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Preprint ARTICLE | doi:10.20944/preprints202105.0525.v1

Food Enrichment with Glycyrrhiza Glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats – Possible Implications for COVID-19

Daniela Jezova, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Harald Murck

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; glycyrrhizin; mineralocorticoid receptor; toll like receptor 4; angiotensin converting enzyme; aldosterone

Online: 21 May 2021 (15:11:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0184.v1

Building Smart and Resilient Urban Futures by Setting a Mission for Sustainability in the Post COVID-19 Era

Christina Kakderi, Eleni Oikonomaki, Ilektra Papadaki

Subject: Business, Economics And Management, Accounting And Taxation Keywords: urban planning; COVID-19; urban mobility; sustainability; smart cities; smart growth; pandemic; resilience

Online: 10 May 2021 (12:31:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0024.v1

COVID-19 Crisis Management and Cost Estimation Models: Bureaucratic Government Coaction Vs. Spontaneous Social Coordination

Jesús Huerta de Soto, Philipp Bagus, Antonio Sánchez-Bayón

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Decision Making; Cost Estimation; COVID-19 Crisis; Health Economics; Wellbeing Economics; Political Economy

Online: 4 May 2021 (15:27:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0530.v1

ISIDOG Consensus Guidelines on Covid-19 Vaccination for Women before, during and after Pregnancy

Gilbert Gerard Ghislain Donders, Svitrigaile Grinceviciene, Kai Haldre, Risa Lonnee-Hofmann, Francesca Donders, Aristotelis Tsiakalos, Albert Adriaanse, Jose Martinez de Oliveira, Kevin Ault, Werner Mendling

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: vaccine, pregnancy complication, SARS-CoV-2, COVID-19, maternal complications, pandemic, prevention, safety

Online: 20 April 2021 (11:22:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202104.0398.v1

A Two-Stage Polynomial and Nonlinear Growth Approach for Modeling the COVID-19 Outbreak in Mexico

Rafael Perez Abreu, Samantha Estrada, Héctor de-la-Torre-Gutiérrez

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: COVID-19; epidemic modeling; time series forecasting; nonlinear growth models; Prais-Winsten estimation

Online: 15 April 2021 (07:44:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0383.v1

Future of Construction Industry: COVID-19 and Its Implications on Construction Projects and Risk Management – A Review

Kushal Adhikari, Lochana Poudyal

Subject: Engineering, Automotive Engineering Keywords: COVID-19; pandemic; construction project; risk management; use of technology; recovery and resilience

Online: 14 April 2021 (14:12:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0369.v1

A Blockchain Use Case in Cold Chain to Minimize the Risk of COVID-19 Infection

Adnan Iftekhar, Xiaohui Cui

Subject: Social Sciences, Safety Research Keywords: Cold supply chain; Meat Supply Chain; Food Safety; COVID-19; Blockchain; Hyperledger Fabric

Online: 14 April 2021 (12:18:24 CEST)

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Working Paper ARTICLE

A Comparison of the Level of Acceptance and Hesitancy towards the Influenza Vaccine and the Forthcoming COVID-19 Vaccine in the Medical Community

Magdalena Grochowska, Aleksandra Ratajczak, Gabriela Zdunek, Aleksander Adamiec, Paweł Waszkiewicz, Wojciech Feleszko

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccine; vaccine hesitancy; Healthcare Workers; Flu vaccine; Influenza; SARS-CoV-2

Online: 12 April 2021 (12:33:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0193.v2

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

Ralf Duerr, Keaton M. Crosse, Ana Mayela Valero Jimenez, Meike Dittmann

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; HIV; zoonotic viruses; COVID-19 and AIDS pandemics; viral entry

Online: 8 April 2021 (10:51:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0132.v1

Analyzing the Factors Affecting the COVID-19 Risk Level in the US Counties

Samira Ziyadidegan, Moein Razavi, Homa Pesarakli, Amir Hossein Javid

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: multinomial logistic regression; K-means clustering; COVID-19; SARS-CoV-2; meteorological variables

Online: 5 April 2021 (12:49:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0008.v1

Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections–A Systematic Review and Meta-Analysis

Min Xian Wang, Sylvia Xiao Wei Gwee, Junxiong Pang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: micronutrients supplementation; micronutrients deficiency; prevention and treatment; novel coronavirus; COVID-19; SARS; MERS

Online: 1 April 2021 (10:21:32 CEST)

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Preprint ESSAY | doi:10.20944/preprints202009.0225.v2

Are Health Innovations Techno-economic or Social Values in a period of a Health Crisis? A Reflection on the Field of Public Health through the Examples of Ebola and Covid-19

Marietou Niang, Sophie Dupéré, Hassane Alami, Marie-Pierre Gagnon

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: health innovation; technological innovation; social innovation; public health; global health; Ebola; Covid-19

Online: 30 March 2021 (10:29:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0710.v1

Increased Angiotensin-Converting Enzyme 2, sRAGE and iMmune Activation, but Lowered Calcium and Magnesium In COVID-19: Association With Chest CT Abnormalities and Lowered Peripheral Oxygen Saturation

Hussein Al-Hakeim, Hawraa Al-Jassas, Gerwyn Morris, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; sRAGE; ACE2; inflammation; immune; oxidative stress; IL-6; IL-10; biomarkers

Online: 29 March 2021 (17:03:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0396.v1

Machine Learning on the COVID-19 Pandemic, Human Mobility, and Air Quality: A Review

Md Mokhlesur Rahman, Kamal Chandra Paul, Md. Amjad Hossain, G. G. Md. Nawaz Ali, Md. Shahinoor Rahman, Jean-Claude Thill

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: COVID-19; Coronavirus; Pandemic; Machine Learning; Public Health; Human Mobility; Air Quality; Review

Online: 15 March 2021 (14:50:24 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202103.0192.v1

Radial Extracorporeal Shock Wave Therapy to Support Breathing in Case of Coronavirus Disease 2019 (COVID-19): A Case Report

Peter Stiller, Christoph Schmitz

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; shortness of breath; chest pain; radial extracorporeal shock wave therapy; rESWT

Online: 5 March 2021 (17:02:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0089.v1

Gender and Socio-Economic Issues in the Clinical Assessment of Orthopaedic Patients During the COVID-19 Pandemic

Lorenzo Moretti, Davide Bizzoca, Elsa Vitale, Michelangelo Delmedico, Antonio Spinarelli, Flavio Azzola, Giuseppe Solarino, Biagio Moretti

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Covid-19 perception; general well-being; orthopaedic patients; gender; pandemic; socio-economic issues.

