Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202401.1879.v1

Deep Learning for Built-up Fractional Mapping using Sentinel-2 images: A Case Study in Delhi, India

Abhishek Rawat, Prasun Kumar Gupta, Claudio Persello

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: fractional mapping; built-up; deep learning; Global Human Settlement Layer; Sustainability

Online: 26 January 2024 (09:41:31 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0836.v1

Lightweight Context-aware Feature Transformer Network for Human Pose Estimation

Yanli Ma, Qingxuan Shi, Fan Zhang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Human pose estimation; Expressive power of features; Feature refinement; Global dependencies

Online: 11 January 2024 (10:24:37 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1800.v1

Diversity, Mechanism of Action and Sequences of Plant, Animal and Human Antimicrobial Peptides

Galina Satchanska, Slavena Tihomirova Davidova, Alexandra Alexandrova Gergova

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Plant AMPs; animal MPs; human AMPs; mechnism of action; AMP sequnces

Online: 25 December 2023 (11:25:34 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0807.v1

Voice-Cloning Artificial-Intelligence Speakers Can Also Mimic Human-Specific Vocal Expression

Wenjun Chen, Xiaoming Jiang

Subject: Social Sciences, Cognitive Science Keywords: Voice cloning; Affective computing; Vocal confidence; Social AI; Human-computer interaction

Online: 13 December 2023 (04:14:46 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1166.v1

Acid-Sensing Ion Channels Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body

Graciela Martínez-Barbero, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, Benjamín Martín-Biedma, Olivia García-Suárez, Jorge Feito, Teresa Cobo, José A. Vega

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: carotid body; glomus cells; nerves; acid-sensing ion channels; immunohistochemistry; human

Online: 20 November 2023 (07:38:39 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202311.1092.v1

Assessing Impact of Microplastics on Aquatic Food System and Human Health

Mahmudul Hasan Mithun, Auditi kar, Atiqur Rahman Sunny, Masum Billah, Sharif Ahmed Sazzad, Sadeques Salehin, Al Maksud Foysal, Nusrat Jahan, Koushikur Rahman, Abdulla Al Shiam, Redoyan Chowdhury, Jubayer Arafat, Abdul Baten

Subject: Biology And Life Sciences, Aquatic Science Keywords: Micro-plastics; routes of MPs; eco-toxicology; aquatic organisms; human exposure

Online: 17 November 2023 (02:27:47 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.0197.v1

A Systematic Review of Recent Deep Learning Approaches for 3D Human Pose Estimation

Amal EL KAID, Karim BAÏNA

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: 3D human pose estimation; systematic literature survey; deep learning based methods

Online: 3 November 2023 (03:48:59 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.1441.v1

Roundabout Trajectory Planning: Integrating Human Driving Models for Autonomous Vehicles

Salvatore Leonardi, Natalia Distefano

Subject: Engineering, Transportation Science And Technology Keywords: Autonomous vehicles; Human driving models; Roundabouts; Speed profiles; Traffic-free planning

Online: 24 October 2023 (07:55:00 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0334.v1

Molnupiravir Revisited—Critical Assessment of Studies in Animal Models of COVID-19

Henrik Berg Rasmussen, And Peter Riis Hansen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: molnupiravir; COVID-19; antiviral efficacy; animal models; animal-to-human extrapolation

Online: 6 September 2023 (05:07:55 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0003.v1

Human Milk Redox Homeostasis: The Gestational Pathologies Effect

Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Human milk; breastfeeding; GSH; LOOHs; preeclampsia; gestational diabetes mellitus; newborn nutrition

Online: 1 September 2023 (13:45:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0679.v1

Exposure to the Fermented Red Beetroot Juice in Relation to the Level of Perfluoroalkyl Substances in the Human Body Fluids and Blood Parameters

Magdalena Surma, Tomasz Sawicki, Mariusz Piskuła, Wiesław Wiczkowski

Subject: Chemistry And Materials Science, Food Chemistry Keywords: perfluoroalkyl substances; fermented red beetroot juice; human body fluids; blood parameters

Online: 9 August 2023 (05:43:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1052.v1

Performance Analysis of a Solar-Powered Evaporative Cooling System

Karim Choubani, Mohammed A Almeshaal, Mohamed Ben Rabha

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Evaporative cooling; Solar energy; Performance analysis; Simulation; human comfort; environmental impact

Online: 14 June 2023 (13:49:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0186.v1

Age Estimation in Human Gait Extraction using A Combination of Multi-Energy Image with Invariant Moment

Nasser Al Musalhi, Erbuğ Çelebi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: age estimation; AFDEI; CNN; human gait; neural networks; GEI; invariant moments

Online: 5 June 2023 (08:12:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1894.v1

Analysis of Relation Between Brainwave Activity and Reaction Time of Short-Haul Pilots Based on EEG Data

Bartosz Binias, Dariusz Myszor, Sandra Binias, Krzysztof Cyran

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Aircraft control human factors; Cognitive workload; Data Mining; Electroencephalography; Fatigue; Safety

Online: 26 May 2023 (08:40:35 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0242.v1

An In vitro Model of Chlamydia trachomatis Infection in Human Dendritic Cells

Zoe Mallonga, Luis Filgueira

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chlamydia trachomatis; elementary bodies; human dendritic cells; in vitro; reticulate bodies

Online: 4 May 2023 (08:57:52 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202304.0542.v1

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Giovanna Milano, Giovanni Guarducci, Nicola Nante, Emanuele Montomoli, Ilaria Manini

Subject: Public Health And Healthcare, Primary Health Care Keywords: Human papillomavirus; Epidemiology; Prevention Strategies; Vaccination; Screening; Cervical Cancer; Gender Gap

Online: 19 April 2023 (04:32:32 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0183.v1

Human Activity Recognition-based Cyber-Physical System Security Through IoT-Cloud Computing

Sandesh Achar, Nuruzzaman Faruqui, Md Whaiduzzaman, Albara Awajan, Moutaz Alazab

Subject: Computer Science And Mathematics, Security Systems Keywords: Cyber-physical security; Human activity recognition; GoogleNet; BiLSTM; Deep Learning; Algorithm

Online: 10 March 2023 (02:07:09 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0007.v1

A Virus Genetic System To Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B Variants

Xuan Zhou, Giorgia Cimato, Yi-Hua Zhou, Giada Frascaroli, And Wolfram Brune

Subject: Biology And Life Sciences, Virology Keywords: Human herpesvirus 5; glycoprotein B; UL55; cell-cell fusion; entry; infectivity

Online: 1 March 2023 (03:05:22 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202302.0256.v1

Pathways for the Valorization of Animal and Human Waste to Biofuels, Sustainable Materials and Value-Added Chemicals

Jude A. Okolie, Toheeb Jimoh, Olugbenga Akande, Patrick U. Okoye, Chukwuma C. Ogbaga, Adekunle A. Adeleke, Peter P. Ikubanni, Fatih Gulec, Andrew Nosakhare Amenaghawon

Subject: Engineering, Energy And Fuel Technology Keywords: Thermochemical conversion; biological conversion; human excreta; waste-to-energy; livestock manure

