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Preprint ARTICLE | doi:10.20944/preprints202111.0396.v1

Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption

Michael Baker

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Progesterone Receptor; Mineralocorticoid Receptor; Evolution; Zebrafish

Online: 22 November 2021 (13:52:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0197.v1

An Assessment of Starch Composition and Gelatinization in Traditional and Non-traditional Dog Food Formulations

Erin Perry, Alyssa Ann Valach, Jesse Marie Francis, George E Moore

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: dog food; starch; novel ingredient; starch gelatinization

Online: 10 November 2021 (08:53:05 CET)

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Gelatinization of starch content in pet foods can be impacted by several factors including moisture, retention time, and ingredients used. Starch gelatinization has been associated with digestibility but isn’t well studied using ingredients common in non-traditional canine diets. The objective of this research was to examine the impacts of dietary ingredient profile (traditional vs non-traditional) and assess impacts to total starch content and starch gelatinization. Traditional diets (n = 10) utilizing meat-based ingredients including chicken, chicken by-product meal, meat and bone meal and plant-based ingredients including rice, barley, oats, and corn were examined in comparison with non-traditional diets (n = 10) utilizing meat-based ingredients including alligator, buffalo, venison, kangaroo, squid, quail, rabbit, rabbit and salmon along with plant-based ingredients including tapioca, peas, chickpeas, lentils, potato, and pumpkin. Representative samples were collected via grab sample technique (5 samples/diet) and were assessed for total starch content as well as percent starch gelatinization. Difference between ingredient type was assessed using a Students t-test in SAS 9.4. Significance was set at P < 0.05. Distribution of total starch content based on ingredient type (traditional vs non-traditional) revealed that mean total starch content was higher in traditional diets as compared to non-traditional diets (P <0.0001). Conversely, starch gelatinization was found to be higher in non-traditional diets (P < 0.0001). Total starch content and total gelatinized starch had a strong negative correlation (P < 0.01) in traditional diets, though no correlation was observed in non-traditional diets. This negative correlation indicates a decrease in total gelatinized starch associated with increased total starch content. These novel data reveal important differences between starch content and gelatinization and could impact manufacturing processes for ingredient types as well as feeding recommendations. Unpredicted variation between ingredient formulations could potentially lead to decreased digestibility and absorption and may result in nutrient deficiencies.

Preprint ARTICLE | doi:10.20944/preprints202110.0345.v1

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Nicola Magnavita, Reparata Rosa Di Prinzio, Gabriele Arnesano, Anna Cerrina, Maddalena Gabriele, Sergio Garbarino, Martina Gasbarri, Angela Iuliano, Marcella Labella, Carmela Matera, Igor Mauro, Franca Barbic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Loss of consciousness; Mental health; Working life; Effort Reward Imbalance; Sleep Dis-orders; Health promotion; Workplace

Online: 25 October 2021 (11:54:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0206.v1

Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Sharon Chanshan Wu, Karl Munger

Subject: Biology And Life Sciences, Virology Keywords: CT antigens; HNSCC; HPV

Online: 13 October 2021 (15:23:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0198.v1

Cell Cycle Regulation and DNA Damage Response Networks in Diffuse-and Intestinal-Type Gastric Cancer

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: BRCA1; cancer stem cell; cell cycle; epithelial-mesenchymal transition; DNA damage response; gastric cancer; molecular network

Online: 13 October 2021 (11:06:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0386.v1

Evaluating GraphQL and REST API Services Performance in a Massive and Intensive Accessible Information System

Armin Lawi, Benny L. E. Panggabean, Takaichi Yoshida

Subject: Computer Science And Mathematics, Information Systems Keywords: information systems; middleware applications; Application Programming Interfaces (APIs); web services; Quality of Services (QoS); performance evaluation

Online: 22 September 2021 (13:29:56 CEST)

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Working Paper REVIEW

Microbiota-Immune Interactions in Ulcerative Colitis and Colitis-Associated Cancer, and Emerging Microbiota-Based Therapies

Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ulcerative colitis; inflammatory bowel disease; pediatrics; FMT; probiotics; synbiotics; antibiotics; prebiotics; fecal microbiota transplant; colitis-associated cancer; colorectal cancer; CAC; CRC; dysbiosis

Online: 20 September 2021 (14:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0515.v1

Decomposition of Dimethoate and Omethoate in Aqueous Solutions – Half-Life, Neurotoxicity and Mechanism of Hydrolysis

