ARTICLE
|
doi:10.20944/preprints202002.0003.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture
Online: 3 February 2020 (03:16:54 CET)
ARTICLE
|
doi:10.20944/preprints201904.0200.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
adipose-derived; bone regeneration; cartilage regeneration; clinical application; clinical studies; differentiation; hair loss; induced pluripotent stem cells; maxillary sinus augmentation; osteoarthritis; pluripotency; regenerative
Online: 17 April 2019 (11:25:14 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0646.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
androgen deprivation therapy (ADT); anti-tumor efficacy of hormones; estetrol (E4); High-dose estetrol (HDE4); PCombi study; testosterone (T); prostate-specific antigen (PSA); follicle-stimulating hormone (FSH); insulin-like growth factor-1 (IGF-1)
Online: 11 June 2024 (08:12:13 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0009.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
EGFR mutation; osimertinib; acquired resistance; secondary mutations; novel drugs; non-small cell lung cancer; epithelial to mesenchymal transition; MET gene amplification; Ba/F3 cells
Online: 4 June 2024 (02:53:41 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0637.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
blue laser; erythrocytes; red blood cells; low level laser irradiation; low level laser therapy; laser irradiation with a wavelength of 445 nm; periodontal disease
Online: 10 May 2024 (12:13:21 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0575.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Di(2-ethylhexyl) phthalate (DEHP); Endocrine disrupting compound (EDC); sex steroid receptor; Runt-related transcription factor 2 (Runx2); oxidant-antioxidant system; osteoblastic cells; bone
Online: 8 January 2024 (07:14:11 CET)
ARTICLE
|
doi:10.20944/preprints202312.0115.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
glial cells; neurogenesis; vasculogenic mimicry; microchanneling; central nervous system; peripheral nervous system; 2D and 3D serum replacement culture; glycoconjugates; vesicles
Online: 4 December 2023 (04:14:33 CET)
ARTICLE
|
doi:10.20944/preprints202309.1105.v2
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
herbal medicine products; benzo[a]pyrene-induced in vitro toxicity; B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE); benzo[a]pyrene (B[a]P); HepG2 cells
Online: 25 March 2024 (09:03:11 CET)
ARTICLE
|
doi:10.20944/preprints202201.0380.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Therapeutic biomarkers; circulating tumor cells; Immunocytochemistry; targeted therapy; Fluorescence in situ hybridization (FISH); Immune Checkpoint Inhibitors; Liquid Biopsy; Hormonal Treatments; Breast Cancer; Lung Cancer
Online: 25 January 2022 (11:31:05 CET)
ARTICLE
|
doi:10.20944/preprints202403.0042.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
Hematopoietic stem and progenitor cell (HSPC); acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); leukemic stem cell (LSC) CD34; CD38; CD45RA; CD123; PD-L1; flow cytometry; t-SNE; high-dimensional space analyses; classification; dimensionality reduction; immunophenotyping
Online: 4 March 2024 (01:30:54 CET)
ARTICLE
|
doi:10.20944/preprints202104.0020.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
hepatitis C virus; hepatocellular carcinoma; immunotherapy; multi-component DNA vaccine; nucleocapsid (core) protein; telomerase reverse transcriptase; eukaryotic expression; CD4+ and CD8+ T cell response; immune suppression; assays of reporter expression; induction of type I interferons
Online: 1 April 2021 (13:18:59 CEST)
ARTICLE
|
doi:10.20944/preprints202401.1915.v1
Subject:
Medicine And Pharmacology,
Veterinary Medicine
Keywords:
Equine; mesenchymal stem/stromal cells; synovial membrane mesenchymal stem cell; umbilical cord conditioned medium; clinical case; cartilage; subchondral bone; osteoarthritis; allogeneic cell-based therapies; horses.