Online: 15 February 2023 (08:45:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0073.v1

Human Movements Are Shaped by Utilizing Sensory Information: A Stochastic Optimum Model

Mehran Emadi Andani

Subject: Engineering, Bioengineering Keywords: human motor planning; sensory information; statistical model; minimum jerk; motor decomposition

Online: 3 February 2023 (10:33:27 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0242.v1

Residents’ Perceptions on Ecosystem Services Provided by the Urban Green Spaces in Malaysia

Tan How Ying, Abu SMG Kibria, Tapan Kumar Nath

Subject: Social Sciences, Geography, Planning And Development Keywords: Cities; urban residents; human perception; ecosystem services; nature-based so-lutions

Online: 13 January 2023 (07:56:25 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202210.0038.v1

Minimalised Three-Dimensional Human Midbrain In Vitro Model for Neurotoxicity Evaluation of DYRK1 Inhibitors

Xiao Wan, Vincent Fagan, Paul Brennan, Daniel Ebner

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: three-dimensional in vitro model; DYRK1; human midbrain; neural progenitor cells

Online: 5 October 2022 (11:29:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0271.v1

Does the Restriction of Human Mobility Significantly Control COVID-19 Transmission in Jakarta, Indonesia? Global Versus Local Regression Models

I Gede Nyoman Mindra Jaya, Anna Chadidjah, Gumgum Darmawan, Jane Christine Princidy, And Farah Kristiani

Subject: Computer Science And Mathematics, Analysis Keywords: COVID-19; human mobility; spatial autocorrelation; temporal autocorrelation; Facebook mobility data

Online: 19 September 2022 (09:33:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0250.v1

An Impact Study on the Use of Telework during Covid-19 Pandemics

Simona Vasilache, Ahmed Hasan Shakir

Subject: Business, Economics And Management, Business And Management Keywords: Management; telework; communication; human resource management; business; digitalization; Covid-19 pandemic

Online: 15 August 2022 (05:57:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0341.v1

A Mixed-Method National Study of Public Health Core Competencies in Undergraduate Medical Schools in Thailand to Find out the Need for Transformative Changes

Myo Nyein Aung, Vanich Vanapruks, Pornchai Sithisarankul, Pajaree Yenbutra, Suthee Rattanamongkolgul, Krishna Suvarnabhumi, Pongsak Wannakrairot

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: medical education; public health; medical schools; community; global health; human resource

Online: 25 May 2022 (04:03:49 CEST)

Show abstract| Download PDF| Share

Background: With new challenges to the health system, many new competencies within the scope of teaching public health need to be addressed in medical schools’ curricula such as disaster risk management and health system science. The aims of this study were to identify the needs of public health competencies for medical doctors in Thailand and to assess the level of integration for technical collaboration in teaching public health. Method: A total of 17 out of 21 Thai medical schools participated in the national survey. Qualitative inquiries applied focus group interviews of community representatives from ten sample villages and in-depth interviews of representatives from stakeholder organizations particularly employers. The list of public health competencies framework recommended by WHO-SEARO was applied. Quantitative analysis applied descriptive analysis using STATA 15 and qualitative findings were validated by interrelating the meaning of themes from Word Clouds created in NVivo12. Data integration applied a mixed-method Quan-qual approach. Results: 17 medical schools returned the questionnaires (80.95 % yield). The most common regionally-defined public health competencies (in over 70% of schools) were shown to be: Biostatistics, Community Medicine, Epidemiology, Family Medicine, Medical Ethics and Professional Laws, Preventive Medicine, Health Promotion, Holistic Care, and Research. The curriculum in only one medical school lacked Health Economics, whilst Disaster Management was lacking in two other schools. Discipline-based subjects were found to be more prevalent than interdisciplinary competencies. A variety of methods were being applied for teaching public health. The majority of the schools applied lecture as the main teaching method and multiple-choice questions as the main assessment method. Thai communities expect the doctors to get in touch with the community more often, lead the primary health care team through training the health professionals and community health volunteers, and educate the community for better health. Conclusion: Human resource is the main challenge in addressing interdisciplinary competencies. It is necessary to establish a collaborating mechanism among the big and small medical schools and the faculties of public health to improve the teaching of public health to undergraduate students in medical schools. There is also a need to strengthen the health system science and leadership so that future MDs can lead health service delivery according to the needs of their employers such as the Ministry of Public Health and the Rural Doctors Association. The findings of this study may help to identify a national framework of public health core competencies for medical schools and create a common platform for interdisciplinary collaborations.

Preprint ARTICLE | doi:10.20944/preprints202203.0189.v1

On Developing Human Centric Digital Tweens

Akpofure A. Enughwure, Francesco Lelli

Subject: Computer Science And Mathematics, Information Systems Keywords: Smart device; Users behavior; human computer interaction; exploratory analysis; statistical methods

Online: 14 March 2022 (12:28:44 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0358.v1

Differential Impacts of Climatic and Land Use Changes on Habitat Suitability and Protected Area Adequacy Across the Asian Elephant’s Range

Wei Yang, Yuanxu Ma, Linhai Jing, Siyuan Wang, Zhongchang Sun, Yunwei Tang, Hui Li

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Asian elephant; MaxEnt; habitat suitability; protected area; climate change; human footprint

Online: 28 February 2022 (12:00:28 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0229.v1

Assessment of K-Struvite Precipitation as a Means of Nutrient Recovery From Source Separated Human Urine

Işık Kabdaşlı, Sezen Kuşçuoğlu, Olcay Tünay, Alessio Siciliano

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: human urine; K-struvite precipitation; nutrient recovery; operation parameters; solid phases

Online: 14 December 2021 (11:46:20 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0016.v1

Comparison Between Tailor-Made-ANN Techniques and Fuzzy c-Mean Clustering Technique in Industrial Laborers' Accident-Rates Prediction Modelling Based on Human Factors

Muhammad M.A.S. Mahmoud

Subject: Computer Science And Mathematics, Computer Science Keywords: Industrial Laborers, Accident rate, Artificial neural network, Human factor, Predictive models

Online: 1 July 2021 (11:17:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0497.v1

Metal(loids) Bioaccessibility in Road Dusts from the Surrounding Villages of an Active Mine

Carla Candeias, Paula F. Ávila, Eduardo Ferreira da Silva, Fernando Rocha

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: road dusts; active mine; metal(loids); oral bioaccessibility; human health risk

Online: 21 May 2021 (07:44:30 CEST)

Show abstract| Download PDF| Share

Working Paper REVIEW

The Mother of All Battles: Viruses vs. Humans. Can Humans Avoid Extinction in 50-100 Years?

