log files and monitoring data to identify patterns and detect anomalies over time. Methods: The key idea is to use on one side natural language processing solutions to detect problems at service level, extracting words that represent anomalies. Clustering and topic modeling techniques have been used to identify patterns and group them with respect to topics. On the other side time series anomaly detection technique has been applied to sensors data in order to combine problems found in the log files with problems stored in the monitoring data. Results: We have tested our approach on a real data center equipped with log files and monitoring data that can characterize the behaviour of physical and virtual resources in production. We have observed a correspondence between anomalies in log files and monitoring data, e.g. an increase in memory usage or machine load. The results are extremely promising. Conclusion: Our model requires to integrate site administrators' expertise in order to consider all critical scenario in the data center and understand results properly.

The effective integration of aerial remote sensing data and ground multi-source data has always been one of the difficulties of quantitative remote sensing. A new monitoring mode is designed which installs the hyperspectral imager on the UAV and places a buoy spectrometer on the river. Water samples are collected simultaneously to obtain in situ assay data of total phosphorus, total nitrogen, COD, turbidity and chlorophyll during data collection. The cross correlogram spectral matching (CCSM) algorithm is used to match the data of the buoy spectrometer with the UAV spectral data to reduce the UAV data noise significantly. An absorption characteristics recognition algorithm (ACR) is designed to realize a new method for comparing UAV data with laboratory data. This method takes into account the spectral characteristics and the correlation characteristics of test data synchronously. It is concluded that the most accurate water quality parameters can be calculated by using the regression method under five scales after the regression tests of multiple linear regression method (MLR), support vector machine method (SVM) and neural network (NN) method. This new working mode of integrating spectral imager data with point spectrometer data will become a trend in water quality monitoring.

Additive manufacturing (3D printing) and computer-aided design (CAD) still have limited up-take in biomedical and bioengineering research and education, despite the significant potential of these technologies. The utility of organ-scale 3D-printed models of living structures is widely appreciated, while the workflows for microscopy data translation into tactile-accessible replicas are not well developed yet. Here, we demonstrate an accessible and reproducible CAD-based methodology for generating 3D-printed scalable models of human cells cultured in vitro and imaged using conventional scanning confocal microscopy and fused deposition modelling (FDM) 3D printing. We termed this technology CiTo-3DP (Cells-in-Touch for 3D Printing). As a proof-of-concept, we created CiTo-3DP models of human pancreatic cancer cells and healthy dermal fibroblasts by using selectively stained nuclei and the cytoskeleton components (f-actin and α-smooth muscle actin). The production of dismountable sets of cellular components was al-so shown. The CiTo-3DP approach can be adapted to comprehensively present various cell types, subcellular structures and extracellular matrices. We envisage that the resulting CAD and 3D printed models could be used for further applications, including but not limited to in silico simulations for biology, medicine, pharmacological research, tissue engineering, morphometrical analysis, multiphysics modelling, education, rehabilitation of visually impaired people, and integration into virtual reality.

The Short-Term Assessment of Risk and Treatability (START) is deemed the most appropriate instrument for assessing violence risks and management because of its balanced approach between dynamic risk and protective factors. Although several facets of reliability and predictive validity of this tool were strong, its inter-rater reliability, construct validity, and implementation in Asian population were under-investigated. The objective of this research was to examine the inter-rater reliability and construct validity of the START: Thai version within forensic psychiatric inpatients. The participants consisted of 118 forensic psychiatric inpatients hospitalized at Galya Rajanagarindra Institute in Thailand. Trained mental health professionals (i.e., psychiatrists, forensic nurses, clinical psychologists, social workers, and occupational therapists) assessed each participant across twenty domains of the Thai START. The inter-rater reliability was examined using the intraclass correlation coefficient and a confirmatory factor analysis for ordinal data was used to test the construct validity of the scale. The main finding showed a good-to-excellent inter-rater reliability and supported two relational constructs (i.e., strength vs vulnerability subscales) of the Thai START. The Thai START is a promising tool for using in Thai forensic psychiatric setting but some items were not significant in contributing to the scale. This study also provides the guideline for implementing the tool in non-Western forensic psychiatric populations.

(1) The article is devoted to the development of a theoretical and algorithmic basis for numerical modeling of the spontaneous potential method (SP) as applied to the study of sandy-argillaceous reservoirs. (2) In terms of coupled flows, we consider a physical-mathematical model of SP signals from an electrochemical source, with regard to the case of fluid-saturated shaly sandstone. (3) An algorithm for 2D finite-element modeling of SP signals was developed and implemented in software, along with its internal and external testing with analytical solutions. The numerical SP modeling was carried out, with determining the dependences on the reservoir thickness and porosity, the amount of argillaceous material and the type of minerals. We performed a comparative analysis of the simulated and field SP data, using the results of laboratory core examinations taken from wells in a number of fields in the Latitudinal Ob Region of Western Siberia. (4) The results of the study may be used either for the development of the existing SP techniques, by providing them with a consistent computational model, or for the design of new experimental approaches.

ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome) is a chronic, complex, heterogeneous disease that affects millions and lacks both diagnostics and treatments. Big data, or the collection of vast quantities of data that can be mined for information, has transformed the understanding of many complex illnesses like cancer (1,2) and multiple sclerosis (3,4), by dissecting heterogeneity, identifying subtypes, and enabling the development of personalized treatments. It is possible that big data can reveal the same for ME/CFS. Solve M.E. developed and launched the You + ME Registry to collect longitudinal health data from people with ME/CFS, people with Long COVID (LC) and control volunteers using rigorous protocols designed to harmonize with other groups collecting data from similar groups of people. The Registry is an invaluable resource because it integrates with a symptom tracking app, as well as a biorepository, to provide a robust and rich dataset that is available to qualified researchers. Accordingly, it facilitates collaboration that may ultimately uncover causes and help accelerate the development of therapies.

Technological advances such as blockchain, artificial intelligence, big data, social media, geographic information systems represent a building block of the digital transformation that supports the resilience of the food supply chain (FSC) and increases its efficiency. This paper reviews the literature surrounding digitalization in FSCs. A bibliometric and key-route main path analysis was carried out to objectively and analytically uncover the knowledge development in digitalization within the context of sustainable FSCs. The research began with the selection of 2140 articles published nearly over five decades. Then, the articles were examined according to several bibliometric metrics such as year of publication, countries, institutions, sources, authors, and keywords frequency. A keyword co-occurrence network was generated to cluster the relevant literature. Findings of the review and bibliometric analysis indicate that research at the intersection of technology and the FSC has gained substantial interest from scholars. On the basis of keyword co-occurrence network, the literature is focused on the role of information communication technology for agriculture and food security, food waste and circular economy, and the merge of the Internet of Things and blockchain in the FSC. The analysis of the key-route main path uncovers three critical periods marking the development of technology-enabled FSCs. The study offers scholars a better understanding of digitalization within the agri-food industry and the current knowledge gaps for future research. Practitioners may find the review useful to remain ahead of the latest discussions of technology-enabled FSCs. To the authors’ best knowledge, the current study is one of the few endeavors to explore technology-enabled FSCs using a comprehensive sample of journals articles published during the past five decades.

The advent of high throughput sequencing has enabled researchers to systematically evaluate the genetic variations in cancer, resulting in identifying many cancer-associated genes. Although cancers in the same tissue are widely categorized in the same group, they demonstrate many differences concerning their mutational profiles. Hence there is no “silver bullet” for the treatment of a cancer type. This reveals the importance of developing a pipeline to identify cancer-associated genes accurately and re-classify patients with similar mutational profiles. Classification of cancer patients with similar mutational profiles may help discover subtypes of cancer patients who might benefit from specific treatment types. In this study, we propose a new machine learning pipeline to identify protein-coding genes mutated in a significant portion of samples to identify cancer subtypes. We applied our pipeline to 12270 samples collected from the International Cancer Genome Consortium (ICGC), covering 19 cancer types. Here we identified 17 different cancer subtypes. Comprehensive phenotypic and genotypic analysis indicates distinguishable properties, including unique cancer-related signaling pathways, in which, for most of them, targeted treatment options are currently available. This new subtyping approach offers a novel opportunity for cancer drug development based on the mutational profile of patients. We also comprehensive study the causes of mutations among samples in each subtype by mining the mutational signatures, which provides important insight into their active molecular mechanisms. Some of the pathways we identified in most subtypes, including the cell cycle and the Axon guidance pathways, are frequently observed in cancer disease. Interestingly, we also identified several mutated genes and different rates of mutation in multiple cancer subtypes. In addition, our study on “gene-motif” suggests the importance of considering both the context of the mutations and mutational processes in identifying cancer-associated genes. The source codes for our proposed clustering pipeline and analysis are publicly available at: https://github.com/bcb-sut/Pan-Cancer.

The digital transformation of healthcare is advancing, leading to an increasing availability of clinical data for research. Perioperative big data initiatives were established to monitor treatment quality and benchmark outcomes. However, big data analyzes have long exceeded the status of pure quality surveillance instruments. Large retrospective studies nowadays often represent the first approach to new questions in clinical research and pave the way for more expensive and resource intensive prospective trials. As a consequence, utilization of big data in acute pain and regional anesthesia research considerably increased over the last decade. Multicentric clinical registries and administrative databases (e.g., healthcare claims databases) have collected millions of cases until today, on which basis several important research questions were approached. In acute pain research, big data was used to assess postoperative pain outcomes, opioid utilization, and the efficiency of multimodal pain management strategies. In regional anesthesia, adverse events and potential benefits of regional anesthesia on postoperative morbidity and mortality were evaluated. This article provides a narrative review on the growing importance of big data for research in acute postoperative pain and regional anesthesia.

Disparities between fold amplitude (A) and intrusion thickness (Hsill) are critical in identifying elastic or inelastic deformation in a forced fold. However, accurate measurement of these two parameters is challenging because of the limit in separability and detectability for the seismic data. In the TZ-47 exploring area from the Tarim Basin, Northwest China, we combined wireline data and 3-D seismic data, to accurately constrain the fold amplitude and total thickness of sills that inducing the roof uplift. The measurement results show that the forced fold amplitude is 155 m and the total sill thickness is 148.4 m. When using a magma density of 2.7 g/cm3, and solid rock density of 3 g/cm3, the molten magma thickness at the time of intrusion would be 153.8 m, which is almost no difference from the forced fold amplitude. Therefore, the TZ-47 fold is a pure elastic forced fold induced by emplacement of multiple sills. Measurement solely based on seismic data may not be able to detect some thin interlayers and may result in large errors.

Depending on the characteristics of the industrial area, toxicity evaluation of human body, risk assessment and health impact assessment may directly cause cancer due to air pollution. Environmental data collection is from August 2018 to January 31, 2019, and the average, minimum, and maximum values of air pollution data respectively. According to the global data on global trends using the Big Data, high blood pressure is confirmed at 33rd place in the world, and myocardial infarction among the environmental diseases is confirmed to be lower than Korea. Disease that occurred in Jeolla province industrial complex considering the characteristics of our country was identified as representative. Air pollutants are considered to be the causes of allergic diseases in Korea. PM10 was found to be higher than the control area (28.8804348 (㎍ / ㎥), 31.7065217 (㎍ / ㎥) and 32.8532609 (㎍ / ㎥). The mean concentrations of PM2.5 in the middle and high exposure areas were lower than those of the control areas, but the highest in the intermediate exposure areas was 16.5978261 (㎍ / ㎥), 16.1086957 (㎍ / ㎥) and 17.1847826 (㎍ / ㎥) respectively. The relationship between the major variables of environmental exposure in Yeosu was confirmed to be correlated with high blood pressure, chronic obstructive pulmonary disease (COPD), bronchitis, cerebrovascular, diabetes, thyroid disease, sinus infection, anemia and pneumonia.

Significant amounts of anthropogenic radionuclides were introduced in ocean waters following nuclear atmospheric tests and development of the nuclear industry. Dispersion of artificial dissolved radionuclides has been extensively measured for decades over the European continental shelf. The radionuclide measurement and release fluxes databases provided here represent an exceptional opportunity to validate dispersion hydrodynamic models. MARS hydrodynamic model have been applied at different scales to reproduce in realistic conditions the measured dispersion. Specific methods have been developed to obtain qualitative and quantitative results and perform model/measurement comparisons. Model validation concerns short to large scales with dedicated surveys following the dispersion: it was performed within two and three dimensions framework and from minutes and hours following a release up to several years. Results are presented concerning the dispersion of radionuclides in marine systems deduced from standalone measurements, or according to model comparisons. It allows characterising dispersion over the continental shelf, pathways, transit times, budgets and source terms. This review exhibits the main features retained from the point of view of radiotracers, hydrodynamic models and model/measurement methods with perspectives of applications in other areas or oceanographic domains.

