ARTICLE
|
doi:10.20944/preprints202407.0891.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
multi-drug-resistant bacteria; triphenyl phosphonium salts; mitochondria target bola-amphiphiles; membranes permeabilization; MICs determination; time-killing experiments; cytotoxicity studies
Online: 11 July 2024 (11:27:17 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0875.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
humidity variation; temperature variation; X-ray crystallography; peptides; polymorphism; octreotide; drug stability; in situ X-ray powder diffraction
Online: 15 April 2024 (11:34:32 CEST)
ARTICLE
|
doi:10.20944/preprints202403.0045.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
heterograft copolymer; hydrogel; alginate; thermo-responsive; pH-responsive; poly(2- vinyl pyridine)-b-polyethylene oxide; diblock copolymer micelles; drug delivery
Online: 1 March 2024 (12:03:46 CET)
ARTICLE
|
doi:10.20944/preprints202312.1519.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Durysta, Bimatoprost; Ciliary Sulcus, Middle Space Operations; MiSO; Middle Space Therapeutics; MiST; ArcScan; Ultrasound; Depot; Drug Delivery; Posterior Chamber; Sulcus
Online: 20 December 2023 (09:09:38 CET)
REVIEW
|
doi:10.20944/preprints202312.1173.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
Alzheimer’s disease; transgenic animal model; amyloidogenesis; amyloid-beta; peptide; isoaspartate; zinc; α4β2 nicotinic acetylcholine receptor; aggregation seeding; anti-amyloid drug
Online: 15 December 2023 (12:23:06 CET)
REVIEW
|
doi:10.20944/preprints202312.0387.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
big data; not-so-big data; molecular design; drug design; machine learning; artificial intelligence; descriptor; computer-generated descriptors; property; regression
Online: 6 December 2023 (10:19:02 CET)
ARTICLE
|
doi:10.20944/preprints202308.1493.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
silver nanoparticles; chlorhexidine; conjunction; complexation; surface functionalization; nano-scaled drug delivery; antimicrobial synergism; antiviral activity; Camellia sinensis catechins; green synthesis
Online: 22 August 2023 (09:52:09 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1334.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
victimizing and perpetrating violence; interpersonal and intimate violence; harmful alcohol and drug use; mental health symptoms; paths of violence; gender
Online: 18 May 2023 (10:46:13 CEST)
REVIEW
|
doi:10.20944/preprints202303.0464.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Therapeutic proteins; Recombinant proteins; Repurposing; Reinventing, Drug-antibody combinations, AI/ML, Efficacy improvement, Immunogenicity; Artificial Intelligence; mRNA; High throughput analysis
Online: 27 March 2023 (14:02:03 CEST)
REVIEW
Subject:
Biology And Life Sciences,
Virology
Keywords:
Chikungunya virus; alphavirus; antiviral therapy; direct-acting antivirals; host-directed antivirals; in silico screening; in vivo validation; antiviral drug development
Online: 10 June 2021 (09:15:45 CEST)
ARTICLE
|
doi:10.20944/preprints202101.0478.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
ocular drug delivery system; topical liposomes; posterior segment of the eye; safety and toler-ability; biologic activity; diabetic macular edema
Online: 25 January 2021 (10:48:51 CET)
REVIEW
|
doi:10.20944/preprints201812.0170.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
bacterial nanocellulose; nanofibrillated nanocellulose; animal nanocellulose; algal nanocellulose; tissue engineering; tissue repair; wound dressing; cell delivery; drug delivery; antimicrobial properties
Online: 14 December 2018 (06:44:53 CET)
ARTICLE
|
doi:10.20944/preprints202407.1672.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune imbalance; Immune Imbalance Transcriptomics; IIT; B-cell lymphoma; Systemic Lupus Erythematosus (SLE); RNA-seq; algorithm; drug discovery; cancer; autoimmune disease
Online: 22 July 2024 (09:33:39 CEST)
REVIEW
|
doi:10.20944/preprints202405.1223.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
antipsychotic drug; M4 and M1 receptor agonist; negative schizophrenia symptoms; neural network; schizophrenia; trace-amine-associated receptor 1 agonist; ulataront; xanomeline
Online: 20 May 2024 (12:31:08 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0133.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation
Online: 4 July 2023 (08:01:27 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0322.v1
Subject:
Computer Science And Mathematics,
Computer Science
Keywords:
Hemolytic peptide; Network science; Half-Space Proximal Networks; Metadata Networks; Visual mining; Cluster analysis; Motif discovery; StarPep toolbox; Peptide drug discovery
Online: 17 March 2023 (10:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202206.0177.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet
Online: 13 June 2022 (09:49:32 CEST)
REVIEW
|
doi:10.20944/preprints202205.0037.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor
Online: 5 May 2022 (12:23:27 CEST)
ARTICLE
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Sepiapterin; triacetyl-β-cyclodextrin (TAβCD); hydrophilic drug/cyclodextrin complexes; spray-drying; methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone) (mPEG-PCL) nanoparticles
Online: 24 May 2019 (11:42:42 CEST)
REVIEW
|
doi:10.20944/preprints201805.0426.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
biological activity; crosslinking; drug delivery; cosmetic; food-supplement; functionalization; hyaluronan applications; hyaluronan derivatives; hyaluronan synthases; hyaluronic acid; hyaluronidases; physico-chemical properties
Online: 29 May 2018 (12:13:48 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0245.v1
Subject:
Chemistry And Materials Science,
Polymers And Plastics
Keywords:
Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.