Eleftherios Diamandis

Subject: Biology And Life Sciences, Virology Keywords: pandemics; contagious diseases; human race extinction; viruses; microbiome; COVID-19; blindness

Online: 14 April 2021 (17:53:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0192.v1

Eco-Efficiency and Human Capital Efficiency on the Example of Small and Medium-Sized Family Farms in the Selected European Countries

Jan Polcyn

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Eco-Efficiency; Human Capital Efficiency; family farms; TOPSIS-CRITIC; sustainable development

Online: 7 April 2021 (11:24:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0391.v2

Role of Traditional Ethnobotanical Knowledge and Indigenous Communities in Achieving Sustainable Development Goals

Ajay Kumar, Sushil Kumar, Komal Komal, Nirala Ramachiary, Pardeep Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sustainable Development Goals; Ethnobotany; Human Health; Poverty; Traditional Knowledge; Sustainable Agriculture

Online: 20 January 2021 (11:04:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0763.v1

Nonlocal Reaction-Diffusion Models of Heterogeneous Wealth Distribution

Malay Banerjee, Sergei V. Petrovskii, Vitaly Volpert

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: human population dynamics; wealth distribution; nonlocal consumption of resources; spatial patterns

Online: 30 December 2020 (16:35:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0613.v1

Comparative Study of Thermal Comfort Indices: A Melbourne CBD Case Study

Anne WM Ng, Nitin Muttil, Fatma Balany, Bruke Zegeye

Subject: Engineering, Automotive Engineering Keywords: Green Infrastructure (GI); Human Thermal Comfort (HTC); ENVI-met; microclimate; modelling

Online: 24 November 2020 (10:58:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0001.v1

Dual-Task Effect on Cognitive and Body Function, β-amyloid Levels in Alzheimer's Dementia Patients: a Randomized Controlled Trial

Seung Min Nam, SEONG-GIL KIM

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Alzheimer’s Disease; Task Performance; Cognition; Human Activities; Amyloid Beta Protein; Dementia

Online: 2 November 2020 (08:06:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0190.v1

Examining the Change of Human Mobility Adherent to Social Restriction Policies and its Effect on COVID-19 Cases in Australia

Siqin Wang, Yan Liu, Tao Hu

Subject: Social Sciences, Geography, Planning And Development Keywords: human mobility; COVID-19 spread; global pandemic; social restriction policy; Australia

Online: 8 September 2020 (11:31:16 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0306.v1

Inhibition of Butyrylcholinesterase by Glycyrol, a Coumarin, Isolated from Glycyrrhiza Uralensis

Geum Seok Jeong, Myung-Gyun Kang, Joon Yeop Lee, Sang Ryong Lee, Daeui Park, MyoungLae Cho, Hoon Kim

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Glycyrrhiza uralensis; Glycyrol; Liquiritigenin; cholinesterases; human monoamine oxidases; kinetics; docking simulation.

Online: 13 August 2020 (12:11:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0456.v1

High-efficiency Non-viral Transfection of Human Primary T Lymphocytes

Hossein Khanahmad, Ilnaz Rahimmanesh, Mehdi Totonchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Human primary T cells; Cancer immunotherapy; Gene delivery; Protamine sulfate; Transfection

Online: 28 May 2020 (11:33:47 CEST)

Show abstract| Download PDF| Share

Preprint HYPOTHESIS | doi:10.20944/preprints202003.0238.v1

A Feedback Loop Between Human Self-Domestication and Dog Domestication Contributing to Language Evolution?

Antonio Benítez-Burraco, Daniela Pörtl, Christoph Jung

Subject: Social Sciences, Behavior Sciences Keywords: dog domestication; human self-domestication; aggression; prosociality; language evolution; cognitive disorders

Online: 15 March 2020 (02:24:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202001.0238.v1

Geochemical, Mineralogical and Morphological Characterisation of Road Dust and Associated Health Risks

Carla Candeias, Estela Vicente, Mário Tomé, Fernando Rocha, Paula Ávila, Alves Celia

Subject: Environmental And Earth Sciences, Environmental Science Keywords: road dust; , traffic; , PM10 emission factors; Enrichment Index; human health risk

Online: 21 January 2020 (10:46:59 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0249.v1

Finding a Tandem Repeats Motifs in the Completed Genomes of Human Coronavirus (hku1) Which is Identified as a Hotspot Region for the Viruses Recombination by Using Regular Expression Language

Mohammed Ahmed Ezzelregal Hassan, Mohamed Elsayed Hasan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: repeats blocks; repeater finder regular expression; tandem repeats of human coronavirus

Online: 22 October 2019 (04:11:40 CEST)

Show abstract| Download PDF| Share

A lot of research studies have been surveyed the completed genomes of prokaryotic and eukaryotic and focused on the correlation between the percentage of microsatellite sequences in completed genomes and the whole size of the organism genomes. There are fewer studies made in repetitive sequences otherwise simple sequence repeats or long tandem repeats of virus genomes. simple sequence repeats (SSRs) are the most important regions for recombination and moving repeats blocks from site to another site in the genomes. A tool was programmed and designed by visual basic 6.0 to find the long tandem repeats in DNA sequences of the small genomes. The tool named “Repeater Finder Regular Expression”, (RFRE) Version 1.0, 2016. The tool was utilized to discover different pattern of long tandem repeats (LTR) motifs on the completed genomes of human corona virus strains by using a joined regular expression language. In this study, a twenty-nine accession numbers of human coronavirus completed genomes, (hku1) strains were retrieved from the Genbank. The researcher can write a different regular expression patterns and joined regular expression patterns through the designed tool to search and find a specific motif of nucleotide sequences inside the complete genomes. The RFRE tool searched and found three different total lengths of a perfect long tandem repeats (240bp, 300bp and 480bp). A Dot plot gave a picture view for the long tandem repeat sequences in the completed genome sequence (KF430201.1) of human coronavirus. The genomic dot plot tool YASS was used as a genomic similarity searching tool to check for the uninterrupted repeats and confirm the sensitivity of the (RFRE) tool. To identify the recombination site in the genomes of human coronavirus the RAT tool was applied to find the recombination sites between the completed genomes of human corona viruses .The RAT tool recognized the recombination site in the nucleotide position (3012) and at the same time this recombination site position (3012) was also recognized as a beginning position of a long tandem repeat. A precise motif was predicted from the translated repeats of Human Corona Virus which found by PRATT tool. There was a relationship between the total length of long tandem repeats and genome size of Human Corona Virus and the correlation value R²was equal to (0,451). In conclusion, this study presented the importance of finding the long tandem repeats of human coronavirus and gives a relationship between the completed genome size of human coronavirus types and long tandem repeats. The nucleotide position (3012) was a hot spot site for a recombination among the complete genomes of human coronavirus and also identified as a repetitive site in the genomes of human corona virus (hku1). The repeats in human coronavirus (hku1) were predicated to be a main major role of virus evolution.