Ecosystem surveillance monitoring is critical to managing natural resources and especially so under changing environments. Despite this importance, the design and implementation of monitoring programs across large temporal and spatial scales has been hampered by the lack of appropriately standardised methods and data streams. To address this gap, we outline a surveillance monitoring method based on permanent plots and voucher samples suited to rangeland environments around the world that is repeatable, cost-effective, appropriate for large-scale comparisons and adaptable to other global biomes. The method provides comprehensive data on vegetation composition and structure along with soil attributes relevant to plant growth, delivered as a combination of modules that can be targeted for different purposes or available resources. Plots are located in a stratified design across vegetation units, landforms and climates to enhance continental and global comparisons. Changes are investigated through revisits. Vegetation is measured to inform on composition, cover and structure. Samples of vegetation and soils are collected and tracked by barcode labels and stored long-term for subsequent analysis. Technology is used to enhance the accuracy of field methods, including differential GPS r plot locations, instrument based Leaf Area Index (LAI) measures, and three dimensional photo-panoramas for advanced analysis. A key feature of the method is the use of electronic field data collection to enhance data delivery into a publicly-accessible database.Our method is pragmatic, whilst still providing consistent data, information and samples on key vegetation and soil attributes. The method is operational and has been applied at more than 704 field locations across the Australian rangelands as part of the Ecosystem Surveillance program of the Terrestrial Ecosystem Research Network (TERN). The methodology enables continental analyses, and has been tested in communities broadly representative of rangelands globally, with components being applicable to other biomes. Here we also recommend the consultative process and guiding principles that drove the development of this method as an approach for development of the method into other biomes. The consistent, standardised and objective method enables continental, and potentially global analyses than were not previously possible with disparate programs and datasets.

This data descriptor summarizes the process applied and data gathered from 50 publications/papers reporting on the use of photography generated by tourists, tour operators and members of the public, with a particular focus on the crowdsourcing of photographs through online platforms and social networking sites (SNSs) as a method of research for wildlife conservation and ecotourism. The papers were collected in a systematic literature review to inform a pilot study of the feasibility of using SNSs to crowdsource georeferenced photographs of endangered Bornean Pygmy Elephants (Elephas maximus borneensis) taken by ecotourists along the Lower Kinabatangan River region of Sabah, Malaysia. Papers were sourced using the Murdoch University Findit online-search tool to search over 100 databases, including Proquest, Scopus and Web of Science. The criteria for a paper to be included in the review (and shared via the dataset attached to this this data descriptor) were that it was peer-reviewed, published in English, between 1997 and the 31 December 2017, had the full text accessible online and reported on a study or studies that utilized photographs that tourists, tour operators and/or members of the public generated and shared via SNSs or online platforms.

Evaporation is one of the main processes in the hydrological cycle, and it is one of the most critical factors in agricultural, hydrological, and meteorological studies. Due to the interactions of multiple climatic factors, the evaporation is a complex and nonlinear phenomenon; therefore, the data-based methods can be used to have precise estimations of it. In this regard, in the present study, Gaussian Process Regression (GPR), Nearest-Neighbor (IBK), Random Forest (RF) and Support Vector Regression (SVR) were used to estimate the pan evaporation (PE) in the meteorological stations of Golestan Province, Iran. For this purpose, meteorological data including PE, temperature (T), relative humidity (RH), wind speed (W) and sunny hours (S) collected from the Gonbad-e Kavus, Gorgan and Bandar Torkman stations from 2011 through 2017. The accuracy of the studied methods was determined using the statistical indices of Root Mean Squared Error (RMSE), correlation coefficient (R) and Mean Absolute Error (MAE). Furthermore, the Taylor charts utilized for evaluating the accuracy of the mentioned models. The outcome indicates that the optimum state of Gonbad-e Kavus, Gorgan and Bandar Torkman stations, Gaussian Process Regression (GPR) with the error values of 1.521, 1.244, and 1.254, the Nearest-Neighbor (IBK) with error values of 1.991, 1.775, and 1.577, Random Forest (RF) with error values of 1.614, 1.337, and 1.316, and Support Vector Regression (SVR) with error values of 1.55, 1.262, and 1.275, respectively, have more appropriate performances in estimating PE. It found that GPR for Gonbad-e Kavus Station with input parameters of T, W and S and GPR for Gorgan and Bandar Torkmen stations with input parameters of T, RH, W, and S had the most accurate performances and proposed for precise estimation of PE. Due to the high rate of evaporation in Iran and the lack of measurement instruments, the findings of the current study indicated that the PE values might be estimated with few easily measured meteorological parameters accurately.

A multi-decadal change analysis of the irrigation ponds in Taoyuan, Taiwan was conducted by using multi-source data including digitized ancient maps, declassified single-band CORONA satellite images, and multispectral SPOT images. Supervised LULC classifications were conducted using four textural features derived from the single-band CORONA images and spectral features derived from SPOT images. Post-classification analysis revealed that the number of irrigation ponds in the study area decreased during the post-World War II farmland consolidation period (1945 – 1965) and the subsequent industrialization period (1970 – 2000). However, efforts on restoration of irrigation ponds in recent years have resulted in gradual increases in the number (9%) and total area (12%) of irrigation ponds in the study area.

Impervious surface mapping with high-resolution remote sensing imagery has attracted increasing interest as it can provide detailed information for urban structure and distribution. Previous studies have suggested that the combination of LiDAR data and high-resolution imagery for impervious surface mapping performs better than using only high-resolution imagery. However, due to the high cost of the acquisition of LiDAR data, it is difficult to obtain the multi-sensor remote sensing data acquired at the same acquisition time for impervious surface mapping. Consequently, real landscape changes between multi-sensor remote sensing data at different acquisition times would lead to the error of misclassification in impervious surface mapping. This issue has mostly been neglected in previous works. Furthermore, the observation differences generated from multi-sensor data, including the problems of misregistration, missing data in LiDAR data, and shadow in high-resolution images would also challenge the final mapping result in the fusion of LiDAR data and high-resolution images. In order to conquer these problems, we propose an improved impervious surface mapping method incorporating both LiDAR data and high-resolution imagery at different acquisition times in consideration of real landscape changes and observation differences. In the proposed method, a multi-sensor change detection by supervised multivariate alteration detection is employed to obtain changed areas and misregistration areas. The no-data areas in the LiDAR data and the shadow areas in the high-resolution imagery are extracted by independent classification yielded by its corresponding single sensor data. Finally, an object-based post-classification fusion is proposed to take advantage of independent classification results with single-sensor data and the joint classification result with stacked multi-sensor data. Experiments covering the study site in Buffalo, NY, USA demonstrate that our method can accurately detect landscape changes and obviously improve the performance of impervious surface mapping.

Spatio-temporal aspects of data lead to critical information. Sensors capture data at all scales continually so it is imperative that useful information be extracted ubiquitously and regularly. Location plays a vital part by helping understand relations between datasets. It is crucial to link developmental works with spatial attributes and current challenge is to create an open platform that manages real-time sensor data and provides critical spatial analytics atop expert domain knowledge provided in the system. That is a two-faced problem where the solution tackles not only data from multiple sources but also runs data management platform, a spatial data infrastructure(SDI) as backbone framework able to harness sensor web(SW). The paper proposes development of such a globally shared open spatial expert system(ES), SmaCiSENS, a first of a kind geo-enabled knowledge based(KB) ES for multiple fields, smarter cities to climate modeling. SmaCiSENS is integration of SW and SDI with domain KB on data and problems, ready to infer solutions. The paper describes an architecture for semantic enablement for SW, SDI; connect interfaces, functions of SDI and SW, and sensor data application program interfaces (APIs) to better manage climate modeling, geohazard, global changes, and other vital areas of attention and action.

Wind turbine plants are complex dynamic and uncertain processes driven by stochastic inputs and disturbances, as well as different loads represented by gyroscopic, centrifugal, and gravitational forces. Moreover, as their aerodynamic models are nonlinear, both modelling and control become challenging problems. On one hand, high-fidelity simulators should contain different parameters and variables in order to accurately describe the main dynamic system behaviour. Therefore, the development of modelling and control for wind turbine systems should consider these complexity aspects. On the other hand, these control solutions have to include the main wind turbine dynamic characteristics without becoming too complicated. The main point of this paper is thus to provide two practical examples of development of robust control strategies when applied to a simulated wind turbine plant. Experiments with the wind turbine simulator and the Monte–Carlo tools represent the instruments for assessing the robustness and reliability aspects of the developed control methodologies when the model-reality mismatch and measurement errors are also considered. Advantages and drawbacks of these regulation methods are also highlighted with respect to different control strategies via proper performance metrics.

Increasingly, there is a focus on utilising renewable energy resources in a bid to fulfil increasing energy requirements and mitigate the climate change impacts of fossil fuels. While most renewable resources are free, the technology used to usefully convert such resources is not and there is an increasing focus on improving the conversion economy and efficiency. To this end, advanced control technologies can have a significant impact and is already a relatively mature technology for wind turbines. Though hydroelectric plants can use simple regulation systems, significant benefits have been shown to accrue from the appropriate use of the same control methods designed for wind turbine plants. This represents the key point of the paper. In fact, to date, the application communities connected with wind and hydraulic energies have had little communication, resulting in little cross fertilisation of control ideas and experience, particularly from the more mature wind area to hydrodynamic systems. Therefore, this paper examines the models and the application of control technology across both domains, both from a comparative and contrasting point of view, with the aim of identifying commonalities in models and control objectives, as well as potential solutions. Key comparative reference points include the articulation of the exployed models, specification of control objectives, development of high--fidelity simulators, and development of solution concepts. Not least, in terms of realistic system requirements are the set of physical and constraints under which such renewable energy systems must operate, and the need to provide reliable and robust control solutions, which respect the often remote and relatively inaccessible location of many onshore and offshore deployments.

This paper presents a thermal runaway prognosis scheme based on the big-data platform and entropy method for battery systems in electric vehicles. It can simultaneously realize the diagnosis and prognosis of thermal runaway caused by the temperature fault through monitoring battery temperature during vehicular operations. A vast quantity of real-time voltage monitoring data was collected in the National Service and Management Center for Electric Vehicles (NSMC-EV) in Beijing to verify the effectiveness of the presented method. The results show that the proposed method can accurately forecast both the time and location of the temperature fault within battery packs. Furthermore, a temperature security management strategy for thermal runaway is proposed on the basis of the Z-score approach and the abnormity coefficient is set to make real-time precaution of temperature abnormity.

Current language models have achieved remarkable success in NLP tasks. Nonetheless, individual decoding methods face difficulties in realizing the immense potential of these models. The challenge is primarily due to the lack of a decoding framework that can integrate language models and decoding methods. We introduce the DecoStrat which bridges the gap between language modeling and the decoding process in D2T generation. By leveraging language models, DecoStrat facilitates the exploration of alternative decoding methods tailored to specific tasks. We fine-tune the model on the MultiWOZ dataset to meet task-specific requirements and employ it to generate output(s) through multiple interactive modules of the framework. The Director module orchestrates the decoding processes, engaging the Generator to produce output(s) text based on the selected decoding method and input data. The Manager module enforces a selection strategy, integrating Ranker and Selector to identify the optimal result. Evaluations on the stated dataset show that DecoStrat effectively produces diverse and accurate output, with MBR variants consistently outperforming other methods. DecoStrat with the T5-small model surpasses some baseline. Generally, the findings highlight DecoStrat's potential for optimizing decoding methods in diverse real-world applications.

Social media platforms have become pivotal tools for small and medium-sized enterprises (SMEs), offering vast opportunities for enhanced organizational engagement. However, these platforms also present challenges such as data privacy concerns, feedback management, and content saturation. This systematic review critically evaluates the existing literature on the dual role of social media in fostering organizational engagement while addressing key barriers faced by SMEs. We systematically assessed 104 peer-reviewed articles sourced from Scopus, Web of Science, and Google Scholar, focusing on the impact of social media on marketing strategies and organizational outcomes in SMEs. The Newcastle-Ottawa Scale was used for quality assessment, and effect measures, including mean difference and odds ratio, were employed to evaluate performance metrics such as customer engagement, business performance, and long-term organizational impact. Key findings indicate that 74% of SMEs reported improvements in brand visibility, with customer engagement increasing by 65%. However, significant concerns were identified, with 45% of studies highlighting privacy issues and 52% addressing challenges in managing negative feedback. The review emphasizes that while social media can enhance market reach and customer interaction, its effectiveness largely depends on strategic content management and planning. This review provides actionable insights for SMEs aiming to optimize social media use, highlighting the need for future research to address privacy management and feedback strategies for sustained success.

This study utilizes a combination of optical PlanetScope imagery and Synthetic Aperture Radar (SAR) data from Sentinel-1 to investigate land cover changes in Dili, Timor-Leste, following Tropical Cyclone Seroja. The primary objective is to evaluate how integrating these datasets enhances disaster monitoring and response in flood-affected areas. The Random Forest classifier, known for its robustness in handling high-dimensional and noisy data, was applied to classify land cover into six distinct classes: vegetation, water, built-up areas, bare soil, clouds, and shadows. The classification was performed across three phases—pre-disaster, post-disaster, and recovery—using Google Earth Engine (GEE). Binary segmentation using Otsu thresholding was applied to the SAR images to refine the classification by delineating water bodies from non-water areas. The study achieved high classification accuracy, with overall accuracy ranging from 97.2% to 98.7%, and the Kappa index, which measures agreement between classified and reference data, remained consistently strong, indicating reliable model performance. Key results include a significant increase in water bodies and extensive damage to vegetation and built-up areas during the post-disaster phase, followed by partial recovery in the subsequent period. Despite the high accuracy, urban areas posed classification challenges due to misclassification between built-up and bare soil categories. This research offers a methodological framework for integrating optical and SAR data with machine learning for land cover change detection in post-disaster scenarios. The societal benefits of this study include improved disaster preparedness, enhanced recovery planning, and valuable insights into flood impact mitigation in regions like Timor-Leste, where technical and data limitations persist.