Online: 2 March 2021 (12:34:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0194.v1

From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers During the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study

Sofia Pappa, Nikolaos Athanasiou, Nikolaos Sakkas, Stavros Patrinos, Elpitha Sakka, Zafeiria Barmparessou, Stamatoula Tsikrika, Andreas Adraktas, Athanasia Pataka, Ilias Migdalis, Sofia Gida, Paraskevi Katsaounou

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; health care workers; Greece; mental health; depression; anxiety; traumatic stress; burnout

Online: 8 February 2021 (11:41:59 CET)

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Working Paper ARTICLE

Twitter as a Tool for Citizen Education and Sustainable Cities after COVID-19

David Caldevilla-Domínguez, Almudena Barrientos-Báez, Graciela Padilla-Castillo

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Covid-19; Twitter; sustainable cities; sustainable citizenship; environmental awareness; responsible consumption; sustainable tourism

Online: 5 February 2021 (22:15:27 CET)

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Working Paper REVIEW

A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry

Adrián Pedreira, Yeşim Taşkın, Míriam R. García

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SARS-CoV-2; COVID-19 pandemic; food industry; disinfection trade-offs; one-health

Online: 15 December 2020 (12:58:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0176.v1

Why Appreciation of Pulmonary Vitamin D Metabolism Should Temper Expectations for Vitamin D Supplementation to Reduce Disease Severity and Improve Clinical Outcome of COVID-19

Rob Janssen, Jona Walk, Jody M.W. van den Ouweland

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Vitamin D; COVID-19; SARS-CoV-2; endothelialithis; CYP27B1; vitamin D receptor; CYP24A1

Online: 7 December 2020 (19:43:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0613.v3

Review of Infective Dose, Routes of Transmission, and Outcome of COVID-19 Caused by the SARS-CoV-2 Virus: Comparison with Other Respiratory Viruses

Sedighe Karimzadeh, Raj Bhopal, Huy Nguyen Tien

Subject: Biology And Life Sciences, Virology Keywords: infective dose; SARS-CoV-2; COVID-19; respiratory viruses; viral load; viral dynamics

Online: 7 December 2020 (11:36:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0099.v1

The Safety and Security Measures of the Selected Universities in Nueva Ecija, Philippines: Its Combat to COVID–19 Pandemic

Jennilyn C. Mina, Januaryn Jose B. Aydinan, Romeo B. Campos, Shirley P. Aye-eo

Subject: Social Sciences, Safety Research Keywords: COVID–19; combat; Inter–Agency Task Force (IATF); pandemic; safety and security; university

Online: 4 December 2020 (11:09:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0097.v1

Therapeutic potential of mesenchymal stem/stromal cells-derived exosomes in acute respiratory distress syndrome and COVID-19

Yueyuan Zhou, Yusuke Yamamoto, Zhongdang Xiao, Takahiro Ochiya

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: acute respiratory distress syndrome; mesenchymal stem/stromal cells,; exosome; COVID-19; Clinical trials

Online: 4 December 2020 (10:10:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0065.v1

A Pre-aggregation Fuzzy Collaborative Intelligence-based Fuzzy Analytic Hierarchy Process Approach for Selecting Alternative Suppliers amid the COVID-19 Pandemic

Toly Chen, Hsin-Chieh Wu

Subject: Social Sciences, Decision Sciences Keywords: group decision-making; fuzzy analytic hierarchy process; consensus; wafer foundry; COVID-19 pandemic

Online: 2 December 2020 (14:10:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0038.v1

Sociodemographic Predictors of Changes in Physical Activity, Screen Time, and Sleep Among Toddlers and Pre-Schoolers in Chile During the COVID-19 Pandemic

Nicolas Aguilar-Farias, Marcelo Toledo-Vargas, Sebastian Miranda-Marquez, Andrea Cortinez-O'Ryan, Carlos Cristi-Montero, Fernando Rodriguez-Rodriguez, Pia Martino-Fuentealba, Anthony D. Okely, Borja del Pozo Cruz

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: physical activity; sedentary behaviour; sleep; active play; outdoor time; movement behaviours; COVID-19

Online: 1 December 2020 (16:08:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0021.v1

Predicting Trends of Coronavirus Disease (COVID19) Using SIRD and Gaussian-SIRD Models

Ahmad Sedaghat, Amir Mosavi

Subject: Computer Science And Mathematics, Analysis Keywords: Coronavirus disease; COVID-19; outbreak model; Gaussian-SIRD model; SIRD model; epidemiological model

Online: 1 December 2020 (13:11:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0375.v1

COVID-Well: Evaluation of the Implementation of Supported Wellbeing Centres for Hospital Employees During the COVID-19 Pandemic

Holly Blake, Mehmet Yildirim, Ben Wood, Steph Knowles, Helen Mancini, Emma Coyne, Joanne Cooper

Subject: Social Sciences, Psychology Keywords: COVID-19; pandemic; healthcare workers; psychological wellbeing; mental health; wobble rooms; wellbeing centres

Online: 13 November 2020 (12:35:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0690.v1

Personnel Well-being in the Helsinki University Hospital During the COVID-19 Pandemic – A Prospective Cohort Study

Henna Haravuori, Kristiina Junttila, Toni Haapa, Katinka Tuisku, Anne Kujala, Tom Rosenström, Jaana Suvisaari, Eero Pukkala, Tanja Laukkala, Pekka Jylha

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 Pandemic; Finland; health care personnel; psychological distress; post-traumatic stress disorder

Online: 28 September 2020 (15:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0486.v1

A Meta-analysis of Comorbidities in COVID-19: Which Diseases increase the Susceptibility of SARS-CoV-2 Infection?

Srinivasan Ramachandran, Manoj Kumar Singh, Ahmed Mobeen, Amit Chandra, Sweta Joshi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; comorbidity; SARS-CoV-2; leukemia; NAFLD; psoriasis; cancer; type II diabetes

Online: 21 September 2020 (03:32:58 CEST)

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Background: Comorbidities have been frequently reported in COVID-19 patients, which often lead to more severe outcomes. The underlying molecular mechanisms behind these clinical observations have not yet been explained. Herein, we investigated the disease-specific gene expression signatures that may induce susceptibility to SARS-CoV-2 infection. Methods: We studied 30 frequently occurring acute, chronic, or infectious diseases of recent times that have shown comorbidity in one or another respiratory disease(s) caused by pathogenic human infecting coronaviruses, especially SARS-CoV-2. We retrieved array-based gene expression data for each disease and control from relevant datasets. Subsequently, all the datasets were quantile normalized, and log-2 transformed data was used for analysis. Results The expression of ACE2 receptor and host proteases, namely FURIN and TMPRSS2 that are essential for cellular entry of SARS-CoV-2, was upregulated in all six studied subtypes of leukemia (hereafter, referred as leukemia). The expression of ACE2 was also increased in psoriasis, lung cancer, Non-alcoholic fatty liver disease (NAFLD), breast cancer, and pulmonary arterial hypertension patients. The expression of FURIN was higher in psoriasis, NAFLD, lung cancer, and in type II diabetic liver, whereas it was lowered in breast cancer. Similarly, the expression of TMPRSS2 was increased during lung cancer and type II diabetes; it was decreased during psoriasis, NAFLD, lung cancer, breast cancer, and cervical cancer.Furthermore, a heightened expression of genes that are involved in immune response was observed in leukemia patients, as shown by the higher expression of IFNA2, IFNA8, IFNA10, IFNA14, IFNA16, IFNA21, IFNB1, CXCL10, and IL6. The expression of JAK1, STAT1, IL6, and CXCL10 was higher in NAFLD. Besides, JAK1 and STAT1 were upregulated in type II diabetic muscles. In addition, most of the upregulated genes in COVID-19 patients showed a similar trend in leukemia, NAFLD, and psoriasis. Furthermore, SARS-CoV-2, SARS-CoV and MERS CoV, were found to commonly alter two genes, namely, CARBONIC ANHYDRASE 11 and CLUSTERIN.Conclusions: The genes that may confer susceptibility to SARS-CoV-2 infection are mostly upregulated in leukemia patients; hence, leukemia patients are relatively more susceptible to develop COVID-19, followed by other chronic disorders, such as, NAFLD, type II diabetes, psoriasis, and hypertension. This study identifies key genes that are altered in the studied diseases types, which may aid in the infection of SARS-CoV-2 and underlie COVID-19 associated comorbidities.