Preprint ARTICLE | doi:10.20944/preprints201909.0149.v1

Stimulation of Human Osteoblast Differentiation in Magneto-Mechanically Actuated Ferromagnetic Fibre Networks

Galit Katarivas Levy, Mark A. Birch, Roger A. Brooks, Suresh Neelakantan, Athina E. Markaki

Subject: Chemistry And Materials Science, Biomaterials Keywords: magneto-mechanical actuation; fibre networks; human osteoblasts; mineralization; in vitro osteogenesis

Online: 15 September 2019 (06:13:38 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint COMMUNICATION | doi:10.20944/preprints201909.0089.v1

Are Karst Rocky Desertification Areas Affected by Increasing Human Activity in Southern China? An Empirical Analysis from Nighttime Light Data

Kaifang Shi, Qingyuan Yang, Yuanqing Li

Subject: Social Sciences, Geography, Planning And Development Keywords: nighttime light data; human activities; karst rocky desertification; environmental impact; China

Online: 8 September 2019 (16:49:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201904.0264.v1

Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem Cells

Maria Pitrone, Giuseppe Pizzolanti, Antonina Coppola, Laura Tomasello, Stefania Martorana, Gianni Pantuso, Carla Giordano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human adipose stem cell; NANOG; cell cycle regulation; DNMT1; lentiviral transduction

Online: 24 April 2019 (10:45:01 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0325.v1

Performance Enhancement of Solar Photovoltaic Panels using Air-water Mixture and Sustainable Solutions to Off-Grid Electrification

Nithin Sha Najeeb, Prashant Kumar Soori, Iyad Al Madanat

Subject: Engineering, Electrical And Electronic Engineering Keywords: Dust Accumulation; Human Machine Interface (HMI); Programmable Logic Controller (PLC); Soiling

Online: 15 October 2018 (16:36:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0101.v1

Tougher Targets for China’s Clean Air Cities? Implications from Air Quality Assessment in Shenzhen

Dian Huang, Qinglan Li, Guangxin Li, Xiaoxue Wang, Liqun Sun

Subject: Environmental And Earth Sciences, Environmental Science Keywords: air pollution; air quality standard; spatial pattern; variability; human health protection

Online: 5 October 2018 (14:15:36 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201805.0130.v1

Urban Sloths: Public Knowledge, Opinions and Interactions

Kissia Ferreira Pereira, Robert John Young, Vanner Boere, Ita de Oliveira e Silva

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: brown-throated sloth; human-animal interactions; questionnaire; urban wildlife; Bradypus variegatus

Online: 8 May 2018 (10:53:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201804.0044.v1

Latent Factors Limiting the Performance of sEMG-Interfaces

Sergey Lobov, Nadia Krilova, Innokentiy Kastalskiy, Victor Kazantsev, Valeri A. Makarov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: electromyography; human-computer interface; motor control; pattern classification; artificial neural networks

Online: 4 April 2018 (05:07:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201803.0176.v1

The Effects of One-Child Policy on the Economy and the Environment in an OLG Framework

Peter J. Stauvermann, Jin Hu, Ronald Ravinesh Kumar

Subject: Business, Economics And Management, Economics Keywords: one-child policy; environment; OLG model; fertility; human capital; child tax

Online: 20 March 2018 (09:09:16 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201803.0170.v1

Oral Dysbiotic Communities and Their Implications in Systemic Diseases

Preethi Sudhakara, Abishek Gupta, Anshumouli Bhardwaj, Aruni Wilson

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral dysbiosis; human oral microbiome; yet-un cultivable organisms; systemic diseases

Online: 20 March 2018 (07:06:45 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201712.0198.v1

Local Perceptions on Conservation of Wild Chimpanzees (Pan troglodytes verus) in the Réserve Naturelle Communautaire de Dindéfélo, Southeast of Senegal

Mónica Arias, Liliana Pacheco, Déborah Temple, Virginie Lippens, Manel Lopez-Bejar, Xavier Manteca

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: local perceptions; chimpanzees; conservation; natural resources; human-chimpanzees conflict; traditional beliefs

Online: 29 December 2017 (08:00:35 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201711.0199.v2

Self-Sampling for HPV Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Sarah Gupta, Christina Palmer, Elisabeth M. Bik, Juan P. Cardenas, Harold Nuñez, Laurens Kraal, Sara Bird, Jennie Bowers, Alison Smith, Nathaniel A. Walton, Audrey D. Goddard, Daniel E. Almonacid, Jessica Richman, Zachary S. Apte

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: human papillomavirus; HPV; cervical cancer; cancer screening; self-sampling; vaginal microbiome

Online: 1 December 2017 (07:19:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201710.0042.v1

Validity and Reliability of the Kinovea Program in Obtaining Angular and Distance Dimensions

Albert Puig-Diví, Josep Maria Padullés-Riu, Albert Busquets-Faciaben, Xavier Padullés-Chando, Carles Escalona-Marfil, Daniel Marcos-Ruiz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: free software; human motion; Kinovea; low cost; reliability; validity; video analysis

Online: 9 October 2017 (05:07:57 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201706.0120.v1

Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells

Yu-Jen Wu, Chih-I Liu, Zhong-Hao Din, Te-Chih Cheng, Jui-Hsin Su

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: sinulariolide; human bladder cancer; migration; invasion; PI3K/AKT/mTOR signaling pathway

Online: 27 June 2017 (06:23:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201704.0030.v1

Automatic Localization Algorithm for Ultrasound Breast Tumors Based on Human Visual Mechanism

Yuting Xie, Ke Chen, Jiangli Lin

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Automatic localization; human visual mechanism; superpixel contrast feature; ultrasound breast tumor.

Online: 5 April 2017 (15:50:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201703.0076.v1

Mercury Levels in Human Hair and Farmed Fish near Artisanal and Small-Scale Gold Mining Communities in the Madre de Dios River Basin, Peru

Aubrey L. Langeland, Rebecca D. Hardin, Richard L. Neitzel

Subject: Biology And Life Sciences, Toxicology Keywords: mercury; exposure assessment; human health; artisanal and small-scale gold mining

Online: 14 March 2017 (08:40:59 CET)

Show abstract| Download PDF| Supplementary Files| Share

Artisanal and small-scale gold mining (ASGM) has been an important source of income for communities in the Madre de Dios River Basin in Peru for hundreds of years. However, in recent decades, the scale of ASGM activities in the region has increased dramatically, and exposures to a variety of occupational and environmental hazards related to ASGM, including mercury, are becoming more widespread. The aims of our study were to: (1) examine patterns in the total hair mercury level of human participants in several communities in the region and compare these results to the 2.2 µg/g total hair mercury level equivalent to the World Health Organization (WHO) Expert Committee of Food Additives (JECFA)’s Provisional Tolerable Weekly Intake (PTWI); and (2), to measure the mercury levels of paco (Piaractus brachypomus) fish raised in local aquaculture ponds, in order to compare these levels to the EPA Fish Tissue Residue Criterion of 0.3 µg Hg/g fish (wet weight). We collected hair samples from 80 participants in four communities (one control and three where ASGM activities occurred) in the region, and collected 111 samples from fish raised in 24 local aquaculture farms. We then analyzed the samples for total mercury. Total mercury levels in hair were statistically significantly higher in the mining communities than in the control community, and increased with increasing distance away from the Madre de Dios headwaters (as the crow flies), did not differ by sex, and frequently exceeded the reference level. Regression analyses indicated that higher hair mercury levels were associated with residence in ASGM communities. The analysis of paco fish samples found no samples that exceeded the EPA tissue residue criterion. Collectively, these results align with other recent studies showing that ASGM activities are associated with elevated human mercury exposure. The fish farmed through the relatively new process of aquaculture in ASGM areas appeared to have little potential to contribute to human mercury exposure. More research is needed on human health risks associated with ASGM to discern occupational, residential, and nutritional exposure, especially through tracking temporal changes in mercury levels as fish ponds age, and assessing levels in different farmed fish species. Additionally, research is needed to definitively determine that elevated mercury levels in humans and fish result from the elemental mercury from mining, rather than from a different source, such as the mercury released from soil erosion during deforestation events from mining or other activities.