Vladan J. Anićijević, Milena Petković, Igor A Pašti, Tamara Lazarević-Pašti

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: organophosphate; pesticide; pH stability; toxicity; Apis mellifera

Online: 27 August 2021 (10:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0008.v2

The Green Deal, National Energy and Climate Plans in Europe: Member States’ Compliance and Strategies

Georgios Maris, Floros Flouros

Subject: Social Sciences, Political Science Keywords: European Union; Energy; Environment; Compliance; Green Deal; NECP; Strategy

Online: 16 July 2021 (16:39:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0694.v1

Energy Consumption and Usage Reduction in Lecture Halls, Kwame Nkrumah University of Science and Technology

Pius Nimoh, Daniel Duah, Alexander Marful

Subject: Social Sciences, Psychology Keywords: Electric energy; Occupant behavior; energy efficiency; lecture halls

Online: 29 June 2021 (08:44:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0632.v1

Opportunities for and Limits to Cooperation between School and Families in Sustainable Public Food Procurement

Elena Pagliarino, Elena Santanera

Subject: Business, Economics And Management, Accounting And Taxation Keywords: school catering; sustainable food; public procurement; parents; children; food choices; involvement; Covid-19 pandemic.

Online: 28 June 2021 (09:52:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0522.v1

Dementia Risk and Prevention in Low and Middle-income Country Settings – Focus on Tanzania Mainland

Charles Kakilla

Subject: Social Sciences, Psychology Keywords: Dementia; prevalence; Tanzania; sustainable development goals

Online: 21 June 2021 (15:22:37 CEST)

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Working Paper ARTICLE

Weekly and Daily Tooth Brushing by Care Staff Reduces Gingivitis and Calculus in Racing Greyhounds

Nicola Jane Rooney, Katie Wonham, Katherine McIndoe, Rachel A Casey, Emily Jayne Blackwell, William J Browne

Subject: Social Sciences, Psychology Keywords: teeth; greyhound; intervention; brushing; calculus; gingivitis; dental; periodontal

Online: 19 May 2021 (07:53:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0372.v1

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

Rohit Sharma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Aging; Microbiome; Probiotics; Cellular senescence; SASP; Stress; Immunity

Online: 17 May 2021 (08:51:53 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202104.0780.v1

Response to Combination of Pembrolizumab and Axitinib in Hereditary Leyomiomatosis and Renal Cell Cancer (HLRCC)

Ibon Gurruchaga Sotés, Carmen Santander Lobera

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hereditary Leyomiomatosis and Renal Cell Cancer; Pembrolizumab; Axitinib

Online: 29 April 2021 (15:38:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0759.v1

Healthy Lifestyles in Italian and Latvian University Students, According to Demographics, Study Course, and Nationality

ANTONIO CICCHELLA, Svetlana Usca, Helena Vecenane

Subject: Social Sciences, Psychology Keywords: Healthy lifestyles; sport studies; physical activity; socio-economic wellness; emotional wellness; occupational wellness; Psychological wellness

Online: 28 April 2021 (17:09:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0202.v2

Real-Time Musculoskeletal Kinematics and Dynamics Analysis Using Marker- and IMU-based Solutions in Rehabilitation

Dimitar Stanev, Konstantinos Filip, Dimitrios Bitzas, Sokratis Zouras, Georgios Giarmatzis, Dimitrios Tsaopoulos, Konstantinos Moustakas

Subject: Engineering, Automotive Engineering Keywords: musculoskeletal; kinematics; dynamics; muscle forces; joint reactions; ground reactions; inertial measurement units

Online: 26 February 2021 (12:07:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0111.v1

Comparison of CMIP6 and CMIP5 Models in Simulating Mean and Extreme Precipitation over East Africa

Brian AYUGI, Jiang Zhidong, Huanhuan Zhu, Hamida Ngoma, Hassen Babaousmail, Karim Rizwan, Victor Dike

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: CMIP5/6; Precipitation; Climate extremes; evaluation; East Africa

Online: 3 February 2021 (10:22:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0458.v1

Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke

Shashank Shekhar, Yedan Liu, Shaoxun Wang, Huawei Zhang, Xing Fang, Jin Zhang, Letao Fan, Baoying Zheng, Richard Roman, Zhen Wang, Fan Fan, George Booz

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: blood-brain barrier; transient receptor potential cation channels; ischemic stroke; neuroprotection; calcium signaling; cAMP response element-binding protein

Online: 25 January 2021 (09:20:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0415.v1

Nutritional Support of Neurodevelopment and Cognitive Function in Healthy Children – An Update and Novel Insights

Kathrin Cohen Kadosh, Leilani Muhardi, Panam Parikh, Melissa Basso, Hamid Jan Jan Mohamed, Titis Prawitasari, Samuel Folake, Guansheng Ma, J.M.W Geurts

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: nutrition; brain; neurodevelopment; childhood; gut-brain axis; psychobiotics; macronutrients, micronutrients.