Preprint ARTICLE | doi:10.20944/preprints202008.0695.v1

Intention of Tourism Practitioners to Behave Actively Prevent COVID-19 in Zhangjiajie

Hongjiu Tang, Zhaoyin Liu

Subject: Social Sciences, Geography, Planning And Development Keywords: Tourism livelihood income; prevent COVID-19; protective intention; merged model; local tourism practitioners

Online: 31 August 2020 (04:37:04 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202008.0648.v1

Downward Trend in the Indices of Death Rate in the COVID-19 Pandemic: Evaluating Alternative Hypotheses

Milind Watve, Sonali Shinde, Pratima Ranade

Subject: Biology And Life Sciences, Virology Keywords: Covid-19; case fatality rate; infection fatality rate; evolution of virulence; evolutionary medicine

Online: 30 August 2020 (10:26:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0408.v1

Assessment of the Presence of Symptoms, Individual Protection Measures (IPM) and Suspect Screening Measures (SSM) of COVID-19 in Federal Police Officers from a Regional Police Station in Brazil

Jefferson Aparecido Dias, Eduardo Federighi Baisi Chagas, Cláudia Rucco Penteado Detregiachi, Fernanda Mesquita Serva, Piero Biteli, Claudemir Gregório Mendes, Elídia Fabiana de Souza Xavier, Carlos Francisco Bitencourt Jorge, Tereza Lais Menegucci Zutin, Mateus Cezar dos Santos, Daniela Vieira Buchaim, Rogério Leone Buchaim

Subject: Biology And Life Sciences, Virology Keywords: covid-19 antibody; coronavirus; immunoglobulin; police officer; quality of life; SARS-CoV-2

Online: 19 August 2020 (09:55:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0312.v1

Virion Structure and Mechanism of Propagation of Coronaviruses including SARS-CoV 2 (COVID -19 ) and some Meaningful Points for Drug or Vaccine Development

Swapan Ghosh

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2(COVID-19); + ssRNA; ribosomal – framshift; Pseudoknot; replication; model; drug; vaccine

Online: 14 August 2020 (08:26:31 CEST)

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SARS-CoV-2 or COVID-19, a new seventh human corona virus, has out-broken in Wuhan, China since 31^st December 2019, and quickly escalated to take the form of pandemic which killed many human beings throughout almost all countries across continents. The rapidity of its transmission from human to human is far greater than all previous human corona viruses which came into existence like SARS-CoV, MERS-CoV, etc. The nucleotide sequence of SARS-CoV-2 (isolates Wuhan-Hu-1) is 29,875 bp in ss-RNA. Symptoms of SARS-CoV-2 infected pneumonia include from asymptomatic to high fever and/or respiratory illnesses. Coronavirus virion (spherical/round /elliptical in shape) consists of three parts- outer membrane or envelope, nucleocapsid and genome (RNA). SARS-CoV-2 was shown to use receptor, angiotensin converting enzyme 2 (ACE2) for attachment to the cells through its surface spike (S) protein (S1), and the virion enters into the host cell through two routes- direct membrane fusion and endocytotic pathway. The RNA of SARS-CoV acts directly as mRNA and here minus(-) 1 programmed ribosomal frameshift (-1PRF) is being operated by slippery sequence and pseudoknot, so it translates 16 nonstructural proteins including RNA dependent RNA replicase. Then genomic RNA replicated continuously on – strand RNA template and subgenomic RNA transcribed discontinuously on –RNA template to sgmRNA. Subgenomic RNAs/sgmRNAs synthesize all structural proteins. This article takes into consideration the details of established theories of viral structure, viral attachment, mode of entry into human cells, different models of replication and transcription of virus genome proposed by eminent scientists over the years, and makes an in depth examination highlighting meaningful points or important target cites of viral propagation or synthesis, which are conserved, for prompt development of potent drugs or vaccine to counter COVID-19 for which human race is anxiously and eagerly waiting.

Preprint REVIEW | doi:10.20944/preprints202008.0166.v1

Antibody Response and Therapy in COVID-19 Patients: Significance in Vaccine Development

Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, You-Wen He

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19, seroconversion, neutralizing antibody, spike protein, SARS-CoV-2, convalescent plasma, vaccine

Online: 6 August 2020 (12:16:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0163.v1

Is There a Relationship Between Climate, Morphology and Urbanization and COVID19? Preliminary Analysis of Environmental and Pandemic Data in the Lombardy Region (Northern Italy)

Massimiliano Fazzini, Claudio Bna, Alessandro Cecili, Andrea Giuliacci, Sonia Illuminati, Fabrizio Pregliasco, Claudia Baresi, Enrico Miccadei

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Coronavirus disease 2019 (COVID-19), temperate sub-continental climate, Lombardy, temperature, solar radiation

Online: 6 August 2020 (11:39:41 CEST)

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The coronavirus disease 2019 (COVID-19) pandemic is the defining global health and socioeconomic crisis of our time and represents the greatest challenge faced by the world since the end of the Second World War. The academic literature indicates that climatic features, specifically the temperature and absolute humidity, are very important factors affecting infectious pulmonary disease epidemics (e.g., SARS, MERS); however, the influence of climatic parameters on COVID-19 remains extremely controversial. The goal of this study is to quantify the existing relationship between several daily climate parameters (temperature, relative humidity, accumulated precipitation, solar radiation, wind direction and intensity, and evaporation), local morphological parameters, and new daily positive swabs for COVID-19, which represents the only parameter that can be statistically used to quantify the pandemic. The daily deaths parameter was not considered because it is not reliable due to frequent administrative errors. Daily data on meteorological conditions and new cases of COVID-19 were collected for the Lombardy area from March 1, 2020, to April 20, 2020. This region in Italy exhibited the largest number of official deaths in the world per million inhabitants, with a value of approximately 1700 per million on june 30, 2020. Moreover, the apparent lethality was approximately 17% in this area, mainly due to the considerable housing density and the extensive presence of industrial and craft areas. The Mann-Kendall test and multivariate statistical analysis showed that none of the considered climatic variables exhibited statistically significant relationships with the epidemiological evolution of COVID-19, at least in the spring months in temperate subcontinental climate areas, with the exception of solar radiation, which was directly related and showed an otherwise low explained variability of approximately 20%. Furthermore, the average temperatures of two highly representative meteorological stations of Molise and Lucania, the most weakly affected by the pandemic. The temperatures at these stations were approximately 1.5°C lower than that in the cities in Lombardy of Bergamo and Brescia, again confirming that a significant relationship between the increase in temperature and decrease in virology from COVID-19 was not evident, at least in the Italian peninsula.

Preprint ARTICLE | doi:10.20944/preprints202008.0059.v1

Design and Performance Investigation of a Low Cost Portable Ventilator for COVID-19 Patients

Mustefa Jibril, Messay Tadese, Nuriye Hassen

Subject: Engineering, Control And Systems Engineering Keywords: Ventilator; COVID-19; DC motor; Proportional Integral Derivative; Full State Feedback H2 controller

Online: 3 August 2020 (00:41:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0664.v1

Assessment of the Psychological Impact and Perceived Stress Due to COVID-19 Lockdown in Young Adult Population of India.