Online: 18 April 2018 (16:28:21 CEST)
REVIEW
|
doi:10.20944/preprints202312.1480.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nano-drugs; Nanoparticle; Delivery System; Vaccine; Liposome; Exosome; Stealth Effect; SLN; Inclusion and Dispersion Systems; Solid State Reactive Mixing; Nanosome; Drug Carrier
Online: 20 December 2023 (10:54:31 CET)
REVIEW
|
doi:10.20944/preprints202307.1284.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cancer; tumourigenesis; drug resistance; signalling pathways; Wnt/β-catenin pathway; JAK/STAT pathway; PI3K/Akt/mTOR pathway; RAS/RAF/MAPK/ERK signalling
Online: 19 July 2023 (09:14:02 CEST)
ARTICLE
|
doi:10.20944/preprints202306.1818.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Alternative Splicing; two-colour (GFP/RFP) Fluorescent Reporter; MAPT; Exon-Skipping; FTDP-17; High Content Screening; siRNA; Nucleic Acids Therapeutics; Drug discovery
Online: 26 June 2023 (13:55:26 CEST)
ARTICLE
|
doi:10.20944/preprints202305.1948.v1
Subject:
Public Health And Healthcare,
Public Health And Health Services
Keywords:
Kyrgyz Republic; drug-sensitive pulmonary TB; electronic register system; paper-based records; completeness; concordance; treatment initiation; treatment outcomes; SORT IT; operational research
Online: 29 May 2023 (02:49:28 CEST)
ARTICLE
|
doi:10.20944/preprints202202.0194.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
antifungal resistance; isavuconazole; cystic fibrosis; pulmonary disease; Aspergillus fumigatus; pulmonary aspergillosis; respiratory disease; antifungal stewardship; therapeutic drug monitoring; minimum inhibitory concentration (MIC)
Online: 16 February 2022 (05:12:39 CET)
REVIEW
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Parkinson’s disease; precision medicine; personalized medicine; GBA; Glucocerebrosidase; GCase; LRRK2; Leucine-rich repeat kinase-2; Dopamine; PD drug trials; PD risk variants
Online: 14 September 2020 (00:22:59 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0070.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer growth; tumor metastasis; cancer's Warburg effect; p53; p53 (re)activators; mitochondrial apoptosis; cytochrome c release; tumoricidal drug effect
Online: 4 January 2024 (09:34:19 CET)
ARTICLE
|
doi:10.20944/preprints202002.0003.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture
Online: 3 February 2020 (03:16:54 CET)
REVIEW
|
doi:10.20944/preprints202309.0459.v2
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
migraine disorders; headache disorders; nociceptive pain; analgesics; calcitonin gene-related peptide; pituitary adenylate cyclase-activating polypeptide (PACAP); vasoactive intestinal peptide; adrenomedullin; neuropeptides; drug development
Online: 17 October 2023 (10:50:15 CEST)
ARTICLE
|
doi:10.20944/preprints202405.1511.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Breast cancer; network pharmacology; text mining; drug therapy; genes; pathway analysis; biological process; protein-protein interaction; degree and betweenness; molecular docking; meristematic cells; anti-mitotic; hepatotoxicity
Online: 23 May 2024 (07:34:57 CEST)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
ARTICLE
|
doi:10.20944/preprints202308.1047.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
Age-related Macular Degeneration (AMD); Cornea; docosahexaenoic acid (DHA); drug delivery; non-invasive ocular delivery platform (NIODP); ocular disease; omega-3; retina; retinal delivery; retinal dis
Online: 14 August 2023 (15:18:22 CEST)
REVIEW
|
doi:10.20944/preprints201912.0386.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology
Online: 29 December 2019 (13:46:21 CET)
REVIEW
|