Preprint ARTICLE | doi:10.20944/preprints202407.0869.v1

Bridging the Embodiment Gap: Embodied AI for Enhanced Human-Machine Collaboration and Learning in Dynamic Environments

Emmanuel Idowu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: embodied AI, human-machine collaboration, dynamic environments, robotics, physical interaction, adaptive learning, situational awareness, real-time decision-making, human-computer interaction, AI in the physical world.

Online: 10 July 2024 (14:00:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0588.v2

Saudi Arabia's Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak: Consequences, Reactions, and Takeaways

IZERE Salomon

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Public health; global health security; MERS-CoV; outbreak; Saudi Arabia

Online: 9 April 2024 (10:04:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.2063.v1

The predicate of the current mathematical knowledge increases the constructive mathematics what is impossible for the empirical sciences

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: composite numbers of the form 2^(2^n)+1, constructive algorithms, current mathematical knowledge, decidable sets X⊆N, epistemic notions, informal notions, known algorithms, known elements of N, primes of the form n^2+1, primes of the form n!+1, primes of the form 2^(2^n)+1

Online: 31 July 2023 (10:54:27 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202406.0884.v1

Advancements in the Application of CO₂ Capture and 2 Utilization Technologies—a Comprehensive Review

Queendarlyn Adaobi Nwabueze, Smith Leggett

Subject: Engineering, Energy And Fuel Technology Keywords: CO₂ Capture &; Utilization; CO₂ emissions; flue gas; industrial fuels; petrochemicals

Online: 13 June 2024 (05:13:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1035.v1

Universal mRNA-based HIV Vaccine for Acute and Latent Infections

Sarfaraz K. Niazi, Matthias Magoola

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: HIV-1 1; HIV-2 2; surface proteins 3; Nef proteins 4; mRNA delivery 5; Universal vaccine.

Online: 18 March 2024 (11:24:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0437.v1

Synthesis, Characterization and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2- thiouracil and 6-Propyl-2-thiouracil

Petja Emilova Marinova, Mariyan Nedelchev Hristov, Slava Hristova Tsoneva, Nikola Tomov Burdzhiev, Denica Eliyanova Blazheva, Aleksandar Krasimirov Slavchev, Evelina Konstantinova Varbanova, Plamen Nikolov Penchev

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: 6-methyl-2-thiouracil, 6-propyl-2-thiouracil; complexation, copper(II) complexes, palladium(II) complexes, antimicrobial activity

Online: 7 November 2023 (10:37:37 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202310.1793.v1

The Antidepressant Activity Taurine Containing Derivative of 4-Phenylpyrrolidone-2 in a Model of Chronic Unpredictable Mild Stress

Denis A Borozdenko, Darya I. Gonchar, Vlada I. Bogorodova, Dmitri V. Tarasenko, Eugene P Kramarova, Svetlana S. Khovanova, Yaroslav V. Golubev, Nina M. Kiseleva, Tatiana Anatolievna Shmigol, Aiarpi A. Ezdoglian, Konstantin A. Sobyanin, Vadim V. Negrebetsky, Yuri. I. Baukov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: fluoxetine 1; antidepressant activity 2; chronic unpredictable mild stress 3; 4-phenylpyrrolidinone-2 derivative 4; hormones 5

Online: 27 October 2023 (12:53:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1726.v1

Optimal Consumption and Robust Portfolio Choice for the 3/2 and 4/2 Stochastic Volatility Models

Yuyang Cheng, Marcos Escobar-Anel

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: 4/2 stochastic volatility model; CRRA utility; optimal portfolio choice and consumption; Heston’s process; 3/2 process

Online: 24 August 2023 (07:23:19 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202010.0316.v1

In-Silico Study of the Immune Systems Associated Genes in Case of Type-2 Diabetes with Insulin Action and Resistance and in Obesity

Basmah Medhat Eldakhakhny, Hadeel Al Sadoun, Hani Choudhry, Mohammad Mobashir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Type 2 diabetes; cancer; shared pathways; shared genes and proteins; relationship between cancer and type 2 diabetes

Online: 15 October 2020 (09:47:35 CEST)

Show abstract| Download PDF| Share

Obesity, type 2 diabetes, and different forms of cancers are among the leading human diseases and highly complex in terms of diagnostic and therapeutic approaches. Diabetes and cancer are among the most frequent and complex diseases and based on epidemiological evidence and study it can be concluded that the patients suffering from diabetes are considered to be significantly at higher risk for a number of cancer types. Both these diseases are among the highly complex and heterogeneous in nature. There are a number of evidences which support the hypothesis that these diseases interlinked and obesity may aggravate the risk(s) of both these diseases type 2 diabetes and different types of cancers. Multi-level unwanted alterations such as (epi-)genetic alterations, changes at the transcriptional level, and altered signaling pathways (receptor, cytoplasmic, and nuclear level) are the major source which promotes a number of complex diseases and such heterogeneous level of complexities are considered as the major barrier in the development of therapeutic. With so many known challenges, it is critical to understand the relationships and the common shared causes between type 2 diabetes and cancer which is difficult to unravel and understand. Furthermore, the real complexity arises during diagnosis from contended corroborations that specific drug(s) (individually or in combination) during diagnosis process of type 2 diabetes may increase or decrease the cancer risk or affect cancer prognosis. In this review article, we have presented the recent and most updated evidences from the studies where the origin, biological background, correlation between them have been presented or proved. Furthermore, we have summarized the methodological challenges and tasks that are frequently encountered. we have also outlined the physiological links between type 2 diabetes and cancers. Finally, we have presented and summarized the outline of the hallmarks for both these diseases diabetes and cancer.

Preprint ARTICLE | doi:10.20944/preprints201704.0016.v1

Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress

Yanli Liu, Hongxu Yang, Yinhua Zhao, Min Zhang, Yongjin Chen

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: periodontitis; the periodontal ligament stem cells; the nuclear factor-erythroid 2-related factor 2; oxidative stress; apoptosis

Online: 4 April 2017 (08:58:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0420.v7

A Common Approach to Three Open Problems in Number Theory

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Brocard's problem; Brocard-Ramanujan equation x!+1=y^2; composite Fermat numbers; composite numbers of the form 2^(2^n)+1; Erd\"os' equation x(x+1)=y!