Sreelakshmi M, Irfanul Haque, Sarita Jangra Bhyan, Ankit Gaur, Aashi Jain, Amrita Kumari, Besty Thomas, Nancy Goel, Rashi Chauhan

Subject: Social Sciences, Psychology Keywords: COVID-19 lockdown; psychological impact; perceived stresses-R scale; PSS scale; young adults

Online: 28 July 2020 (04:39:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0591.v1

A CNN Classification Model For Diagnosis Covid19

Ahmed Abdullah Farid, hatem khater, gamal selim

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Bacterial -Viral Pneumonia; COVID-19; X-ray Image; Deep Learning; Convolution Neural Network

Online: 24 July 2020 (14:02:07 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0488.v1

D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV

Babu Bassa, Brown Olen

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV; SARS-CoV; COVID-19; Sarbecovirus; D614G; Spike glycoprotein; Coronavirus; Alignment-free

Online: 21 July 2020 (12:47:13 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202007.0341.v1

The Appropriateness of Invasive Ventilation in COVID-19 Positive Cancer Patients: The Hardest Decision for Oncologists

Michele Ghidini, Alice Indini, Erika Rijavec, Claudia Bareggi, Monica Cattaneo, Barbara Galassi, Donatella Gambini, Francesco Grossi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19; invasive ventilation; cancer; ICU; ONCOVID-ICU; Milano Policlinico; SOFA score; ARDS

Online: 16 July 2020 (04:17:32 CEST)

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Working Paper ARTICLE

Epidemic Dynamics and Clinical Features of COVID-19 and Government Measures to Control Disease Transmission in Southern Hainan Island, China

Bei Wang, Qin-Yi Chen, Sen Lin, Hua Zhang, Chang-Feng Lin, Zhi-Yong Liu, Zhi-Quan Wu, Juan Chen, Dong Liang, Yan-Tao Liu, Ya-Yun Tan, Chong-Hao Xing, Da-Ying YangYang, Min-Jie Gao, Ri-Xia Lin, Ling Lin

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2; epidemic dynamics; disease control; clinical features; tropical area

Online: 8 July 2020 (12:30:52 CEST)

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Objective: The objective of this study is to determine the epidemic dynamics and clinical features of COVID-19 in southern Hainan Island, China, and provide experience for other tropical areas of the world. Methods: This retrospective study included confirmed cases of COVID-19 in southern Hainan. All enrolled patients were treated in Sanya, and data on epidemiological and clinical features of the disease and infection prevention and control measures adopted by the local government during the epidemic were collected. Results: Of the 74 cases, 71 (95.95%) were imported from Wuhan, Hubei Province (47, 63.51%), other cities in Hubei Province (11, 14.86%), or provinces other than Hubei and Hainan (13, 17.57%). Three (4.06%) patients were infected in southern Hainan, including one autochthonous case in Sanya. Fifty-four cases (72.97%) were detected in Sanya, and 27 cases (27.03%) were diagnosed in other cities. The rate of severe or critical cases was 28.38% (21/74), and mortality was 2.7% (2/74). The serum lactate levels and base excess of severe-critical patients were higher than those of patients with mild-moderate disease. Multivariate logistic regression analysis showed that chronic conditions were risk factors for severe and critical COVID-19. Seventy-four patients were diagnosed with COVID-19 over a 22-day period in Sanya, and the epidemic period in the city was 48 days. The outbreak was controlled rapidly because the local government adopted strict infection prevention and control measures. Conclusions: The clinical characteristics of COVID-19 in Hainan Island were similar to those reported in other regions. In Sanya, the rate of severe and very severe cases was higher than in other regions; however, most cases were imported, and there was only one autochthonous case. The rapid control of the outbreak in Sanya may be related to the tropical climate, adoption of strict infection prevention and control measures, daily reporting of new cases, increased public awareness about the epidemic, and other emergency actions implemented by the local government.

Preprint ARTICLE | doi:10.20944/preprints202007.0054.v1

Factors Associated with Perception of Risk and Knowledge of Contracting the Novel COVID-19 among Adults in Bangladesh: Analysis of Online Surveys

Tanvir Abir, Nazmul Ahsan Kalimullah, Uchechukwu Levi Osuagwu, Dewan Muhammad Nur -A Yazdani, Abdullah Al Mamun, Taha Husain, Palash Basak, P. Yukthamarani Permarupan, Kingsley Agho

Subject: Social Sciences, Cognitive Science Keywords: COVID-19; Knowledge; Perception of Risk; Pandemic Outbreak; Disease Control; Cross-sectional Study

Online: 5 July 2020 (08:10:36 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202006.0325.v1

National Health-GIS Portal-A Conceptual Framework for Effective Epidemic Management and Control in India

Vikram Ranga, Padmini Pani, Shruti Kanga, Gowhar Meraj, Majid Farooq, M. S. Nathawat, Suraj Kumar Singh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: GIS; health Infrastructure; National Portal; COVID-19; Hot-Spot mapping; Accessibility to services

Online: 28 June 2020 (09:00:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0216.v2

Detection and Survival of SARS-coronavirus in Human Stool, Urine, Wastewater and Sludge

Andrew Singer, Rachel Wray

Subject: Biology And Life Sciences, Virology Keywords: SARS-coronavirus; Severe Acute Respiratory Syndrome; COVID-19; Stool; Urine; Wastewater; Wastewater-based epidemiology

Online: 18 June 2020 (09:29:00 CEST)

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Working Paper ARTICLE

COVID19 Detection from Radiographs: Is Deep Learning Able to Handle the Crisis?

Muhammad Saqib, Saeed Anwar, Abbas Anwar, Lars Petersson, Nabin Sharma, Michael Blumenstein

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: COVID-19; Deep learning; Convolutional neural network; Computed Tomography; X-Rays; Classification; Detection

Online: 14 June 2020 (17:51:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0143.v1

Assessing Impacts of COVID-19 on Aquatic Food System and Small-Scale Fisheries in Bangladesh

Atiqur Rahman Sunny, Sharif Ahmed Sazzad, Gopal Chandra Datta, Ashoke Kumar Sarker, Md. Ashrafuzzaman, Shamsul H. Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: COVID-19; Corona virus; Aquatic food system; Food security; Small-scale fisheries; Bangladesh

Online: 12 June 2020 (08:25:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0103.v1

Cytokine Release Syndrome-Associated Encephalopathy in Patients with COVID-19

Peggy Perrin, Nicolas Collongues, Seyyid Baloglu, Dimitri Bedo, Xavier Bassand, Thomas Lavaux, Gabriela Gautier, Nicolas Keller, Stephane Kremer, Samira Fafi-Kremer, Bruno Moulin, Ilies Benotmane, Sophie Caillard

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: clinical medecine; physiopathology; COVID-19; neurological manifestations; kidney disease; cytokine; corticosteroids; intravenous immunoglobulins

Online: 7 June 2020 (15:50:37 CEST)

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Working Paper BRIEF REPORT

Is H34 of ACE2 an indicator of the susceptibility to SARS-CoV-2? Clues from multi-species sequence analyses

Jianghai Lin, Fengjuan Lyu, Wenjuan Xiao, Yuan Xu, Zehuan Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; Angiotensin-converting enzyme 2; susceptibility; livestock; aquatic mammals

Online: 7 June 2020 (08:18:54 CEST)

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Working Paper ARTICLE

Public Perceptions and Commitment to Social Distancing during COVID-19 Pandemic: A National Survey in Saudi Arabia

Abdu Aldarhami, Abdulrhman S. Bazaid, Omar W. Althomali, Naif K. Binsaleh

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: COVID-19; SARS-CoV2; Public AwareneSs; Public Practice; Social Distancing and Saudi Arabia

Online: 31 May 2020 (21:27:01 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0480.v1

SARS-CoV2 at the Alveolar Epithelial-Endothelial Interface – A Hypothesis for the Pathogenesis of COVID-19

Alejandro Acosta Saltos, Francia Carolina Acosta Saltos

Subject: Biology And Life Sciences, Virology Keywords: endothelial; infection; basement membrane; fibroblast; fibrosis; nsp7; hypothesis; pathogenesis; COVID-19; SARS-CoV2

Online: 31 May 2020 (16:28:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0403.v1

Environmental Impact of Corona Virus (COVID-19) and Nationwide Lockdown in India: An Alarm to Future Lockdown Strategies

Suresh Kumar, Shishir Bhardwaj, Akash Singh, Hemant K. Singh, Puneet Singh, Uzzwal K. Sharma

Subject: Environmental And Earth Sciences, Environmental Science Keywords: zoonotic; corona virus; COVID-19; SARS; MERS; global health emergency; India; lockdown strategies