Online: 16 December 2020 (13:52:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0572.v1

Determinants Associated with Fruit and Vegetable Consumption in East and Southeast Asia: A Systematic Review

Jason Tsz Him Cheung, Johnson Lok, Stuart Gietel-Basten, Keumseok Koh

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Fruit and vegetable (FV) consumption; Food businesses; Food environments; Asia

Online: 23 November 2020 (09:23:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0440.v1

Methotrexate Gold Nanocarriers: Loading and Release Study. Its Activity in Colon and Lung Cancer Cells

Beatriz Álvarez-González, Marisa Rozalen, María Fernández-Perales, Miguel A. Álvarez, Manuel Sánchez-Polo

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Au nanoparticles; nanocarriers; methotrexate; anticancer drug; chemotherapeutics; controlled release

Online: 16 November 2020 (17:38:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0417.v1

Age and Reproduction of Wild-Born and Escaped Mink (Neovison vison) Caught in Danish Nature

Sussie Pagh, Cino Pertoldi, Mariann Chriel, Trine Hammer Jensen, Trine Hammer Jensen, Sussi Madsen, David Chr. Evar Kraft, Toke Munk Schou, Mette Sif Hansen

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: placental scars; demography; litter size; fecundity; turnover

Online: 16 November 2020 (11:47:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0295.v3

Detection and Imaging of Damages and Defects in Fibre-Reinforced Composites by Resonance Magnetic Technique

Carine Alves, Janete Oliveira, Alberto Tannus, Alessandra Tarpani, José Tarpani

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: damage and defect assessment; magnetic resonance imaging; polymer matrix composite

Online: 4 November 2020 (10:17:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0515.v1

Solar PV Frequency Control in the U.S. EI and ERCOT Interconnections — Case Studies and Recommendations

Shutang You

Subject: Engineering, Energy And Fuel Technology Keywords: PV; frequency control; droop; inertia; grid standards

Online: 26 October 2020 (11:13:04 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202010.0262.v1

Modification of Monocyte Count and Subsets During Human Cytomegalovirus Replication in vivo and Glucocorticoid Therapy

Przemyslaw Zdziarski, Andrzej Gamian

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cytomegalovirus (CMV); definitions of cytomegalovirus disease; logarithmic phase infection; innate immune response; CD14; monocytes; nonclassical monocytes; HLA-DR; adaptive immune response; interferon; monocytosis

Online: 13 October 2020 (08:52:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0097.v1

Timing of Spheno-Occipital Synchondrosis Ossification in Children and Adolescents with Cleft Lip and Palate

Francisco Vale, Inês Francisco, António Lucas, Ana Roseiro, Francisco Caramelo, Adriana Sobral

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cleft lip; cleft palate; cone-beam computed tomography

Online: 5 October 2020 (15:18:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0738.v1

Eulerian and Lagrangian Comparison of Primary and Secondary Wind Jets in the Tokar Gap Region

Larry Pratt, E. Jason Albright, Irina Rypina, Houshuo Jiang

Subject: Physical Sciences, Acoustics Keywords: coastal wind jets; Red Sea; Lagrangian pathways; hydraulics; dust storms; hydraulic jumps

Online: 30 September 2020 (10:41:43 CEST)

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The Lagrangian and Eulerian structure and dynamics of a strong wind event in the Tokar Gap region are described using a WRF model hindcast for 2008. Winds in the Tokar Gap reach 25 m s-1 and remain coherent as a jet far out over the Red Sea, whereas equally strong wind jets occurring in neighboring gaps are attenuated abruptly by a jump-like hydraulic transition that occur just offshore of the Sudan coast. The transition is made possible by the supercritical nature of the jets, which are fed by air that spills down from passes at relatively high elevation. By contrast, the spilling flow in the ravine-like Tokar Gap does not become substantially supercritical and therefore does not undergo a jump, and also carries more total horizontal momentum. The Tokar Wind Jet carries some air parcels across the Red Sea and into Saudi Arabia, whereas air parcel trajectories in the neighboring jets ascend as they cross through the jumps, then veer sharply to the southeast and do not cross the Red Sea. The mountain parameter Nh/U is estimated to lie in the rage 1.0-4.0 for the general region, a result roughly consistent with a primary gap jet having a long extension, and supercritical jets spilling down from higher elevation passes. The strong event is marked by the formation of a cyclonic cell near the upstream entrance to the Tokar Gap, a feature absent from the more moderate events that occur throughout the summer. The cell contains descending air parcels that are fed into the primary and secondary jets. An analysis of the Bernoulli function along air parcel trajectories reveals an approximate balance between the loss of potential energy and gain of internal energy and pressure, with surprisingly little contribution from kinetic energy, along the path of the descending flow. All jets attain the critical wind speed nominally required to loft dust into the atmosphere, though only the Tokar Gap has a broad, delta region with plentiful deposits of silt.