Serious crime modelling typically needs to be undertaken securely behind a firewall where police knowledge and capabilities can remain undisclosed. Data informing an ongoing incident is often sparse, with a large proportion of relevant data only coming to light after the incident culminates or after police intervene - by which point it is too late to make use of the data to aid real-time decision making for the incident in question. Much of the data that is available to police to support real-time decision making is highly confidential so cannot be shared with academics, and is therefore missing to them. In this paper, we describe the development of a formal protocol where a graphical model is used as a framework for securely translating a model designed by an academic team to a model for use by a police team. We then show, for the first time, how libraries of these models can be built and used for real-time decision support to circumvent the challenges of data missingness and tardiness seen in such a secure environment. The parallel development described by this protocol ensures that any sensitive information collected by police, and missing to academics, remains secured behind a firewall. The protocol nevertheless guides police so that they are able to combine the typically incomplete data streams that are open source with their more sensitive information in a formal and justifiable way. We illustrate the application of this protocol by describing how a new entry - a suspected vehicle attack - can be embedded into such a police library of criminal plots.

This study investigates the transformative impact of technology adoption on retail marketing strategies, focusing on artificial intelligence (AI), big data analytics, augmented reality (AR), virtual reality (VR), mobile technology, and automated customer service solutions. Through qualitative research methods, including interviews and thematic analysis, insights were gathered from industry stakeholders across diverse retail sectors. The findings reveal that AI facilitates personalized marketing through data-driven insights, enhancing customer satisfaction and loyalty. Big data analytics enable retailers to forecast trends, optimize inventory, and tailor marketing strategies to consumer preferences effectively. AR and VR technologies enrich customer experiences by offering immersive and interactive shopping environments, bridging the gap between physical and digital retail spaces. Mobile technology supports omni-channel strategies, providing seamless integration and personalized interactions across platforms. The COVID-19 pandemic accelerated digital transformation in retail, emphasizing the resilience and adaptability of technology-driven strategies in navigating disruptions. AI-powered chatbots and virtual assistants streamline customer service operations, enhancing efficiency and customer satisfaction.

Digital marketing adoption in the multinational Fast-Moving Consumer Goods (FMCG) sector presents both challenges and opportunities that significantly impact organizational strategies and market competitiveness. This qualitative study explores the complexities surrounding digital marketing adoption through interviews with 45 participants from multinational FMCG companies. The research investigates key barriers such as organizational resistance, technological constraints, and concerns over data privacy and security, while also examining the benefits of enhanced consumer engagement, global market reach, and data-driven decision making. Findings reveal that organizational resistance remains a formidable barrier, driven by senior management's cautious approach to digital transformation and concerns over return on investment (ROI) amidst rapidly evolving digital landscapes. Technological challenges, including outdated systems and limited budgets for technology upgrades, further hinder comprehensive digital integration. Moreover, navigating regulatory frameworks and addressing consumer trust in data privacy emerge as critical considerations for FMCG companies seeking to leverage digital strategies effectively. Conversely, digital marketing adoption offers substantial opportunities. Enhanced consumer engagement through personalized and interactive campaigns allows companies to strengthen brand-consumer relationships and foster loyalty. The global reach facilitated by digital platforms enables multinational FMCG firms to expand market presence, penetrate new markets, and adapt marketing strategies to diverse consumer preferences worldwide. Data-driven decision making emerges as pivotal, leveraging analytics to optimize marketing strategies, measure campaign effectiveness, and anticipate consumer behaviors in real-time. Strategies for overcoming barriers emphasize building internal digital capabilities through training, recruitment, and cross-functional collaboration. Aligning digital strategies with overarching business objectives and integrating digital efforts with traditional marketing channels are crucial for creating cohesive and effective campaigns. Embracing innovation, flexibility, and agility in adapting to technological advancements are essential for maintaining competitiveness and relevance in a rapidly evolving digital landscape. Looking forward, emerging trends such as AI and machine learning integration for predictive analytics, sustainability-focused marketing initiatives, and the evolution towards omnichannel strategies are poised to reshape digital marketing practices in the FMCG sector. By aligning strategies with these trends, FMCG companies can harness digital technologies to drive sustainable growth, enhance market competitiveness, and meet evolving consumer expectations in a digitally-driven global marketplace.

Fusing data from many sources helps to achieve higher results of analysis. In this work, we present a new algorithm to fuse data from multiple cameras with data from multiple lidars. This algorithm was developed to increase the sensitivity and specificity of autonomous vehicle perception systems, where the most accurate sensors measuring the vehicle’s surroundings are cameras and lidar devices. Perception systems based on data from one type of sensor do not use complete information and have lower quality. The camera provides two-dimensional images; lidar produces three-dimensional point clouds. We developed a method for matching pixels on a pair of stereoscopic images using dynamic programming inspired by an algorithm to match sequences of amino acids used in bioinformatics. We improve the quality of the basic algorithm using additional data from edge detectors. We also improve the algorithm performance by reducing the size of matched pixels determined by available car speeds. We perform point cloud densification in the final step of our method, fusing lidar output data with stereovision output. We implemented our algorithm in C++ with Python API, and we provided the open-source library named Stereo PCD. This library very efficiently fuses data from multiple cameras and multiple lidars. In the article, we present the results of our approach to benchmark databases in terms of quality and performance. We compare our algorithm with other popular methods.

Toll plaza optimization is essential for improving traffic flow and easing congestion on road networks. This study aims to suggest and assess potential optimization solutions for the Peshawar toll plaza, considering variables like traffic volume, toll-collecting effectiveness, and customer facilitation. Different resources are used for data collection, like the National Highway Authority of Pakistan. Physical data is collected from the established Toll Plaza of Peshawar, along with the development of each line. The goal of this study is to suggest and assess potential optimization solutions for the Peshawar toll plaza, considering variables like traffic volume, toll-collecting effectiveness, and customer happiness. The analysis of present traffic patterns, the detection of bottlenecks, and the creation of plans to ease congestion and enhance overall traffic flow are all part of the optimization process. The approaches used in this study include data analysis, simulation, and traffic modeling. PTV VISSIM is software for transportation planning, design, and analysis. The simulations consider various conditions, such as variable traffic volumes, toll collection methods, and lane configurations. When comparing the different optimization strategies, performance indicators like trip time, latency, and queue length are utilized to determine which approach is practical. Waiting time Vs. Existing each lane, etc, is explained. In the end, comparing queue lengths and throughput across different lane scenarios shows that maximizing throughput with existing lanes yields up to 45% improvement with E-tag lanes, 40% with existing E-tag lanes, 38% with E-tag plus additional toll and cash lanes, 32% with three cash lanes, and 28% with two E-tag lanes. Failure to regularly monitor and adjust the existing lane pattern scenario based on traffic patterns can lead to queues being 20% longer. Without proactive evaluation and optimization, there is a potential 63% opportunity for queue length improvement

In the rapidly evolving field of real estate economics, the prediction of house prices continues to be a complex challenge, intricately tied to a multitude of socio-economic factors. However, traditional predictive models have often overlooked the spatial interdependencies that play a vital role in shaping housing prices. This study applies Graph Neural Networks (GNNs) on Open Statistics Knowledge Graphs to model spatial dependencies and predict house prices across Scotland’s 2011 data zones. To this end, integrated statistical indicators are retrieved from the official Scottish Open Government Data portal. The three representative GNN algorithms employed - ChebNet, GCN, and GraphSAGE - demonstrate higher prediction accuracy than traditional models, including the tabular-based XGBoost and a simple Multi-Layer Perceptron (MLP). In addition, local and global explainability are employed to increase transparency and trust in the predictions made by the most accurate GNN - GraphSAGE. The global feature importance is determined by a logistic regression surrogate model while the local, region-level understanding of the GNN predictions is achieved through the use of GNNExplainer. Explainaibility results are compared with those from a previous work that applied the XGBoost machine learning algorithm and the SHapley Additive exPlanations (SHAP) explainability framework on the same dataset. Interestingly, both global surrogate model and the SHAP approach underscored the Comparative Illness Factor, a health indicator, and the ratio of detached dwellings as the most crucial features in the global explainability. In the case of local explanations, while both methods showed similar results, the GNN approach provided a richer, more comprehensive understanding of the predictions for two specific data zones.

Using both GRACE satellite data and statistical records, we apply the advanced Super-SBM model in this study to evaluate the efficiency of water resource utilization in 34 prefecture-level cities across three provinces in Northeast China from 2003 to 2020. Furthermore, we employ the Tobit model to examine the factors influencing efficiency. Our findings suggest that while spatial clustering is moderately low, the efficiency of water resource utilization in the Northeast Region is praiseworthy and significantly correlates with the level of technological advancement. Four distinct categories can be identified among the prefecture-level cities based on the scale and technological efficiency of water resource utilization. To promote enhanced utilization of water resources, different regions should implement measures that are specifically tailored to their unique circumstances.

The availability of current land cover and land use (LCLU) information for monitoring the status of land resources has considerable value in ensuring sustainable land use planning. Similarly, the need to provide updated information on the extent of LCLU change in West Africa has become apparent, given the increasing demand for land resources driven by the rapid population growth in the sub-region. SERVIR West Africa, a regional consortium jointly supported by USAID and NASA to foster the use of geospatial and earth observation data and science for decision-making on critical environmental and food security challenges, in collaboration with the Food and Agriculture Organization of the United Nations (FAO), is building technical capacity in the sub-region to develop and implement harmonized regional land cover classification system for LULC change monitoring in West Africa, based on the Land Cover Meta Language (LCML-ISO 19144-2). This article focuses on the process, potential opportunities, outputs of this collaboration, exemplary use cases, and recommendations for the next steps.

The traditional manual recording of vaccination records in Germany faced challenges during the COVID-19 pandemic, prompting the introduction of a Covid smartphone app with QR codes. However, this solution brought new challenges, emphasizing the need for a centrally managed European digital vaccination record for efficiency and validity. Thus, this study assesses the feasibility of using the HL7 FHIR standard in the healthcare industry for implementing a digital vaccination pass management and monitoring system. The system aims to offer convenience and improved efficiency for both patients and healthcare providers while promoting interoperability with other healthcare systems. We developed a prototype using modern technologies, such as React, Quarkus, and Keycloak, evaluating the applicability of FHIR in promoting interoperability within the healthcare industry. Results indicate potential benefits for patients and healthcare providers, offering secure access to immunization records, personalized recommendations, and streamlined management. However, challenges in integrating nuanced vaccination processes into the standardized FHIR system, necessitating custom extensions, and issues with manual data entry and identity provider integration, pose obstacles. Despite these challenges, the study suggests that implementing HL7 FHIR can enhance efficiency, data accessibility, and accuracy in the vaccination process, supporting broader digitization efforts in the German healthcare system and beyond.

There are many applications of anomaly detection in IoT domain. IoT technology consists of large number of interconnecting digital devices not only generating huge data continuously but also making real-time computations. Since IoT devices are highly exposed due to Internet, they frequently meet with the challenges of illegitimate accesses in the form of intrusions, anomaly, fraud, etc. Identifying these illegitimate accesses in IoT domain can be an exciting research problem. In numerous applications fuzzy clustering and rough set theory have been successfully employed. As the data generated in IoT domains are high-dimensional, the clustering methods used for lower dimensional data cannot be applied efficiently. In this article, mixed approaches consisting of nano topology and fuzzy clustering techniques are proposed for anomaly detection. First of all, the nano topology is generated to find lower dimensional apace and then a couple of well-known fuzzy clustering techniques are employed on it for the efficient anomaly detection. The effectiveness of the proposed approaches is evaluated using time-complexity analysis, experimental studies with a synthetic dataset and a real-life dataset along with comparative studies with traditional fuzzy clustering approaches namely fuzzy c-means clustering (FCM) algorithm, Gustafson-Kessel (GK) Algorithm, Gath-Geva (GG) Algorithm, Mahalanobis Distance based Fuzzy C-Means algorithm (M-FCM), and Common Mahalanobis Distance based Fuzzy C-Means algorithm (CM-FCM). Experimentally, it has been found that the proposed approaches outperform the aforesaid algorithms in terms of detection rates, accuracy rates, false alarm rates and computational times.

WBAN is a blessing to mankind because it can monitor people's health and activities regardless of place or time. It brings feasibility in patients’ treatment. The main problems with WBAN, however, are related to the security and privacy of health data. To prevent data misuse, health information should be safeguarded. On the other hand, the medical professional needs to receive the patient's health information promptly. As security of health data impact human life greatly so secure an efficient method is required. Efficient cryptographic technique for data protection of wireless body area network is proposed. This research aims to provide data protection in WBAN to increase data security and efficient transmission. The suggested approach offers effective security with quick key generation, quick encryption, and secure data transmission across the network. The proposed methodology is considered to be secure and will consume less time. The proposed method further uses a less complex encryption algorithm. The less complex the approach is the higher performance it will provide in wireless network. The proposed methodology will prevent many attacks, which makes the proposed approach highly suitable for wireless body area network’s security.

Hungary's first national park was created in 1973 in the Hortobágy area to protect Europe's largest contiguous steppe area with its flora and fauna. The Hortobágy National Park - the Puszta was inscribed on the UNESCO World Heritage List as a cultural landscape in 1999. The park's outstanding importance is due to the predominantly non-arboreal steppe vegetation, home to a unique bird fauna, and the alkaline and chernozem soils with a complex, mosaic-like spatial structure. In addition, the landscape of the Hortobágy has a pastoral history stretching back thousands of years. Several hypotheses have been put forward, which suggest that the alkaline soils and the habitats that cover them were formed as a result of human activities related to river regulation that began in the second half of the 19th century. However, palaeoecological and palaeobiological studies over the last 30-40 years have pointed to the natural origin of the alkaline steppes, dating back to the end of the Ice Age. For thousands of years human activities, in particular grazing by domestic animals, hardly influenced the natural evolution of the area. Drainage of marshy and flooded areas began in the 19th century, and the introduction of more and more intensive agriculture, had a significant impact on the landscape. This paper aims to describe the past natural development of this special alkaline steppe ecosystem, with particular reference to the impacts of past and present human activities, including conservation measures.