Online: 24 May 2020 (19:34:03 CEST)

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Global emerge of zoonotic novel corona virus (COVID-19) became a pandemic and its effect to mankind is talk of the town now a days. This tiny, invisible enemy has affected every country in the world and almost every living directly or indirectly and nationwide complete lockdown has triggered a short-term environmental impact. Since 2003, corona virus came into existence in the form of Severe Acute Respiratory Syndrome (SARS) and more evolved Middle East Respiratory Syndrome (MERS) in 2012. This time, at the end of December 2019, outbreak of novel corona virus COVID-19 (also known as SARS-CoV₂, nCoV-2019) draw attention as global health emergency. World Health Organization (WHO) report says that the outbreak of this virus is so immense, it has already affected 35,57,235 people and caused death to 2,45,150 people worldwide and 46,433 Indians got affected with 1568 death as on 5^th May 2020 (2:00 am) and these numbers are increasing exponentially day by day. Virologist, micro-biologist and science community are hammering their head very hard to find out cure and vaccine against this powerful virus and to prevent mass demise of mankind. In order to curb the spread of COVID-19, Janta curfew on 22.03.2020 and nationwide complete lockdown was implemented in India for 21 days (phase-I, from 25.03.2020 to 14.04.2020) to stop community transmission of third stage, for 19 days (phase-II, 15.04.2020 to 03.05.2020) and 14 days (phase-III, 04.05.2020 to 17.05.2020) complete lockdown to minimize the community transmission effect. During complete lockdown and quarantine period a drastic change in Earth’s atmosphere, including reduction in emission of greenhouse gases, air pollution (~50% fall in air quality index), noise pollution, water pollution and solid waste pollution, have been recorded by government agencies as well as private agencies. In this paper we considered data of Janta curfew, phase-I and phase-II lockdown to link between geological and environmental aspect related to environmental impact due to emerge of COVID-19 and massive reduction in pollution level during complete lockdown in India. We propose future lockdown strategies to minimize the emission of greenhouse gas by ~100 Mt to ~200Mt (3.33% to 6.66%) of GHG_total per year by 2-4 days per month nationwide lockdown or ~70 Mt to ~140 Mt (2.33% to 4.66%) of GHG_total per year by 2-4 days per month complete lockdown of energy sectors only.

Preprint ARTICLE | doi:10.20944/preprints202005.0365.v1

Molecular Modelling and Docking Experiments Examining the Interaction between SARS-CoV-2 Spike Glycoprotein and Neuronal Nicotinic Acetylcholine Receptors

Konstantinos Farsalinos, Elias Eliopoulos, Demetres Leonidas, Georgios Papadopoulos, Socrates Tzartos, Konstantinos Poulas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; smoking; nicotine; nicotinic cholinergic system; inflammation; acetylcholine receptors

Online: 23 May 2020 (10:06:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0202.v1

Assessment of the Weekly Fluctuations of the Covid-19 Cases in Italy and Worldwide

Pier Luigi Bragato

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Covid-19 pandemic; weekly fluctuations; delayed recognition of new cases; health system situation

Online: 12 May 2020 (05:23:58 CEST)

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Preprint ESSAY | doi:10.20944/preprints202004.0447.v2

China Neighborhood and Village Committee confront the COVID-19 Pandemic；Cultural History and Tracking back Review of Relevant Public Health Events in Last Century

Huibing Tan, Yunge Jia, Yinhua Li, Wei Hou

Subject: Social Sciences, Sociology Keywords: neighborhood committee; collective responsibility; Baojia system; COVID-19 pandemic; Wu Lien-teh; China

Online: 27 April 2020 (03:07:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0439.v1

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

Umesh Kalathiya, Monikaben Padariya, Marcos Mayordomo, Małgorzata Lisowska, Judith Nicholson, Ashita Singh, Maciej Baginski, Robin Fåhraeus, Neil Carragher, Kathryn Ball, Juergen Haas, Alison Daniels, Ted R. Hupp, Javier Antonio Alfaro

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; spike glycoprotein; variability; molecular docking; molecular dynamics; inhibitors

Online: 24 April 2020 (11:42:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0383.v1

Artificial Intelligence (AI) and Big Data for Coronavirus (COVID-19) Pandemic: A Survey on the State-of-the-Arts

Quoc-Viet Pham, Dinh C. Nguyen, Thien Huynh-The, Won-Joo Hwang, Pubudu N. Pathirana

Subject: Medicine And Pharmacology, Other Keywords: COVID-19; coronavirus pandemic; big data; epidemic outbreak; artificial intelligence (AI); deep learning

Online: 21 April 2020 (09:01:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0334.v1

Molecular Docking and Molecular Dynamic Study of Two Viral Proteins Associated with SARS-CoV-2 with Ivermectin

Lenin Andres Gonzalez Paz, Carla A. Lossada, Luis S. Moncayo, Freddy Romero, J. L. Paz, Joan Vera-Villalobos, Aleivi E. Perez, Ernesto San-Blas, Ysaias J. Alvarado

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: SARS-COV-2; folding/unfolding; antiparasitic; molecular docking; molecular dynamics; COVID-19; Ivermectin

Online: 19 April 2020 (06:56:09 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0290.v1

COVID-19 Pandemic and the Digital Revolution in Academia and Higher Education

Wadim Strielkowski

Subject: Social Sciences, Education Keywords: academia; higher education; coronavirus pandemic; online tuition; social distancing; COVID-19; digital revolution

Online: 17 April 2020 (01:56:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0272.v1

Anosmia and Ageusia as Initial or Unique Symptoms after SARS-COV-2 Virus Infection

Calixto Machado, Joel Victor Gutierrez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2 (CoV-2); COVID-19; coronavirus; pandemic; smell; anosmia; taste; ageusia

Online: 16 April 2020 (12:42:44 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0269.v1

Antibiotics Against COVID-19 and Mitochondria? Urgent Thinking Out of the Box

Jaroslaw Tyszka, Karolina Kobos, Aleksandra Tyszka

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: COVID-19; SARS-CoV-2; pandemic; antibiotics; immune response; mitochondria; epidemiology; health policy

Online: 16 April 2020 (12:14:30 CEST)

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Italian, Spanish, French vs German, Austrian or Norwegian COVID-19 tracks? Antibiotics might have a partial impact on COVID-19 death rates in various countries. Our working hypotheses based on recent publications is that that antibiotics may be a major factor that negatively affects patients’ immune system during viral infections. We are all aware that there is no specific and effective medical treatment for COVID-19 so far. However, we know that our immune system is the only efficient weapon that fights against this syndrome right now. In fact, antibiotics are very often prescribed to prevent secondary infections following an antiviral immune response. Various antibiotic therapies have also been commonly applied to support COVID-19 treatments in China and Italy. Unfortunately, the frequent antibiotic off-site targets include mitochondria that are genetically and evolutionary closely linked to bacteria. Mitochondria are multifunctional organelles responsible for bioenergetics in nearly all our cells, acting as signaling hubs in antiviral and antibacterial immune responses. Several studies have demonstrated that mitochondria are vulnerable to antibacterial treatments, interrupting their physiology. Inhibition of these processes by antibiotics might render the immune system less capable of fighting acute COVID-19 viral infections. Some antibiotics, including those prescribed for COVID-19 in Wuhan, have been shown to inhibit the synthesis of mitochondrial DNA. The question is whether antibiotics support such a treatment or weaken patient immune responses in this case. This hypothesis should be evaluated based on comparative clinical data that seem to be unavailable at the moment. Possibly the COVID-19 risk group should be extended to all patients being treated with antibiotics, including those who finished antibiotic therapies days up to several months before SARS-CoV-2 infection. We therefore urge health service response groups to evaluate the impact of antibiotics on COVID-19 recovery vs death retrospective data. We would like to motivate international, national and local health authorities to share available clinical treatment data, discuss and optimize treatment strategies.

