Controlled drainage (CD) is an important agricultural measure for maintaining soil moisture and nutrients, controlling groundwater level, and increasing crop yield. In arid regions, CD can be used to improve the water supply in agriculture and reduce environmental pollution. In this study, we investigated the effect of CD, including a drainage depth of 40 cm (CWT1) and 70 cm (CWT2) during the plant growth period, free drainage (FD), and open ditch drainage (OD) on the migration of water, nutrients, and salts in the soil; the dynamics of groundwater level; the loss of soil nitrogen; and the growth of oilseed sunflower plants. Compared with FD, CD increased the water and nutrient content in the soil, reduced nitrogen loss, and enhanced the ability of the soil to continuously supply nitrogen to the oilseed sunflower plants, which benefited plant growth at later growth stages and reduced environmental pollution. During the period between irrigation at the budding stage and harvest stage, the average soil water content in the 0–20 cm soil layer in CWT1 increased by 3.67%, 4.78%, and 0.55%, respectively, compared with that in CWT2, FD, and OD. The soil mineral content in CWT1 was 25.17%, 35.05%, and 17.78% higher than that in CWT2, FD, and OD, respectively, indicating that higher soil salinity occurred at the later stage of plant growth in CWT1, which actually had little effect on the plants due to their enhanced salt tolerance and increased need for water and nutrients at that stage. In addition, CD delayed the decline in groundwater level, which allowed the plants to use groundwater at later growth stages, and as a result the yield and water use efficiency were improved. CWT1 significantly increased oilseed sunflower yield by 4.52–11.14% and increased water use efficiency by 1.16–10.8%. Moreover, CWT1 also increased the survival rate of the oilseed sunflower plants by 2.62–2.92%, and the plants demonstrated good growth. Therefore, under CD conditions, plants used soil water and nitrogen more efficiently and, as a result, their productivity was increased, and the water quality was improved.

To close the nutrient-related yield gaps in maize, balanced nutrition using primary and secondary macronutrients as well as micronutrients is recommended. Multi-nutrient diagnostic field trials were conducted in Guinea Savanna of Nigeria to assess the interactive effects of macronutrients and micronutrients on maize grain yields, nutrient uptake as well as N, P and K use efficiencies. The treatments consisted of a control (zero fertilizer applied), an NPK treatment and 10 other treatments in which macronutrient (Mg, S) and/or micronutrients (B, and Zn) were added to the NPK. The experiment was laid out in Randomized Complete Block Design with 3 replications. Data collected were subjected to mixed model with nutrient management strategy as fixed effects while replication nested in location and interaction between location and nutrient management strategy as random effects. The results revealed significant effects (P < 0.05) of nutrient management strategy on maize yield, nutrient uptake and nutrient use efficiencies of N, P and K. The study revealed that yield advantage over the recommended NPK fertilizer as a result of application macronutrients and micronutrients were highest with Mg in Lere (2.4 t ha⁻¹), S + B + Zn in Faskari (2.8 t ha⁻¹), S + B in Doguwa (1.5 t ha⁻¹) and S + Zn in Toro (2.4 t ha⁻¹). Addition of Mg, S and B significantly increases macronutrient uptakes over the recommended NPK only. Agronomic use efficiency, internal utilization efficiency, apparent recovery efficiency and partial factor productivity were significantly increased with the addition of S, Mg, and B but were not improved with Zn application. It was concluded that nutrient limitations to maize in the Guinea Savanna go beyond N, P and K. This study recommends that S, Mg, and B are needed to improve maize productivity and engender improve the use efficiency of NPK fertilizers.

Self-enhancement (SE) is often overlooked as a fundamental cognitive ability mediated via the Pre-Frontal Cortex (PFC). Here we present research that establishes the relationship between the PFC, SE, and the potential evolved beneficial mechanisms. Specifically, we believe there is now enough evidence to speculate that SE exists to provide significant benefits and should be considered a normal aspect of the self. Whatever the metabolic or social cost, the upside of SE is great enough that it is a core and fundamental psychological construct. Furthermore, though entirely theoretical, we suggest that a critical reason the PFC has evolved so significantly in Homo sapien is to, in part, sustain SE. We therefore elaborate as to its proximate and ultimate mechanisms.

An analysis of the consistency of the Abraham and Minkowski momenta in the determination of the photon trajectory was carried out considering a new principle of conservation of the photon's mechanical energy, in which the photon conserves translational energy in orbital angular momentum when transiting between two media, introducing the relativistic energy wave (REW). The confrontation between REW and the recent theory of space-time waves (ST) was considered, pondering your differences. Throughout this study it was possible to verify that the Abraham momentum appears a relativistic photon ignition device in the transition between two media, acting as the hidden momentum of the Minkowski’s relativistic momentum. The wavy behavior in the matter is relativistic, and the relativistic trajectory appears with delays and advances, with points of synchronization between source-observer. The classical or relativistic trajectories are determined as a function of the angle of incidence and the relative refractive index, by one of two distinct non-additive torques, the classic by Abraham or the relativistic by Minkowski. It was found that the same analysis conducted under the principle of conservation of the mechanical energy of the photon can be treated by an new Doppler, Relativistic Apparent, that can be confused with other Dopplers in the treatment of redshift from distant sources. It was found that the conservation of energy in Orbital Angular Momentum (OAM), in the interaction with matter, explains that the synchronization instants are found in the inversion of the OAM, where the advances and delays of REW occur under negligible variations of the OAM, however, opposites.

The Sustainable Development Goals (SDGs) purport to report holistically on progress towards sustainability and do so using more than 231 discrete indicators with a primary objective to achieve a balance between the environment, social and economic aspects of development. The research question underpinning the analyses presented in this paper is: are the indicators in the SDGs sufficient and fit-for-purpose to assess the trajectory of natural resources towards sustainability? We extracted the SDG indicators that monitor the state of natural resources, or alternately support policy or governance for their protection, and determined if these are adequate to provide the essential data on natural resources to achieve the aims of the SDGs. The indicators are clustered into four natural resource categories; land, water (both marine and freshwater), air and biodiversity. Indicators for monitoring land resources show that the most comprehensive land resource indicator, for degraded land, is not fully implemented and that missing from land monitoring is an evaluation of vegetation health outside of forests and mountains, the condition of soils, and most importantly the overall health of terrestrial ecosystems. Indicators for monitoring water resources have substantial gaps, unable to properly monitor water quality, water stress, many aspects of marine resources and most significantly, the health of fresh and salt water ecosystems. Indicators for monitoring of air have recently become more comprehensive, but linkage to IPCC results would benefit both programmes. Monitoring of biodiversity is perhaps the greatest weakness of the SDG Agenda, having no comprehensive assessment even though narrow aspects are monitored. Again, deliberate linkages to other global biodiversity programmes (e.g. CBD and the Post 2020 Biodiversity Framework; IPBES; Living Planet, etc.) are recommended on condition that data can be defined at a country level. While the SDG list of indicators in support of natural resource is moderately comprehensive, it lacks holistic monitoring in relation to evaluation of ecosystems and biodiversity to the extent that these missing but vital measures of sustainability threaten the entire SDG Agenda. In addition, an emerging issue is that even where there are appropriate indicators, the amount of country-level data remains inadequate to fully evaluate sustainability. This signals the delicate balance between the extent and complexity of the SDG Agenda and uptake at a country level

Despite needs for new therapies and improvements in existing approaches in cardiovascular, pulmonary, endocrine, and renal disease, investment in these areas is lagging relative to other specialties. This article summarizes a meeting of key stakeholders of U.S. Food and Drug Administration (FDA) officials, representatives from academia, national organizations, and patients and caregivers. The purpose was to identify and discuss high-priority issues, establish areas of common interest, and explore opportunities for collaboration. During the meeting (September 2016), the construct of a “multimorbidity continuum” emerged, in which chronic diseases are understood as their effects on the whole rather than individual organ systems. Cross-disciplinary priorities included: 1) the need to generate greater high-quality evidence at lower cost; 2) the imperative to develop and implement patient-centered approaches to clinical investigations; 3) the importance of trial participation in under-represented populations, particularly with comorbid conditions, and 4) the need for progress in tobacco regulation. Representatives from each therapeutic area reported on their consensus priorities, and FDA representatives discussed the agency’s role in facilitating broader approaches to therapeutic development and evaluation of disease as linked across organ systems rather than in isolation, and emphasized the importance of patient engagement, collaboration and communication across stakeholders.

Academic publishing is undergoing a highly transformative process, and many rules and value systems that were in place for years are being challenged in unprecedented forms leading to the evolution of novel ways of dealing with new pressures. One of the most important aspects of an integrated and valid academic literature is the ability to screen publications for errors during peer review to weed out mistakes, fraud and inconsistencies, such that the final published product represents a product that has value, intellectually, and otherwise. It is difficult to claim the existence of perfect manuscripts. The level of errors that exist in a manuscript will depend on the rigor of the research group and of the peer review process that was used to screen that paper. When errors slip into a final published paper, either through honest error or misconduct, and are not detected during peer review and editorial screening, but are spotted during post-publication peer review, an opportunity is created to set the record straight, and to correct it. To date, the most common forms of correcting the literature have been errata, corrigenda, expressions of concern, and retractions. Despite this range of corrective measures, which represent artificially created corrals around pockets of imperfect literature, certain cases do not quite fit this mold, and new suggested measures for correcting the literature have been proposed, including manuscript versioning, amendments, partial retractions and retract and replace. In this commentary, a discussion of the evolving correction of the literature is provided, as are perspectives of the risks and benefits of such new measures to improve it.

Weather has significant impact on growth and plants development. It is important to analyze the influence of changing climate conditions on expression of plants agronomical characters. Two flax varieties were grown from 1987 to 2018 in the North-West of Russia. Whether conditions and their influence on flax agronomic characters were analyzed using variance and correlations analyses. Significant influence of year conditions on the manifestation of all evaluated characters was revealed. Starting from June high temperatures accelerate the development of plants at all stages. Prolongation of germination - flowering period is the most important for fiber productivity improvement. Oppositely, for formation of high quality fiber fast ripening in hot weather after flowering is preferable. Such data give possibility to predict the amount and quality of yield. Usage of weather conditions data also permits to compare results obtained in different years. Suggested method of year’s meteorological conditions classification can be used in other genebanks for systematization and analyses of crops field evaluation results. Correlation analyses reviled 3 correlated pleiades: (1) pleiade of productivity, (2) pleiade of fiber quality and yield, (3) pleiade of the growing season phases duration, the sums of active temperatures and precipitation during each period. Great influence of growing conditions on economically valuable traits indicates the necessity of searching for genotypes with stable characters manifestation for breeding new varieties, which will give stable yield and fiber of good quality.

This study explores the application of the Fully Convolutional Network (FCN) algorithm to the field of meteorology, specifically for the short-term nowcasting of severe convective weather events such as hail, convective wind gust (CG) and thunderstorms, short-term heavy rain(STHR) in Gansu. Training data comes from the European Center for Medium-Range Weather Forecasts (ECMWF) and real-time ground observations, the performance of the proposed FCN model based on 2017 to 2021 training datasets demonstrate a high prediction accuracy, with an overall error rate of 16.6%. Furthermore, the model exhibited an error rate of 18.6% across both severe and non-severe weather conditions when testing against the 2022 dataset. Operational deployment in 2023 has yielded an average Critical Success Index (CSI) of 24.3%, a Probability of Detection (POD) of 62.6%, and a False Alarm Ratio (FAR) of 71.2% for these convective events. It is noteworthy that the predicting performance for STHR was particularly effective with the highest POD and CSI, as well as the lowest FAR. CG and hail predictions had comparable CSI and FAR scores, although the POD for CG surpassed that for hail. The FCN model’s optimal performance for hail prediction occurred at the 4th, 8th, and 10th forecast hours, while for CG, the 6th hour was most accurate, and for STHR, the 2nd and 4th hours were most effective. These findings underscore the FCN model's ideal suitability for short-term forecasting of severe convective weather, presenting extensive prospects for the automation of meteorological operations in the future.

We present our preliminary experience with transarterial radioembolization (TARE) with Yt-trium-90, and investigate the influence of additional treatments, injected activity, mean dose to the tumor on overall survival (OS). Our database was interrogated to retrieve patients who had undergone TARE with Yttrium-90 (90Y) glass or resin microspheres. The following information were searched: 1) type of pathology; 2) sex; 3) age; 4) administered activity; 5) mean dose to the tumor; 6) additional treatments; 7) OS. The OS of the different groups of patients were compared (p<0.05). A bivariate correlation (p<0.05) was used to investigate the association between injected activity and OS, and between mean dose to the tumor on OS. Thirty-nine patients were retrieved (Sex: 27 M, 12 F; mean age: 61.26 ± 14.95 years): 23 with hepatocellular carcinoma (HCC) and 16 with colorectal cancer (CRC) liver metastasis. Globally, patients with HCC demonstrated a sig-nificantly longer OS than those with CRC liver metastasis (22.66±19.11 vs. 10.41±8.75 months; p=0.022). Among patients with CRC liver metastasis, those receiving TARE and additional treatment demonstrated a longer OS than patients receiving only TARE (23.50±19.76 months vs. 8.54±5.31; p=0.018), there was a direct correlation between injected activity and OS (R=0.55, p=0.034) and between mean activity reaching the tumor and OS (R=0.812; p=0.008). Patients with HCC receiving TARE achieved a longer OS than those with CRC liver metastasis. Additional treatments, increasing injected activity and higher mean dose to the tumor seem beneficial for outcome, especially in patients with CRC liver metastases.