Falls are extremely damaging to the elderly. The number of elderly who have experienced falls has increased over the years, several of the elderly stay alone or in in badly maintained elderly homes. This makes a low-cost fall detection system a necessity. There has been huge improvements in terms of IoT systems, ML algorithms. Varied data sets have been collected across the world for fall detection. These data sets have a very little in common among them, in terms of user demographics, sensors used, the ADL and Fall activities Hence in this paper we present a data set that has wide user demographics, we used various sensors – such as accelerometer, gyroscope, magnetometer and hear rate. We used wrist worn sensors to collect data. In this paper we present a detailed analysis of the data set we collected using common ML algorithms such as – Naïve Bayes (NB), K Nearest Neighbor (KNN), Logistic Regression (LR), Random Forest (RF) and Support Vector Machines (SVM). We analyzed the performance of these algorithms for variations in accuracy with respect to age, gender, height, weight and health issues and we have identified outliers by analyzing each incorrect prediction. This paper provides the complete details of the data collection methodology, The methods used for analysis and presents the results of analysis in complete detail.

Integrating systems acquired from third parties and legacies has become of great necessity in companies. This is mainly due to the need to exchange information between entities, such as banks, suppliers, customers, allies, etc. Therefore, it is essential to guarantee the integrity of the data and keep the integration up to date with the changes that can occur. Furthermore, reducing the transaction risk and avoiding losing information is necessary. Implementing this complex task involving technological and business challenges requires appropriate architecture implementation. This article presents an architecture named Dynamic Canonical Data Model through agnostic messages. The contribution involves treating the low link in integrating software units, also called the integration of loosely coupled software units. In particular, it focuses on internal data and external data integration. The proposal reduces their integration, maintenance time, and cost, maximizing their scalability and promoting reuse. To illustrate their components, a case study undertaken at the Mexican Logistics Company Paquetexpress is presented. The company has evaluated different enterprise application integration systems over 26 years to achieve a standardized integration. The article describes an architecture designed and implemented for this delivery company in a real-world case. The implementation’s source code was registered in the National Registry of Copyrights of Mexico.

The divination function of China's Yijing has led to its circulation for thousands of years. In our exploration of Yijing's characteristics using big data, we have discovered variations in results between the coin toss method and the ancient yarrow-stalk method of divination, known as "the number for the great expansion method of divination(大衍之数)". The yarrow-stalk method serves as the fundamental method of divination in Yijing and continues to hold significance in studying the essential characteristics of Yijing. Despite the complexity of yarrow calculations, advancements in computer technology and big data have simplified its application. By employing the yarrow-stalk method, we simulated changes in the 64 hexagrams, calculated probabilities and proportions of hexagram alterations, and derived fundamental characteristics and patterns of hexagrams. Additionally, we constructed the spatial representation of lines and hexagrams. Through a binary system rearrangement, we created a 64x64 matrix illustrating hexagram transformations. Subsequently, we generated 100 million random hexagrams and analyzed line and hexagram changes accordingly. Our findings indicate the following:(1) Big data analysis reveals evident asymmetry in the hexagrams obtained through the yarrow-stalk method, with a triangular fractal characteristic forming the background.(2) Each of the 64 hexagrams exhibits a distinct probability distribution when transforming into other hexagrams, which can be categorized into five types.(3)The occurrence probabilities of Laoyang, Laoyin, Shaoyang, and Shaoyin are 18.61%, 6.387%, 31.38%, and 43.62% respectively. The probabilities of Yin and Yang occurrences are nearly equal, each close to 50%. However, the probability of Laoyang is approximately three times higher than that of Laoyin.(4) Visualized and analyzed the characteristics of hexagram changes greater than 100000 times using 3D statistical maps and Sankey diagram.These results demonstrate that the yarrow-stalk method effectively unveils the characteristics and underlying patterns of the 64 hexagrams. This study provides a novel approach for scientifically exploring the internal laws governing the 64 hexagrams in Yijing.

Hand gestures are an essential part of human-to-human communication and interaction, and therefore for technical applications, the aim is increasingly to achieve interaction between humans and computers that is as natural as possible, for example by means of natural language or hand gestures. In the context of human-machine interaction research, these methods are consequently being explored more and more. However, the realization of natural communication between humans and computers is a major challenge. In the field of hand gesture recognition, research approaches are being pursued that use additional hardware such as special gloves to classify gestures with high accuracy. Recently, deep learning techniques using artificial neural networks have been increasingly proposed for the problem of gesture recognition without using such tools. In this context, in our approach convolutional neural network (CNN) will be explored in detail for the task of hand gesture recognition. CNN is a deep neural network that can be used in the field of visual object processing and classification. The goal of this work is to recognize ten types of static hand gestures in front of complex backgrounds and different hand sizes based on raw images without the use of extra hardware. We achieved good results with a CNN network architecture consisting of seven layers. Through data augmentation and skin segmentation, a significant increase of the model accuracy was achieved. On public benchmarks the ten gestures have been classified almost perfectly with a testing accuracy of 96.5%

Finding anomalies in the real-time system is recognized as one of most challenging study in information security. It has so many applications like IoT, and Stock-Market. In any IoT system the data generated are real-time, and temporal in nature. Since due to the extreme exposure to Internet and interconnectivity of devices, the IoT systems often face issues like fraud, anomalies, intrusions etc. Discovering anomaly in such domain can be interesting. Clustering and rough set theory have been tried in many cases. Considering the time-stamp associated with IoT data, time-dependent patterns like periodic clusters can be generated which could be helpful for the efficient detection of anomalies by providing more in-depth analysis of the system. In this paper, a mixed method comprising of nano topology, a modified k-means clustering and an interval superimposition technique is used for finding fuzzy periodic clusters in the subspace generated by the nano topology. For every clusters there will be an associated sequence of time-intervals where it exists. The sequence time-intervals accompanying with each clusters may exhibit some remarkable patterns. For example, there may exist different types of periodicity namely yearly, monthly, daily, and hourly etc. For finding such fuzzy periodicity, an operation called interval-superimposition has been used. The time-intervals associated with each cluster are superimposed if they have reasonable overlapping. Each superimposed time-interval generates a fuzzy time-interval. The data instances are thought to be anomalous if they either belong to sparse clusters or don't belong to any clusters. The efficacy of the method can be assessed by means of both time-complexity analysis and comparative studies with existing clustering-based anomaly detection algorithms with a real-life and a synthetic dataset. It can been found experimentally that our method can extract anomaly with 98% of accuracy and it runs cubic time approximately.

Data from ocean color (OC) remote sensing are considered a cost-effective tool for the study of biogeochemical processes globally. Satellite-derived chlorophyll, for instance, is considered an Essential Climate Variable since it is helpful in detecting climate change impacts. Google Earth Engine (GEE) is a planetary scale tool for remote sensing data analysis. Along with OC data, such tools allow an unprecedented spatial and temporal scale analysis of water quality monitoring in a way that has never been done before. Although OC data have been routinely collected at medium (~1 km) and more recently at high (~250 m) spatial resolution, only coarse resolution (≥4 km) data are available in GEE, making them unattractive for applications in the coastal regions. Data reprojection is needed prior to making OC data readily available in the GEE. In this paper, we introduce a simple but practical procedure to reproject and ingest OC data into GEE. The procedure is applicable to OC swath (Level-2) data and is easily adaptable to higher-level products. The results showed consistent distributions between swath and reprojected data, building confidence in the introduced framework. The study aims to start a discussion on making high resolution OC data readily available in GEE.

INT-FFT algorithm presented in this work uses an interpolation methodology to densify 3D-GPR datasets to sharpen images obtained in GPR surveys obtained in an archaeological context. It allows the reconstruction of missing data from the combined use of mathematical transforms (e.g., the Fourier and Curvelet transform) and predictive filters. This technique makes it possible to calculate the missing signal simply by meeting two requirements: the data in the frequency domain must be limited in a range of values and must be able to be represented by a distribution of Fourier coefficients (verified conditions). The INT-FFT algorithm uses an open-access routine (Suinterp, Seismic Unix) to interpolate the GPR profiles based on seismic trace interpolation. This process uses automatic event identification routines by calculating spatial derivatives to identify discontinuities in space by detecting very subtle changes in the signal, thus allowing for more efficient interpolation without artifacts or signal deterioration. We successfully tested the approach using GPR datasets from the Roman Villa of Horta da Torre (Fronteira, Portugal). The results show an increase in the geometric sharpness of the GPR reflectors and have not produced any numerical artifacts. The tests performed to apply the methodology to GPR-3D data allowed for assessing the interpolation efficiency, the level of recovery of missing data, and the level of information lost when one chooses to increase the distance between profiles in the acquisition stage of the data.

Background: Immunoglobulin A nephropathy (IgAN) is a complex autoimmune disease, and the exact pathogenesis remains to be elucidated. Methods: We conducted summary data-based Mendelian randomization (SMR) analysis and performed functional mapping and annotation using FUMA to explore genetic loci that are po-tentially involved in the pathogenies of IgAN. Both analyses used summarized data of a recent genome-wide association study (GWAS) on IgANs, which included 477,784 Europeans (15,587 cases and 462,197 controls) and 175,359 East Asians (71 cases and 175,288 controls). We performed separate SMR analysis using CAGE and GTEx eQTL data. Results: Using the CAGE eQTL data, our SMR analysis identified 32 probes tagging 25 unique genes that were pleiotropically/potentially causally associated with IgAN, with the top three probes being ILMN_2150787 (tagging HLA-C, PSMR=2.10×10-18), ILMN_1682717 (tagging IER3, PSMR=1.07×10-16) and ILMN_1661439 (tagging FLOT1, PSMR=1.16×10-14). Using GTEx eQTL data, our SMR analysis identified 24 probes tagging 24 unique genes, with the top three probes being ENSG00000271581.1 (tagging XXbac-BPG248L24.12, PSMR=1.44×10-10), ENSG00000186470.9 (tagging BTN3A2, PSMR=2.28×10-10), and ENSG00000224389.4 (tagging C4B, PSMR=1.23×10-9). FUMA analysis identified 3 independent, significant and lead SNPs, 2 genomic risk loci and 39 genes. Conclusion: We identified many genetic variants/loci that are potentially involved in the patho-genesis of IgAN.

Biocultural heritage preservation relies on ethnobotanical knowledge and the paleoethnobotanical data used in (re)constructing histories of human-biota interactions. Biocultural heritage, defined as the knowledge and practices of Indigenous and Local peoples and their biological relatives, is often guarded information, meant for specific audiences and withheld from other social circles. As such, these forms of heritage and knowledge must also be included in the ongoing data sovereignty discussions and movement. In this paper we share the process and design decisions behind creating an online database for ethnobotanical knowledge and associated paleoethnobotanical data, using a content management system designed to foreground Indigenous and local perspectives. Our main purpose is to suggest the Mukurtu content management system, originally designed for physical items of cultural importance, be considered as a potential tool for digitizing and ethically circulating biocultural heritage, including paleoethnobotanical resources. With this database, we aim to create access to biocultural heritage and paleoethnobotanical considerations for a variety of audiences while also respecting the protected and sensitive natures of Indigenous and local knowledges.

Discrete, logic-based models are increasingly used to describe biological mechanisms. Initially introduced to study gene regulation, these models evolved to cover various molecular mechanisms, such as signalling, transcription factor cooperativity, and even metabolic processes. The abstract nature and amenability of discrete models to robust mathematical analyses make them appropriate for addressing a wide range of complex biological problems. Recent technological breakthroughs have generated a wealth of high throughput data. Novel, literature-based representations of biological processes and emerging algorithms offer new opportunities for model construction. Here, we review up-to-date efforts to address challenging biological questions by incorporating omic data into logic-based models, and discuss critical difficulties in constructing and analysing integrative, large-scale, logic-based models of biological mechanisms.

Background: The liver is involved in disseminated tuberculosis in more than 80% of the cases while primary liver involvement is rare, representing < 1% of all cases. Hepatic tuberculosis (TB) can be treated by conventional anti-TB therapy, however, diagnosing this disease still remains a challenge. The diagnosis might be particularly difficult in patients with a single liver lesion that could be misdiagnosed as a tumor or other focal liver lesions. While computed tomography and magnetic resonance imaging findings have been described, there is a paucity of literature on contrast-enhanced ultrasound (CEUS) features of hepatic TB. Case Summary: herein, we describe a case of a patient with tuberculous lymphadenopathy and chronic HCV-related liver disease who developed a single macronodular hepatic TB lesion. Due to the finding of a hepatocellular carcinoma (HCC) highly suggestive CEUS pattern, specifically a LR5 category according to the Liver Imaging Reporting and Data System (LI-RADS), and a good response to antitubercular therapy, a non-invasive diagnosis of HCC was made, and the patient underwent liver resection. We also review the published literature on imaging features of hepatic TB and discuss the diagnostic challenge represented by hepatic TB when occurs as a single focal liver lesion. Conclusions: this report shows for the first time that CEUS pattern of hepatic TB might be misinterpreted as HCC and specific imaging features are lacking. Personal history and epidemiological data are mandatory in interpreting CEUS findings of a focal liver lesion even when the imaging pattern is highly suggestive of HCC.