Preprint ARTICLE | doi:10.20944/preprints202004.0266.v1

A Suggestion from South Korea for Treatment of Mild or Asymptomatic COVID-19 Infected Patients: Living and Treatment Support Center

EunKyo Kang

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; mild patients; quarantine facility; video-consultation; living and treatment support center

Online: 16 April 2020 (08:23:06 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0247.v1

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Smarajit Maiti, Amrita Banerjee

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS CoV-2; COVID 19; pandemic global-outbreak; Spike glycoprotein; ACE2; PatchDock; hydroxychloroquine

Online: 15 April 2020 (10:50:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0184.v1

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

Ujjwal Neogi, Kyle J. Hill, Anoop T. Ambikan, Xiao Heng, Thomas P. Quinn, Siddappa N. Byrareddy, Anders Sönnerborg, Stefan G. Sarafianos, Kamal Singh

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Coronavirus; SARS-CoV; MERS-CoV; SARS-CoV-2; COVID-19; RNA polymerase; nsp12

Online: 12 April 2020 (05:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0161.v2

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2

Olujide O. Olubiyi, Maryam Olagunju, Monika Keutmann, Jennifer Loschwitz, Birgit Strodel

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition

Online: 1 June 2020 (02:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0057.v1

Automated Measurement of Attitudes Towards Social Distancing Using Social Media: A COVID-19 Case Study

A. S. M. Kayes, Md. Saiful Islam, Paul A. Watters, Alex Ng, Humayun Kayesh

Subject: Computer Science And Mathematics, Computer Science Keywords: COVID-19; social distancing model; sentiment analysis; physical distancing; social media; measuring attitudes

Online: 6 April 2020 (12:50:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0456.v1

The Impact of Isolation on the Transmission of COVID-19 and Estimation of Potential Second Epidemic in China

Haitao Song, Fang Liu, Feng Li, Xiaochun Cao, Hao Wang, Zhongwei Jia, Huaiping Zhu, Michael Li, Wei Lin, Hong Yang, Jianghong Hu, Zhen Jin

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; mathematical model; basic reproduction number; potential second epidemic; isolation; close contacts

Online: 31 March 2020 (10:20:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0444.v1

Rapid Prototyping of Reusable 3D-Printed N95 Equivalent Respirators at the George Washington University

Destie Provenzano, Yuan James Rao, Konstantin Mitic, Sofian N. Obaid, Dominique Pierce, James Huckenpahler, Jeffrey Berger, Sharad Goyal, Murray H. Loew

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: COVID-19; SARS-CoV-2; coronavirus; novel coronavirus; 3D printing; N95; respirator; mask

Online: 31 March 2020 (04:44:06 CEST)

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Working Paper ARTICLE

Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes of 52,251 Patients with Confirmed COVID-19 Infection: A Systematic Review and Meta-Analysis

Ali Pormohammad, Saeed Ghorbani, Behzad Baradaran, Alireza Khatam, Raymond Turner, Mohammad Ali Mansournia, Demetrios N. Kyriacou, Juan-Pablo Idrovo, Nathan C. Bahr

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; SARS-CoV-2; coronavirus; severe acute respiratory syndrome coronavirus; meta-analysis

Online: 16 March 2020 (01:06:04 CET)

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Introduction: The 2019 novel coronavirus (COVID-19) is very contagious, and can be transmitted to other people by droplet, aerosol, sneezing, infected surface, and cough. There is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial. Method: We searched all relevant literature published up to February 28, 2020, from Embase, Scopus, PubMed, Web of Science, and the Cochrane library to collect the studies that reported clinical and laboratory characteristics of COVID-19 infected patients. The study quality was assessed with the Critical Appraisal Checklist. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Result: Twenty studies were included in the meta-analysis, including a total of 52,251 patients with confirmed COVID-19 infection. 69.5% (95% CI 54.5-81, p < 0.001) of patients had a history of recent travel to Wuhan, contact with people from Wuhan, or lived in Wuhan. The most common symptoms among COVID-19 infected patients were fever 85.6 % (95% CI 73 -93, p < 0.001), and cough 63 % (95% CI 55.5-70, p < 0.001), respectively. The laboratory analysis showed that thrombocytosis was present in 91% (95% CI 81-98, p < 0.001) CRP was elevated in 81% (95% CI 65-91, p < 0.001), and lymphopenia in 62.5% of cases (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 76.8% (95% CI 62.5-87, p < 0.001) and consolidation in 75.5% (95% CI 50.5-91, p < 0.001) of patients. Most patients (85.4%) were hospitalized, 20.6% of patients were admitted to the ICU in critical condition, and the mortality rate was 5.6%. Conclusions: Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. Thombocytosis, lymphopenia, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. The most common radiographic sign was bilateral involvement in and consolidation. Among Chinese patients with COVID-19, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases.

Working Paper ARTICLE

Virtual Screening and Molecular Dynamics on Blockage of Key Drug Targets as Treatment for COVID-19 Caused by SARS-CoV-2

Ailan Huang, Xue Tang, Huimin Wu, Jun Zhang, Wanqi Wang, Zhiwei Wang, Li Song, Min-an Zhai, Lihui Zhao, Hailong Yang, Xiaohui Ma, Shuiping Zhou, Jinyong Cai

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; SARS-CoV-2; 3CLpro; PLpro; RdRp; AAK1; inhibitor; dock; molecular dynamics

Online: 15 March 2020 (02:34:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0085.v1

Structural Elucidation of SARS-CoV-2 Vital Proteins: Computational Methods Reveal Potential Drug Candidates Against Main Protease, Nsp12 RNA-dependent RNA Polymerase and Nsp13 Helicase

Muhammad Usman Mirza, Matheus Froeyen

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; CoV-Mpro; CoV-Nsp12 polymerase; CoV-Nsp13 helicase

Online: 5 March 2020 (11:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0308.v1

Pharmacoinformatics and Molecular Dynamic Simulation Studies Reveal Potential Inhibitors of SARS-CoV-2 Main Protease 3CL^pro

Mubarak A. Alamri, Muhammad Tahir ul Qamar, Safar M. Alqahtani

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; 3CL protease; molecular docking; molecular dynamics and simulations

Online: 23 February 2020 (02:17:46 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202409.1388.v1

Automating Portfolio Replication with Stock Market Algorithms

Srinivas Raju Gottimukkala

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: financial; portfolios; S&; P 500; stakeholders; stock

Online: 20 September 2024 (03:35:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1703.v1

A Single Dose Intraperitoneal Injection of P. gingivalis Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brain of Adult Zebrafish

Malik Adewoyin, Hamarsha Mohamed, Rasaq Akinsola, Seong Lin Teoh, Mohammad Noor Amall Azmai, Noraini Abu Bakar, Nurrul Shaqinah Nasruddin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: P. gingivalis; Outer membrane vesicles; Neuroinflammation

Online: 25 August 2024 (06:38:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0689.v1

Exploration of the Commonalities and Specificities in Wheat Respond to Aluminum Toxicity and Low Phosphorus via Transcriptomics and Targeted Metabolomics Study

Daozhen Luo, Qing Li, Fei Pang, Wenjie Zhang, Yangrui Li, Yongxiu Xing, Dengfeng Dong

Subject: Biology And Life Sciences, Plant Sciences Keywords: wheat root; transcriptomic; metabolomic; Al tolerance; P efficiency

Online: 12 August 2024 (04:42:00 CEST)