Online: 26 January 2024 (13:56:06 CET)
ARTICLE
|
doi:10.20944/preprints202311.1139.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
non-small cell lung cancer; ionizing radiation; DNA repair; PrimPol; DNA damage tolerance; translesion synthesis; Pol iota (Polι ); clonogenic survival; cancer stem-like cells
Online: 17 November 2023 (07:47:41 CET)
ARTICLE
|
doi:10.20944/preprints202207.0358.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Foot-and-mouth disease virus; safe sample transport; single-stranded positive-sense RNA; TRIzol extraction; naked RNA; infectivity; RNA transfection; lipofectamine; self-transfection; BHK cells
Online: 25 July 2022 (08:14:51 CEST)
REVIEW
|
doi:10.20944/preprints202110.0016.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
prostate cancer; castrate-resistant growth; metastases; androgen receptor; glucocorticoid receptor; cytokines; transmembrane receptors; cell signaling; pharmacological targeting; neuroendocrine differentiation; lineage plasticity; prostate cancer stem cells
Online: 1 October 2021 (12:19:03 CEST)
ARTICLE
|
doi:10.20944/preprints202108.0202.v1
Subject:
Medicine And Pharmacology,
Surgery
Keywords:
congenital breast asymmetry; PROM, autologous fat injections, fat grafting, lipograft, implant augmentation, breast augmentation, 3D volumetry, three-dimensional imaging, Breast-QTM; human adipose stem cells
Online: 9 August 2021 (15:06:09 CEST)
REVIEW
|
doi:10.20944/preprints202106.0337.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
alcohol use disorders (AUD); cancer, ethanol oxidative and nonoxidative metabolism, acetaldehyde, reactive oxygen species (ROS), DNA adducts, protein damage, cancer stem cells (CSC), epigenetic changes.
Online: 14 June 2021 (09:03:43 CEST)
ARTICLE
|
doi:10.20944/preprints201912.0133.v1
Subject:
Biology And Life Sciences,
Plant Sciences
Keywords:
advanced glycation end products (ages); drought; glycation; sh-sy5y human neuroblastoma cells; metabolomics; osmotic stress; pea (pisum sativum l.); pro-inflammatory; seeds; seed metabolism; signaling
Online: 10 December 2019 (14:53:42 CET)
REVIEW
|
doi:10.20944/preprints201908.0234.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
osteoarthritis; articular cartilage; degeneration; regeneration; therapeutic protein; growth factor; protein production platform; protein packaging cell line; transforming growth factor β (TGF-β); GP2-293 cells
Online: 23 August 2019 (03:33:49 CEST)
REVIEW
|
doi:10.20944/preprints202209.0482.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Telomerase reverse transcriptase; TERT; TERT promoter; TERTp; human papillomavirus; HPV; Epstein Barr virus (EBV); Kaposi sarcoma-associated herpesvirus; HHV-8; hepatitis B virus; HBV; hepatitis C virus; HCV; human T-cell leukemia virus-1; HTLV-1
Online: 30 September 2022 (10:11:58 CEST)
ARTICLE
|
doi:10.20944/preprints202201.0382.v1
Subject:
Physical Sciences,
Fluids And Plasmas Physics
Keywords:
pressure loss along length; Darcy hydraulic friction coefficient; local pressure loss in T-Junction; hydraulically short pressure pipeline; local resistance coefficient; flow rate; Reynolds number; flow rate; absolute and relative roughness of pipeline walls; turbulent flow mode
Online: 25 January 2022 (11:55:56 CET)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
REVIEW
|
doi:10.20944/preprints202306.0833.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Cancer-testis-antigens; parthenogenetic; polyploid giant cancer cells; PGCCs; genome fragility; phylostratigraphic analysis; innate immunity-placentation; endogenous retroviruses; sex determination; male infertility; endocrine disruption; environmental pollution
Online: 12 June 2023 (12:59:23 CEST)
REVIEW
|
doi:10.20944/preprints201809.0217.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Premature ovarian insufficiency, POI; Gene therapy; Menopause; SAL-like 4 genes, SALL4; Follicle-stimulating hormone (FSH); Basonuclin-1; Replication-incompetent adenoviral vector, Ad; Stem cells, SC.