Online: 18 May 2023 (08:25:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0659.v1

SARS-CoV-2 Infection: Molecular Mechanisms of Endothelial Dysfunction in COVID-19 Patients

Laurence Bouillet, Alban DEROUX, Meryem BENMARCE, Chloé GUERIN, Laura BOUVET, Olivia GARNIER, Donald K. MARTIN, ISABELLE VILGRAIN

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Endothelium; VE-cadherin; ACE2; SARS-CoV2 infection; Long COVID syndrome

Online: 9 June 2023 (03:43:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0228.v1

Reactogenicity of mRNA and non-mRNA Based COVID-19 Vaccines Among Lactating Mother and Baby Dyads

Beth Jacob-Chow, Vasundhara Kandarpa Lakshmi, Hon Kit Cheang, Le Ye Lee, Jia Ming Low, Amin Zubair

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 vaccines; SARS-CoV2; lactation; mother-child dyads; reactogenicity

Online: 17 May 2022 (10:31:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202204.0006.v1

Ethical-Attitudinal Profile Towards a New Normality in Future Peruvian Educators

Francisco F. Reluz-Barturén, Nelly Dioses-Lescano, Humberto Iván Morales-Huamán, Doris Díaz- De Angulo, Fiorela A. Fernández Otoya, Luisín A. Taboada Montaño

Subject: Social Sciences, Education Keywords: Teacher training; moral education; values system; higher education; SARS-CoV2

Online: 1 April 2022 (11:29:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0738.v1

Impact of the Coronavirus Pandemic on Science and Society: Insights from Temporal Bibliometric Networks

Ramya Gupta, Abhishek Prasad, Suresh Babu, Gitanjali Yadav

Subject: Computer Science And Mathematics, Analysis Keywords: bibliometry; coronavirus; text and data mining; SARS; MERS; COVID-19

Online: 31 March 2021 (17:30:56 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202005.0192.v1

Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2

Dapeng Zhou, Chenghao Wu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: SARS-CoV2; corona virus; affinity proteomics; glycoproteins; glycoprotein-binding domains

Online: 11 May 2020 (10:24:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202005.0160.v1

COVID-19 and Kawasaki Like Disease: The Known-Known, the Unknown-Known and the Unknown-Unknown

Aurélie Morand, Diego Urbina, Alexandre Fabre

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Sars-Cov2; Covid-19; Children; Kawasaki disease; toxic shock syndrome

Online: 9 May 2020 (09:01:24 CEST)

Show abstract| Download PDF| Share

In the end of April nearly 100 cases of children aged between 6 month and 9 years with Kawasaki like disease were reported (mostly in Europe) probably linked to COVID-19. With the increasing awareness of this condition the number of cases reported is increasing worldwide. We aim to sum up the known data about this new entity based on published data (in a case report, a series of 8 cases and in newspapers and society statement) and using our knowledge of classical Kawasaki disease. It seems to be a post infectious disease with an onset between 2-4 weeks after the infection, probably in genetically predisposed children aged between 6 month to 17 years. A very rough estimation of incidence based on current data from Bergamo, Italy, and New York State and a lot assumption is between 0.016% (95% CI:0.013-0.02%) - 0.31% (95% CI: 0.2-0.47%) of infected children. Clinical signs overlaps with Kawasaki disease in some children, but another feature is prominent gastrointestinal manifestations. For the 9 detailed patients most had incomplete presentation for Kawasaki disease (with a mean 1.7 (+/-1.2) criteria per patient for the 5 non fever criterion) and only one had a classical form. In some cases, presentation is closer to toxic shock syndrome or isolated myocarditis. Persistent fever seems to be constant and biological exploration are consistent with inflammation (elevated CRP, ferritin and D-Dimers). Management is described as supportive and children seem to improve rapidly, but can require cardiac or respiratory support. In date of 11 may 2020 there is 4 deaths confirmed linked to these new entities (1 in UK and 3 in New York). Paediatricians and general practitioners need to be aware of these possible evolution following COVID-19 infection. However it seems to be rare and children are probably still spared from most morbidities and mortality linked to COVID-19 infection .There are need of published detailed cohorts to better delineate these entities.

Working Paper CONCEPT PAPER

Infection-Genomics of COVID-19: Are Some Communities Resistant?

R. Manjunatha Kini, Swati Kundu

Subject: Biology And Life Sciences, Virology Keywords: ACE2; Spike protein; SARS-CoV2; death rate; polymorphism; isoform variant; CD157, sankramikogenomics

Online: 17 May 2020 (14:51:39 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0034.v2

Spatial Distribution of Amino Acids of the SARS-CoV2 Proteins

Ranjeet Kumar Rout, Sk Sarif Hassan

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Shannon entropy; Hurst exponent; Amino acid; Frequency distribution; \& SARS-CoV2

Online: 6 April 2020 (14:00:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0344.v1

A Quantitative Genomic View of the Coronaviruses: SARS-COV2

Sk Sarif Hassan, Ranjeet Kumar Rout, Vipul Sharma

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: fractal dimension; Shannon entropy; Hurst Exponent; GC Content & SARS-CoV2

Online: 23 March 2020 (07:23:40 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.2179.v1

Cement Clinker Modified by Photocatalyst – Selected Mechanical Properties and Photocatalytic Activity during NO and BTEX Decomposition

Magdalena Janus, Jarosław Strzałkowski, Kamila Zając, Ewelina Kusiak-Nejman

Subject: Engineering, Civil Engineering Keywords: photocatalysis 2; photoactive cement 3; NO decomposition

Online: 29 August 2024 (14:28:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0162.v1

Effectiveness of Smartphone App for the treatment of Pediatric Obesity: A Prospective Longitudinal Study

Giuseppina Rosaria Umano, Mariapia Masino, Grazia Cirillo, Giulia Rondinelli, Francesca Massa, Giuseppe Salvatore R.C. Mangoni di Santo Stefano, Anna Di Sessa, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Pietro Buono

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity 1; treatment 2; m-Health 3

Online: 2 August 2024 (12:58:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1375.v1

Evaluation of CacyBP/SIP Expression and Its Relationship With ERK1/2 and p38 Kinase in Testicular Seminoma

Grzegorz Młynarczyk, Natalia Domian, Alicja Lewandowska, Adam Novák, Irena Kasacka

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CacyBP/SIP; ERK1/2; p38; seminoma; testis

Online: 17 July 2024 (04:56:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1779.v1

Investigation on UV Degradation and Mechanism of 6:2 Fluorotelomer Sulfonamide Alkyl Betaine, Based on Model Compound Perfluorooctanoic Acid

Naveed Ahmed, Marion Martienssen, Maria CONCETTA Bruzzoniti, Marion Martienssen, Maria Concetta Bruzzoniti, Ramona Riedel

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: PFOA; 6:2 FTAB; decomposition; photolysis; scavenger

Online: 24 January 2024 (13:38:41 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1953.v1

Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands

Ke Yang, Haibo Ge, Ziting Xu, Zhi Li, Chong Liu

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: palladium-catalyzed; 2-pyridone ligand; tertiary aldehydes