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Aluminum (Al) toxicity and low phosphorus availability (LP) are the top two co-existing edaphic constraints limiting agriculture productivity in acid soils. Plants have evolved versatile mechanisms to cope with the two stresses alone or simultaneously. However, the specific and common molecular mechanisms, especially those on flavonoids and carbohydrate metabolism, are still unclear. Laboratory studies were conducted on two wheat genotypes, Fielder (Al-tolerant and P-efficient) and Ardito (Al-sensitive and P-inefficient), exposed to 50 μM Al and 2 μM Pi (LP) in hydroponic solutions. After 4 days of stress, wheat roots were analyzed via transcriptomic and targeted metabolomic techniques. A total of 2296 differentially expressed genes (DEGs, 1535 up and 761 down) under Al and 3029 DEGs (1591 up and 1438 down) under LP were identified in Fielder. Similarly, 4404 DEGs (3191 up and 1213 down) under Al and 1430 DEGs (1176 up and 254 down) under LP were identified in Ardito. The GO annotation analysis results that 4079 DEGs annotated to the metabolic processes term. These DEGs were significantly enriched in the phenylpropanoid, flavonoid, flavone and flavonol biosynthesis, and carbohydrate metabolism pathways by performing the KEGG enrichment analysis. The targeted metabolome analysis detected 19 flavonoids and 15 carbohydrate components in Fielder and Ardito under Al and LP. More responsive genes and metabolites were involved in flavonoid metabolism under LP than Al in the Fielder, while an opposite trend in the Ardito. In the carbohydrate metabolism pathway, the genes and metabolites were higher in Fielder than in Ardito. The combined transcriptome and metabolome analysis revealed that the flavonoid and carbohydrate genes and metabolites differed between Fielder and Ardito under Al and LP, which may be an important reason for Fielder’s high Al and LP resistance. The results of this study lay a foundation for pyramiding genes and breeding multi-resistance varieties.

Preprint COMMUNICATION | doi:10.20944/preprints202310.0489.v1

Improved Breakdown Strength and Restrained Leakage Current of Sandwich Structure Ferroelectric Polymers Utilizing Ultra-Thin Al2O3 Nanosheets

Yi Zeng, Hao Pan, Zhong-Hui Shen, Yang Shen, Zhi-Fu Liu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: nanosheet; Al2O3; P(VDF-HFP); breakdown strength; leakage

Online: 9 October 2023 (10:35:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0749.v1

Biomarkers in IBD: What to Utilize for the Diagnosis?

Renata D'Incà, Giulia Sturniolo

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: fecal calprotectin; C reactive protein; p-ANCA; ASCA

Online: 9 August 2023 (10:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1531.v1

Effects of Single Nucleotide Polymorphism BsmI of the Vitamin D Receptor (VDR) Gene on VDR, SOD-2, and CYP24A1 Gene Expression in Subjects with Low Serum Vitamin D Levels

Vanessa Rosa Retamoso, Fernanda Barbisan, Graziela Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Vieira Dos Santos, Lyana Berro Feijóo, Matias Nunes Frizzo, Ivana Beatrice Mânica Da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli

Subject: Public Health And Healthcare, Other Keywords: vitamin D; hypovitaminosis; Cytochorme P 450 (CYP); SOD2

Online: 21 July 2023 (13:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0746.v1

ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Q347, Q725, Q990 to Confer Cellular Resistance to the Anticancer Drug Taxol

Keerthana Sasitharan, Hamzah Asad Iqbal, Foteini Bifsa, Aleksandra Olszewska, Kenneth Linton

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: ABC transporter; ABCB1; P-glycoprotein; taxol; drug recognition

Online: 31 May 2021 (11:27:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0680.v1

Upstream Open Reading Frames (uORFs) in the Apicomplexan Parasites Plasmodium falciparum and Toxoplasma gondii: Small yet Powerful Regulators of Translation

Chhaminder Kaur, Swati Patankar

Subject: Biology And Life Sciences, Parasitology Keywords: P. falciparum; T. gondii; upstream ORFs; translational regulation

Online: 26 April 2021 (15:11:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0435.v1

New Recommendation for Subjective Video Quality Assessment Methods for Recognition Tasks

Mikołaj Leszczuk, Lucjan Janowski

Subject: Engineering, Electrical And Electronic Engineering Keywords: QoS; QoE; ITU-T; TRV; P.912; CCTV

Online: 22 January 2021 (08:43:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0117.v1

Bayés’ Syndrome – A Comprehensive Short Review

Emma Murariu, Attila Frigy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiography; P-wave; interatrial conduction block; atrial fibrillation

Online: 7 July 2020 (08:43:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0196.v1

New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme

Iris Chiara Salaroglio, Elena Gazzano, Joanna Kopecka, Konstantin Chegaev, Costanzo Costamagna, Roberta Fruttero, Stefano Guglielmo, Chiara Riganti

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: P-glycoprotein; glioblastoma multiforme; brain-blood barrier; doxorubicin

Online: 14 May 2018 (12:50:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0275.v1

Perspective of Utilization of The Spaceborne P-Band SAR Together With L/S-Band SAR

Boris Kutuza, Anatoliy Kalinkevich, Alexander Zakharov, Vladimir Stasevich, Yuri Smirnov, Vladimir Turuk, Victor Plushchev

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: synthetic aperture radar; P-band radar; thematic applications

Online: 30 March 2018 (15:51:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0033.v1

Red Algae Bloom Detection in Occhito Lake Combining MERIS and MODIS Data

Raffaella Matarrese, Nicolas Guyennon, Diego Copetti

Subject: Environmental And Earth Sciences, Environmental Science Keywords: P. rubescens algal bloom; remote sensing; MERIS; MODIS

Online: 10 September 2017 (07:36:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0003.v1

Some Inequalities Bounding Certain Ratios of the (p,k)-Gamma Function

Kwara Nantomah

Subject: Computer Science And Mathematics, Analysis Keywords: gamma function; polygamma function; (p,k)-analogue; inequality

Online: 1 December 2016 (10:10:13 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints201608.0191.v1

688,112 Statistical Results: Content Mining Psychology Articles for Statistical Test Results

Chris H. J. Hartgerink

Subject: Social Sciences, Behavior Sciences Keywords: nhst; p-values; apa; content mining; tdm; errors

Online: 23 August 2016 (10:33:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0791.v1

A Bptf Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Triple Negative Breast Cancer Cells to Chemotherapy

Melanie M. Sinanian, Afshan Rahman, Ahmed M. Elshazly, Victoria L. Neely, Balaji Nagarajan, Glen E. Kellogg, April L. Risinger, David A. Gewirtz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: p-gp; p-glycoprotein; AU1; BPTF inhibitor; triple negative breast cancer; efflux pump; multidrug resistance; multidrug resistance pump; breast cancer

Online: 12 June 2024 (11:58:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0142.v1

Continuous Non-Archimedean and p-adic Welch Bounds

K. Mahesh Krishna

Subject: Computer Science And Mathematics, Analysis Keywords: Non-Archimedean valued field; Non-Archimedean Banach space; p-adic number field; p-adic Banach space; Welch bound; Zauner conjecture

Online: 12 September 2022 (09:51:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0005.v1

Non-Archimedean and p-adic Functional Welch Bounds

K. MAHESH KRISHNA

Subject: Computer Science And Mathematics, Analysis Keywords: Non-Archimedean valued ﬁeld; Non-Archimedean Banach space; p-adic number ﬁeld; p-adic Banach space; Welch bound; Zauner conjecture

Online: 1 September 2022 (04:13:43 CEST)