Nonparametric assessments of police technical and scale efficiency is challenging because of the stochastic nature of criminal behavior and because of the subjective dependence on multiple decision criteria, which can lead to a more or less efficiency prospect depending on the regulation, necessity, or organizational objective. There is a trade-off between efficiency and effectiveness in many police performance assessments, i.e., efficient departments (producing more clear-ups with a given resource) are crime-specialized or cannot reproduce those good results effectively on more severe or complex occurrences. This study proposes a combined methodology for carrying out efficiency and effectiveness analysis of Police departments. A conditional non-parametric approach, which allows to include crime as an external factor in the analysis, is combined with a non-compensatory ranking based on the PROMETHEE II methodology for the approach illustrated on the multidimensional efficiency and effectiveness comparison of 145 Pernambuco (Brazil)'s police departments. The application results offer compelling perspectives for public administrations concerning the strategic prioritization of units for rewards or interventions.

Data integration has been proven to provide valuable information. The information extracted using data integration in the form of multiblock analysis can pinpoint both common and unique trends in the different blocks. When working with small multiblock datasets the number of possible integration methods is drastically reduced. To investigate the application of multiblock analysis in cases where one has few number of samples, we studied a small metabolomic multiblock dataset containing six blocks (i.e. tissue types), only including common metabolites. We used a single model multiblock analysis method called Joint and unique multiblock analysis (JUMBA) and compare it to a commonly used method, concatenated PCA. These methods were used to detect trends in the dataset and identify underlying factors responsible for metabolic variations. Using JUMBA, we were able to interpret the extracted components and link them to relevant biological properties. JUMBA shows how the observations are related to one another, the stability of these relationships and to what extent each of the blocks contribute to the components. These results indicate that multiblock methods can be useful even with a small number of samples.

While the COVID-19 outbreak was reported to first originate from Wuhan, China, it has been declared as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 by WHO, and it has spread to over 180 countries by the time of this paper was being composed. As the disease spreads around the globe, it has evolved into a worldwide pandemic, endangering the state of global public health and becoming a serious threat to the global community. To combat and prevent the spread of the disease, all individuals should be well-informed of the rapidly changing state of COVID-19. In the endeavor of accomplishing this objective, a COVID-19 real-time analytical tracker has been built to provide the latest status of the disease and relevant analytical insights. The real-time tracker is designed to cater to the general audience without advanced statistical aptitude. It aims to communicate insights through various straightforward and concise data visualizations that are supported by sound statistical foundations and reliable data sources. This paper aims to discuss the major methodologies which are utilized to generate the insights displayed on the real-time tracker, which include real-time data retrieval, normalization techniques, ARIMA time-series forecasting, and logistic regression models. In addition to introducing the details and motivations of the utilized methodologies, the paper additionally features some key discoveries that have been derived in regard to COVID-19 using the methodologies.

The article describes the results of comparison of occurence of buildings (and address points) in Poland with delimitations of land use belonging to particular classes in the CORINE Land Cover (CLC) 2018 dataset. Large discrepancies have been identified, which reach on average approx. 34% of addresses and 35% of buildings located outside class 1 (artificial surfaces), mainly on terrains of class 2 (agricultural areas). Among single-family buildings it was 37% and among new addresses (forecasted or ‘under construction’ buildings) – as much as 50%. This puts a question mark over the possibility of using CLC data with resolution of 25 ha for monitoring of spatial planning and development in Poland for purposes of the diagnosis and assessment of the scale of dispersion of built-up areas. It is worth carrying out similar analyses in other countries, known for the deconcentration processes and a relatively large share of dispersed settlement e.g. other CEE countries, Spain, Portugal, Italy.

In order to perceive the behavior presented by the multiphase chemical reactors, the ant colony optimization algorithm was combined with computational fluid dynamics (CFD) data. This intelligent algorithm creates a probabilistic technique for computing flow and it can predict various levels of three-dimensional bubble column reactor (BCR). This artificial ant algorithm is mimicking real ant behavior. This method can anticipate the flow characteristics in the reactor using almost 30 % of the whole data in the domain. Following discovering the suitable parameters, the method is used for predicting the points not being simulated with CFD, which represent mesh refinement of Ant colony method. In addition, it is possible to anticipate the bubble-column reactors in the absence of numerical results or training of exact values of evaluated data. The major benefits include reduced computational costs and time savings. The results show a great agreement between ant colony prediction and CFD outputs in different sections of the BCR. The combination of ant colony system and neural network framework can provide the smart structure to estimate biological and nature physics base phenomena. The ant colony optimization algorithm (ACO) framework based on ant behavior can solve all local mathematical answers throughout 3D bubble column reactor. The integration of all local answers can provide the overall solution in the reactor for different characteristics. This new overview of modelling can illustrate new sight into biological behavior in nature.

Validation and verification are the critical requirements in the knowledge acquisition method for the clinical decision support system (CDSS). After acquiring the medical knowledge from diverse sources, the rigorous validation and formal verification process are required before creating the final knowledge model. Previously, we have proposed a hybrid knowledge acquisition method for acquiring medical knowledge from clinical practice guidelines (CPGs) and patient data in the Smart CDSS for treatment of oral cavity cancer. The final knowledge model was created by combining knowledge models obtained from CPGs and patient data after passing through a rigorous validation process. However, detailed analysis shows that due to lack of formal verification process, it involves various inconsistencies in knowledge relevant to the formalism of knowledge, conformance to CPGs, quality of knowledge, and complexities of knowledge acquisition artifacts. Therefore, it is required to enhance a hybrid knowledge acquisition method that thwarts the inconsistencies using formal verification. This paper presents the verification process using the Z formal method and its outcome as an enhanced acquisition method – known as the refined knowledge acquisition (ReKA) method. The ReKA method adopted verification method and explored the mechanism of theorem proving using the Z notation. It enables to identify inconsistencies in the validation process used for hybrid knowledge acquisition. Additionally, it refines the hybrid knowledge acquisition method by discovering the missing steps in the current validation process at the acquisition stage. Consequently, ReKA adds a set of nine additional criteria to be used to have a final valid refined clinical knowledge model. The criteria ensure the validity of final knowledge model concerning formalism of knowledge, conformance to GPGs, quality of the knowledge, usage of stringent conditions and treatment plans, and inconsistencies possibly resulting from the complexities. Evaluation, using four medical knowledge acquisition scenarios, shows that newly added knowledge in CDSS due to the addition of criteria by ReKA method always produces a valid knowledge model. The final knowledge model was also evaluated with 1229 oral cavity patient cases, which outperformed with an accuracy of 72.57\% compared to a similar approach with an accuracy of 69.7\%. Furthermore, ReKA method identified a set of decision paths (about 47.8%) in the existing approach, which results in a final knowledge model with low quality, non-conformed from standard CPGs. In conclusion, ReKA is formally proved method which always yields valid knowledge model having high quality, supporting local practices, and influenced from standard guidelines.

The interest on the use of renewable energy resources is increasing, especially towards wind and hydro powers, which should be efficiently converted into electric energy via suitable technology tools. To this aim, data--driven control techniques represent viable strategies that can be employed for this purpose, due to the features of these nonlinear dynamic processes working over a wide range of operating conditions, driven by stochastic inputs, excitations and disturbances. Some of the considered methods, such as fuzzy and adaptive self--tuning controllers, were already verified on wind turbine systems, and similar advantages may thus derive from their appropriate implementation and application to hydroelectric plants. These issues represent the key features of the work, which provides some guidelines on the design and the application of these control strategies to these energy conversion systems. The working conditions of these systems will be also taken into account in order to highlight the reliability and robustness characteristics of the developed control strategies, especially interesting for remote and relatively inaccessible location of many installations.

The topic of technology development and its disruptive effects has been the subject of much debate over the last 20 years with numerous theories at both macro and micro scale offering potential models of technology progression and disruption. This paper focuses on how the potential theories of technology progression can be integrated and considers whether suitable indicators of this progression and any subsequent disruptive effects (particularly considering these geographically) might be derived, based on the use of big data analytic techniques. Given the magnitude of the economic, social and political implications of many disruptive technologies, the ability to quantify disruptive change at the earliest possible stage could deliver major returns by reducing uncertainty, assisting public policy intervention and managing the technology transition through disruption into deployment. However, determining when this stage has been reached is problematic because small random effects in the timing, direction of development, the availability of essential supportive technologies or “platform” technologies, market response or government policy can all result in failure of a technology, its form of adoption or optimality of implementation. This paper reviews some of the key models of technology evolution and their disruptive effect including, in particular, the geographical spread of disruption. It suggests a methodology for utilising the recent explosion of open and web-discoverable data to determine a methodology to achieve this earlier determination and considers the potential exploitation of big data modelling and predictive analytical techniques to achieve this goal.

The interest on the use of renewable energy resources is increasing, especially towards wind and hydro powers, which should be efficiently converted into electric energy via suitable technology tools. To this aim, self--tuning control techniques represent viable strategies that can be employed for this purpose, due to the features of these nonlinear dynamic processes working over a wide range of operating conditions, driven by stochastic inputs, excitations and disturbances. Some of the considered methods were already verified on wind turbine systems, and important advantages may thus derive from the appropriate implementation of the same control schemes for hydroelectric plants. This represents the key point of the work, which provides some guidelines on the design and the application of these control strategies to these energy conversion systems. In fact, it seems that investigations related with both wind and hydraulic energies present a reduced number of common aspects, thus leading to little exchange and share of possible common points. This consideration is particularly valid with reference to the more established wind area when compared to hydroelectric systems. In this way, this work recalls the models of wind turbine and hydroelectric system, and investigates the application of different control solutions. The scope is to analyse common points in the control objectives and the achievable results from the application of different solutions. Another important point of this investigation regards the analysis of the exploited benchmark models, their control objectives, and the development of the control solutions. The working conditions of these energy conversion systems will be also taken into account in order to highlight the reliability and robustness characteristics of the developed control strategies, especially interesting for remote and relatively inaccessible location of many installations.

Malawi has developed an excellent, nation-wide system for monitoring people infected with HIV and keeping track of key epidemic markers. Their success lies in two things: the focus on simplicity and the use of data collection not only to track the epidemic and identify problems but also to give regular feedback and support to every clinic in the country. This achievement is the more remarkable given that Malawi is one of the poorest countries in the world, ranking 190 out of 194 countries by GDP, but has one of the most severe epidemics of HIV in the world, ranking 9th out of 168 countries by HIV prevalence. We first discuss the current state and likely future epidemic trends in Malawi: unless we know where we are and where we are going we cannot decide what to do or how to do it to in order to achieve a better outcome. We then discuss the history and development of Malawi’s patient monitoring system, as reported in their Integrated HIV Program Reports,ix which have been published quarterly since the beginning of 2004. We consider the current state of patient monitoring and support as reflected in the most recent report for the third quarter (Q3) of 2016 and comment on some of the questions that this raises. Finally, we consider ways in which the current system could be improved by strengthening Malawi’s analytical capacity and making better use of this unique data set. The focus here is on HIV in adultsv because if ART is initiated early in all adults living with HIV this should include testing all pregnant women for HIV and starting them on treatment immediately. However, PMTCT is especially important and care must be given to reducing MTCT and identifying the long-term child survivors of mother-to-child transmission and this demands a complementary assessment. There is an ongoing debate about the relative merits of treatment and prevention in reducing transmission and it should be made clear that the primary reason for starting people on treatment early is that it is in the best interest of the individual patient to start treatment as soon as possible after becoming infected. Allowing a person’s immune system to deteriorate to any degree is not consistent with the clinician’s commitment to ‘first do no harm’ and even those with the highest CD4⁺ cell count are at a substantially increased risk of death. What matters, therefore, is to get as many people as possible onto ART, ensure that they remain virally suppressed, and consider prevention in this context.

Naturally occurring small molecules include a large variety of natural products from different sources that have confirmed activity against epigenetic targets. In this work we review chemoinformatic, molecular modeling and other computational approaches that have been used to uncover natural products as inhibitors of DNA metiltransferases, a major family of epigenetic targets with significant potential for the treatment of cancer and several other diseases. Examples of these computational approaches include docking, similarity-based virtual screening, and pharmacophore modeling. It is also commented the chemoinformatic-based exploration of the chemical space of naturally occurring compounds as epigenetic modulators which may have significant implications in epigenetic drug discovery and nutriepigenetics.

This paper presents a method for a decentralised peer-to-peer software license validation system using cryptocurrency blockchain technology to ameliorate software piracy, and to provide a mechanism for software developers to protect copyrighted works. Protecting software copyright has been an issue since the late 1970's and software license validation has been a primary method employed in an attempt to minimise software piracy and protect software copyright. The method described creates an ecosystem in which the rights and privileges of participants are observed.

The fault diagnosis of wind farms has been proven to be a challenging task and motivates the research activities carried out through this work. Therefore, this paper deals with the fault diagnosis of a wind park benchmark model, and it considers viable solutions to the problem of earlier fault detection and isolation. The design of the fault indicator involves data-driven approaches, as they can represent effective tools for coping with poor analytical knowledge of the system dynamics, noise, uncertainty and disturbances. In particular, the proposed data-driven solutions rely on fuzzy models and neural networks that are used to describe the strongly nonlinear relationships between measurement and faults. The chosen architectures rely on nonlinear autoregressive with exogenous input models, as they can represent the dynamic evolution of the system along time. The developed fault diagnosis schemes are tested by means of a high-fidelity benchmark model, that simulates the normal and the faulty behaviour of a wind farm installation. The achieved performances are also compared with those of a model-based approach relying on nonlinear differential geometry tools. Finally, a Monte-Carlo analysis validates the robustness and the reliability of the proposed solutions against typical parameter uncertainties and disturbances.