Preprint ARTICLE | doi:10.20944/preprints202009.0567.v1

Common Barriers, Attitudes and Practices of Veterinary Practitioners Regarding Antimicrobial Resistance and Stewardship in Bangladesh

Md. Sahidur Rahman, Nazifa Rafa

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: antimicrobial resistance; antimicrobial stewardship; barriers; perception; survey; veterinary practitioners

Online: 24 September 2020 (04:41:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0164.v2

Resistance and Resilience of Pelagic and Littoral Fishes to Drought in the San Francisco Estuary

Brian Mahardja, Vanessa Tobias, Shruti Khanna, Lara Mitchell, Peggy Lehman, Ted Sommer, Larry Brown, Steve Culberson, J. Louise Conrad

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: drought; climate variability; resilience; resistance; estuary; fish; extreme events; Delta Smelt; Chinook Salmon; Largemouth Bass

Online: 23 July 2020 (10:30:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0476.v1

Detection and Mitigation of RPL Rank and Version Number Attacks in Smart Internet of Things

Zahrah A. Almusaylim, Abdulaziz Alhumam, Wathiq Mansoor, Pushpita Chatterjee, Noor Zaman Jhanjhi

Subject: Engineering, Electrical And Electronic Engineering Keywords: IoT; Security; Smart IoT; Rank Attacks; RPL; Version Number Attack; attack model

Online: 21 July 2020 (10:54:38 CEST)

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Working Paper ARTICLE

Marital Domestic Violence and Maternal Health in Nigeria: Evidence from the Demographic and Health Survey

Atsiya Pius Amos, Hauwa Mohammed Maimona, Godiya Atsiya Pius

Subject: Business, Economics And Management, Economics Keywords: Non-cooperative Household Model; Domestic Violence; Maternal Health

Online: 11 July 2020 (03:49:45 CEST)

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There is increasing evidence that the non-cooperative models describe household structures in developing countries more succinctly compared with the unitary model. Domestic violence against women, which is pervasive in Nigeria even though likely to be under-reported, will need to be understood within the framework of non-cooperative relationship between couples. In this study, we identify factors of domestic violence against women within couples who were currently in marital or cohabiting partnerships. Also, we investigate whether domestic violence influences the decision of women to terminate pregnancies. We use data from the 2018 Nigeria Demographic and Health Survey (NDHS). Multivariate logistic regressions were used to model the predictors of domestic violence, and its influence on the decision to terminate pregnancies among married women. Of the 8,910 married women interviewed for domestic violence, 35.33% had ever experienced a form of domestic violence. We discover that women: with higher education, that is not poor, and resides in urban areas have 44%, 18% and 15% reductions in the odds of experience domestic violence respectively. On the other hand, women who are employed, own land, having husbands/partners that are employed in the agricultural sector, and drink alcohol have 1.16, 1.2, 2.07, and 2.8 times increased odds of experiencing domestic violence accordingly. Also, we uncover that currently married women experiencing domestic violence have 1.25 times increased odds of terminating pregnancies compared with their counterparts that are not experiencing domestic violence. Effectively, poverty, low levels of education, residing in rural areas, drinking habit of husbands/partners, employment, marital capital, and land ownership status of women are risk factors of domestic violence against married women in Nigeria but can be affected by policies and programmes. Importantly, public actions to contain domestic violence in order to improve maternal health should be implemented in the context of the dynamics of a non-cooperative relationship existing between married couples.