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We prove the non-Archimedean (resp. p-adic) Banach space version of non-Archimedean (resp. p-adic) Welch bounds recently obtained by M. Krishna. More precisely, we prove following results. \begin{enumerate}[\upshape(i)] \item Let $\mathbb{K}$ be a non-Archimedean (complete) valued field satisfying $\left|\sum_{j=1}^{n}\lambda_j^2\right|=\max_{1\leq j \leq n}|\lambda_j|^2$ for all $ \lambda_j \in \mathbb{K}, 1\leq j \leq n$, for all $n \in \mathbb{N}.$ Let $\mathcal{X}$ be a $d$-dimensional non-Archimedean Banach space over $\mathbb{K}$. If $\{\tau_j\}_{j=1}^n$ is any collection in $\mathcal{X}$ and $\{f_j\}_{j=1}^n$ is any collection in $\mathcal{X}^*$ (dual of $\mathcal{X}$) satisfying $f_j(\tau_j) =1$ for all $1\leq j \leq n$ and the operator $S_{f, \tau} : \text{Sym}^m(\mathcal{X})\ni x \mapsto \sum_{j=1}^nf_j^{\otimes m}(x)\tau_j^{\otimes m} \in \text{Sym}^m(\mathcal{X})$, is diagonalizable, then \begin{align}\label{NONFUNCTIONALWELCH} \max_{1\leq j,k \leq n, j \neq k}\{|n|, |f_j(\tau_k)f_k(\tau_j)|^{m} \}\geq \frac{|n|^2}{\left|{d+m-1 \choose m}\right| }. \end{align} We call Inequality (\ref{NONFUNCTIONALWELCH}) as non-Archimedean functional Welch bounds. \item For a prime $p$, let $\mathbb{Q}_p$ be the p-adic number field. Let $\mathcal{X}$ be a $d$-dimensional p-adic Banach space over $\mathbb{Q}_p$. If $\{\tau_j\}_{j=1}^n$ is any collection in $\mathcal{X}$ and $\{f_j\}_{j=1}^n$ is any collection in $\mathcal{X}^*$ (dual of $\mathcal{X}$) satisfying $f_j(\tau_j) =1$ for all $1\leq j \leq n$ and there exists $b \in \mathbb{Q}_p$ such that $ \sum_{j=1}^{n}f_j^{\otimes m}(x) \tau_j^{\otimes m} =bx$ for all $ x \in \text{Sym}^m(\mathcal{X}),$ then \begin{align}\label{PADICFUNCTIONALWELCH} \max_{1\leq j,k \leq n, j \neq k}\{|n|, |f_j(\tau_k)f_k(\tau_j)|^{m} \}\geq \frac{|n|^2}{\left|{d+m-1 \choose m}\right| }. \end{align} We call Inequality (\ref{PADICFUNCTIONALWELCH}) as p-adic functional Welch bounds. \end{enumerate} We formulate non-Archimedean functional and p-adic functional Zauner conjectures.

Preprint COMMUNICATION | doi:10.20944/preprints202403.0753.v1

Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases

Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Yuji Fujikura, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Akihiko Kawana, Susumu Matukuma, Yuji Tanaka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ambulatory electrocardiographic markers; coronavirus disease-19; COVID-19; global cardiac ischemia; Holter electrocardiograph; myocardial remodeling; SARS-CoV-2; sudden cardiac death

Online: 13 March 2024 (07:31:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0464.v1

Prognosis of COVID-19 in Patients with Liver and Kidney Diseases: An Early Systematic Review and Meta-Analysis

Tope Oyelade, Jaber Alqahtani, Gabriele Canciani

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: COVID-19; SARS-CoV-19; Hepatitis B and C; Cirrhosis; Chronic Kidney Disease; Alcohol-related Liver Disease; Non-alcoholic Steatohepatitis; Necrosis

Online: 25 April 2020 (16:46:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.2337.v1

Bulk and Single-Cell RNA-seq Elucidates Etiology of Severe COVID-19

Lukasz B Huminiecki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; transcriptomics; RNA-seq; scRNA-seq; inflammation; pneumonia; neuronal COVID; acute respiratory disease syndrome; multisystem inflammatory syndrome

Online: 30 December 2023 (16:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1285.v1

Impact of a Near-Surface Plasma Region on the Bow Shock Wave and Aerodynamic Characteristics of a High-Speed Model in Xenon

Olga A. Azarova, Tatiana A. Lapushkina, Oleg V. Kravchenko

Subject: Engineering, Aerospace Engineering Keywords:

supersonic flow; bow shock wave control; near-surface energy deposition; glow gas discharge; discharge plasma parameters; drag force control

Online: 16 October 2024 (10:49:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1701.v1

Satisfaction and Workload as Predictors of Psychological Distress in Professionals of Psychosocial Care Centers During the COVID-19 Pandemic

Debora Maria Salimon Pinto, Luciano Garcia Lourenção, Letícia Palota Eid, Maria Amélia Zanom Ponce, Júlio César André, Emilia Batista Mourão Tiol, Bianca Cristina Ciccone Giacon-Arruda, Guilherme de Oliveira Arruda, Maria da Graça Girade Souza, Natália Sperli Geraldes Marin dos Santos Sasaki, Emerson Roberto Santos, William Donegá Martinez, Ana Carolina Santos Costa, Ana Maria Rita Pedroso Vilela Torres Carvalho Engel, Amilton José da Silva Júnior, João Daniel de Souza Menezes, Alexandre Lins Werneck, Marise Ramos de Souza, Marlene Andrade Martins, Gabriele Cássia Santos Silva, Matheus Querino da Silva, Daniele Alcalá Pompeo

Subject: Public Health And Healthcare, Nursing Keywords: mental health; occupational health; job satisfaction; mental health services; Covid-19; health per-sonnel

Online: 22 October 2024 (12:06:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0405.v1

Assessing the Effects of Unit-Based Pricing on Household Waste Reduction During COVID-19 in Japan

Michiko Karasawa, Hiroyuki Taguchi

Subject: Social Sciences, Urban Studies And Planning Keywords: COVID-19; Japan; unit-based pricing; simple unit pricing; two-tiered pricing; household waste

Online: 7 October 2024 (11:27:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2456.v1

The COVID-19 Pandemic's Impact on Eating Disorders: An Italian Residential Center Perspective

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Stefania Palermo, Annaluce Caputo, Ilona Forte, Antonella Boccia, Anna Longobardi, Marilena Di Pierro, Ernesta Panarello, Annarita Mainardi, Rossella Bonifacio, Emanuela Ferrara, Alessandra Marenna, Martina Piacente, Luca Steardo jr, Paolo Meneguzzo, Mauro Cozzolino, Giulio Corrivetti

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; Eating Disorders; Anorexia Nervosa: Bulimia Nervosa; Mental Health; Retrospective Analysis; Pandemic Impact

Online: 1 October 2024 (08:38:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0331.v1

Did the COVID-19 Crisis Reframe Public Awareness of Environmental Topics as Humanity’s Existential Risks? A Case from the UK

Andreas Y Troumbis

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Existential risks; COVID-19; Difference-in-Differences; environmental topics; biodiversity; climate change; sustainability; UK

Online: 5 September 2024 (04:53:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0370.v1

Comparison of Whole Genome Sequencing versus Pcr Kit for Detection of COVID-19 Variants in Wastewater

Michelle M. Jarvie, Thu N.T. Nguyen, Benjamin Southwell, Derek Wright

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: keyword 1; Covid-19 2; PCR 3; Whole genome sequencing 4; Wastewater-based epidemiology

Online: 4 September 2024 (14:49:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1323.v1

The Long-Term Effect of Mourning during the COVID-19 Pandemic: How Were People Affected by Direct Losses and Media Exposure to Death?

Barbara Caci, Giulia Giordano

Subject: Social Sciences, Psychology Keywords: COVID-19 pandemic; mental health; anxiety; depression; stress; mourning; vicarious grief; media exposure; neuroticism

Online: 19 June 2024 (16:35:15 CEST)

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