The susceptible-infected-recovered/removed-vaccinated (SIRV) epidemics model is an important generalization of the SIR epidemics model as it accounts quantitatively for the effects of vaccination campaigns on the temporal evolution of epidemics outbreaks. Additional to the time-dependent infection ($a(t)$) and recovery ($\mu (t)$) rates, regulating the transitions between the compartments $S\to I$ and $I\to R$, respectively, the time-dependent vaccination rate $v(t)$ accounts for the transition between the compartments $S\to V$ of susceptible to vaccinated fractions. An accurate analytical approximation is derived for arbitrary and different temporal dependencies of the rates which is valid for all times after the start of the epidemics for which the cumulative fraction of new infections $J(t)\ll 1$. As vaccination campaigns automatically reduce the rate of new infections by transferring susceptible to vaccinated persons, the limit $J(t)\ll 1$ is even better fulfilled than in the SIR-epidemics model. The comparison of the analytical approximation for the temporal dependence of the rate of new infections $\jt(t)=a(t)S(t)I(t)$, the corresponding cumulative fraction $J(t)$, and $V(t)$, respectively, with the exact numerical solution of the SIRV-equations for different illustrative examples proves the accuracy of our approach. The considered illustrative examples include the cases of stationary ratios with a delayed start of vaccinations, and an oscillating ratio of recovery to infection rate with a delayed vaccination at constant rate. The proposed analytical approximation is self-regulating as the final analytical expression for the cumulative fraction $\jinf $ after infinite time allows us to check the validity of the original assumption $J(t)\le \jinf \ll 1$.

The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1, supresses their kinase activity, and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.

Enforcement of animal welfare statutes are the primary protection given for the maintenance of animal welfare and prevention of cruelty. It is speculated that animal law enforcement in Australia has a number of weakness in the enforcement model. These weaknesses create a gap between the goals of animal law enforcement and the reality of the animal law justice system. This gap is defined as the ‘enforcement gap’. This paper identifies and investigates the causes of this gap. The hypothesized causes discussed are (1) the impact the public can have on reporting animal cruelty, (2) the reliance on charitable organizations as enforcement bodies, (3) the inconsistencies in animal welfare legislation, and (4) the role of the sentencing courts. Thus, the causes of the enforcement gap are multifactorial; derived from all stages of the enforcement process. Further research is needed to investigate the concepts raised in this paper. However, it is likely that a combination of structural change to enforcement agencies, legislative reform and public education is required to reduce the enforcement gap.

Platinum(II) complexes have been found to be effective against cancer cells. Cisplatin curbs cell replication by interacting with the deoxyribonucleic acid (DNA), eventually leading to cell death and reducing cell proliferation. In order to investigate the ability of platinum complexes to affect cancer cells, two examples from the class of polyflurophenylorganoamidoplatinum(II) complexes were synthesised and tested on isolated DNA. The two compounds trans-[N,N’-bis(1,2,3,5,6-pentafluorophenyl)ethane-1,2-diaminato(1-)](2,3,4,5,6-pentafluorobenzoato)(pyridine)platinum(II) (PFB), and trans-[N,N’-bis(1,2,3,5,6-pentafluorophenyl)ethane-1,2-diaminato(1-)](2,4,6-trimethylbenzoato)(pyridine)platinum(II) (TMB) were compared with cisplatin through their reaction with DNA. Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy was applied to analyse the interaction of the Pt^(II) complexes with DNA in the hydrated, dehydrated and rehydrated state. These were compared with control DNA in acetone/water (PFB, TMB) and isotonic saline (cisplatin) under the same conditions. Principle Component Analysis (PCA) was applied to compare the ATR-FTIR spectra of the untreated control DNA with spectra of PFB and TMB treated DNA samples. Disruptions in the conformation of DNA treated with the Pt^(II) complexes upon rehydration were mainly observed by monitoring the position of the IR-band around 1711 cm^-1 assigned to the DNA base-stacking vibration. Furthermore, other intensity changes in the phosphodiester bands of DNA at ~1234 cm^-1 and 1225 cm^-1 and shifts in the dianionic phosphodiester vibration at 966 cm^-1 were observed. The isolated double stranded DNA (dsDNA) or single stranded DNA (ssDNA) showed different structural changes when incubated with the studied compounds. PCA confirmed PFB had the most dramatic effect by denaturing both dsDNA and ssDNA. Both compounds, along with cisplatin, induced changes in DNA bands at 1711, 1088, 1051 and 966 cm^-1 indicative of DNA conformation changes. The ability to monitor conformational change with infrared spectroscopy paves the way for a sensor to screen for new anticancer therapeutic agents.

Many dioecious plants have sex chromosomes that are cytologically heteromorphic, but about half of species lack cytological differences between males and females and are thus homomorphic. Very little is known about the size and content of the non-recombining sex-determining region (SDR) in these species. Here, we assess the size and content of the SDR of the diploid dioecious herb Mercurialis annua, which has homomorphic sex chromosomes and shows signatures of mild Y-chromosome degeneration. We used RNAseq to identify new Y-linked markers for M. annua. Twelve of 24 transcripts with male-specific and male-biased expression could only be PCR-amplified from males and are thus Y-linked. We found a further six Y-linked sequences that were present in males but not females using genome capture data from multiple populations. We used the Y-linked sequences to identify and sequence 17 sex-linked bacterial artificial chromosomes (BACs), which form 11 groups of non-overlapping sequence, covering a total sequence length of about 1.5 Mb. Content analysis of this region suggests it is enriched for repeats, has a low gene density and contains few candidate sex-determining genes. The BACs map to a subset of the sex-linked region of the genetic map, which is estimated to be at least 14.5 Mb. This is substantially larger than estimates for other dioecious plants with homomorphic sex chromosomes, especially given the small genome size of M. annua. Our data provide a rare, high-resolution view of the homomorphic Y chromosome of a dioecious plant.

Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegeneration. The engineered binding protein β-wrapin AS69 binds monomeric αSyn. AS69 reduces primary and secondary nucleation as well as fibril elongation in vitro. It also mitigates aSyn pathology in a mouse model based on intrastriatal injection of aSyn pre-formed fibrils (PFF). Since the PFF-based model does not represent all aspects of PD, we tested here whether AS69 can reduce neurodegeneration resulting from αSyn overexpression. Human A53T-αSyn was overexpressed in the mouse Substantia nigra (SN) by using recombinant adeno-associated viral vector (rAAV). AS69 was also expressed by rAAV transduction. Behavioral tests and immunofluorescence stainings were used as outcomes.Transduction with rAAV-αSyn resulted in αSyn pathology as reported by phospho-αSyn staining and caused degeneration of dopaminergic neurons in the SN. The co-expression of rAAV-AS69 did not reduce αSyn pathology or degeneration of dopaminergic neurons. We conclude that αSyn monomer binding by rAAV-AS69 was insufficient to protect from aSyn pathology resulting from αSyn overexpression.

Manure-compost-soil is the main pathway for the use of agricultural livestock waste. Biochar, regarded as the conditioner, was beneficial to nitrogen fixation during aerobic composting, and was to the enhancement of soil organic matter (OM) and nitrogen content, when applied with compost to the soil. But, the manure-compost-soil process was also related to microbial succession, whether biochar could affect this succession was not studied. In this paper, we investigated the influence of biochar on the manure-compost-soil process and its microbial community succession. Compared with the control group, biochar increased the OM and total nitrogen content of the compost. Biochar, compost and biochar-based compost improved the total carbon (TC) and OM of the soil. The genera of the initial composting sample were Saccharomonospora, Atopostipes and Lactobacillus, and were eliminated after high-temperature fermentation. Lysobacter, Glutamicibacter and Streptomyces were the dominant genera in the soil samples, promoting plant growth. Nocardiopsis, Saccharomonospora, Bacillus and Oceanobacillus dominated the genera in the whole manure-compost-soil process. Thus, aerobic composting could eliminate the toxic or negative bacteria that were directly input into the soil by manure. Those genera from compost or biochar-based compost flux into the soil could make an important contribution to OM’s cycle.

Renewable Energy Communities (RECs), strongly sustained by the European Community as a viable way to fasten low carbon transition, slowly develop in Italy for regulatory . This study delves into the framework of RECs and explores the perspective of the specifically small and medium industries in the Lombardy region of Italy through a survey. Our findings reveal that while SMEs exhibit interest in RECs, there is a notable gap in knowledge and engagement. We argue that the active involvement of Public Administration Bodies (PABs) is crucial in disseminating information about RECs and highlighting their benefits. The survey results, elaborated through a non-parametric test (Mann-Whitney U test) indicate that PABs play a pivotal role in influencing SMEs' perceptions and willingness to participate in RECs. The data suggest that more direct and effective communication strategies by PABs could significantly enhance SMEs' understanding and involvement in RECs. This research underscores the need for targeted and strategic efforts by PABs to foster a more informed and proactive approach among SMEs towards renewable energy initiatives. Such endeavors could be instrumental in accelerating the adoption of RECs, contributing to a more sustainable and resilient energy future.

A new approach is presented for dynamic modeling of chemical and isotopic evolution of C1-3 during the hydrocarbon generation process. Based on systematic data obtained from published papers for pyrolysis of various hydrocarbon sources(type I kerogen/source rock, type II kerogen/source rock, type III kerogen/source rock, crude oil, asphalt, etc), the empirical evolution framework of chemical and isotopic composition of C1-3 during the hydrocarbon generation process was built. Although the empirical framework was built only by fitting large amount of pyrolysis data, the chemical and isotopic composition of C1-3 derived from the pyrolysis experiments all follow the evolution laws, convincing us that it is applicable to the thermal evolution process of various hydrocarbon sources. Based on the simplified formula of the isotopic composition of mixed natural gas at different maturities (δ13Cmixed) δ13Cmixed=(X〖*n〗_iA 〖*δ〗^13 C_iA+Y〖*n〗_iB 〖*δ〗^13 C_iB)/(X〖*n〗_iA+Y〖*n〗_iB ), it can be derived that the cumulative isotopic composition of alkane generated in certain maturity interval can be expressed by the integral of the product of instantaneous isotopic composition and instantaneous yield at certain maturity point, and then divided by the cumulative yield of alkane generated in corresponding maturity interval. Thus, the cumulative isotopic composition(A(X)), cumulative yield(B(X)), instantaneous isotope(C(X)),and instantaneous yield(D(x)) in the dynamic model comply with the following formula during the maturity interval of (X0-X) A(X)=(∫_(X_0)^X▒〖C(X)*D(X)dx〗)/(B(X)), where A(X) and B(X) can be obtained by fitting of pyrolysis data, and D(x) can also be obtained from the derivation of B(X). The dynamic model was applied on the pyrolysis data of Pingliang Shale to illustrate the quantitative evolution of cumulative yield ,instantaneous yield, cumulative isotope and instantaneous isotope of C1-3 with increasing maturity.The dynamic model can quantify the yield of methane, ethane and propane as well as δ13C1, δ13C2 and δ13C3 respectively during the hydrocarbon generation process, which is of great significance to evaluate the natural gas resources of hydrocarbon source rock with different maturity and to identify the origin and evolutionary process of hydrocarbons by chemical and isotopic data. Moreover, this model provides an approach to study the dynamic evolution of isotope series of C1-3 (including reversed isotopic series), which is hopeful to reveal the mechanism responsible for isotopic reversal when combined with post-generation studies.

This study aimed to investigate the impact of incorporating Refuse Derived Fuel (RDF) into a production brick mixture in order to mitigate difficulties encountered in the production environment. Three distinct tests were conducted to assess the preparation process. The first test served as a reference, utilizing 100% clay material without RDF. The second test involved the inclusion of 10% RDF, obtained from a waste factory, with a grain size less than 20mm. In the third test, the RDF was mixed with silica sand after undergoing hammer milling with a 2mm sieve, followed by a 10% incorporation into the mixture. The primary objective was to comprehend the behavior of these mixtures in two critical stages: extrusion and drying. Extrusion performance was evaluated by examining the shaping process from the mold, vacuum conditions within the extruder, and the cutting of wet sample bricks. Furthermore, the drying procedure was assessed in terms of shrinkage, drying sensitivity, and appearance. Comparisons were made among the three test scenarios to identify the influence of RDF on these key parameters. Preliminary results indicate that the inclusion of RDF impacted the extrusion process. The addition of RDF resulted in variations in the flow characteristics of the mixture, affecting the shape formation from the mold and the vacuum conditions within the extruder. Additionally, the cutting of wet sample bricks exhibited some differences compared to the reference test. Concerning the drying phase, the presence of RDF influenced shrinkage behavior and drying sensitivity. The mixture with RDF showed different shrinkage patterns compared to the reference, and its drying sensitivity was altered. Moreover, the appearance of the bricks after drying exhibited notable variations due to the incorporation of RDF. In conclusion, incorporating RDF in the brick mixture introduces changes in both the extrusion and drying stages. The alteration in flow characteristics and vacuum conditions during extrusion, as well as the variations in shrinkage, drying sensitivity, and appearance during drying, suggest that further investigation is necessary to optimize the incorporation of RDF for improved brick production. These findings contribute to the understanding of the challenges and opportunities associated with the utilization of RDF in brick manufacturing processes.

Anorectal malformations (ARMs) represent a wide spectrum of congenital anomalies of the anus and rectum, of which more than half are syndromic. Their etiology is highly heterogeneous and still poorly understood. We report a 4-year-old girl who initially presented with an isolated ARM, and subsequently developed a global developmental delay as part of an ARID1B-related Coffin-Siris syndrome (CSS). The co-occurrence of ARMs and CSS in an individual is unexpected since both diseases are very rare. A review of the literature enabled us to identify 12 individuals with both CSS and ARMs. Among these 12 individuals, 9 had a variant in ARID1A, 2 in ARID1B, and 1 in SMARCA4. This more frequent than expected association between CSS and ARM indicates that some ARMs are likely a rare consequence of CSS, especially for ARID1A-related CSS.

This research identifies the resilience factors of tax centers in Cameroon. To do so, we use binary logistic regression on data collected from tax revenue mobilization centers (TRMC). the results show that the digitization of the tax system and leadership are factors in absorbing the crisis. Access to electricity and staff at the center are the recovery factors for the level of revenue after the crisis. We recommend that public institutions improve the digitalization processes of tax administrations. The transmission channels of digitization such as access to electricity and telecommunications networks must be ensured in the tax centers. Furthermore, we propose to increase the number of tax centers or to build tax kiosks to reduce the distance between taxpayers and their centers of attachment.