Estimating ground surface PM2.5 with fine spatiotemporal resolution is a critical technique for exposure assessments in epidemiological studies of its health risks. Previous studies have utilized monitoring, satellite remote sensing or air quality modeling data to evaluate the spatiotemporal variations of PM2.5 concentrations, but such studies rarely combined these data simultaneously. We develop a three-stage model to fuse PM2.5 monitoring data, satellite-derived aerosol optical depth (AOD) and community multi-scale air quality (CMAQ) simulations together and apply it to estimate daily PM2.5 at a spatial resolution of 0.1˚ over China. Performance of the three-stage model is evaluated using a cross-validation (CV) method step by step. CV results show that the finally fused estimator of PM2.5 is in good agreement with the observational data (RMSE = 23.00 μg/m^3 and R2 = 0.72) and outperforms either AOD-retrieved PM2.5 (R2 = 0.62) or CMAQ simulations (R2 = 0.51). According to step-specific CVs, in data fusion, AOD-retrieved PM2.5 plays a key role to reduce mean bias, whereas CMAQ provides all-spacetime-covered predictions, which avoids sampling bias caused by non-random incompleteness in satellite-derived AOD. Our fused products are more capable than either CMAQ simulations or AOD-based estimates in characterizing the polluting procedure during haze episodes and thus can support both chronic and acute exposure assessments of ambient PM2.5. Based on the products, averaged concentration of annual exposure to PM2.5 was 55.75 μg/m3, while averaged count of polluted days (PM2.5 > 75 μg/m3) was 81, across China during 2014. Fused estimates will be publicly available for future health-related studies.

Appropriate estimation of soil settlement is of significant importance since it directly influences the performance of building and infrastructures that are built on soil. In particular, the settlement of fine-grained soils is critical because of low permeability and continuous settlement with time. Coefficient of consolidation (Cc) is a key parameter to estimate settlement of fine-grained soil layers. However, estimation of this parameter is time consuming, needs skilled technicians, and specific equipment. In this study, Cc was estimated using several soil parameters such as liquid limit (LL), plastic limit (PL), and initial void ratio (e0). Estimating such parameters in laboratory is straight forward and needs substantially less time and cost compared to conventional tests to estimate Cc such as Oedometer test. This study presents a novel prediction model for Cc of fine-grained soils using gene-expression programming (GEP). GEP is a biologically inspired technique capable of offering closed-form solution for the optimal solution. A database consisted of 108 different data points was used to develop the model. A closed-form equation solution was derived to estimate Cc based on LL, PL, and e0. The performance of developed GEP-based model was evaluated through coefficient of determination (R2), root mean squared error (RMSE), and mean average error (MAE). High R2 and low error values indicated the descent performance of the model. Furthermore, the model was evaluated using the additional performance measures and met all the suggested criteria. Furthermore, the model had a better performance in terms of R2, RMSE, and MAE compared to most of existing models. It is expected that the developed model will decrease the time and cost associate with determining Cc of fine-grained soils.

Appropriate estimation of soil settlement is of significant importance since it directly influences the performance of building and infrastructures that are built on soil. In particular, the settlement of fine-grained soils is critical because of low permeability and continuous settlement with time. Coefficient of consolidation (C_c) is a key parameter to estimate settlement of fine-grained soil layers. However, estimation of this parameter is time consuming, needs skilled technicians, and specific equipment. In this study, C_c was estimated using several soil parameters such as liquid limit (LL), plastic limit (PL), and initial void ratio (e₀). Estimating such parameters in laboratory is straight forward and needs substantially less time and cost compared to conventional tests to estimate C_c such as oedometer test. This study presents a novel prediction model for C_c of fine-grained soils using gene-expression programming (GEP). GEP is a biologically inspired technique capable of offering closed-form solution for the optimal solution. A database consisted of 108 different data points was used to develop the model. A closed-form equation solution was derived to estimate C_c based on LL, PL, and e₀. The performance of developed GEP-based model was evaluated through coefficient of determination (R²), root mean squared error (RMSE), and mean average error (MAE). High R² and low error values indicated the descent performance of the model. Furthermore, the model was evaluated using the additional performance measures and met all the suggested criteria. Furthermore, the model had a better performance in terms of R², RMSE, and MAE compared to most of existing models. It is expected that the developed model will decrease the time and cost associate with determining C_c of fine-grained soils.Keywords: evolutionary model, gene-expression programming (GEP), prediction, soil compression index, estimation, soil engineering, soil informatics, civil engineering, machine learning, data science, big data, soft computing, deep learning, forecasting, subject classification codes, construction informatics, computational intelligence (CI), artificial intelligence (AI), estimation

Across the power grid infrastructure, deployed power transmission systems are susceptible to incipient faults that interrupt standard operations. These incipient faults can range from being benign in impact to causing massive hardware damage and even loss of life. The power grid is continuously monitored, and incipient faults are recorded by Digital Fault Recorders (DFRs) to mitigate such outcomes. DFR recorded data allows power quality forensics and event analysis, but this capability comes at the cost of high data storage and data transmission requirements. It is common for data older than two weeks to be overwritten due to storage limitations and without being analyzed. This inhibits the creation of long-term data libraries that would enable incipient fault forensics and the characterization of behavior that precedes them, which limits the development and implementation of preventive measures; thus, there is a critical need to reduce DFR recorded data storage requirements. This work addresses this critical need by leveraging the cyclic and residual histograms and introducing the frequency, and Root Means Squared (RMS) histograms, which alleviate current high data storage requirements and provides effective Incipient Fault Prediction (IFP). The residual, frequency, and RMS histograms are an extension of the cyclic histogram, reduce the date storage requirement by up to 99.58%, can be generated on the DFR without interrupting its normal operations, and are capable of predicting voltage arcing six hours before it is strong enough to trigger a DFR recorded event.

There have been multiple technological advancements that promise to gradually enable devices to measure and record signals with high resolution and accuracy in the domain of Brain Computer Interfaces (BCI). Multi-modal BCIs have been able to gain significant traction given the potential to enhance signal processing by integrating different recording modalities. In this review, we explore the integration of multiple neuroimaging and neurophysiological modalities including Electroencephalography (EEG), Magnetoencephalography (MEG), Functional Magnetic Resonance Imaging (fMRI), Electrocorticography (ECoG), and Single-Unit Activity (SUA). This multimodal approach leverages the high temporal resolution of EEG and MEG with the spatial precision of fMRI, the invasive yet precise nature of ECoG, and the single-neuron specificity provided by SUA. The paper highlights the advantages of integrating multiple modalities, such as increased accuracy and reliability, and discusses the challenges and limitations of multimodal integration. Furthermore, we explain the data acquisition approaches for each of these modalities. We also demonstrate various software programs that help in extracting, cleaning, and refining the data. We conclude this paper with discussion on the available literature highlighting recent advances, challenges, and future directions for each of these modalities.

In today's technologically advanced landscape, sensors feed critical data for accurate decision-making and actions. Ensuring the integrity and reliability of sensor data is paramount to system performance and security. This paper introduces an innovative approach utilizing discrete wavelet transforms (DWT) embedded within microcontrollers to scrutinize sensor data meticulously. Our methodology aims to detect and isolate malfunctions, misuse, or any anomalies before they permeate the system, potentially causing widespread disruption. By leveraging the power of wavelet-based analysis, we embed computational intelligence directly into the microcontrollers, enabling them to monitor and validate their outputs in real-time. This proactive anomaly detection framework is designed to distinguish between normal and aberrant sensor behaviors, thereby safeguarding the system from erroneous data propagation. Our approach significantly enhances the reliability of embedded systems, providing a robust defense against false data injection attacks and contributing to overall cybersecurity.

In developing nations, such as Ekiti State, Nigeria, the use of remote sensing data, especially satellite and UAV imagery, remains significantly underutilized in land administration. This limits the potential of multi-resolution imagery in land governance and socio-economic development. This study examines factors influencing UAV adoption for land administration in Nigeria, mapping six distinct rural, peri-urban, and urban sites, and creating orthomosaics with resolutions ranging from 2.2cm to 3.39cm. Boundaries were manually delineated from multi-resolution orthomosaics to acquire coordinates, and parcel areas were calculated. Using 0.05m UAV imagery as the reference, the Root Mean Square Error (RMSE) was computed to evaluate 0.1, 0.5, and 1m orthomosaics' accuracy for boundary delineation across the six geographical contexts. The Normalized Parcel Area Error (NPAE) was also calculated to determine how the multi-resolution imageries affected the property areas. Results showed a consistent increase in error with increasing resolution (0.1m to 1m) in formal areas (Igedora, Maryland, Okebola) with physical demarcations, from 0.117m to 1.747m RMSE. In contrast, informal settlements exhibited inconsistent error values, indicating a differing impact of resolution on error between formal and informal areas. The research demonstrates the role of physical demarcations in facilitating cadastral mapping, with formal settlements demonstrating the highest suitability. This study recommends the use of imagery resolution specific to each context, offering guidance for improved land governance. Implications and recommendations include promoting awareness of settlement typologies in aerial imagery use for cadastral mapping, leveraging UAVs for high-resolution aerial imagery, and addressing regulatory challenges to promote UAV adoption. Finally, the RMSE and NPAE values can serve as metrics for assessing different resolution images’ fitness for cadastral mapping.

This paper comprehensively explores the integration of cloud computing and advanced recommendation systems, emphasizing their pivotal roles in enhancing user experiences and operational efficiencies across digital platforms. It reviews the evolution of recommendation algorithms, highlighting their application in diverse domains such as e-commerce and media. The study evaluates the performance of advanced models like UniLLMRec against traditional counterparts using datasets from news and e-commerce domains. Additionally, the paper discusses the infrastructure architecture of cloud computing, demonstrating its capability to support scalable and efficient data processing. Through experimental insights and methodology, the research underscores the transformative impact of cloud technologies on optimizing recommendation system performance, thereby advancing digital engagement and competitiveness.

The application of the latest technological innovations has been promoted worldwide to increase farm productivity, including in salt farming. This research aims to determine the determinants of adoption decisions for salt production technology called geomembrane and estimate the adoption impact on technical efficiency. The data in this study is cross-sectional from 215 small-scale salt farmers on Madura Island, East Java, Indonesia. The data was analyzed using logistic regression to identify which factors influenced farmers’ decisions to use geomembrane. The influence of adoption on farmers' technical efficiency was then assessed using propensity score matching (PSM) and data envelopment analysis (DEA). The findings indicate that age and the dummy variables of gender, land ownership, profit-sharing involvement, and membership in the People's Salt Business Group (KUGAR) all had a significant impact on adoption rates. The findings of controlling matched samples using the PSM process reveal that geomembrane application improves and greatly increases farmers' technical efficiency. Those who used geomembranes displayed greater technical efficiency than those who did not. These findings imply that salt production technology should be promoted more to increase productivity, especially geomembrane adoption, through outreach and dissemination of information, including for landowners involved in the profit-sharing system.

A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

The focus of our study was the changes in the composition of semi-natural dry grasslands in Hungary. Since these valuable habitats were created with the help of humans, their preservation also requires regular treatment. Our mowing experiment aimed to investigate the suppression of the native Calamagrostis epigejos L. Roth. In Hungary, in the Cserhát Mountains, eight permanent plots were mowed twice a year. The vegetation was sampled annually between 2001 and 2011. The effects of mowing were investigated with repeated measures analysis of variance (ANOVA). After 10 years, the C. epigejos cover of the mowed plots decreased significantly, from the initial average of 62.38 to 7.50%. Surprisingly, we also experienced a similar decrease in the control plots. Regular treatment also had a positive effect on the number of species and diversity. Species richness increased continuously in both treatment types, which indicates the combined effect of vegetation succession and treatment. The biomass growth of other Poaceae and Fabaceae species, which are important from a grassland management perspective, was also facilitated by mowing. Our results suggest that long-term in situ experiments and continuous botanical studies are needed to establish a reliable utilization of grasslands.

In this work we looked for a stable and accurate procedure to perform feature selection in datasets with a much higher number of predictors than individuals, as in Genome-Wide Association Studies. Due to the instability in feature selection when many potential predictors are measured, a variable selection procedure is proposed that combines several replications of shrinkage regression models. A weighted formulation is used to define the final predictors. The procedure is applied to investigate Single Nucleotide Polymorphisms (SNPs) predictors associated to Alzheimer’s disease in the Alzheimer’s disease Neuroimaging Initiative (ADNI) dataset. Two data scenarios are investigated: one considering only the set of SNPs and another with the covariates age, sex, educational level and APOE4 genotype. The SNP rs2075650 and the APOE4 genotype are given as risk factors for AD, which is in line with the literature, and other four new SNPs are pointed, opening new hypotheses for in vivo analyses. These experiments demonstrate the potential of the new method for stable feature selection.