doi:10.20944/preprints202401.1443.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models
Online: 19 January 2024 (09:32:31 CET)
REVIEW
|
doi:10.20944/preprints202305.1078.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
bacterial resistance; methicillin-resistant S. aureus (MRSA); multi drug resistant (MDR) bacteria; Cannabis sativa; phytocannabinoids (PCs); endocannabinois (ECs); synthetic cannabinoids (SCs); synthetic procedures; cannabichromene (CBC); cannabigerol (CBG); cannabidiol (CBC)
Online: 16 May 2023 (04:29:36 CEST)
REVIEW
|
doi:10.20944/preprints202305.0658.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nanotechnology application; nano-suspension techniques; nano-emulsion techniques; bioactive constituents of plant; phytochemicals (PHYs); poor water solubility; drug delivery systems (DDSs); toxicological risks of NPs; clinical application of NPs
Online: 9 May 2023 (12:50:27 CEST)
ARTICLE
|
doi:10.20944/preprints201810.0088.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
There are many molecules used as drug carrier. TUD-1 is a newly synthesized mesoporous silica (SM) molecule possess two important features; consists of mesoporous so it is very suitable to be drug carrier in addition to that it has the ability to induce apoptosis in cancer cells. However, the effect of TUD-1 appears to act as cell death inducer, regardless of whether it is necrosis or apoptosis. Unfortunately, recent studies indicate that a proportion of cells undergo necrosis rather than apoptosis, which limits the use of TUD-1 as a secure treatment. On the other hand, lithium considered as necrosis inhibitor element. Hence, current study based on the idea of production a new Li/TUD-1 by incorporated mesoporous silica (TUD-1 type) with lithium in order to produce a new compound that has the ability to activate apoptosis by mesoporous silica (TUD-1 type) and at the same time can inhibit the activity of necrosis by lithium. Herein, lithium was incorporated in TUD-1 mesoporous silica by
Online: 4 October 2018 (15:54:02 CEST)
REVIEW
|
doi:10.20944/preprints202407.1534.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
lymphoma; B‐cell; hematologic neoplasms; bruton tyrosine kinase; protein kinase inhibitors; drug resistance; neoplasm; ibrutinib; pirtobrutinib; molecular targeted therapy; chronic lymphocytic leukemia; hematopoietic stem cell transplantation; covalent inhibitors; protein degradation
Online: 18 July 2024 (17:24:05 CEST)
REVIEW
|
doi:10.20944/preprints202407.1456.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
advanced therapy medicinal products (ATMPs); chimeric antigen receptors (CAR-T cells); B acute lymphoblastic leukaemia (B-ALL); food and drug administration (FDA); systemic lupus erythematosus (SLE); idiopathic inflammatory myositis (IIM); systemic sclerosis (SS); memorial sloan kettering cancer centre (MSKCC); hematopoietic stem cell transplantation [HSCT], non-Hodgkin’ s cell lymphoma (NHCL); multiple myeloma (MM); follicular lymphoma; (FL); large B cell-lymphoma (LBCL); mantle cell lymphoma (MCL); myeloid-derived suppressor cells (MDSCs); rheumatoid arthritis (RA); immune effector cell-associated neurotoxicity syndrome (ICANS); natural killer group member D ligands (NKG2DLs); acute myelogenous leukaemia (AML)
Online: 18 July 2024 (08:03:12 CEST)
REVIEW
|
doi:10.20944/preprints202405.0500.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
Gilbert’ s syndrome (GS), Genetic variations, Protective effects of Gilbert’ s syndrome, Cancer risk, Drug interactions, Pharmacokinetic abnormalities, Clinical implications of Gilbert’ s Syndrome, Effect on NASH, Liver transplantation, Psychology and GS
Online: 9 May 2024 (02:57:19 CEST)