Variation in metabolite profiles of under high salinity and nitrogen constraint conditions are the key issues of study at the present. To investigate the optimum NaCl and NaNO3 concentration and the corresponding metabolic pathways of astaxanthin accumulation in H. pluvialis, a 26-day batch culture experiment of H. pluvialis treated under the variable concentration gradients of NaCl and NaNO₃ were conducted. The results indicated that 7.5g•L^-1 and nitrogen-deficient were the optimum NaCl and NaNO₃ concentration for the astaxanthin accumulation according to single factor experiments respectively, under which the highest contents of astaxanthin accumulated in H. pluvialis reached up to 7.51mg•L^-1 and 5.60mg•L^-1. A total of 132 metabolites were analysed using LC-MS/MS technique, among which 30 differential metabolites with statistical significance were highlighted. Subsequently, 18 and 10 differential metabolic pathways in the high salinity and nitrogen-deficient treatments with statistic significance were enriched and annotated respectively. Furthermore, the metabolic networks related to the astaxanthin accumulation were constucted based on the crucial pathways and metabolites. Moreover, the major carbon metabolism in H. pluvialis under the high salinity and nitrogen deficient stress were presented, which exhibited the characteristics in the identified metabolites changes under the different stress conditions. The results did not only demonstrate the differential metabolic networks and the distinct changes in the metabolites involved in the major carbon metabolism, related to the astaxanthin accumulation in H. pluvialis under the different stress factors, but provided the regulation targets for astaxanthin production in practice.

Despite recent advancements, therapies remain ineffective against advanced oral squamous cell carcinoma (OSCC), resulting in unsatisfactory therapeutic outcomes. Cold atmospheric plasma (CAP) offers a promising approach in the treatment of malignant neoplasms. Yet, the exact mechanisms driving CAP-induced cancer cell death are not fully understood. This study revealed a significant reduction in the viability of OSCC cell lines, inactivation of AKT and ERK, and the downregulation of the miR-21, miR-31, miR-134, miR-146a and miR-211 expression followed the CAP treatment. Pretreatment with ZVAD, 3-MA, and Fer-1 synergistically reduced CAP-induced cell death, indicating a combined induction of variable death pathways by CAP. Activation of AKT and ERK, alongside combined treatments using death inhibitors and miRNA mimics, counteracted the cell mortality associated with CAP. CAP-induced downregulation of miR-21, miR-31, miR-187 and miR-211 expression was rescued by AKT and ERK activation. Additionally, CAP treatments notably inhibited the growth of SAS cell xenografts on nude mice. The reduced expression of oncogenic miRNAs in vivo aligned with in vitro findings. In conclusion, our study indicates that CAP jet treatment diminishes OSCC cell viability by abrogating survival signals and oncogenic miRNA expression.

The demand for industries to enhance sustainability is rising in response to climate change worries. A pervasive and intensifying worldwide environmental problem, plastic pollution has a particularly severe impact on climate change. The production of significant volumes of plastic garbage occurs mostly in Asian regions. So, it's commonplace to talk about pro-environmental conduct nowadays. Indonesia and Taiwan are chosen as case studies of developed and developing regions, respectively. The cultural differences between the two areas do, however, exist in terms of environmental values, and this further influences consumer behavior. In order to understand how environmental education has influenced pro-environmental behavior, this study examines how environmental attitude, knowledge, motivation, and intention have changed as a result of environmental education. By sending electronic questionnaires to a sample of 235 respondents (110 Indonesian and 125 Taiwanese), gathered between March 11 and April 30, 2023, we employ quantitative approaches and data-gathering procedures. The CB-Structural Equation Modelling with AMOS analytical tool is used to examine the data. We are able to draw important conclusions from the study of differences between Indonesian and Taiwanese and make suggestions for more research as well as theoretical and managerial ramifications.

The rapid development of the regional economy in China has led to the rise of local ecological risks. It is very important to provide enjoyable ecosystem services to residents while reducing ecological risks. In order to understand spatial relationships between ecosystem services and ecological risks, we took Chongqing as an example in this study to assess the spatial relationship between ecosystem services and ecological risks at the county scale based on the ES-DPSIR system. The main findings include: (1) significant variation in the spatial distribution of the comprehensive ecosystem service index, where the lowest ecosystem service index (0.013) was found in the main urban area of Chongqing and the scores gradually increased outward from this center, reaching 0.689 in the outermost areas, (2) the increase of the comprehensive ecological risk index from east to west, ranging from -0.134 to 0.333, (3) the spatial relationship between ecosystem services and ecological risks was prominent, with 52.63% of the districts and counties being imbalanced or mild imbalanced, and (4) the significant differences between development trends of ecosystem services-ecological risks, including 60.53% being imbalanced districts and 30.47% mildly balanced. Overall, it was necessary to improve the relationship between ecosystem services and ecological risks in Chongqing by reducing ecological risks., and these research results could provide effective approaches and technical support for improving regional ecological security and enhancing ecosystem service capabilities.

We have previously reported on the diachronical changes in the narrative structure of research articles (RAs) and review manuscripts, using corpora of abstracts from MEDLINE. The present study investigates 5 linguistic dimensions (D1-5) of the text, following Biber’s well established Multimensional Analysis, on the same corpora, to assess how writing practices have changed in these two biomedical literature sub-genres over the years. Our analysis encompassed a sample of more than 1.2 million subtracts from manuscripts that were published over the course of more than 30 years. Both RAs and reviews have reinforced their informational, emotionally detached tone (D1), and have progressively refrained from the use of narrative devices (D2), while increasing their context-independent content (D3). Both RAs and reviews have displayed low levels of overt persuasion (D4), while steering away from abstract content to focus on a more marked author agency and identity adfirmation. When the linguistic features that underly these 5 dimensions are compared, it becomes apparent that RAs and review papers have often changed quite independently, both usually converging to standardized stylistic canons.

The unique characteristics of frescoes on overseas Chinese buildings can attest to the integration and historical background of Chinese and Western cultures. Reasonable analysis and preservation of overseas Chinese frescoes can provide sustainable development for culture and history. This research adopts the image analysis technology based on artificial intelligence, and proposes a ResNet-34 model and method integrating transfer learning. This deep learning model can identify and classify the source of the frescoes of the emigrants, and can effectively deal with the problems such as the small number of fresco images on the emigrants' buildings, poor quality, difficulty in feature extraction, and similar pattern text and style. The experimental results show that the training process of the model proposed in this article is stable. On the constructed Jiangmen and Haikou fresco JHD datasets, the final accuracy is 98.41%, and the recall rate is 98.53%. The above evaluation indicators are superior to classic models such as AlexNet, GoogLeNet, and VGGNet. It can be seen that the model in this article has strong generalization ability and is not prone to overfitting. It can effectively identify and classify the cultural connotations and regions of frescoes.

The effects of various drawing parameters and annealing processes on the structure and properties of Cu-Ag wires, containing 1 wt% silver, were investigated using specialized equipment including fine wire drawing machines, very fine wire drawing machines, heat treatment equipment, tensile testing machines, microcomputer-controlled electronic universal testers, resistance testers, and scanning electron microscopes. The results revealed that continuous drawing of Cu-1%Ag alloy wires led to elongation of the grains, resulting in a uniform and tightly fibrous microstructure. Moreover, the tensile strength of the alloy wire increased from 670 MPa to 783.9 MPa after a single-pass with a deformation of 14%. Subsequently, when the wire was drawn at a speed of 500 m/min, the tensile strength further increased to 820.1 MPa. After annealing the Փ0.08 mm Cu-1% Ag alloy wire, an increase in annealing temperature up to 500°C resulted in the wire's tensile strength decreasing from 820.1 MPa to 377.5 MPa. Simultaneously, the elongation increased from 1.94% to 15.21%, and the resistivity decreased from 1.931×10-8Ω·m to 1.723×10-8Ω·m. Additionally, when annealing was conducted at a rate of 80 m/min, the wire resistivity dropped to 1.635×10-8Ω·m.

In this study we assessed the electrical and optical behavior of semiconductor hybrid films fabricate from octaethyl-21H,23H-porphine copper (CuP), embedded in polymethylmethacrylate (PMMA), and polystyrene (PS). The hybrid films were characterized structurally and morphologically by means of Infrared spectroscopy (IR), atomic force microscopy (AFM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). Subsequently, the PMMA:CuP and PS:CuP hybrid films were evaluated optically by UV-vis spectroscopy, as well as electrically, with the four-point collinear method. Hybrid films present a homogeneous and low roughness morphology, besides; the PS matrix allows the crystallization of the porphin, while the PMMA promotes the amorphous structure in CuP. The polymeric matrix also has an effect on the optical behavior of the films, since the smallest optical gap (2.16 eV) and onset gap (1.89 eV) and the highest transparency are obtained in the film with a PMMA matrix. Finally, the electrical behavior in hybrid films is also affected by the matrix: the largest amount of current carried is around 0.01 A for PS:CuP film, while for PMMA:CuP film it is 0.0015 A. Thanks to the above properties, hybrid films are promising candidates for use in optoelectronic devices.

Off-road vehicles and transportation are vital for agricultural economics, yet the transition to green energies is challenging. To make this application easier, a tool that enables the testing of heavy-duty off-road vehicles in various scenarios was created. Based on the methods of the World Harmonized Transient Cycle, a new Hybrid Operational Cycle that reflects the features of agricultural work was created and applied in a graphical model simulation. This was a newly developed methodology. The cycle and the model were based on gathered research data. A numerical model of a medium-power tractor with an internal combustion engine and a series-hybrid setup was created, and simulations were performed in Matlab and AVL Cruise. The research compared both diesel and hybrid vehicles in terms of their power production, fuel consumption, and efficiency in fieldwork and transportation scenarios. The research showed that a series-hybrid transmission can achieve an efficiency similar to that of tractors with a continuously variable transmission (CVT), but with the use of an electric powertrain, there is still an opportunity to exploit energy regeneration in transportation and under low-load conditions. The designed model also may be used for the development of control algorithms for hybrid drives and the improvement of the efficiency thereof.

Depression and obesity are highly comorbid with one another, with evidence for bidirectional causal links between each disorder and a shared biological basis. The available evidence suggests that genetic factors play a major role in influencing both the occurrence of comorbid depression and obesity, their courses, and their response to existing treatments. The current paper is a scoping review of studies that have evaluated the contribution of specific genetic variants to the comorbidity between obesity and depression. Based on a search of the PubMed and EMBASE databases, 28 studies were included in this review, covering 54 candidate genes. Positive associations were identified for fourteen genetic loci (AKR1C2, APOA5, COMT, DAT1, FTO, KCNE1, MAOA, MC4R, MCHR2, NPY2R, NR3C1, Ob, PCSK9 and TAL1). Replicated findings across two or more independent samples were observed for the FTO and MC4R genes. Many of these gene products represent novel molecular targets for the pharmacological management of obesity which are not pharmacologically influenced by existing anti-obesity or antidepressant medications. The implications of these associations for future drug development are discussed, with an emphasis on recent evidence on the polygenic architecture of comorbid depression and obesity, and on a precision medicine approach to these conditions.

Evolutionary, sequence and structural analyses of tRNA variable (V) loops provides a new understanding. Type I tRNA V loops have a primordial length of 5 nt, and type II tRNA V loops have a primordial length of 14 nt. Sequence-based alignments of type I and type II V loops gave deceptive results. Type II V loops are characterized by the trajectory of the V arm, the size and sequence of the loop and the first and last V loop nucleotides and their known contacts. Depending on the V arm trajectory, type II V stems and loops can be interaction sites for aminoacyl-tRNA synthetases. So, type II V arms for tRNALeu, tRNASer and tRNATyr (found in Bacteria) were coevolved and selected to distinguish determinants to support cognate tRNA charging. The alignment of type I and type II V loops was adjusted based on tRNA evolution. Results are consistent with Archaea being an older and simpler life form than Bacteria. TRNAome sequences were derived from radiation of an ordered tRNAPri (Pri for primordial) sequence comprised of known RNA repeats and inverted repeats. V loop and tRNA sequences, therefore, convey a history of the primary successful pathway in the origin of life.

Background: This study aimed to evaluate whether measles vaccine uptake can be predicted directly or indirectly by parental perceptions about the availability of measles vaccine services with parental hesitancy towards the measles vaccine as a potential mediator. Methods: This was a community-based cross-sectional study conducted at Omdurman locality in Khartoum state, Sudan in February 2019. The study population included parents/ guardians having at least one child aged 2 -3 years old. Mediation analysis was conducted using two models, the ordinary least squares path analysis and multiple logistic regression. Results: a total of 495 responded and the mean age of the mothers who participated in the study was 31.1 (SD=5.73). A half of the respondents (50.1%) completed university education and nearly three-quarters of the respondents (74.7%) were housewives. After controlling for the other factors, including the mother’s age and the number of children, parental perception about the accessibility and availability of the measles vaccine influences the uptake of the measles vaccine indirectly through the mediation effect of measles vaccine hesitancy. Conclusions: We suggest that intervening in measles vaccine hesitancy in addition to measles vaccination access issues will have positive impact on the uptake and coverage of the measles vaccine in Sudan.

Background: The trends in the role of the germline in epigenetic transgenerational inheritance starts with the environmental factors acting on the first generation of a gestating mother. These factors influence the developing second-generation fetus by altering gonadal development, thereby reprogramming the primordial germ cell DNA methylation and leading to consequences that would be seen along generations. Objective: Despite these epigenetic factors now surfacing, the few available studies are on animal-based experiments and to make follow up on human intergenerational trials might take decades. To this response, this study aimed to determine the influence of parental energy, toxicant exposure, age and nutrient restriction on the early life of offspring growth in Gambia. Method: The study was on population-based observational study on parental energy influence, toxicant exposure, age, and nutrient restriction on offspring growth in Gambia. Results: This study showed that parents who worked in industrial areas were more likely to have offspring with poor psychosocial skills. In addition, mothers who are exposed to oxidative stress and high temperature are more likely to have offspring with poor psychosocial skills. Mothers who consumed a high protein diet were almost three more likely to have infants with good psychosocial skills in their offspring. Furthermore, there was a negative correlation between maternal stress during pregnancy and psychosocial skills of offspring. Conclusion: This study was able ascertain if maternal diet during gestation, toxicant exposure, maternal stress and parental smoking habits have influence on the early life of offspring. While the study is recommending a large sample size study to eliminate selection bias, there should be an increased level of awareness of mothers on their offspring's health and their husbands' lifestyles that might influence the adulthood health of offspring.