Preprint ARTICLE | doi:10.20944/preprints202006.0302.v1

Gender Matters: Climate Change, Gender Bias, and Women's Farming in the Global South and North

Tricia Glazebrook, Samantha Noll, Emmanuela Opoku

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Africa/Ghana; climate change; farming/farmers; food security; gender inequality; global South/North; hunger; justice; land

Online: 24 June 2020 (14:31:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0126.v1

Predictive Value of CCNB1, BUB1B and TTK in the Progression and Prognosis of Lung Adenocarcinoma

Lecai Xiong, Yuquan Bai, Minglin Zhu, Zetian Yang, Jinping Zhao, Hexiao Tang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CCNB1; BUB1B; TTK; lung cancer; protein‑protein interaction network

Online: 10 June 2020 (05:12:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0050.v1

Competitive Neurocognitive Functions Can Tell Us What to Learn and When: In Schools and Beyond

Dezso Nemeth, Kate Schipper, Claire Pleche, Karolina Janacsek

Subject: Social Sciences, Behavior Sciences Keywords: competitive learning and memory functions; cognitive development; basal ganglia; medial temporal lobe; prefrontal cortex; model-based learning; model-free learning

Online: 5 June 2020 (14:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0224.v2

Evaluation of Sources and Ecological Risk of PAHs in Different Layers of Soil and Groundwater

Predrag Ilić, Dragana Nešković Markić, Ljiljana Stojanović Bjelić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: soil; groundwaters; polycyclic aromatic hydrocarbons (PAHs); industrial complex; ecological risk; contamination

Online: 8 March 2020 (16:24:28 CET)

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Working Paper REVIEW

Review of Potential High-Leverage and Inexpensive Mitigations for Reducing Risk in Epidemics and Pandemics

David Manheim, David Denkenberger

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Mitigation; Risk Reduction; Global Catastrophic Biological Risk; Epidemics; Disease X; Literature Review; Pandemics; Value of Information; Existential Risk

Online: 28 February 2020 (12:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0148.v1

CDC37 and HSP90 are Essential for Stressome Release and Tumor Progression in Resistant Prostate Cancer

Takanori Eguchi, Chiharu Sogawa, Kisho Ono, Masaki Matsumoto, Manh Tien Tran, Yuka Okusha, Benjamin Lang, Kuniaki Okamoto, Stuart Calderwood

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cell stress response; stressome; extracellular vesicle; heat shock protein 90 (HSP90); cell division control 37 (CDC37); prostate cancer; exosome; ectosome

Online: 11 February 2020 (14:50:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0350.v3

Aflatoxins: Production, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries

Noreddine Benkerroum

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aflatoxins; incidence; toxicity; risk assessment; biocontrol; atoxigenic A. flavus

Online: 5 January 2020 (16:44:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0172.v1

RNA viruses of Amblyomma variegatum and Rhipicephalus microplus and Cattle Susceptibility in the French Antilles

Mathilde Gondard, Sarah Temmam, Elodie Devillers, Valerie Pinarello, Thomas Bigot, Delphine Chretien, Rosalie Aprelon, Muriel Vayssier-Taussat, Emmanuel Albina, Marc Eloit, Sara Moutaller

Subject: Biology And Life Sciences, Virology Keywords: ticks; cattle, rna viruses; next-generation sequencing; phylogeny; microfluidic real-time pcr technology; Caribbean; lips

Online: 12 December 2019 (12:29:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0119.v1

Statistical Analysis and Forecasting of Price and Mileage Correlation for Second-hand Cars in Australia

Chinedu G. Agokei, Bomonyo J. Afa

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: second-hand cars; p-values; confidence interval; non-parametric bootstrapping; correlation

Online: 10 November 2019 (16:46:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0320.v1

Water, Livelihoods and Migration in SIDS: Climate Change and Future Prospects for Carriacou, West Indies

Adrian Cashman, David Yawson

Subject: Social Sciences, Geography, Planning And Development Keywords: water; agriculture; migration; caribbean sids; climate change

Online: 29 September 2019 (02:54:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0187.v1

Basic Mechanism of Sweating and Its Role in Temperature and Appetite Regulation: An Ayurvedic Perspective

Sushil Kumar Dubey, Anam Aftab, Suyash Tripathi, Ramesh Kant Dubey, Shivani Srivastava, Yamini Bhusan Tripathi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sweat; sveda; Pitta; Svedavaha srotasa; thermoregulation; digestion; Agni

Online: 18 August 2019 (02:18:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0042.v1

English Language Proficiency and Immigrant Families Annual Earnings and Medical Care Spending in the USA

Ibrahim Niankara

Subject: Business, Economics And Management, Economics Keywords: English proficiency, Earnings, Immigrants, MCMC, Medical Care Spending

Online: 2 July 2019 (11:37:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0264.v1