AbstractThe escalating impact of artificial intelligence (AI) has birthed the fascinating technology of deepfakes, capable of meticulously crafting hyper-realistic audio-visual manipulations. Within the realm of healthcare, this technology presents a double-edged sword, brimming with potential for revolutionizing various facets of care delivery while simultaneously harboring significant ethical and practical challenges. This research delves into the complex narrative surrounding AI deepfakes in healthcare, meticulously analyzing both the exciting opportunities they offer, and the inherent risks associated with their implementation.Background:Traditional healthcare practices face limitations in patient engagement, accessibility, and training efficacy. Deepfakes, with their ability to simulate real-world scenarios and interactions, emerge as a potential solution, offering personalized patient education, immersive mental health interventions, remote consultations with virtual avatars, and realistic training simulations for medical professionals.Objective:This research aims to comprehensively understand the multifaceted impact of AI deepfakes in healthcare systems. It seeks to: Identify and analyze the potential benefits of deepfakes in specific healthcare applications. Assess the ethical and practical challenges associated with deepfake implementation in healthcare settings. Propose recommendations for safe, responsible, and ethical integration of deepfakes within the healthcare system.Results/Conclusion:The research findings illuminate a landscape replete with opportunities and challenges. Deepfakes offer the potential to enhance patient education, personalize mental health interventions, facilitate remote consultations, and revolutionize medical training. However, concerns regarding misinformation, ethical breaches, data privacy, and technical limitations pose significant challenges.The conclusion emphasizes the need for a balanced approach that capitalizes on the innovative potential of deepfakes while mitigating potential harm. Collaborative efforts involving healthcare professionals, technologists, and policymakers are crucial for establishing ethical frameworks, ensuring responsible development, and harnessing the positive power of deepfakes to build a future where healthcare benefits from cutting-edge technology while prioritizing patient well-being and ethical principles.

Ridge regression is one of the most popular shrinkage estimation methods for linear models. Ridge regression effectively estimates regression coefficients in the presence of high-dimensional regressors. Recently, a generalized ridge estimator was suggested by generalizing the uniform shrinkage of ridge regression to the non-uniform shrinkage, which was shown to perform well under sparse and high-dimensional linear models. In this paper, we introduce our newly developed R package “g.ridge” (the first version published on 2023-12-07 at https://cran.r-project.org/package=g.ridge) that implements both the ridge estimator and generalized ridge estimators. The package equips with the generalized cross-validation for automatic estimation of shrinkage parameters. The package also includes a convenient tool for generating a design matrix. By simulations, we test the performance of the R package under sparse and high-dimensional settings with the normal and skew-normal error distributions. From the simulation results, we conclude that the generalized ridge estimator is superior to the benchmark ridge estimator based on “glmnet”, and hence, it can be the most recommended estimator under sparse and high-dimensional models. We demonstrate the package using the intracerebral hemorrhage data.

Abstract Big datasets are becoming increasingly common and can be challenging to understand and apply in public health. One method for lowering the dimensionality of these datasets and improving interpretability while minimizing information loss is data reduction using principal component analysis (PCA). It achieves this by successively maximizing variance through the creation of new, uncorrelated variables. PCA is an adaptive data analysis technique because it simplifies the process of finding new variables, or principal components, by solving an eigenvalue or eigenvector problem. These new variables are determined by the dataset being used, rather than by the analyst starting from scratch. It is also adaptable in another way because varieties of the method have been designed to adjust to various data structures and types. However, there are serious problems in the theoretical understanding and practical application of PCA in public health researchers, whereas its application is becoming popular in developing countries. Therefore, this article, which concentrated on using PCA to reduce data, began by outlining the fundamental concepts of PCA and going over what it can and cannot do, as well as when and how to use it. We also discussed the fundamental assumptions, benefits, and drawbacks of PCA. Furthermore, this article demonstrated and resolved PCA practical application problems in public health that most scholars are unaware of, such as variable preparation, variable inclusion and exclusion criteria for PCA, iteration steps, wealth index analysis, interpretation, and ranking.

Digital twins are gaining in popularity for simulating complex natural and urban environments. In this context, accurate segmentation of objects within 3D urban environments is of crucial importance. The aim of this project is to develop a methodology for extracting buildings from textured 3D meshes. To this end, PicassoNet-II, a semantic segmentation architecture is employed. The methodology also incorporates Markov field-based contextual analysis to assess post-segmentation features. In addition, building instantiation is performed using cluster analysis algorithms. Training this model to fit various datasets requires a large amount of annotated data, both from Quebec City, Canada, and from simulated data. Experimental results show that the use of simulated data improves segmentation accuracy, and the DBScan algorithm proves effective in extracting isolated buildings. This project paves the way for improved applications in 3D urban modeling, offering opportunities in fields ranging from urban planning to resource management. The positive results with simulated data reinforce the impact of this research on improving digital models of our ever-changing urban environments.

Cyber diplomacy is critical in dealing with evolving cybersecurity dangers and possibilities in the digital era. This article investigates the impact of Artificial Intelligence (AI), the Internet of Things (IoT), Blockchains, and Quantum Computing on cyber diplomacy. AI holds the potential for proactive threat identification and response, while IoT enables international information sharing. Blockchains enable secure data sharing and document verification, but they also pose new threats, such as AI-driven cyber-attacks, IoT privacy breaches, blockchain vulnerabilities, and the potential for quantum computing to break encryption. This article conducts case study reviews, in combination with secondary data analysis, and emphasises the value of international cooperation in developing global norms and frameworks to control responsible technology adoption. Cyber diplomacy can promote cybersecurity, protect national interests, and foster mutual trust among nations in the digital sphere by capitalising on possibilities and reducing threats.

Foundational and state-of-the-art anomaly detection methods through power system state estimation are reviewed. The traditional components for bad data detection such as chi-square testing, residual-based methods, and hypothesis testing are discussed to explain the motivations for recent anomaly detection methods given the increasing complexity of power grids, energy management systems, and cyber-threats. In particular, state estimation anomaly detection based on data-driven quickest change detection and artificial intelligence are discussed and directions for research are suggested with particular emphasis on considerations of the future smart grid.

Diabetes mellitus is a chronic disease that affects millions of people worldwide. Article focuses on detecting the presence of diabetes in patients using microarray gene data obtained from the pancreas. Handle the high-dimensional nature of the data, four different dimensionality reduction techniques, namely Bessel Function, Discrete Cosine Transform (DCT), Least Square Linear Regression (LSLR), and Artificial Algae Algorithm (AAA) are used. After reduced the data, Meta-heuristic algorithms are applied like Dragonfly Optimization Algorithm (DOA) and Elephant Herding Optimization Algorithm (EHO) for feature selection. Ten classification techniques are using to classify the data in both the format like without feature selection method and with feature selection method. The classification techniques are Non-Linear Regression (NLR), Linear Regression (LR), Gaussian Mixture Model (GMM), Expectation Maximum (EM), Bayesian Linear Discriminant Classifier (BLDC), Logistic Regression (LoR), Softmax Discriminant Classifier (SDC), Support Vector Machine (SVM) with linear kernel, Support Vector Machine (SVM) with polynomial kernel, and Support Vector Machine (SVM) with Radial Basis Function (RBF) kernel. Results showed that the AAA with SVM(RBF) achieved an accuracy of 90% without feature selection. However, when feature selection was applied, with EHO of AAA with SVM(RBF) exhibited the highest accuracy of 95.714%, followed closely by with DOA of AAA with SVM (RBF) at 94.28%.

In the last decades, climate and environmental changes have highlighted the fragility and vulnerability of the landscape, especially in mountain areas where the effects are most severe. The strategy for hazard mitigation must deploy synergistic actions based on a thorough knowledge of the territory and its phenomena to enable integrated and effective land planning and management through suitable communication tools. This study promotes the methodological setup of a Landscape Digital Twin to establish a multi-disciplinary and multi-scalar hazards overview according to a matrix framework implementable over time and space. The original contribution to the research addresses a holistic vision that combines meaningfully qualitative with quantitative approaches to generate risk maps by integrating various indicators within a multi-hazard framework from the socio-economic perspective. This contribution presents road network risk analysis by exploiting flooding and landslide scenarios. The critical road segments or nodes most vulnerable or impacted by network performance and accessibility can be identified with minimal preprocessing from credible open-source sources. The method's applicability is tested in a Piedmont Region, northern Italy case study. The integration proposed will help generate comprehensive risk analysis maps that effectively portray the interconnectedness among natural hazards, infrastructure, and socio-economic factors fostering more resilient decision-making processes.

The land subsidence occurring in goafs after coal mining is a protracted process. The accurate prediction of long-term land subsidence in goafs relies heavily on the availability of long-term monitoring data. However, the scarcity of continuous long-term land subsidence monitoring data subsequent to the cessation of mining significantly hinders the accurate prediction of long-term land subsidence in goafs. To address this challenge, this study proposes an innovative method based on Interferometric Synthetic Aperture Radar (InSAR) for predicting long-term land subsidence of goafs following coal mining. The proposed method employs a concatenation approach that integrates multiple short-term monitoring data from different coal faces, each with distinct cessation times, into a cohesive and uniform long-term sequence by normalizing the subsidence rates. The method was verified using actual monitoring data from the Yangquan No.2 mine in Shanxi Province, China. Initially, coal faces with same shapes but varying cessation times were selected for analysis. Using InSAR monitoring data collected between June and December of 2016, the average subsidence rate corresponding to the duration after coal mining cessation of each coal face was back-calculated. Subsequently, a function relating subsidence rate to the duration after coal mining cessation was fitted to the data. Finally, the relationship between cumulative subsidence and the duration after coal mining cessation was derived by integrating the function. The results indicated that the relationship between subsidence rate and duration after coal mining cessation followed an exponential function for a given coal face, whereas the relationship between cumulative subsidence and duration after coal mining cessation conformed to the Knothe time function. Notably, after the cessation of coal mining, significant land subsidence persisted in the goaf of the Yangquan No.2 mine for a duration ranging from 5 to 10 years. The cumulative subsidence curve along the long axis of the coal face ultimately exhibited an inclined W-shape. The proposed method enables the quantitative prediction of residual land subsidence in goafs, even in cases where continuous long-term monitoring data are insufficient, thus providing valuable guidance for construction decisions above the goaf.

Virtual assistants (VAs) have gained widespread popularity across a wide range of applications, and the integration of Large Language Models (LLMs) such as ChatGPT has opened up new possibilities for developing even more sophisticated VAs. However, this integration poses new ethical issues and challenges that must be carefully considered, particularly as these systems are increasingly used in public services: transfer of personal data, decision-making transparency, potential biases, and privacy risks. This paper, an extension of the work presented at IberSPEECH 2022, analyzes the current regulatory framework for AI-based VAs in Europe and delves into ethical issues in depth, examining potential benefits and drawbacks of integrating LLMs with VAs. Based on the analysis, this paper argues that the development and use of VAs powered by LLMs should be guided by a set of ethical principles that prioritize transparency, fairness, and harm prevention. The paper presents specific guidelines for the ethical use and development of this technology, including recommendations for data privacy, bias mitigation, and user control. By implementing these guidelines, the potential benefits of VAs powered by LLMs can be fully realized while minimizing the risks of harm and ensuring that ethical considerations are at the forefront of the development process.

Knowledge of wave climate is essential for efficient management of the world's coastal areas. Senegal is a relevant case given its high coastal vulnerability to energetic wave conditions. This study investigates wave climates along the coastal zone of Senegal based on a new high-resolution hindcast covering the period 1980-2021. This study evaluates the average, seasonal and extreme values for the wave significant heights (Hs), periods (Tm02/Tp) and mean directions (DIR). In boreal Winter, the wave climate is dominated by swells coming from the North-Atlantic lows, while in boreal Summer, the Southern Coast (from Dakar to Casamance) is exposed to swells generated in the South-Atlantic Ocean. Throughout their refraction around Dakar Peninsula, NW swells rotate by ~100° from NW to SW, while their Hs is roughly halved when reaching the Southern Coast of Senegal. Over the studied period, trends in Hs are weak (~0.6 cm.decade-1) on the Northern Coast, double on the Southern coast (~1.2 cm.decade-1), mostly due to an increase during boreal Summer (2 cm.decade-1). The wave periods show weak trends (~0.05 s.decade-1) and DIRs show weak counterclockwise rotation (-1°.decade-1). These trends are explained by the main climate modes of the Atlantic Ocean (NAO/EA during Winter, SAM during Summer) and are important for future research and long-term monitoring of the Senegalese Coast.

Knowing, with reasonable accuracy, the dry matter (DM) content of Hass avocado fruit will help determine when the fruit must be harvested. The reliability of predictive models based on near infrared spectra for DM quantification depends on the ability of the spectra to be representative of the DM gradient within a whole fruit. The aim of this work was to develop a methodology to determine the optimum number of spectra to develop a robust model for DM content quantification. Three spectra were recorded for each zone of the intact fruit: peduncle, equator, and base. Each scanning point was sampled, and the DM content was determined using oven drying. Two-way ANOVA confirmed the DM gradient within the whole fruit. This gradient was observed within spectra using the RMS (root mean square) criterion and PCA. The PLS models showed that at least one spectrum per zone could be enough to construct an efficient and robust model for dry matter quantification.

This work discusses diatomic molecular spectroscopy of laser-induced plasma and analysis of data records, specifically signatures of cyanide, CN. Line strength data from various databases are compared for simulation of the CN, B2Σ+⟶X2Σ+, Δv=0 sequence. Of interest are recent predictions using an astrophysical database, i.e., ExoMol, a laser-induced fluorescence database, i.e., LIFBASE, and a program for simulating rotational, vibrational and electronic spectra, i.e., PGOPHER. Cyanide spectra that are predicted from these databases are compared with line strength data that are in use by the author for the last three decades in the analysis of laser-plasma emission spectra. Comparisons with experimental laser-plasma records are communicated as well, and for spectral resolutions of 33 and 110 picometer. The accuracy of the CN line strength data is better than one picometer. Laboratory experiments utilize 308-nm, 35-picosecond bursts within an overall 1-nanosecond pulse-width, and 1064-nm, 6-ns pulse-width radiation. Experimental results are compared with predictions. Differences of the databases are elaborated for equilibrium of rotational and vibrational modes and at an internal, molecular temperature of the order of 8,000 Kelvin. Applications of accurate CN data include for example combustion diagnosis, chemistry, and supersonic and hypersonic expansion diagnosis. The cyanide molecule is also of interest in the study of astrophysical phenomena.