Online: 12 September 2018 (11:06:42 CEST)
REVIEW
|
doi:10.20944/preprints202406.0771.v1
Subject:
Medicine And Pharmacology,
Otolaryngology
Keywords:
anti-cancer therapy; carcinogenesis; cell plasticity; chemoresistance; head and neck cancer (HNC); head and neck squamous cell carcinoma (HNSCC); mesenchymal stromal cells (MSCs); tumour niche; tumour environment
Online: 12 June 2024 (14:44:09 CEST)
REVIEW
|
doi:10.20944/preprints202007.0674.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
osteoarthritis; articular cartilage; degeneration; regeneration; therapeutic protein; growth factor; protein production platform; protein packaging cell line; transforming growth factor β (TGF-β); GP2-293 cells; TissueGene-C
Online: 28 July 2020 (10:16:51 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Neuroendocrine Neoplasms; NOTCH; cancer driven genes; mutational mechanism; germline mutations.; small cell lung carcinoma; pancreatic NET; small bowel NET; medullary thyroid carcinoma; malignant castration-resistant prostatic cells
Online: 23 July 2019 (10:34:50 CEST)
ARTICLE
|
doi:10.20944/preprints201807.0317.v3
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Boswellia serrata Roxb.; Curcuma longa L.; intestinal bowel diseases (IBD); Caco-2; PBMC; HMC-1.1; mast cells; cytokines; trans epithelial electrical resistance (TEER); reactive oxygen species (ROS)
Online: 8 November 2018 (04:53:46 CET)
ARTICLE
|
doi:10.20944/preprints202311.1694.v1
Subject:
Engineering,
Electrical And Electronic Engineering
Keywords:
Cu-(In,Ga)-Se2 (CIGSe) solar cells; Two-segment process; Metal-alloy compositions; Internal/External quantum efficiencies (IQE/EQE); Sustainable development goal; Eco-friendly community
Online: 27 November 2023 (11:51:53 CET)
ARTICLE
|
doi:10.20944/preprints202304.0625.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adverse drug reaction; cisplatin liposomes; circulating tumor cells; enhanced permeability and retention effect; nephrotoxicity; pulmonary metastasis of pancreatic cancer; quality of life; recurrent liver metastases from primary nasal cancer
Online: 20 April 2023 (07:52:10 CEST)
ARTICLE
|
doi:10.20944/preprints202211.0080.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Tumor initiation; Germ cell traits of tumors; Primordial germ cell-like tumor cells; Somatic to Pri-mordial germ cell-like transformation; Embryonic/germ cell hypothesis of tumor; Breast cancer
Online: 4 November 2022 (01:04:58 CET)
REVIEW
|
doi:10.20944/preprints202402.0456.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)
Online: 7 February 2024 (17:08:39 CET)
HYPOTHESIS
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
environment; virus; pollutant; evolution; exaptation; stem cells; transposons; APOBEC; ADAR,; ORF2p; cancer; Eco-Evo-Devo; symbiosis; ecological genomics; environmental stress; genetic recombination; biological plasticity; hypermutation; epigenetics; fractal systems; natural selection
Online: 19 July 2020 (19:35:46 CEST)
ARTICLE
|
doi:10.20944/preprints201901.0245.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
Osteomeles Schwerinae; diabetic retinopathy (DR); spontaneously diabetic Torii (SDT) rat; human retinal microvascular endothelial cells (HRMECs); advanced glycation end products (AGEs); retinal apoptosis; oxidative stress; mitochondrial function; adjunctive effect; combination therapy
Online: 24 January 2019 (08:37:29 CET)
HYPOTHESIS
|
doi:10.20944/preprints202109.0372.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Endometriosis; microchimerism; maternal microchimerism; reproduction; gynaecology; etiology; auto-immune; immune response; hormonal; vascular; genetic; hereditary; male; fetal; fetus; stem cells; pregnancy; Műllerianosis; embryology; ROS; apoptosis; disease; endometrium; basalis; menstruation; post-menopausal; neurogenesis
Online: 22 September 2021 (10:27:52 CEST)
ARTICLE
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