Online: 30 November 2023 (05:45:42 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0086.v1

mtDNA Single Nucleotide Variants Associated with Type 2 Diabetes

Enrique García Gaona, Alheli García Gregorio, Camila García Jimenez, Mildred Alejandra López-Olaiz, Paola Mendoza-Ramírez, Daniel Fernandez-Guzman, Rolando Alberto Pillado Sánchez, Axel David Soto Pacheco, Laura Yareni Zuñiga, María Guadalupe Sánchez-Parada, Ana Elizabeth González Santiago, Luis Miguel Román Pintos, Rolando Castañeda Arellano, Luis Daniel Hernández-Ortega, Arieh Roldán Mercado-Sesma, Felipe de Jesús Orozco-Luna, Carlos Villa Angulo, Rafael Villa Angulo, Raúl C. Baptista-Rosas

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: mtDNA; mitogenome; Type 2 diabetes; polymorphism; SNP

Online: 5 September 2023 (10:22:58 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202309.0211.v1

Long-Term Organ Complications: The True Public Health Concern in SARSCoV-2 Infection

Ronald palacios castrillo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARSCoV-2 virus; Long Covid; Spike protein

Online: 5 September 2023 (05:11:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1466.v1

Non-invasive Assessment of IDH-mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI

Laiz Laura De Godoy, Kheng Choon Lim, Archith Rajan, Gaurav Verma, Mauro Hanaoka, Donald M O’Rourke, John Lee, Arati Desai, Sanjeev Chawla, Suyash Mohan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 2-Hydroxyglutarate; isocitrate dehydrogenase; 1H-MRS; glioma

Online: 21 August 2023 (11:40:38 CEST)

Show abstract| Download PDF| Share

Purpose Isocitrate dehydrogenase (IDH) mutation has become one of the most important prognostic biomarkers in glioma management, indicating better treatment response and prognosis. IDH mutations confer neomorphic activity leading to the conversion of alpha-ketoglutarate (α-KG) to 2-hydroxyglutarate (2HG). The purpose of this study was to investigate the clinical potential of proton MR spectroscopy (1H-MRS) in identifying IDH-mutant gliomas by detecting characteristic resonances of 2HG and its complex interplay with other clinically relevant metabolites. Materials and Methods Thirty-two patients with suspected infiltrative glioma underwent single-voxel (SVS, n=17) and/or single-slice multivoxel (1H-MRSI, n=15) proton MR spectroscopy (1H-MRS) sequence with an optimized echo-time (97ms) on 3T-MRI. Spectroscopy data were analyzed using linear combination (LC) model. Cramer-Rao lower bound (CRLB) values of <40% were considered acceptable for detecting 2HG and <20% for other metabolites. Immunohistochemical analyses for determining IDH mutational status were subsequently performed from resected tumor specimens, and findings were compared with the results from spectral data. Mann-Whitney and Chi-squared tests were performed to ascertain differences in metabolite levels between IDH-mutant and IDH-wild-type gliomas. Receiver operating characteristics (ROC) curve analyses were also performed. Results Data from eight cases were excluded due to poor spectral quality or non-tumor-related etiology, and final data analyses were performed from 24 cases. Of these cases, 9/12 (75%) were correctly identified as IDH-mutant or IDH-wildtype gliomas by SVS and 10/12 (83%) by 1H-MRSI with an overall concordance rate of 79% (19/24). The sensitivity, specificity, positive predictive value, and negative predictive values were 80%, 77%, 86%, and 70%, respectively. The metabolite 2HG was found to be significant in predicting IDH-mutant gliomas by Chi-squared test (p<0.01). The IDH-mutant gliomas also showed significantly higher NAA/Cr ratio (1.20 ± 0.09 versus 0.75 ± 0.12 p= 0.016) and lower Glx/Cr ratio (0.86±0.078 versus 1.88±0.66; p=0.029) than those with IDH wild-type gliomas. The areas under the ROC curves for NAA/Cr and Glx/Cr were 0.808 and 0.786, respectively. Conclusion 1H-MRS may be useful in detecting IDH mutational status in gliomas by detecting 2HG and characteristic patterns of other metabolite ratios (NAA/Cr and Glx/Cr). This has significant clinical implications for prognostication and response assessment to novel targeted therapies in gliomas.

Preprint ARTICLE | doi:10.20944/preprints202305.1183.v1

Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei

Pedro Villarejo-Campos, Mariano García-Arranz, Siyuan Qian, Santos Jiménez de los Galanes, Victor Dominguez-Prieto, Juan Felipe Vélez Pinto, Ismael Guijo Castellano, Montiel Jiménez-Fuertes, Hector Guadalajara, Damian Garcia-Olmo

Subject: Medicine And Pharmacology, Surgery Keywords: pseudomyxoma peritonei; mucin; MUC-2; microbiome; pseudomonas.

Online: 17 May 2023 (04:33:59 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202305.1014.v1

Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border

Murilo Tavares Amorim, Leonardo H. Almeida Hernández, Felipe Gomes Naveca, Ivy Tsuya Essashika Prazeres, Ana Lucia Monteiro Wanzeller, Eliana Vieira Pinto da Silva, Livia M. Neves Casseb, Fábio Silva Da Silva, Sandro Patroca da Silva, Bruno Tardelli Diniz Nunes, Ana Cecilia Ribeiro Cruz

Subject: Biology And Life Sciences, Virology Keywords: arboviruses; dengue virus serotype 2; Cosmopolitan genotype

Online: 15 May 2023 (10:00:46 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0101.v1

Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study

Dipak Kumar Sahoo, Marilyn Martinez, Kimberly Dao, Vojtech Gabriel, Christopher Zdyrski, Albert E. Jergens, Todd Atherly, Chelsea A. Iennarella-Servantez, Laura E. Burns, Dwayne Schrunk, Donna A Volpe, Karin Allenspach, Jonathan P. Mochel

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: canine; 3D organoid; permeability; Caco-2; colon

Online: 6 April 2023 (14:13:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0408.v1

Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in Postmenopausal MRONJ Patient

Sung-Min Park, Jae-Hoon Lee

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Type 2 Diabetes; Osteoporosis; Bisphosphonate; MRONJ; Osteoclast

Online: 31 March 2022 (13:44:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0388.v1

Retrieval of Snow Albedo and Total Ozone Column from Single-View MSI/S-2 Spectral Reflectance Measurements over Antarctica

Alexander Kokhanovsky, Simon Gascoin, Laurent Arnaud, Ghislain Picard

Subject: Environmental And Earth Sciences, Environmental Science Keywords: snow; albedo; total ozone; MSI; S-2

Online: 22 September 2021 (15:25:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0256.v1

Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells

Raquel Luna-Yolba, Justine Marmoiton, Véronique Gigo, Xavier Marechal, Emeline Boet, Ambrine Sahal, Nathalie Alet, Ifat Abramovich, Eyal Gottlieb, Virgile Visentin, Michael R. Paillasse, Jean-Emmanuel Sarry

Subject: Biology And Life Sciences, Aging Keywords: OxPHOS 1; Immune-checkpoints 2; AML 3.