The Kalanchoe genus is composed of more than 100 species that usually thrive in tropical environments, which have been used in folkloric medicine to treat various illnesses, including dermatological conditions. With this, the present study assesses the pharmacognostical and pharmacological properties of different species of the Kalanchoe genus as elements for a potential treatment for dermatological-related conditions, from findings of existing literature and studies. It was analyzed that the Kalanchoe pinnata plant, or one of the most common species of Kalanchoe, have been observed to have distinct morphological and microscopic characteristics. Further, it was discovered that different species of Kalanchoe have anti-inflammatory, antioxidant, antibacterial, and wound healing properties, which enable the plant to be used for dermatological products that are available to the market. With this, it is recommended that further studies be conducted in other understudied species of Kalanchoe regarding their pharmacological properties, as well as the use of other structures of the Kalanchoe plant for treatment of various dermatological conditions.

The different vegetable oils used in canned fish as filling medium have a preserving effect and contribute to the palatability of the product. In this study, the colour of European eels and the filling medium (sunflower oil, olive oil or spicy olive oil) was measured at different steps of the canning process. The sensorial characteristics of canned eels packed in the different oils were also evaluated. Colour scores (CieLab values) were higher in canned eels packed in sunflower and spicy olive oil than in canned eels packed in olive oil. The changes in colour parameters depended on the type of oil, the stage of the process and the storage time. Colour changes in canned eels packed in olive oil were highest during the sterilization process. Spicy olive oil was the filling medium in which the colour change was greatest, probably due to the migration of some of the spice components into the oil. Organoleptic properties were directly related to the type of oil used as the filling medium. The canned eels packed in sunflower oil were those awarded the highest scores in consumer tests, although the preferences varied depending on the age and gender of the consumers.

Climate change is expected to increase the occurrence of droughts with the hydrology in alpine systems being largely determined by snow dynamics. In this paper we propose a methodology to assess the impact of climate change on both meteorological and hydrological droughts taking into account the dynamics of the snow cover area (SCA). We will also analyse the correlation between these types of droughts. We have generated ensembles of local climate scenarios based on regional climate models (RCMs) representative of potential future conditions. We have considered several sources of uncertainty: different historical climate databases, simulations obtained with several RCMs, and some statistical downscaling techniques. We then used a stochastic weather generator (SWG) to generate multiple climatic series preserving the characteristics of the ensemble scenario. These were simulated within a cellular automata (CA) model to generate multiple SCA future series. They were used to calculate multiple series of meteorological drought indices, the Standardized Precipitation Index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI)) and a novel hydrological drought index (Standardized Snow Cover Index (SSCI)). A linear correlation analysis was applied to both types of drought to analyse how they propagate and the time delay between them. We applied the proposed methodology to the Sierra Nevada (southern Spain) where we estimated a general increase in meteorological and hydrological drought magnitude and duration for the horizon 2071-2100 under the RCP 8.5 emission scenario. The SCA droughts also revealed a significant increase in drought intensity. The meteorological drought propagation to SCA droughts is reflected in an immediate or short time (1 month), obtaining significant correlations in lower accumulation periods of drought indices (3 and 6 months). This will allow us to obtain information about meteorological drought from SCA deficits and vice versa.

(1)Background: When the COVID-19 pandemic arrived, changes had to be made to several management aspects at our Pediatric Oncology Center. We investigated how the families per-ceived these changes. (2) Methods: Two questionnaires were developed at the Pediatric Oncology Unit of the Istituto Nazionale dei Tumori in Milan, to explore how the pandemic has affected the experience of patients who had been or were being treated at our hospital, and their families. These were administered to three samples of individuals. (3) Results: Between July and October 2020, 120 questionnaires were administered to parents of patients. The impact of school closures and the impossibility of attending sports and social activities outside the hospital were regarded as im-portant. 77.5% of parents judged the social distancing to have affected their children. Regarding the changes introduced in the management of the ward and outpatient clinic, most parents’ opinions were positive. Differences in the opinions expressed by Groups 2 and 3 were statistically significant on the topic of relationships on the ward and staff workload. The aspect most negatively affected by the pandemic was the support that patients’ parents were able to give each other. Regardless of whether patients were treated before the pandemic or after the first lockdown, their parents of all indicated a strong degree of satisfaction with the care received, and with the organizational ar-rangements. (4) Conclusions: The results of our study point us in the right direction to further improve our daily work and better respond to the needs of our patients and their families.

Testing and isolation have been crucial for controlling the COVID-19 pandemic. Venezuela has one of the weakest testing infrastructures in Latin America and the low number of reported cases in the country has been attributed to substantial underreporting. However, the Venezuelan epidemic seems to have lagged behind other countries in the region, with most cases occurring within the capital region and four border states. Here, we describe the spatial epidemiology of COVID-19 in Venezuela and its relation to population mobility, migration patterns, non-pharmaceutical interventions and fuel availability. Using an SEI metapopulation model, we explore how movement patterns could have driven the observed distribution of cases. Low within-country connectivity most likely delayed the epidemic in most states, except for those bordering Colombia and Brazil where high immigration seeded outbreaks. NPIs slowed early epidemic growth and subsequent fuel shortages appeared to be responsible for limiting the spread of COVID-19 across the country.

The American leafhopper Erasmoneura vulnerata, detected in Europe in early 2000s, has recently become a pest in North-Italian vineyards. Issues were recorded in organic and conventional vine-yards despite the application of insecticides devoted to the control of other pests. Erasmoneura vulnerata completes three generations, and the second generation is frequently associated to large populations. The selection of appropriate active ingredients and the timing of their application is crucial for effective pest control. Field trials were carried out in North-eastern Italy, using a randomized design, to evaluate the impact of insecticides applied against other grapevine leafhoppers on E. vulnerata populations. The beginning of the second generation was selected as best timing for insecticide application. For a number of natural products, two applications were planned. Among the selected insecticides, the most effective were acetamiprid, flupyradifurone and lamb-da-cyhalothrin. Regarding natural products, the most effective was kaolin that could represent an alternative to pyrethrins in organic vineyards. The identification of pest threshold levels and the evaluation of side effects of the most effective insecticides on key natural enemies occurring in vineyards are required

To gain new insights into the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding practices, we systematically searched regional and international databases and screened 1,658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother-children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications were found to be associated with ZIKV RNA in breast milk. This review updates our previous report by synthesizing the evidence from 12 new articles and we find no evidence of mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to completely understand any potential of transmission of ZIKV through breastfeeding.

rdinary people and political leaders must know the sources of greenhouse gas emissions and their effect on global climate change before they have ability to make decisions to reduce emissions and increase sinks of these gases. These people must, however, understand where greenhouse gas emissions are formed and how reductions can be made: they must understand where carbon dioxide sinks are and how to preserve or increase these sinks. North Savo is the example used in this work to describe the present emissions and sinks. There are proposals on what should and could be done to reduce greenhouse gas emissions caused by traffic, heating, forests and agriculture. There are possibilities of reducing emissions of greenhouse gases in traffic and heating in spite of the fact that the province has a low population density with long distances between homes and workplaces and schools, and a cold climate. We believe that research will also find solutions for reducing greenhouse gases and protecting waters, which are used for recreational purposes and for raw water of drinking water in many places. Luckily forests cover large areas of North Savo and their growth is an important carbon dioxide sink. In addition, forest soils serve as a valuable storage of carbon. Besides carbon dioxide emissions, emissions of nitrous oxide and methane must also be considered since they are more potent greenhouse gases than carbon dioxide and land use can thus influence these gas emissions.

Prionace glauca, blue shark is a cosmopolitan species. Together with Carcharhinus falciformis, it co-dominated the landings of carcharhinidae sharks at the Artisanal Fishing Port of Cotonou. The objective of this study is to determine the demographic parameters of the blue shark in Gulf of Guinea marine waters. The different routines of the FISAT II v 1.2 software associated with the empirical equations of Froese and Nohland, allowed the evaluation of the different demographic parameters of the blue shark in Benin's marine waters. From August to December 2015, 244 individuals shark sizes; ranging from 175cm to 325cm were sampled. The total asymptotic length obtained was 341.25cm with a growth rate of 0.35/year, which indicates that the species is growing rapidly and the optimal total length of the species is 232.01cm. The age of first maturity of the species is 3 years with a longevity of 10 years. The exploitation rate is E= 0.74 with total mortality being 2.4; natural mortality is 0.6 and fishing mortality is 1.8. The sex ratio remains in favour of males throughout the study period. Monitoring programme were suggested with effective management measures established and executed for sustainability of the blue shark’s stock in the Gulf of Guinea.

The paper examines the impact of INGOs on the democratization of developing countries. Following the ‘end of history,’ the INGOs multiplied globally, and the number of aids to developing countries was given through them in billions of dollars in the past three decades. It is envisaged that with the increase in their population, the developing countries will be better off with a standard form of living that is attributable to standard democratization. However, despite the billions of dollars spent, the citizens of the developing countries are still worse in poverty, poor leadership, and corruption. On the contrary, some countries, including Nigeria, are threatening legislation that will curtail the INGOs, sighting their opacity and lack of tangible results as reasons. The research used Nigeria as a case study to analyze the methods, approaches, and the capacity of these INGOs and how they affect the democratization of their host countries. Through a review of existing records, non-participatory observations, and reviews of conference proceedings. The paper analyzed the parallel gaps that exist by arguing that, taking a broad, multi-disciplinary method from the various works of literature studied will provide essential conceptual and practical insights that can inform current debates.

Wildland-Urban Interfaces (W-UI) are at high risk of wildfires. Defensible spaces and home ignition zones are the two main aspects to protect lives and livelihoods of W-UI in the United States, Canada and Australia. The different part of the world has different rules and regulations for W-UI land management. We have discussed the defensible spaces in fire-prone areas, current ignition zone distances from structures, building materials, architectural design, the fire resistance trees, ground cover, landscaping and some other precautions to save lives and assets in the prominent fire-prone zones for three different countries (United States, Canada and Australia) of the world.

This retrospective study evaluates the effect of a telemedicine program developed in the central Catalan region in lowering the environmental footprint by reducing the emission of atmospheric pollutants thanks to a reduction in the number of hospital visits involving journeys by road. Between January 2018 and June 2019 a total of 12,322 referrals were made to telemedicine services in the primary care centers, avoiding a total of 9,034 face-to-face visits. In total, the distance saved was 192,682 km, with a total travel time savings of 3,779 hours and a total fuel reduction of 11,754 liters with an associated cost of €15,664. This represents an average reduction of 3,248.3 g of carbon dioxide, 4.05 g of carbon monoxide, 4.86 g of nitric oxide and 3.2 g of sulphur dioxide. This study confirms that telemedicine reduces the environmental impact of atmospheric pollutants emitted by vehicles, reducing the number of journeys made for face-to-face visits and can contribute to environmental sustainability.

The prerogative to narrate the experience of marginal identities, particularly ethno-religious ones, appeared only in the post-occupation era in Iraqi fiction. Traditionally, secular Iraqi discourse struggled to openly address “sectarianism” due to the prevalent notion that sectarian identities are mutually exclusive and oppositional to national identity. It is distinctly in post-2003 Iraq—more precisely, since the sectarian violence of 2006–2007 began to cut across class, civil society, and urban identities—that works which consciously refuse to depict normative Iraqi identities with their mainstream formulations become noticeable. We witness this development first in the Western diaspora, where Iraqi novels exhibit a fascination with the ethno-religious culture of the Iraqi margins or subalterns and impart a message of pluralistic secularism. This paper investigates the origins of the taboo that proscribed articulations of ethno-religious subjectivities in 20^th-century Iraqi fiction, and then culls examples of recent diasporic Iraqi novels in which these subjectivities are encoded and amplified in distinct ways. In the diasporic novel, I argue, modern Iraqi intellectuals attain the conceptual and political distance necessary for contending retrospectively with their formative socialization experiences in Iraq. Through a new medium of marginalization—the diasporic experience of the authors themselves—they are equipped with a newfound desire to unmask subcultures in Iraq and to write more effectively about marginal aspects of Iraqi identity inside and outside the country. These new diasporic writings showcase processes of ethnic and religious socialization in the Iraqi public sphere. The result is deconstruction of mainstream Iraqi identity narratives and instrumentalization of marginal identities in a nonviolent struggle against sectarian violence.

Additive manufacturing (AM) offers customization of microstructure and mechanical properties of fabricated components according to the material selected, and process parameters applied. Selective laser melting (SLM) is the commonly used technique for processing high strength aluminum alloys. Selection of SLM process parameters could control the microstructure of parts and their mechanical properties. However, the process parameters limit and defects obtained inside the as-built parts present obstacles to customized part production. This study investigates the influence of SLM process parameters on the quality of as-built Al6061 and AlSi10Mg parts according to the mutual connection between the microstructure characteristics and mechanical properties. The microstructure of both materials was characterized for different parts processed over a wide range of SLM process parameters. The optimized SLM parameters were investigated to eliminate the internal microstructure defects. The behaviour of mechanical properties of parts was presented through regression models generated from the design of experiment (DOE) analysis for the results of hardness, ultimate tensile strength, and yield strength. A comparison between the results obtained and that reported in the literature is presented to illustrate the influence of process parameters, build environment, and powder characteristics on the quality of parts produced. The results obtained from this study could help to customize the part’s quality by satisfying their design requirements in addition to reducing the as-built defects which in turn reduce the amount of the post-processing needed.