Advanced state-of-the-art technologies, mainly computational intelligence including Machine/Deep Learning and Fuzzy Computing, through applied research, can provide added value to modern science and, in general, to entrepreneurship and the economy. Artificial intelligence is the field of computer science that attempts to model concepts such as learning, adaptability and perception to synthesize intelligent behavior in solving complex problems, utilizing elements of adaptation to the environment and philosophical reasoning. About the science of civil engineering and, in general, the construction industry, which is one of the most important in economic entrepreneurship, both in terms of the size of the workforce employed and the amount of capital invested, the penetration of artificial intelligence is possible to change industry business models, eliminate costly mistakes, reduce Jobsite injuries and generally make large-scale engineering projects more efficient. The purpose of the paper is to present the recent research on artificial intelligence methods (machine-deep learning, computer vision, natural language processing, fuzzy systems, robotics, etc.) and the corresponding related technologies related to it (extensive data analysis, blockchain, cloud computing, internet of things, augmented reality), in the fields of application of civil engineering science, including structural engineering, geotechnical engineering, hydraulics and water resources management, marine and coastal technology, transport and transportation infrastructure, planning and technical project management, critical infrastructure security and disaster mitigation..

It is not easy to dynamically analyze thermal bridges that require multidimensional analysis in building energy simulations, which are mostly one-dimensional platforms. To solve this problem, many studies have been conducted and, recently, a study was conducted to model the thermal bridge based on the data by approaching this in a similar way to steady-state analysis, showing high accuracy. This was an early-stage study, which is only applicable when the indoor temperature is constant. By extending this study, a thermal bridge model that can be applied even when the indoor temperature changes over time is proposed and validated. Since the governing equation, the heat diffusion equation, is linear, the key idea is to create and apply two thermal bridge transfer function models by expressing the heat flow entering the room as a linear combination of the transfer function for indoor temperature and the transfer function for outdoor temperature. For the proposed thermal bridge model, the NRMSE of the model itself showed a high accuracy of 99.9%, and in the verification through annual simulation using the model, the NRMSE showed an accuracy of 88.8%.

With the increase in life expectancy and consequent aging of the world’s population, the prevalence of many neurodegenerative diseases is increasing, without concomitant improvement in diagnostics and therapeutics. These diseases share neuropathological hallmarks, including mitochondrial dysfunction. In fact, as mitochondrial alterations appear prior to neuronal cell death at an early phase of the disease onset, the study and modulation of mitochondrial alterations rise as promising strategies to predict and prevent neurotoxicity and neuronal cell death before the onset of cell viability alterations. In this work, differentiated SH-SY5Y cells were treated with the mitochondrial-targeted neurotoxicants 6-hydroxydopamine and rotenone. These compounds were used at different concentrations and for different time points to understand the similarities and differences in their mechanisms of action. To accomplishing this, data on mitochondrial parameters was acquired and analyzed using unsupervised (hierarchical clustering) and supervised (decision tree) machine learning methods. Both biochemical and computational analyses resulted in an evident distinction between the neurotoxic effects of 6-hydroxydopamine and rotenone, specifically for the highest concentrations of both compounds.

Forest degradation is known to be widespread in the tropics, but is currently very poorly mapped, in part because there is little quantitative data on which satellite sensor characteristics and analysis methods are best at detecting it. To improve this, we used data from the Tropical Forest Degradation Experiment (FODEX) plots in the southern Peruvian Amazon, where different numbers of trees had been removed from four 1 ha forest plots, carefully inventoried by hand and Terrestrial Laser Scanning before and after the logging to give a range of biomass change (ΔAGB) values. We conducted a comparative study of six multispectral optical satellite sensors (WorldView-3, SkySat, SPOT-7, PlanetScope, Sentinel-2 and Landsat 8) at 0.3 – 30 m spatial resolution, to find the best combination of sensor and remote sensing indicator for change detection. Spectral reflectance, the Normalized Difference Vegetation Index (NDVI) and texture parameters were extracted after radiometric calibration and image preprocessing. The strength of the relationships between the change in these values and field-measured ΔAGB (computed in % ha−1) was analysed. The results demonstrate that: (a) texture measures correlates more with ΔAGB than simple spectral parameters; (b) the strongest correlations are achieved for those sensors with spatial resolutions in the intermediate range (1.5 - 10 m), with finer or coarser resolutions producing worse results, and (c) when texture is computed using a moving square window ranging between 9 - 14 m in length. Maps predicting ΔAGB showed very promising results using a NIR-derived texture parameter for 3 m resolution PlanetScope (R2 = 0.97 and RMSE = 1.80 % ha−1), followed by 1.5 m SPOT-7 (R2 = 0.74 and RMSE = 5.25 % ha−1) and 10 m Sentinel-2 (R2 = 0.71 and RMSE = 5.55 % ha−1). Texture models derived from 0.3 m WorldView-3 improved with increasing window size, with highest R2 of 0.62 and RMSE = 6.35 % ha−1 for a window of 14 m in length. The degradation in our field plots is invisible to the 30 m resolution Landsat data. Our findings imply that, at least for lowland Peru, low-medium intensity disturbance can be detected best in optical wavelengths using a texture measure derived from 3 m PlanetScope data. That such data are being collected daily, and currently released free as monthly mosaics over tropical forests as part of the Norway’s International Climate and Forest Initiative (NICFI), is excellent news for monitoring such degradation.

Microturbines can be used not only in models and education but also to propel UAVs. However, their wider adoption is limited by their relatively low efficiency and durability. Validated simulation models are required to monitor their performance, improve their lifetime, and design engine control systems. This study aims at developing a numerical model of a micro gas turbine for prediction and prognostics of engine performance. To build a reliable zero-dimensional model, the available compressor and turbine maps were scaled to the available test bench data with the least squares method, to meet the performance of the engine achieved during bench and flight tests. A steady-state aeroengine model was implemented in GSP and compared with experimental operating points. The selected flight data was then used as input for the transient engine model. The exhaust gas temperature (EGT) and fuel flow were chosen as the two key parameters to validate the model, comparing the numerical predicted values with the experimental ones. The observed difference between the model and the flight data was lower than 3% for both EGT and fuel flow.

The sensitivity of macroscopic mechanical and thermal properties of grey cast iron is computationally investigated for a variety of graphite microstructures over a wide temperature range. In order to represent common graphite microstructures according to DIN EN ISO 945-1, a synthetic approach is used to algorithmically generate simulation domains. The developed mechanical and thermal model is applied in a large simulation study. The study includes statistical volume elements of the graphite microstructures classes GG-15 and IA2 to IA5, with 10 v.-%, 11 v.-% and 12 v.-% graphite, respectively, for a temperature range from 20 °C to 750 °C. Homogenized macroscopic quantities such as the Young's moduli, Poisson's ratios, yield strengths and thermal conductivities are predicted for the different microstructure classes by applying simulation and data analysis tools of the research data infrastructure Kadi4Mat.

The aerospace industry develops prognosis and health management algorithms to ensure better safety on board. Particularly for in-flight controls where jamming is dreaded. For that, vibration signals are monitored to predict future defect occurrences. However, time series are not labeled according to severity level, and the user can only assess the system health from the data mining procedure. To that extent, we developed a clustering algorithm using a deep neural network core. We encoded the time series into pictures to be feed into an artificially trained neural network: U-NET. From the segmented output, one-dimensional information on cluster frontiers is extracted and filtered without any parameter selection. Then, a kernel density estimation finally transforms the signal into an empirical density. Ultimately, a Gaussian mixture model extracts the latter independent components. The method empowered us to reveal different degrees of severity faults in the studied data, with their respective likelihood without prior knowledge. We compared it to state-of-the-art machine learning algorithms. However, internal clustering results evaluation for time series is an open question. As state-of-the-art indexes were not producing relevant results, we built a new indicator to fulfill this task. We applied the whole method to an actuator consisting of an induction machine linked to a ball screw. This study lays the groundwork for future training of diagnosis and prognosis structures in the health management framework.

Geomagnetic induced current (GIC) is a ground end manifestation associated with the space weather perturbations that should be greatly taken into account by the society. Although the GICs implication to the power system is not regular, it can cause large scale of system failure. In equatorial, the power system is considered safe since the most intense of geomagnetic storm happened in high latitude. However, the internal damage due to GICs which finally led to the South African power system failure has totally changed the normal perception. Therefore, a preliminary investigation on the GICs activity in equatorial region is performed to understand the space weather impact to the power system. Time derivative of the horizontal magnetic field component (dB/dt) is done to indicate the GICs activity value based on Faraday’s law. All the reported power failures are compiled to produce the threshold value of dB/dt, which possibly cause the harmful effect to the system. Then, dB/dt analysis is extended to show the pattern of GICs activity in function of magnetic latitude and local time. The results reveal that power network in equatorial region has possibly suffered by GIC. Plus, high number of intense GIC activity in this region occurred during dayside.

How can neuroscience help everyone to live and care for our confined brains? Understanding and studying human behaviour allows us to measure the impact of such confinement on each of us and to identify those who need help. The challenges are to understand the psychological repercussions following confinement and to understand how neuroscience and neurotechnology can be very interesting tools for dealing with the health crisis. Neuroscience is changing our traditional philosophical and ethical views by providing information about the biological basis of our moral behaviour. The exception of the brain is at the heart of neuroethical thinking and discourse. Neuroethics is an interdisciplinary discipline placed at the intersection between the human sciences and the neurosciences, and aims to help understand how knowledge and research in neurosciences and neurotechnologies will affect the future of society, their impact on humans, relationships, daily life, the labour market ... but also how they can help and provide solutions and answers to the questions of citizens in a health crisis. But it's a double-edged sword, collecting and analyzing brain data in real time seems to be increasingly simple and within everyone's reach, without having the hindsight of the real meaning of these data, allowing one day to read people's thoughts, control them and manipulate them. It is becoming clear that the boundaries between medical and non-medical uses of neuroscience and neurotechnology are becoming very porous, inviting us to reflect on neuroethical issues in order to put safeguards on these uses.

In scenarios such as natural disasters and military strike, it is common for unmanned aerial vehicles (UAVs) to form groups to execute reconnaissance and surveillance. To ensure the effectiveness of UAV communications, repeated resource acquisition issues and transmission mechanism design need to be addressed urgently. In this paper, we build an information interaction scenario in a Flying Ad-hoc network (FANET). The data transmission problem with the goal of throughput maximization is modeled as a coalition game framework. Then, a novel mechanism of coalition selection and data transmission based on group-buying is investigated. Since large-scale UAVs will generate high transmission overhead due to the overlapping resource requirements, we propose a resource allocation optimization method based on distributed data content. Comparing existing works, a data transmission and coalition formation mechanism is designed. Then the system model is classified into graph game and coalition formation game. Through the design of the utility function, we prove that both games have stable solutions. We also prove the convergence of the proposed approach with coalition order and Pareto order. Binary log-linear learning based coalition selection algorithm (BLL-CSA) is proposed to explore the stable coalition partition of system model. Simulation results show that the proposed data transmission and coalition formation mechanism can achieve higher data throughput than the other contrast algorithms.

We examine how observations can be used to evaluate an air quality analysis by verifying against passive observations (i.e. cross-validation) that are not used to create the analysis and we compare these verifications to those made against the same set of (active) observations that were used to generate the analysis. The results show that both active and passive observations can be used to evaluate of first moment metrics (e.g. bias) but only passive observations are useful to evaluate second moment metrics such as variance of observed-minus-analysis and correlation between observations and analysis. We derive a set of diagnostics based on passive observation–minus-analysis residuals and we show that the true analysis error variance can be estimated, without relying on any statistical optimality assumption. This diagnostic is used to obtain near optimal analyses that are then used to evaluate the analysis error using several different methods. We compare the estimates according to the method of Hollingsworth Lonnberg, Desroziers, a diagnostic we introduce, and the perceived analysis error computed from the analysis scheme, to conclude that as long as the analysis is optimal, all estimates agrees within a certain error margin. The analysis error variance at passive observation sites is also obtained.

Gender recognition is trivial for physiotherapist, but it is considered a challenge for computers. The electromyography (EMG) and heart rate variability (HRV) were utilized in this work for gender recognition during the stepping exercise using a stepper. The relevant features were extracted and selected. The selected features were then fused to automatically predict gender recognition. However, the feature selection for gender classification became a challenge to ensure better accuracy. Thus, in this paper, a feature selection approach based on both the performance and the diversity between the two features from the rank-score characteristic (RSC) function in a combinatorial fusion approach (CFA) was employed. Then, the features from the selected feature sets were fused using a CFA. The results were then compared with other fusion techniques such as naive bayes (NB), decision tree (J48), k-nearest neighbor (KNN) and support vector machine (SMO). Besides, the results were also compared with previous researches in gender recognition. The experimental results showed that the CFA was efficient for feature selection. The fusion method was also able to improve the accuracy of the gender recognition rate. The CFA provides much better gender classification results which is 94.51% compared to Nazarloo's work (90.34%) and other classifiers.