Online: 9 June 2021 (10:58:20 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0556.v1

Super-Resolution of Sentinel-2 Images at 10m Resolution without Reference Images

Yunhe Li, Bo Li

Subject: Engineering, Automotive Engineering Keywords: super-resolution; generative adversarial network; Sentinel-2

Online: 21 April 2021 (08:25:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202010.0114.v1

Role of Cigarette Smoke on ACE-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model

Massimo Caruso, Alfio Distefano, Rosalia Emma, Michelino Di Rosa, Giuseppe Carota, Sonja Rust, Riccardo Polosa, Pietro Zuccarello, Margherita Ferrante, Giuseppina Raciti, Giovanni Li Volti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ACE-2; nicotine; smoke; cigarette; epithelial cells.

Online: 6 October 2020 (09:43:40 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Bringing Onco-innovation to Europe's Healthcare Systems: The Potential of Biomarker Testing, Real World Evidence, Tumour Agnostic Therapies to Empower Personalised Medicine

Denis Horgan, Gennaro Ciliberto, Pierfranco Conte, Giuseppe Curigliano, Luis Seijo, Luis M. Montuenga, Marina Garassino, Frederique Penault-Llorca, Fabrizia Galli, Isabelle Ray-Coquard, Denis Querleu, Peter Riegman, Keith Kerr, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Benedikt Westphalen, Jasmina Koeva-Balabanova, Angelo Paradiso, Zorana Maravic, Vassiliki Fotaki, Nuria Malats, Chiara Bernini, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan Van Meerbeeck, Michael Duffy, Beata Jagielska, Ettore Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers; BRCA1/2; genomics; European recommendation

Online: 18 August 2020 (16:30:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0307.v1

Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing

Denis Horgan, Gennaro CILIBERTO, Pierfranco Conte, Giuseppe CURIGLIANO, Luis Seijo, Luis M. Montuenga, Luis Paz-Ares, Marina Chiara Garassino, Penault-Llorca Frederique, Fabrizia GALLI, Isabelle Ray-Coquard, Denis Querleu, David R. Baldwin, Susana Banerjee, Peter H.J. Riegman, Keith Kerr, Benjamin Horbach, Reinhard Büttner, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Westphalen Christoph Benedikt, Fabien CALVO, Jasmina Koeva-Balabanova, Stephen Hall, Angelo Virgilio Paradiso, Dipak. Kalra, Christa M. Cobbaert, Rocio Varea Mendez, Zorana Maravic, Vassiliki Fotaki, Jaafar Bennouna, Estelle Cauchin, Núria Malats, Iñaki Gutiérrez-Ibarluzea, Benjamin Gannon, Ken Mastris, Chiara Benini, William M. Gallagher, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan P. van Meerbeeck, Michael Joe Duffy, Elzbieta. Sarnowska, Beata Jagielska, Sarah Mee, Ettore Domenico Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers, BRCA1/2, genomics; European recommendation

Online: 14 August 2020 (04:27:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0218.v1

Walking Speed is the Sole Determinant of Mild Cognitive Impairment in Japanese Patients with type 2 Diabetes Mellitus

Noritaka Machii, Akihiro Kudo, Haruka Saito, Hayato Tanabe, Mariko Iwasaki, Hiroyuki Hirai, Hiroaki Masuzaki, Michio Shimabukuro

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: type 2 diabetes mellitus; walking speed; sarcopenia

Online: 14 April 2020 (08:45:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201912.0219.v1

NOS-2 Participates in the Behavioral Effects of Ethanol Withdrawal in Zebrafish

Suianny Nayara da Silva Chaves, Bruna Patrícia Dutra Costa, Gabriela Cristini Vidal Gomes, Monica Lima-Maximino, Eduardo Pacheco Rico, Caio Maximino

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Nitric oxide; NOS-2; Ethanol withdrawal; Zebrafish

Online: 16 December 2019 (11:54:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201901.0171.v2

Identification of Critical Source Areas (CSAs) and Evaluation of Best Management Practices (BMPs) in Controlling Eutrophication in the Dez River Basin

Hadi Babaei, Mohammad Nazari-Sharabian, Moses Karakouzian, Sajjad Ahmad

Subject: Environmental And Earth Sciences, Environmental Science Keywords: water quality; SWAT; SWAT-CUP; SUFI-2

Online: 18 February 2019 (09:07:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0270.v1

The Geometrical Basis of PT Symmetry

Luis Sanchez-Soto, Juan J. Monzón

Subject: Physical Sciences, Optics And Photonics Keywords: PPT symmetry; SL(2, C); hyperbolic geometry

Online: 12 October 2018 (12:42:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201801.0233.v1

Comparing the Potential of Multispectral and Hyperspectral Data for Monitoring Oil Spill Impact

Shruti Khanna, Maria J. Santos, Susan L. Ustin, Kristen Shapiro, Paul J. Haverkamp, Mui Lay

Subject: Environmental And Earth Sciences, Environmental Science Keywords: vegetation indices; LANDSAT; WorldView-2; RapidEye; AVIRIS

Online: 25 January 2018 (04:37:02 CET)

Show abstract| Download PDF| Share

Oil spills from offshore drilling and coastal refineries often cause degradation of coastal wetlands that can take a long time to recover. Early oil detection may prevent losses and speed up recovery if monitoring of the initial oil extent, oil impact, and recovery are in place. Satellite imagery data can provide a cost-effective alternative to expensive airborne imagery or labor intensive field campaigns for monitoring effects of oil spills on wetlands. However, these satellite data may be restricted in their ability to detect and map ecosystem recovery post-spill given their spectral measurement properties and temporal frequency. In this study, we assessed whether spatial and spectral resolution, and other sensor characteristics influence the ability to detect and map vegetation stress and die-off due to oil. We compared how well three satellite multispectral sensors: WorldView2, RapidEye and Landsat EMT+, match the ability of the airborne hyperspectral AVIRIS sensor to map oil-induced vegetation stress, recovery, and die-off after the DeepWater Horizon oil spill in the Gulf of Mexico in 2010. We found that finer spatial resolution (3.5m) provided better delineation of the oil-impacted wetlands and better detection of vegetation stress along oiled shorelines in saltmarsh wetland ecosystems. As spatial resolution become coarser (3.5m to 30m) the ability to accurately detect and map stressed vegetation decreased. Spectral resolution did improve the detection and mapping of oil-impacted wetlands but less strongly than spatial resolution, suggesting that broad-band data may be sufficient to detect and map oil-impacted wetlands. AVIRIS narrow-band data performs better detecting vegetation stress, followed by WorldView2, RapidEye and then Landsat 15m (pan sharpened) data. Higher quality sensor optics and higher signal-to-noise ratio (SNR) may also improve detection and mapping of oil-impacted wetlands; we found that resampled coarser resolution AVIRIS data with higher SNR performed better than either of the three satellite sensors. The ability to acquire imagery during certain times (midday, low tide, etc.) or a certain date is also important in these tidal wetlands; WorldView2 imagery captured at high-tide detected a narrower band of shoreline affected by oil likely because some of the impacted wetland was below the tideline. These results suggest that while multispectral data may be sufficient for detecting the extent of oil-impacted wetlands, high spectral and spatial resolution, high-quality sensor characteristics, and the ability to control time of image acquisition may improve assessment and monitoring of vegetation stress and recovery post oil spills.

Search Results

3145 articles found