Clupeiformes, such as sardines and herrings, represent an important share of worldwide fisheries. Among those, the European sardine (Sardina pilchardus, Walbaum 1792) exhibits significant commercial relevance. While the last decade showed a steady and sharp decline in capture levels, recent advances in culture husbandry represent promising research avenues. Yet, the complete absence of genomic resources from sardine imposes a severe bottleneck to understand its physiological and ecological requirements. We generated 69 Gbp of paired-end reads using Illumina HiSeq X Ten and assembled a draft genome assembly with an N50 scaffold length of 25579 bp and BUSCO completeness of 82.1% (Actinopterygii). The estimated size of the genome ranges between 655 and 850 Mb. Additionally, we generated a relatively high-level liver transcriptome. To deliver a proof of principle of the value of this dataset, we established the presence and function of enzymes (elovl2, elovl5 and fads2) that have pivotal roles in the biosynthesis of long chain polyunsaturated fatty acids, essential nutrients particularly abundant in oily fish such as sardines. Our study provides the first omics dataset from a valuable economic marine teleost species, the European sardine, an essential resource for their effective conservation, management and sustainable exploitation.

In this review, the author shows that ferritin has documented quantum dot material properties that have been reported in numerous independent studies and can generate coherent electron conduction bands over substantial distances, using quantum coherence. In addition, neuromelanin is a conjugated polymer, and quantum dot/conjugated polymer combinations have been reported in numerous independent studies to generate coherent electron conduction bands for solar photovoltaic applications. Both ferritin and neuromelanin are present in large quantities in the dopamine neurons of the substantia nigra pars compacta and the norepinephrine neurons of the locus coeruleus. The unique structure of subgroups of these neurons that have a large number of axon branches and synapses appears to have evolved to take advantage of these coherent electron conduction bands to coordinate conscious action. Independent clinical and laboratory studies are also reviewed that corroborate this theory of coordinated action in these neuron groups. Proposed research to validate the theory using an existing fluorescent probe material is proposed.

Previous study demonstrated the reconstituted type I collagen matrix extracted from rabbit tendons enabled to regenerate the TMJ disc in the rabbit. The aim of this study was to investigate changes in the extracellular matrix (ECM) and mechanisms of regeneration in TMJ disc. In 36 New Zealand rabbits that underwent a partial discectomy, discs were replaced with reconstituted collagen templates for 3 months. A histological analysis showed that moderate to severe degeneration appeared in partially discectomized joints without implantation. In contrast, discs that received the reconstituted collagen template regenerated, and returned to normal to protect the joint. Cells in the regenerative tissue expressed ECM, and fibers became regular and compact due to tissue remodeling over time. Reparative cells differentiated into chondroblasts, and showed highly dense pericellular fibers. The morphology and collagen composition of the disc and condyle in the 3-month experimental group were similar to those of normal tissues. In conclusion, the reconstituted collagen template facilitated the regeneration of surgically discectomized discs. Type I and type II collagens play a crucial role in the regeneration of articular discs.

Background : The quantification of electromyographic activity using surface electrodes is inval-uable for understanding gait disorders in patients with central nervous system lesions. We propose to evaluate a commercially available low-cost system compared to a reference system in partic-ipants with stroke-related movement disorders in functional situations. Methods : Three hemiparetic participants performed three functional tasks: two treadmill walks at different speeds and a sit-to-stand test. The vastus lateralis and gastrocnemius medialis muscles were equipped with two EMG sensors. The comparison between the two EMG systems was based on 883 identified cycles. Spearman’s correlation coefficients (SC), linear correlation coefficients (LCC), and cross-correlation coefficients (CCC) were calculated. Results : The main results indicate good to very good similarity of the EMG signals collected from the two tested sEMG systems. In the comfortable walking condition, an SC of 0.894±0.091 and an LCC of 0.909±0.094 were noted. In the fast walking condition, an SC of 0.918±0.064 and an LCC of 0.935±0.056 were observed. For the 1-minute sit-to-stand test an SC of 0.880±0.058 and an LCC of 0.881±0.065 were noted. Conclusions : This study demonstrates good to very good similarity between the two sEMG systems, enabling the analysis of muscle activity during functional tasks.

In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO2 NPs).  CRG-CeO2-0.5 and CRG-CeO2-1 composites were prepared by compositing CRG and CeO2 at a weight ratio of 200:1 and 100:1, respectively. Physio-chemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO2 nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO2 exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO2.The biocompatibility of the materials was tested using the NIH 3T3 cell line and all samples were found to be nontoxic. Particularly, CRG-CeO2-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO2 Nps were present in the CRG matrix. Therefore, CRG-CeO2-1 has the potential to be used as a hemostatic agent and wound dressing.

The Ce0.5Y0.35Tb0.15F3 nanoparticles with CeF3 hexagonal structure were synthesized by co-precipitation technique. The average nanoparticle diameter was 14±1 nm. The luminescence decay curves of Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4 – 7F5 transition of Tb3+) conjugated with Radachlorin by means of polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficient for nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between nanoparticle surface and Radachlorin was R0 =4.5 nm. The best results for X-ray induced cytotoxicity was observed for NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation the survival A 549 human lung carcinoma cells decreased by ~12%.

Finding new, safe strategies to prevent and control rheumatoid arthritis is an urgent task. Of particular interest in this regard are bioactive peptides and peptide-rich protein hydrolyzates, which represent a new trend in the development of functional foods and nutraceuticals. The resulting tissue hydrolyzate of the chicken embryo (CETH) has been evaluated for acute toxicity and tested against chronic arthritis induced by Freund's full adjuvant in rats. The anti-arthritic effect of CETH was studied on the 28th day of the experiment after two weeks of oral administration of CETH at doses of 60 and 120 mg/kg body weight. Arthritis was evaluated on the last day of the experiment on the injected animal paw using X-ray computerized microtomography and histopathology analysis methods. The CETH effect was compared with the non-steroidal anti-inflammatory drug diclofenac sodium (5 mg/kg). Oral administration of CETH was accompanied by effective dose-dependent correction of morphological changes caused by the adjuvant injection. CETH had relatively high recovery effects in terms of parameters for reducing inflammatory edema, inhibition of osteolysis, prevention of osteophitosis, reduction of the inflammatory reaction of periarticular tissues, and cartilage degeneration. This study presents a potential theoretical strategy for the safe correction of this pathological process and, for the first time, shows that CETH may be a powerful potential nutraceutical agent or bioactive component of functional products in the treatment of rheumatoid arthritis.

Concern over potential antimony mediated toxicity from mining and smelting activities has instigated novel concepts toward removing aqueous antimony ions. The iron based adsorbent Fe3O4/HCO was found to be efficient for treating antimony-containing wastewater However, ineffective methodology for preparation limited its effective adsorption capacity and thus wider application. In this study, a new type of HCO-doped-(Fe3O4)x adsorbent was prepared by co-precipitation method for doping Fe3O4 into HCO sludge (HCO), thereby improving adsorption performance for Sb(III) and Sb(V) ions, with the maximum adsorbing capacity being 44.46 mg/g and 47.91 mg/g, respectively. According to the results of BET, SEM-EDS, XRD and XPS, it were confirmed that the FeOOH and X≡Fe-OH were formed during the preparation process, bring about the increased the surface area, thus resulting in further increase of surface area, hydroxyl groups and the net negative ionic charge. Moreover, the adsorption kinetics followed the pseudo-second-order kinetic model which indicated that adsorption process of Sb(III)/Sb(V) by HCO-doped-(Fe3O4)x adsorbent was controlled by chemical reaction. The main adsorption mechanism is that antimony ion and amorphous iron oxide X≡Fe-OH undergo coordination exchange reaction and complexation reaction with CeO2 or Ce2O3. Furthermore, HCO-doped-(Fe3O4)x could adapt to wide pH and had stable adsorption ability after regeneration. The good adsorption performance of HCO-doped-(Fe3O4)x makes it a potential applications of adsorbent for removal of antimony.

The present study investigation, our results on characterization of commercially pure-Ti alloy brazed with metallic glass ribbons of Ti20Zr20Cu60-xNix (x = 30, 40, and 50) metallic glass ribbons were produced using a vacuum melt spinner. These ribbons were then used as filler materials for vacuum brazing of two Ti alloy plates at 1268, 1277 and 1279 K for a period of 10 min. Field-Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM) and the energy dispersive X-ray spectroscopy (EDX). The as-spun ribbons showed fully amorphous structure when examined on both surfaces by XRD and also verified by TEM investigation. The brazing joint of two Ti-plates using the metallic glass ribbon when brazed with Ni50 was found to be of very high strength. FESEM characterization of the cross-section of the brazed joints shows sub-micron size grains uniformly distributed in the matrix with brighter appearance. FESEM and EDX analysis revealed that the sub-micron grains are rich in Ti & Ni while the matrix phase mainly consisted of Ti. BSE image along with EDS Analysis indicated that the brazed joint has a presence of NiTi2 and Cu2 (Ni Zr) phases which could be responsible for increase in the strength of the brazed joint.

The rescue, digitisation, quality control, preservation and utilization of long and high quality meteorological and climate records, particularly related to historical marine data, are crucial for advancing our understanding of the Earth's climate system. In combination with land and air measurements, the historical marine records serve as foundational pillars in linking present and past weather and climate information, offering essential insights into natural climate variability, extreme events in marine areas, baseline data for assessing current changes, and inputs for en-hancing predictive climate models and reanalyses. This paper provides an overview of marine data rescue activities covering the past centuries, presents and highlights several ongoing projects across the world and how the data are used in an integrative and international framework. Current and future continuous efforts in data rescue, digitisation, quality control and the de-velopment of temporally high resolution meteorological and climatological observations from the Sea, will greatly help to further complete our understanding and knowledge of the Earth system including extremes, as well as improving the quality of reanalysis.

(1) Background: Various cutaneous adverse drug reactions (ADRs) are observed with the development of mRNA COVID-19 vaccines. To gain insight into the clinicopathologic features, we analyzed the correlation of histological and clinical data in 48 patients with these ADRs.; (2) Methods: Single-center retrospective study in patients with ADRs post-mRNA COVID-19 vaccination (mRNA-1273 and BNT162b2 vaccines).; (3) Results: Distant generalized ADRs prevailed (91%), often appearing clinically as spongiotic dermatitis or maculo-papular exanthema. Histopathological analysis revealed spongiotic changes (46%) and dermal superficial perivascular lympho-histiocytic infiltrates (17%). Eosinophils were found in 66% of biopsies, neutrophils in 29%, and plasma cells only in 8% of biopsies. Most ADRs occurred post-second vaccine dose (44%). Histologically spongiotic changes were associated with clinical features of spongiotic dermatitis in only 50% and maculo-papular exanthema in the remaining patients. ADRs represented an aggravation of preexisting skin disease in 23% of patients. ADRs regressed within 28 days or less in 53% of patients and persisted beyond a month in the remaining patients.; (4) Conclusions: Our study demonstrates a diverse spectrum of generalized ADRs, revealing correlations between histology and clinical features but also instances of divergence. The majority of ADRs are self-limited with a few extending beyond a month.

The concept of the protein powder dispenser was developed on the basis of the results of analyses, studies and customer requirements. The dispenser was assembled using SolidWorks software, which consists of 63 elements, 14 of which are unique parts that are not available on the market. Each part of the dispenser was carefully designed to be injected into the plastic compound. Polypropylene is the perfect material for this dispenser as it is low density, waterproof, insoluble and extremely resistant to tension and bending. High purity propylene polymer can be processed into a tough, rigid and lightweight plastic with relatively low manufacturing costs, replacing expensive materials. The authors' original contributions are the design and manufacture of a dosing device for protein powder, adjustable in 3 heights to be able to dose in containers of different sizes; the design and integration of a mechanism with a precise dosing system, the components being designed so that the parts in contact with the shaft filled with protein powder form a perfectly closed space; the design and integration of the mechanism for adjusting the height of the dispenser.

Tea plants (Camellia sinensis L.) are economically important horticultural crops for industrial use. The drink (tea) obtained from them is used all over the world, and its functional activity is determined by the polyphenols content and composition. Its accumulation is regulated by the action of many environmental factors. This paper presents data on the different intensity (50, 75, and 100 µmol·m−2·s−1) and duration of light exposure on tea plant in vitro cultures. Changes in morphophysiological characteristics, accumulation of carbohydrates and polyphenols, including their monomeric (phenylpropanoids, flavanols) and oligomeric (proanthocyanidins) forms, were studied. The malondialdehyde and photosynthetic pigments (chlorophyll a and b) contents were also analyzed. In the calli grown in light conditions, chloroplasts and anthocyanoplasts formation was noted, which was especially pronounced under the highest illumination intensity. A significant similarity between the growth of callus cultures, the carbohydrates and polyphenols accumulation at 50 and 75 µmol·m−2·s−1 was established. Which wasn’t characteristic of the calli grown at 100 µmol·m−2·s−1. The stress reaction absence in tea callus cultures has been demonstrated, which may be a consequence of the phenolic antioxidants’ accumulation in them. The obtained data evidence that their potential ability to accumulate primary (carbohydrates) and secondary (polyphenols) metabolites depends on the light exposure intensity and duration.

The present review explores the critical role of oxime and oxime ether moieties in enhancing the physicochemical and anticancer properties of structurally diverse molecular frameworks. Specific examples are carefully selected to illustrate the distinct contributions of these functional groups to general strategies for molecular design, modulation of biological activities, computational modeling, and structure-activity relationship studies. An extensive literature search was conducted across three databases, including Pub-Med, Google Scholar, and Scifinder, enabling us to create one of the most comprehensive overviews of how oximes and oxime ethers impact antitumor activities within a wide range of structural frameworks. This search focused on various combinations of keywords or their synonyms, related to the anticancer activity of oximes and oxime ethers, structure-activity relationships, mechanism of action, as well as molecular dynamics and docking studies. Each article was evaluated based on its scientific merit and the depth of the study, resulting in 268 cited references and more than 336 illustrative chemical structures carefully selected to support this analysis. As many previous reviews focus on one subclass of this extensive family of compounds, this report represents one of the rare and fully comprehensive assessments of the anti-cancer potential of this group of molecules across diverse molecular scaffolds.