protein/rna world; plasma membrane; cytoplasm; virus world; pre-retro virus; emergence of dna; transcription and replication; first cells; hyperthermophiles; luca; bacteria and archaea; anoxygenic bacteria; oxygenic bacteria; global distribution of cyanobacteria
Online: 15 October 2019 (11:18:58 CEST)
REVIEW
|
doi:10.20944/preprints202403.1200.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Mast cells; Sentinel cell; Health; Ovulation; Pregnancy; Inflammation; Wound healing; Cell prolif-eration; Angiogenesis; bFGF; VEGF-A; Tissue remodeling; Histamine; Serotonin; Heparin; Proteases; IL-1-alpha; IL-8; TNF-alpha; Nitric oxide; Survival; Progeny
Online: 20 March 2024 (09:50:02 CET)
ARTICLE
Subject:
Environmental And Earth Sciences,
Paleontology
Keywords:
protein/RNA world: plasma membrane; cytoplasm; gene regulation; virus world; pre-retro virus; emergence of DNA; transcription and replication; first cells; hyperthermophiles; LUCA; Bacteria and Archaea; anoxygenic bacteria; oxygenic bacteria; global distribution of cyanobacteria
Online: 12 February 2020 (03:25:07 CET)
ARTICLE
|
doi:10.20944/preprints202309.1265.v1
Subject:
Engineering,
Other
Keywords:
Multijunction solar cells; IIIV semiconductors; TCAD simulation; cell optimization; predictive profiling; CIGS absorbers; spectral utilization; currentvoltage characteristics; external quantum efficiency; GaAs replacement; bottom junction; thin films; high efficiency; photovoltaics; epitaxial growth; stacked junctions; light absorption
Online: 19 September 2023 (07:48:35 CEST)
REVIEW
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress
Online: 22 July 2019 (04:37:27 CEST)
REVIEW
|
doi:10.20944/preprints202401.0124.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Phage display; landscape phage; molecular evolution; affinity selection; recombinant antibodies, PC; prostate specific antigen (PSA); prostate-specific matrix antigen (PSMA); Enzyme-linked immunosorbent assay (ELISA); phage ELISA; phage capture assay; electrochemical biosensor; total prostate-specific antigen (t-PSA); free prostate-specific antigen (F-PSA); electrochemical impedance spectroscopy; label-free immunosensor
Online: 3 January 2024 (10:36:52 CET)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0242.v1
Subject:
Computer Science And Mathematics,
Mathematics
Keywords:
Lorentzian SRT-transformation factors as solutions of oscillation-equations Holger Döring IQ-Berlin-Spandau Germany e-mail:[email protected]:Shown is the derivation of Lorentz-Einstein k-factor in SRT as an amplitude-term of oscillation-differential equations of second order.This case is shown for classical Lorentz-factor as solution of an equation for undamped oscillation as well as the developed theorem as a second solution for advanced SRT of fourth order with an equation for damped oscillation-states.This advanced term allows a calculation for any velocities by real rest mass.key-words: undamped oscillation; SRT; k-factor; Differential-equation of second order; Einstein-Lorentz; Amplitude-analogy; damped oscillation; developed SRT of fourth order
Online: 11 May 2021 (11:16:44 CEST)
REVIEW
|
doi:10.20944/preprints202303.0500.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Oxidative stress and cell death; Reactive oxygen species; ROS; ROS cell death; autophagy; role of antioxidants; eye disease; cornea; lens; epithelium; retinal ganglion cells; retinal pigment epithelium; macular degeneration; antioxidants in the macula; oxidative stress prevention with antioxidants; lifestyle changes; digital eye strain; glaucoma; cataracts; dry eye disease; computer vision syndrome; digital eye strain; diabetic retinopathy; Vitamin A; Vitamin C; copper; glutathione; zinc; selenium; magnesium; blue light damage; UV light damage; blue light reactive oxygen species; autophagy; ferroptosis; ROS cell death; superoxide dismutase; optic nerve gliomas; food deserts; myopia; free radicals
Online: 29 March 2023 (03:33:55 CEST)