Rice provides ~20% of human dietary energy and, for many people, a similar share of their protein. Rice cultivation, however, produces significant greenhouse gas (GHG) emissions, comparable to those from the aviation sector. The main GHG from rice production is methane, mostly a result of conventional rice cultivation (CRC) keeping rice fields continuously flooded during the crop cycle. There is extensive evidence that alternate wetting and drying (AWD) of rice fields substantially reduces methane emissions. AWD is one component of the System of Rice Intensification (SRI), an agroecological approach to the management of plants, water, soil and nutrients practiced by millions of farmers in both lowland irrigated rice and upland rainfed cultivation. Thirteen countries have included SRI in their Nationally Determined Contributions to GHG reduction or climate change mitigation. This article reviews 16 field studies of the net reduction in GHG emissions from the adoption of AWD, eight from the adoption of SRI, and two that compared SRI and AWD. Where available, the review includes data on yield and therefore on carbon dioxide-equivalent GHG emissions per kilogram of rice produced. The evidence indicates that AWD and SRI offer a similar and substantial reduction (~35–41%) in GHG emissions per hectare compared with conventional rice cultivation. However, SRI offers ~66% greater yield than CRC, and therefore greater reduction in emissions per kilogram of rice, ~54% more than AWD. The limited data directly comparing SRI and AWD support this finding. SRI also appears to have greater potential to sequester carbon in the soil. SRI lowers rice farmers’ costs of production, adds to their income and can make climate-friendly methods more attractive. Both AWD and SRI are greatly preferable to current conventional practices, but SRI offers opportunities to contribute to food security while directly addressing the drivers of climate change.

Throughout the world, salinity is a major environmental issue that limits agricultural productivity, particularly in arid and semi-arid regions. In addition, climate change is the most important reason for the salinization of agricultural soils in the world, so it is now essential to find solutions to increase salinity tolerance in plants. This study investigated the potential of arbuscular mycorrhizal fungi (AMF) inoculation to enhance the growth and yield performances of flax under different salinity levels by conducting a pot experiment. The experiment was laid out in a two-factor completely randomized design including AMF inoculation (AMF+: with and AMF-: without inoculation) and irrigation water salinity (0, 50, 100, and 150 mM NaCl). According to the results, it is evident that salt stress caused negative physiological effects, including limited growth, reduced photosynthesis, and decreased nitrogen (N) and phosphorus (P) content in shoots and roots of flax plants. Moreover, mycorrhizal association improved the salt tolerance of the plants by increasing chlorophyll content, enhancing N and P shoot and root contents, and consequently yield parameters, such as seed, and stem fiber yield, particularly at moderate salt concentrations (50 and 100 mM NaCl). As a result of using AMF, flax plants grown under salt stress exhibited tolerance, suggesting that AMF could be applied in saline environments to maintain ecological stability.

In a hypothetical scenario where space travels outside the solar system is possible and affordable, I examine the possible implications of infinite resources and the universalization of freedom in the social and individual spheres. I argue that freedom is the figure of man's emancipation and the supreme end of history, which represents a theme affirming the infinite and indefinite progress of history and science. Also discussed is Bakunin's theory of the critique of contractualism, which denies the idea of a mythical and primordial natural freedom that existed before the constitution of society. Furthermore, I highlight the deep pathos of romantic culture that feeds into Bakunin's anarchist thought and emphasize the relevance of the notion of freedom in the context of future space travel.

This paper is another applied article based on the author's "Unified Theory of Force". The main work of this paper is as follows: (1) Reinterpretation of the Lorentz contraction effect and rigorous proof that the Lorentz contraction is a physical phenomenon based on the conservation of energy and momentum under non-completely symmetrical relative motion effects. This paper proves that the Lorentz contraction effect not only occurs in the direction of motion but also simultaneously in any direction. (2) For the first time, we attempted to explain the physical meaning of the Planck energy formula in theory and associate the Planck energy formula with the Lorentz contraction effect, which can help us to have a deeper understanding of the true physical meaning behind the Planck energy formula. At the same time, we also made reasonable theoretical predictions about the basic structure of photons.

Trauma is one of the most common causes of death or permanent disability in young people, so a timely diagnostic approach is crucial. In polytrauma patients, CEUS has been shown to be more sensitive than US for the detection of solid organ injuries, improving the identification and grading of traumatic abdominal lesions with levels of sensitivity and specificity similar to those seen with MDCT. CEUS is recommended for the diagnostic evaluation of hemodynamically stable patients with isolated blunt moderate-energy abdominal traumas and for the diagnostic follow-up of conservatively managed abdominal traumas. In this pictorial review we illustrate the advantages and disadvantages of CEUS and the procedure details with tips and tricks during investigation of blunt moderate-energy abdominal trauma as well as during follow-up in non-operative management.

Mine waste rock and drainage pose lasting environmental, social, and economic threats to the mining industry, regulatory agencies, and society as a whole. Mine drainage can be alkaline, neutral, moderately or extremely acidic and contains significant levels of sulfate, dissolved iron, and frequently a variety of heavy metals and metalloids, such as cadmium, lead, arsenic, and selenium. In acid neutralization by carbonate and silicate minerals, a range of secondary minerals can form and possibly scavenge these potentially harmful elements. Apart from the extensively-studied microbial-facilitated sulfide oxidation, the diverse microbial communities present in mine rock and drainage may also participate in the formation, dissolution, and transformation of secondary minerals influencing the mobilization of these metals and metalloids. This article reviews major microbial-mediated geochemical processes occurring in mine rock piles that affect drainage chemistry, with a focus on the role of microorganisms in the formation, dissolution and transformation of secondary minerals. Understanding this is crucial for developing biologically-based measures to deal with contaminant release at the source, i.e., source control.

Differentiated instruction has been implemented in classrooms where students who come from various backgrounds require appropriate lessons that are tailored to their varied learning preferences. As the spread of coronavirus 19 (Covid-19) is becoming more rampant, online learning has been lifted up as the main platform of teaching and learning, forcing the need to shift from the conventional face-to-face classroom to online, or virtual, mode of knowledge transfer. Having such global phenomenon affecting education, how does it affect the implementation of differentiated instruction that has been practised regularly by teachers before the wake of Covid-19? Previous studies have shown how it is done in the normal classroom setting, and that the practice of differentiated instruction contributes to students’ motivation as well as academic performance. However, there is a need to explore how do teachers go about with online differentiated instruction and how does it affect the students, since online learning poses various threads to both teachers and students; and thus, one might argue the effectiveness of not only the teaching approach but also the overall teaching and learning outcomes. Borg’s framework of teacher cognition, which has been extensively used in exploring how teachers teach, can be utilized to document the practice of online differentiated instruction. This study aimed to explore the practice of online differentiated instruction by teachers and examined its impact on students’ motivation and academic performance during the Covid-19 outbreak. The participants of this study consists of 247 gifted students from a public school in Malaysia. To meet these aims, this study employed a mixed method research design, utilizing the framework of teacher cognition to explore the teachers’ practice of online differentiated through interviews; and, utilizing a survey design using a questionnaire to determine the impact of online differentiated instruction towards students’ motivation and academic performance. The findings revealed that although online differentiated instruction is feasible, however, appropriate combination of differentiation constructs need to be applied in order to achieve higher motivation and better academic performance among the students.

Urban areas are centres of business and innovation. Freight transport is indispensable for the proper functioning of any modern urban society. Urban areas can’t function without an appropriate freight transport system, due to the need to replenish stocks of food and other goods in retail shops. The complexity of the decisions concerning implementation of measures to improve the movement of goods in the city requires tools designed to support this process. The purpose of this article is to introduce the possibility of applying the Analytic Hierarchy Process (AHP) as well as the Decision Making Trial and Evaluation Laboratory Method (DEMATEL) in choosing a set of measures and in analysing in the field of distribution logistics, which will help to solve the delivery problems and streamline the cargo flows in Szczecin, in the context of sustainable development.

Chronic wounds remain trapped in a pro-inflammatory state, with strategies targeted at inducing re-epithelialization and the proliferative phase of healing desirable. A member of the lectin family, galectin-3 is implicated in regulation of macrophage phenotype and epithelial migration. We investigated if local delivery of galectin-3 enhanced skin healing in a full thickness excisional C57BL/6 mouse model. An electrospun gelatin scaffold loaded with galectin-3 was developed and compared to topical delivery of galectin-3. Electrospun gelatin/galectin-3 scaffolds had an average fiber diameter of 200 nm, with 83% scaffold porosity approximately and am average pore diameter of 1.15 μm. The developed scaffolds supported dermal fibroblasts adhesion, matrix deposition and proliferation in vitro. In vivo treatment of 6 mm full thickness excisional wounds with gelatin/galectin-3 scaffolds did not influence wound closure, re-epithelialization or macrophage phenotypes, but increased collagen synthesis. In comparison, topical delivery of galectin-3 [6.7 µg/ml] significantly increased arginase-I cell density at day 7 versus untreated and gelatin/galectin-3 scaffolds (p<0.05). Preliminary assessment of increasing the concentration of topical galectin-3 demonstrated that at day 7, galectin-3 [12.5 µg/ml] significantly increased both epithelial migration and collagen content in a concentration dependent manner. In conclusion, local delivery of galectin 3 shows potential efficacy in modulating skin healing in a concentration dependent manner.

The development of hybrid rockets offers excellent opportunities for the practical education of students at universities due to a high safety and a relatively low complexity of the rocket propulsion system. During the German educational program STERN, students of the Technische Universität Braunschweig obtain the possibility to design and launch a sounding rocket with a hybrid engine. The design of engine HYDRA 4X is presented and results of first engine tests are discussed. Results for measured regression rates are compared to results from literature. Furthermore, the impact of the lightweight casing material CFRP on the hybrid engine mass and flight apogee altitude is examined for rockets with different total impulse classes (10 to 50 kNs). It is shown that the benefit of a lightweight casing material on engine mass decreases with an increasing total impulse. However, a higher gain on apogee altitude, especially for bigger rockets with a comparable high total impulse is shown.

There are close dynamic relationships among the livelihood, well-being, and ecological environment of farm households. It is of great significance to scientifically clarify the impact of the grain for green policy on the livelihoods and well-being of farm households in mountainous areas. Based on data from a survey of 392 farm households in Zhangbei County, a system of indicators for farm household livelihood assets and farm household well-being was constructed, drawing on a sustainable livelihood framework (SLF). The livelihood assets and well-being levels of different types of farm households were measured, and a multiple linear regression model was used to analyze the impact of the grain for green policy implementation on the well-being levels of farm households. The three main results are as follows: (1) The level of natural assets among the total average livelihood assets of farm households in Zhangbei County is the highest at 0.374, while the level of physical assets is the lowest at 0.018. The level of livelihood assets of returned farmland households (0.948) is lower than that of nonreturned farmland households (1.117). (2) The level of well-being of all farm households in Zhangbei County is 0.517, with the level of wealth contributing the most to the well-being of farm households at 40.20% and the quality of the ecological environment contributing the least at 11.99%. The level of well-being of returned farmland households (0.518) was slightly higher than that of nonreturned farmland households (0.514). (3) The degree of influence of each influence factor on the level of well-being of farm households varies significantly. Household size was the strongest driver, at 0.366, while educational attainment of household members, household labor capacity, annual household expenditure, livelihood diversity, number of large production tools, and total value of livestock were also important drivers of household well-being, and area of arable land is negatively associated with household well-being. There are also differences in the factors influencing the level of well-being of different types of farming households.

The hexaploid bread wheat Triticum aestivum L. (2n = 6x = 42) and the tetraploid durum wheat Triticum durum (2n = 4x = 28) are two commercially the most important wheat species worldwide. These two species are components of the same gene pool, which evolved under different conditions, which made it possible to acquire different adaptations to a wider range of environmental conditions. Identification and characterization of introgressed fragments of one species in the genome of another can help in the search for new loci responsible for economically valuable traits. SNP microarrays provide information on the genotypes of thousands of positions throughout the genome. This information can be used to obtain the distribution of alleles of one species in the genome of another and to determine the location of introgressed fragments. In our work, we used genotyping data from the SNP microarray to identify durum wheat chromosome fragments containing bread wheat alleles in the offspring from crossing bread and durum wheat. We have studied the distribution of the genetic material of bread wheat in 15 combinations from crosses of bread and durum wheat. Introgressed fragments of bread wheat into the durum wheat genome were identified on chromosomes 1A, 1B, 4A, 5B, 6B, and 7A. The introgressed fragments showed polymorphism in different breeding lines. A functional enrichment analysis of genes in the introgression fragments was performed, which showed the presence of statistically significant enrichment of genes responsible for various molecular functions, biological processes and cellular components. The obtained data can be used to identify new QTL of economically valuable traits for obtaining durum wheat varieties with improved agronomic traits.

Background and Objectives: Many epidemiological studies have shown a positive association between black carbon (BC) and the exacerbation of allergic rhinitis and allergic asthma. However, none of the studies in Serbia examined this relationship so far. The aim of this study was to examine the associations between BC and emergency department (ED) visits for allergic rhinitis and allergic asthma in the Užice region of Serbia. Materials and Methods: A time-stratified case-crossover design was applied to 523 ED visits for allergic rhinitis and asthma exacerbation that occurred in the Užice region of Serbia between 2012−2014. Data regarding ED visits were routinely collected in the Health Center of Užice. The daily average concentrations of BC were measured by automatic ambient air quality monitoring stations. Odds ratios and their corresponding 95% confidence intervals were estimated using conditional logistic regression adjusted for the potential confounding influence of weather variables (temperature, humidity, and air pressure). Results: Statistically significant associations were observed between ED visits for allergic rhinitis and 2-day lagged exposure to BC (OR = 3.20; CI = 1.00−10.18; p < 0.05) and allergic asthma and 3-day lagged exposure to BC (OR = 3.23; CI = 1.05−9.95; p < 0.05). Conclusion: Exposure to BC in the Užice region increases the risk of ED visits for allergic rhinitis and asthma, particularly during the heating season.

The paper presents new data on mineralogical-geochemical peculiarities of the granites and pegmatites of the Baikal area (Olkhon Region) with implications for the age, generation conditions and geodynamic settings of magmatism. The early Paleozoic granitoids of the Olkhon region are syncollisional formations produced from the gneiss-schistose substratum of the Olkhon metamorphic sequences. Pegmatoid granites and pegmatites of the Region were generated within a wide age range (458-390 Ma) and include different mineralogical and geochemical types. Amongst the Early Paleozoic granitoids, pegmatoid rocks are products of the collisional magmatism evolution and are similar to granites in terms of the mineral composition and distribution patterns of rare and rare earth elements. On the Olkhon island (Baikal lake) the pegmatite of the Tashkiney vein belong to the Be-Nb-Ta mineralogical-geochemical type demonstrating high contents of W, Sn U, Th and very low concentrations of Li and volatile components (F, B). In the Pryolkhonye area, vein pegmatite Iliksin is with Li, Be, Nb, Ta mineralization (lepidolite, vorobyevite, samarskite et al). The studied pegmatite veins are similar both by the profound negative Ba, Sr, Eu, and Zr anomalies. The zircons from the Tashkiney vein (390±5.0 Ma) and of the Iliksin vein (430.1±2.2 Ma, U-Pb isotope LA ICP MS metod) indicate the formation of pegmatite at the late post-collisional stage of magmatism in the Olkhon Region. As regard to mineralogical and geochemical characteristics, vein pegmatites with amazonite (Ainsky and Ulan-Nur) belong to the Li-F type. The tantalum mineralization, represented by microlites and minerals of the columbite-tantalite group is associated with the Ainsky amazonite pegmatite. As opposed to the Early Paleozoic syncollisional granitoids and pegmatoid formations, the middle Paleozoic vein bodies of pegmatites (Tashkiney, Iliksin, Ainsky, Ulan-Nur) are regarded as rare-metal pegmatites. In terms of geochemical characteristics, they are similar to the rare-metal pegmatoid granites and pegmatites of the intra-plate setting widespread in Mongolia and Transbaikalia. The rare-metal mineralization in the Olkhon region may be genetically related to the evolution of Be-Nb-Ta and Li-F types of the post-collisional granites and pegmatites.

We employed the Riemannian Face Manifold (RFM) as an alternative approach to the conventional linear Euclidean space for explaining the atypicality bias in face likeliness judgments. The RFM posits that the mental representation of faces is better captured as a manifold of stable states, accounting for the nonlinearity in the physical properties of faces. To examine the relationship between physical and psychological distance of morph and typical/atypical faces, we manipulated the parameter k and incorporated a weight function in the Riemannian metric. Our results indicate that the psychological distance between the morph and typical face was longer than that between the morph and atypical face, consistent with prior research on the atypicality bias in perceptual similarity. The RFM approach provides mathematical support and is a powerful tool for studying face perception and recognition, offering potential implications for explaining the other-race effect. Future research can utilize the RFM to investigate individual differences in face recognition abilities and expertise, and how they impact psychological distance and face processing.

In this study we present gas-phase fluorination as a method to create a thin LiF layer on Li6.5La3Zr1.5Ta0.5O12 (LLZTO). We compare these fluorinated films with LiF films produced by RF-magnetron sputtering, where we investigated the interface between the LLZTO and the deposited LiF showing no formation of a reaction layer. Furthermore, we investigate the ability of this LiF layer as a protection layer against Li2CO3 formation in ambient air. By this we show that Li2CO3 formation is absent at the LLZTO surface after 24 h in ambient air supporting the protective character of the formed LiF films and hence could enhance the handling of LLZTO in air for battery production. With respect to the use within hybrid electrolytes consisting of LLZTO and a mixture of polyethylene oxide (PEO) and Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) we also investigated the interface between the formed LiF films and a mixture of PEO LiTFSI by X-ray photoelectron spectroscopy (XPS) showing decomposition of the LiTFSI at the interface.

Globally, 2.2 billion urban residents are living without safely-managed sanitation, the majority of whom are slum residents. To improve the situation, Dhaka Water Supply and Sewerage Authority (DWASA) is implementing the Dhaka Sanitation Improvement Project (DSIP), mostly funded by the World Bank. This study assessed the feasibility of connecting low-income communities (LICs) within the proposed sewerage network by 2025. We conducted nine key-informant interviews from DWASA and City Corporation, and 23 focus-group discussions with landlords, tenants and Community Based Organisations (CBOs) from 16 LICs near the proposed catchment area. To achieve connections, LICs would require improved toilet infrastructures and have to be connected to main roads. Construction of large communal septic tanks is also required where individual toilet connections are difficult. To encourage connection in LICs, income-based or area-based subsidies were recommended. For financing maintenance, respondents suggested monthly fee collection for management of the infrastructure by dividing bill equally among sharing households, or by users per household. Participants also suggested the government's cooperation with development-partners/NGOs to ensure sewerage connection construction, operation and maintenance and prerequisite policy changes such as assuring land tenure.

If students do not fully apply themselves, then they may be considered responsible for the result of being inadequately prepared. +- Nevertheless, student outcomes are more likely to reflect a combination of both effort and systematic problems with overall course architecture. Deficiencies in course design result in inadequate preparation that adversely and directly impacts students’ productivity upon entering the workforce. Such an impact negatively influences students' ability to maintain gainful employment and provide for their families, which inevitably contributes to the development of issues concerning their psychological well-being. It is well-documented that incorporating active learning strategies in course design and delivery can enhance student learning outcomes. Despite the benefit of implementing active learning techniques, rarely in the real world will it be possible for techniques to be used in isolation of one another. Therefore, the purpose of this proposed study is to determine the interactive effects of two active learning strategies because, at a minimum, technique-pairs more accurately represent the application of active learning in the natural educational setting. There is a paucity of evidence in the literature directed toward investigating the interactive effects of multiple active learning techniques that this study is aimed at filling. The significance of this research is that, by determining the interactive effects of paired active learning strategies, other research studies on the beneficial effects of using particular active learning technique-pairs will be documented contributing to the literature so that ultimately classroom instruction may be customized according to the determination of optimal sequencing of strategy-pairs for particular courses, subjects, and desired outcomes that maximize student learning.

Background: Dengue virus (DENV) infection is a significant public health concern in many trop-ical and subtropical regions, where early and rapid detection is crucial for effective patient man-agement and controlling the spread of the disease. Particularly in resource-limited, rural healthcare settings where dengue is endemic, there is a need for diagnostic methods that are both easy to perform and highly sensitive. Objective: This study focuses on the development and validation of a single-tube reverse tran-scription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of DENV. Methodology: The RT-LAMP assay designed in this work combines two sets of primers targeting the 5' and 3'-UTR regions of the dengue virus, aiming to increase the sensitivity of detection. Results: The clinical validation of this COMB-RT-LAMP in samples from febrile individuals with a serological or antigenic diagnosis showed a sensitivity of over 95%. The assay's perfor-mance was statistically compared to standard diagnostic method quantitative reverse transcrip-tion-polymerase chain reaction (qRT-PCR). Conclusions: The findings support the potential of RT-LAMP as a rapid, sensitive, and specific tool for dengue diagnosis and surveillance, particularly suitable for field use in low-resource set-tings.

Autoimmune polyglandular syndrome (APS) comprises a complex association of autoimmune pathological conditions. APS Type 1 originates from loss-of-function mutations in the autoimmune regulatory (AIRE) gene. APS2, APS3, and APS4 are linked to specific HLA alleles within the major histocompatibility complex, with single nucleotide polymorphisms (SNPs) in non-HLA genes also contributing to disease. In general, variability in the AIRE locus and the presence of heterozygous loss-of-function mutations can impact self-antigen presentation in the thymus. In this study, Whole Exome Sequencing (WES) was performed on a sixteen-year-old female APS3A/B patient to investigate the genetic basis of her complex phenotype. The analysis identified two variants (p.Arg111Trp and p.Thr101Ile) of the hepatitis A virus cell receptor 2 gene (HAVCR2) encoding for the TIM-3 (T cell immunoglobulin and mucin domain 3) protein. These variants were predicted, through in silico analysis, to impact protein structure and stability, potentially influencing the patient’s autoimmune phenotype. While Confocal Microscopy analysis revealed no alteration in TIM-3 distribution between PBMCs isolated from the patient and those of a healthy donor, RT-qPCR showed reduced TIM-3 expression in the patient’s cells. A screening conducted on a cohort of thirty APS patients indicated that the p.Thr101Ile and p.Arg111Trp mutations were unique for the proband. This study opens the pathway for the search of TIM-3 variants possibly linked to complex autoimmune phenotypes, highlighting the potential of novel variant discovery in contributing to APS classification and diagnosis.

Inflammatory bowel diseases (IBD) involve chronic inflammation of the gastrointestinal tract, where effector CD4+ T-cells play a central role. Thereby, the recruitment of T-cells into the colonic mucosa represents a key process in IBD. We recently found that CCR9 and DRD5 might form a heteromeric complex on the T-cell surface. The increase of CCL25 production and the reduction in dopamine levels associated with colonic inflammation represent a dual signal stimulating the CCR9:DRD5 heteromer, which promotes the recruitment of CD4+ T-cells into the colonic lamina propria. Here, we aimed to analysing the molecular requirements involved in the heteromer assembly as well as to determining the underlying cellular mechanisms involved in the colonic tropism given by the stimulation of the CCR9:DRD5 complex. The results show that dual stimulation of the CCR9:DRD5 heteromer potentiates the phosphorylation of the myosin light chain 2 (MLC2) and the migration speed in confined microchannels. Accordingly, disrupting the CCR9:DRD5 assembly induced a sharp reduction in the pMLC2 in vitro, decreased the migratory speed in confined microchannels and dampened the recruitment of CD4+ T-cells into the inflamed colonic mucosa. Furthermore, in silico analysis confirmed that the interface of interaction of CCR9:DRD5 is formed by the transmembrane segments 5 and 6 from each protomer. Our findings demonstrated that the CCR9:DRD5 heteromeric complex plays a fundamental role in the migration of CD4+ T-cells into the colonic mucosa upon inflammation. Thereby, disassembling the formation of the CCR9:DRD5 represents an important therapeutic opportunity to treat IBD.

Metallic substrates and polymer adhesive in composite-metal joints have a relatively large coefficient of thermal expansion (CTE) mismatch, which is a barrier in the growing market of electric vehicles and their battery structures. It is reported that adding carbon nanotubes (CNTs) to the adhesive reduces the CTE of the CNT enhanced polymer adhesive multi-material system, therefore when used in adhesively bonded joints it would, theoretically, result in low CTE mismatch in the joint system. The current article presents the influence of two specific mass ratios of CNTs on the CTE of the enhanced polymer. It was observed that the addition of 1.0 wt% and 2.68 wt% of multi-walled CNTs (MWCNTs) decreased the CTE of the polymer adhesive from 7.5e-5 1/C (pristine level) to 5.87e-5 1/C and 4.43e-5 1/C, respectively by 22% and 41% reduction. The reduction in the CTE was predicted, theoretically, which showed that CTE should have been reduced to 3.6e-5 1/C (52% reduction) and 1.4e-5 1/C (81% reduction). This may be due to the fact that, Raman spectroscopy of the MWCNTs identified defects in the raw material, and scanning electron microscopy (SEM) identified agglomeration of MWCNTs on the surface and cross-section of the modified polymers.

(1) Background: The aim of this study is to investigate the diagnostic-therapeutic problem of pelvic recurrence of rectum cancer, highlighting current surgical standards and the possible role of the minimally invasive approach. This retrospective analysis of our surgical case study wishes to enter this debate while suggesting a possible line of action, based on the site of recurrence; (2) Methods: We examined, retrospectively, all the patients diagnosed, between 2008 and 2018, with cancer of the rectum at the "Pietro Valdoni" Department of Surgery and monitored their follow-up for 5 years. The sample consisted of 368 patients with rectal neoplasm, 136 females and 232 males, with an average age of 65.8 (ranging from 37 to 86); (3) Results: In 103 of the cases, the neoplasm was located in the upper rectum (28%), in 119 cases in the middle rectum (32.3%), in 102 cases in the lower rectum (27.7%), in 31 cases (8.4%) at the level of the right/sigma junction and in 13 cases it was not possible to define the site with certainty (3.5%); (4) Conclusions: The discussion re-mains open as to which approach is best at surgical level, whether laparoscopic, robotic or open-air. Our experience informs us that the most dangerous site remains on the anastomotic site.

The paper proposed a modification of the GeoSER(D) model previously developed by us by detailing the age structure of the population, personal schedule on weekdays and working days, and individual health characteristics of the agents, this made it possible to build a more realistic model of the functioning of the city and its residents. The developed model made it possible to simulate the spread of 3 types of the strain of the COVID-19 virus, and to analyze the adequacy of this model in the case of unhindered spread of the virus among city residents. The paper showed that SARS COV 2 spreads mainly from contacts in workplaces and transport, and schoolchildren and preschool children are the consequence, not the initiator of the epidemic. Fluctuations in the dynamics of various indicators of the spread of SARS COV 2 associated with the difference in the daily schedule on weekdays and weekends. It has been shown that people's daily schedules strongly influence the spread of SARS COV 2. For the more contagious "rapid" strains of SARS COV 2 (omicron), immunocompetent people become a significant source of infection. For the less contagious "slow strains" (alpha) of SARS COV 2, the most active source of infection is immunocompromised individuals (pregnant women). The more contagious – "fast" strain of the SARS COV 2 virus (omicron) spreads faster in public transport. For less contagious – "slow" strains of the virus (alpha), the greatest infection occurs due to work and educational contacts.

Background and Objectives: The aim of this study is to investigate the diagnostic-therapeutic prob-lem of pelvic recurrence of rectum cancer, highlighting current surgical standards and the possi-ble role of the minimally invasive approach. This retrospective analysis of our surgical case study wishes to enter this debate while suggesting a possible line of action, based on the site of recur-rence. Materials and Methods: We examined, retrospectively, all the patients diagnosed, between 2008 and 2018, with cancer of the rectum at the "Pietro Valdoni" Department of Surgery and monitored their follow-up for 5 years. The sample consisted of 368 patients with rectal neoplasm, 136 females and 232 males, with an average age of 65.8 (ranging from 37 to 86). In 103 of the cases, the neo-plasm was located in the upper rectum (28%), in 119 cases in the middle rectum (32.3%), in 102 cases in the lower rectum (27.7%), in 31 cases (8.4%) at the level of the right/sigma junction and in 13 cases it was not possible to define the site with certainty (3.5%). Results: We examined all patients diagnosed with cancer of the rectum between 2008 and 2018 at the "Pietro Valdoni" Department of Surgery retrospectively and monitored their follow-up for 5 years. The sample consists of 368 patients with rectal neoplasm, 136 females and 232 males. Conclusions: The discussion remains open as to which approach is best at surgical level, whether laparoscopic, robotic or open-air. Our experience informs us that the most dangerous site remains on the anastomotic site.

The COVID-19 pandemic has affected Bangladesh's economic and social well-being in many ways. During the lockdown, many households lost their full income. The day labors and the slum dwellers including rickshaw pullers, CNG drivers, housemaids, hawkers, and street vendors were the worst victims of this pandemic. Besides the voluntary organizations, the city corporation, being instructed by the central government took the initiative to distribute necessary food as well as financial assistance to the city dwellers to survive during the lockdown. The objective of this study is to identify the satisfaction level of the slum dwellers with the assistance received from the City Corporation and get an idea of how far these supports were enough for them to lead their livelihood. It is a mixed-method research consisting of both qualitative and quantitative approaches. Researchers conducted a field survey in Sylhet City Corporation, the northeastern part of Bangladesh, and collected primary data from eighty respondents through a semi-structured questionnaire along with an interview schedule. Samples have been selected by applying a multistage sampling technique. Researchers analyzed quantitative data using SPSS software and qualitative data using the thematic analysis method. Study findings reveal that, although this aid was very inadequate compared to the needs of the slum dwellers, it was able to alleviate food shortages to some extent in times of extreme hardship. However, some dwellers got deprived of the aid due to having different political ideologies and corruption. Proper aid management, well coordination, and community participation are indispensable for dealing with any crisis.

Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including proliferation and neovascularization. The use of recombinant human bone morphogenic protein 2 (rh-BMP 2) in oral and maxillofacial surgery has seen a tremendous increase, especially with bone grafting materials to promote bone reconstruction processes; even though its interactions with the other essential processes in the human tissues are still not fully clear. investigating the effect of administrating rh-bmp2 on the clinical values of the gingival cell proliferation index Ki67 marker expression in the gingival tissue in comparison with normal human gingival tissue. The study includes 2 groups in a randomized controlled Clinical Trial: 40 gingival samples; 20 normal and 20 have been treated with 0.25µg of rh-BMP2 during dental implantation in the posterior mandible area, taken 3 months later in the time of healing abutments installation using a tissue puncher. Samples will be stained with hematoxylin-eosin and immunohistochemically. The expression of Ki67 will be measured in one way: the number of cells that express the marker. The comparison between groups will be done using One -a way ANOVA test in the numerical data SPSS 17.0 will be used as software. Differences would be considered significant at P=0.05. It is considered that rh-BMP2 can improve gingival tissue proliferation in patients undergoing dental implant treatment, and indicates better healing.

In this paper, we will consider an autonomous two-dimensional ODE Kolmogorov type 1 system with three parameters, which is a particular system of the general predator–prey systems with 2 a Holling type II. By reformulating this system as a set of two second order differential equations, we 3 will investigate the nonlinear dynamics of the system from the Jacobi stability point of view, using 4 the Kosambi-Cartan-Chern (KCC) geometric theory. We will determine the nonlinear connection, the 5 Berwald connection and the five KCC-invariants which express the intrinsic geometric properties 6 of the system, including the deviation curvature tensor. Furthermore, we will obtain necessary and 7 sufficient conditions on the parameters of the system in order to have the Jacobi stability near the 8 equilibrium points and we will point out these on a few examples.

Given the extreme importance of improving the accountability of Private Social Solidarity Institutions (IPSS), both for reasons of legal compliance (hard law) and for reasons of improving legitimacy and notoriety among their stakeholders (soft law), this paper aims to present a framework designed under a more comprehensive research project, for the assessment of IPSS accountability and, consequently, its improvement. This study also present results of the indicators conceived, identifying the main trends of the framework dimensions and sub-dimensions from a pilot test for the years 2018, 2019 and 2020 in Portugal. Given the results, we believe that the framework designed answers the research question: How to promote accountability (social, financial and economic) in the social economy sector, in particular: the case of the IPSS?, however, as this is an exploratory article, it incorporates the limitation that this is a pilot test with only 7 entities.

This document aims to adapt the dimension of the Socially Responsible Brand Personality (SRBP), proposed by Mayorga (2017), in the midst of the Covid-19 pandemic. The interest of this work is to contribute with the management of the CSR, contributing from a communicational perspective with a tool that optimizes the construction of a socially responsible image by the different stakeholders. The results allow us to conclude that there is a structural modification of the brand personality, which can be presumed to be generated by the current environment and can be established as a pillar of CSR management in the new normality.

This study analyzes the relationship between the spread of the SARS-CoV-2 virus (COVID-19) and the mobility patterns of the Portuguese population. By reducing mobility, the idea is that contacts are reduced, countering the spread of the virus in the community. As an indicator of the spread of the virus, the reproduction number (Rt) was used. Data from Google's Community Mobility Reports was used to evaluate changes in mobility patterns. This report uses location data from Android mobile phone users. The locations are divided into retail and recreation, grocery and pharmacy, parks, transit stations, workplaces and residential. In this year of the COVID-19 crisis in Portugal, population mobility patterns have changed over the various phases of the pandemic. At first, all mobility was affected uniformly, with the population avoiding much of the activity outside the home. In a second phase, there was some adaptation, and the areas considered to be of lower risk had less impact, emphasizing the changes in the relationship between daily life and the workplace.

Background: The main factors to influence on the stroking performance of club head are alloy and spring-like effect. Design the structure of new club face to create the fairway wood which can show best stroking feeling and let driving distance become longer. Purpose: The club face of fairway wood is processed through the iron alloy heating procedure and CNC to innovate the club head with high spring-like effect (characteristic time). Method: (1) Use 455 stainless steel processed by heating and aging treatment, to do the analysis on microstructure and mechanical properties. (2) Through CNC to design seven different patterns for the back of club face, each pattern for three club head. The total amount is twenty-one. (3) Make finished product be test the characteristic time and the ability of strike by the practical measurement. (4) To analyze after the compare between three-way ANOVA and LSD. Results: After 455 stainless steel was heated in procedure S850℃-A550℃, mechanical properties became superior and had the better malleability, it is suitable for developing the club face of high spring-like effect. Before and after grinding among three-way ANOVA (pattern*thickness*place), did not achieve the significant level on the figure of characteristic time. Through two-way ANOVA (pattern*place and thickness*place), showed the significant deviation before and after grinding. After doing the crash test by 45m/s, all the results can reach the higher limited standard. Summary: 455 stainless steel was designed with the different club face’s thicknesses of fairway wood can make spring-like effect achieve high characteristic time. The much thinner club face let the characteristic time perform highly. But there was no obvious effects from the patterns of the back club face.

It is standard to identify and compare predicted protein sequence of the Drosha and Pasha genes subsidiary to detection and identification of novel microRNAs in newly sequenced taxa or review of previous deep sequencing data. Drosha and Pasha proteins are the key, conserved members of the ‘microprocessor’ protein complex which facilitates nuclear nuclear localized, pri to pre miRNA processing miRNAs of the canonical eumetazoan complement. Because of the necessity of the microprocessor for production of c anonical eumetazoan miRNA, the detection of both (1) bona fide microRNAs and (2) presence of Drosha/Pasha orthologs (or homologs) is often presented as sufficient to represent a functional canonical eumetazoan microRNA biogenesis pathway. However, the fun ctional role of the Drosha and Pasha homologs sometimes, though not always experimentally validated in non model taxa. Differentiation of ‘bona fide miRNAs’, opposed to ‘non bona fide’ small RNAs of similar size, are also necessary for miRNA identificatio n projects. Recent rubrics are based on structural and sequence elements of the miRNAs themselves, however these inclusion criteria include paraphyletic groupings of miRNAs, for example eumetazoan miRNAs and S treptophyte (green plant) miRNAs which are not produced by the Drosha/Pasha microprocessor mechanism. Therefore, a dichotomy exists between the structural definitions for miRNAs and understanding of the evolutionarily conserved function of the microprocessor and its components. In this article, I re view literature in the context of this topic and discuss philosophical significance for understanding the importance of the microprocessor in understanding the evolutionary and molecular origins of miRNA.

The purpose of this paper is to develop a phytosociological, ecological, cytogenetic, eco-protective and economic study of the vegetation of the wetland ecosystems in the Vlădeasa Massif built by the phytocoenoses of the association Carici echinatae-Sphagnetum (Balázs 1942) Soó 1955. In order to attain the aim and objectives put forward we carried out 10 phytocoenological surveys (surveys) in the phytocoenoses of the ecosystems during the optimal vegetation periods related to the summer-serotinal season in the timeframe 2020-2021. The taxonomically inventoried species were included in an association table by the criteria of their belonging to the basic coenotaxa of the association, alliance, order, vegetation class. The outcomes of the phytocoenosis research of the vegetation of the wetland ecosystems were processed, analysed, interpreted based on tables, histograms, diagrams, regarding the numerical and percentage weight of the species in the ecological categories of bioforms, phytogeographic elements (geoelements) and cytogenetic elements. The ecological behaviour of the species confined in ecosystems was also analysed by their relationship with ecological factors, edaphic soil moisture, air temperature and chemical reaction of the soil. The current state of ecosystems, potential threats, sustainable conservation of biodiversity, dynamics of phytocenoses, economic and scientific relevance were also subjected to research. The results obtained in the surveyed territory were analysed and compared numerically and as percentage with the data provided by two reference scientific works belonging to authors who independently carried out research with a similar topic in two different geographical regions of the Western Carpathians.

The Late Bronze Age on the territory of Southern Transurals is represented by two major archeological cultures: Srubnaya and Andronovskaya (Alakul culture and Fyodorovskaya – type). Their interaction of constitutes a special mix of material cultures which preserves common features of two independent, Srubnaya and Andronovskaya cultures, but also creates novel local material features. These cultural groups are also known to have brought to the region the technology of bronze production. This is evidenced, amongst others, by the proximity of the largest copper mining in the region, Kargaly mines Chernykh (2002). New methods to produce ceramics and to work bones were also developed, combining two traditions, coming from Srubnaya and Andronovskaya cultures respectively. Importantly, the features of these cultures are commonly encountered together in a single cultural horizon across the distribution ares. These diffusion processes took place in a vast area (more than 120,000 km²) andwere reflected in archeological micro-district of the Urshak river basin. We present here the most recent results of the scientific examination of the Late Bronze Age settlements in southern Transurals and attempt to address a peculiar cultural co-habitation of two distinct cultural groups in this region. We also discuss their synchronism based on absolute dates and elaborate on this cultural syncretism in the entire territory of the Volga-Ural region.

Background: In Malaysia, the mortality from melioidosis infection was reported to be higher than in other infectious diseases. The research on melioidosis is still limited in Malaysia but slightly increasing. Objective: To give an overview of the study designs, statistical methods and comparison of research in identifying the predictors of melioidosis mortality in Malaysia between January 2010 to December 2021. This review articles were divided into two sections; Section 1: Review of literature and Section 2: Findings on predictors of melioidosis mortality in Malaysia. Data sources: Pubmed/Medline. Study Eligibility Criteria: Original English-language articles were abstracted. The articles that identified the predictors of melioidosis from mortality in Malaysia only included. Letters to the editor, editorials, reviews, systematic reviews, meta-analysis, case reports and any other ineligible articles were excluded. Results: A total of 7 studies were identified related to predictors of melioidosis mortality in Malaysia. From the selected articles, all of the data were retrospectively collected. Six out of 7 articles (85.7%) used the logistic regression in identifying the predictors of melioidosis mortality. Only 1 (14.3%) used advanced survival analysis methods of Cox regression analysis. Conclusion: Logistic regression methods remain the most common methods of analysis in publications on predictors of melioidosis mortality in Malaysia while retrospective research designs are favoured. There is a limitation of research in predictors of melioidosis mortality and the use of advanced statistical techniques reported using the melioidosis data in Malaysia. More published research on melioidosis will provide input to the clinicians on a more detailed understanding of how to improve the diagnosis of melioidosis and the prognosis factors of this disease.

Background: The hydatidiform moles remain prevalent in spectrum of gesta-tional trophoblastic diseases (GTDs). In resource-limited settings like Rwanda, the definitive diagnosis relies upon single of histomophological diagnosis. The histomorphology alone suffers from high interobserver and intra-observer vari-ability with poor diagnostic reproducibility. The present study aimed at deter-mining the role of p57 immunophenotyping in the validation of histomorpholog-ical diagnosis of hydatidiform moles. Methods: A retrospective cross-sectional study embarked for histological cases collected between January 2017 and June 2020. A review of Hematoxylin &Eosin(H&E) stained slides was performed with subsequent p57 immunohisto-chemical staining. Results: Recorded were 211 retrospective cases of hydatidiform moles and 96 (45.9%) cases were all subjected to p57 immunohistochemical staining consid-ered as gold standard diagnostic modality in the present study. As result, the sensitivity and specificity of the histomophological diagnosis of complete hyda-tidiform mole were estimated at 62.5% and 57.1% respectively with positive and negative likelihood ratio of 0.145 and of 0.54 respectively. PPV and NPV were 81.8% and 29.3%, respectively. Whereas of 57.1% and 79.2% with PPV and NPV of 42.9% and 83.8% respectively for partial hydatidiform moles. Per the Youden J statistics method, the accuracy estimation of histomophological diagnosis of hydatidiform mole (HM) was 0.196 (CHM) and 0.336(PHM). Conclusions: This study highlighted a need to integrate p57 immunostaining in routine histopathological diagnosis of hydatidiform moles refining the defini-tive diagnosis.