Temporally and Spatially Resolved Emission Spectroscopy of Cyanide, Hydrogen and Carbon in Laser-Induced Plasma

Christian G. Parigger, Christopher M. Helstern, Ghaneshwar Gautam

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: laser-induced plasma; atomic spectroscopy; molecular spectroscopy; cyanide; hydrogen; carbon

Online: 26 June 2019 (07:49:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0055.v1

Predictive Capacity of Drug Use, Impulsivity and Sensation-Seeking in Aggressors and Victims of Violence

María del Carmen Pérez-Fuentes, María del Mar Molero Jurado, María del Mar Simón Márquez, José Jesús Gázquez Linares

Subject: Social Sciences, Psychology Keywords: drug, impulsivity, sensation-seeking, peer conflict, adolescent.

Online: 5 March 2019 (11:29:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0283.v1

Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation.

Minh Hoang NGUYEN, Tam Tri LE, Serik MEIRMANOV

Subject: Social Sciences, Education Keywords: depression; acculturation stress; social connectedness; international students, university students, ASSIS, suicidal ideation

Online: 24 December 2018 (14:52:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0239.v1

Determination of Au(III) and Ag(I) in Carbonaceous Shales and Pyrites by Stripping Voltammetry

Nina A. Kolpakova, Zhamilya K. Sabitova, Victor I. Sachkov, Rodion O. Medvedev, Roman A. Nefedov, Vladislav V. Orlov

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: gold; silver; mineral raw materials; carbonaceous shales; stripping voltammetry; graphite electrode modifiers

Online: 20 December 2018 (04:55:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0711.v1

The Interplay of Order and Disorder in the Dynamical Evolution of Physical and Biological Systems

Asima Tripathy, Rajat Kumar Pradhan

Subject: Biology And Life Sciences, Biophysics Keywords: order; entropy; chaos; evolution; cosmic mind; big bang

Online: 30 October 2018 (07:50:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0222.v1

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

Ewa Ambrożewic, Piotr Wojcik, Adam Wronski, Wojciech Luczaj, Anna Jastrząb, Neven Zarkovic, Elżbieta Skrzydlewska

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: psoriasis, arthritis, inflammation, granulocytes, redox signaling, oxidative stress, lipid peroxidation, 4-hydroxynonenal, lipids, endocannabinoid system

Online: 12 September 2018 (13:43:16 CEST)

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Inflammatory granulocytes are characterized by oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important, not yet fully understood, roles in pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis, in comparison to the healthy subjects. The results obtained revealed enhanced activity of pro-oxidant enzymes NADPH and xanthine oxidases in granulocytes, with a decrease of enzymatic and non-enzymatic antioxidants in plasma of psoriatic patients. The Nrf2 and its regulators were increased in both forms of psoriasis, while HO-1 levels were increased only in psoriasis vulgaris. Redox imbalance was associated with decreased levels of phospholipids and of free PUFAs, but with enhanced activity of enzymes involved in lipid metabolism (PLA2, PAF-AH COX1/2) and increased lipid peroxidation products 4-hydroxynonenal (4-HNE), isoprostanes and neuroprostanes. Increased endocannabinoids and GPR55 were observed in both forms of the disease, while expression of CB1 was increased only in pateints with psoriatic arthritis, opposite to CB2, which was increased only in psoriasis vulgaris. Protein modifications by ROS and lipid peroxidation product 4-HNE promoted apoptosis of granulocytes by increased caspases in both forms of psoriasis. This study indicates that excessive activation of granulocytes, causing oxidative stress and lipid modifications, is an important pathophysiology of psoriasis. Consequently, lower Nrf2 activity and CB2 expression may promote progression of psoriasis into advanced, arthritic form of the disease.

Preprint ARTICLE | doi:10.20944/preprints201808.0244.v1

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

Aimy Sebastian, Jiun C. Chang, Melanie E. Mendez, Deepa K. Murugesh, Sarah Hatsell, Aris N. Economides, Blaine A. Christiansen, Gabriela G. Loots

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: osteoarthritis; RNA-seq; STR/ort; C57BL/6; MRL/MpJ; ACL injury; PTOA; regeneration; inflammation; B4galnt2

Online: 14 August 2018 (05:47:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0470.v1

Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities

Woo Sung Park, Hye-Jin Kim, Min Li, Dong-Hoon Lim, Jungmin Kim, Sang-Soo Kwak, Chang-Min Kang, Mario G. Ferruzzi, Mi-Jeong Ahn

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Arthrospira platensis; carotenoids; natural pigments; spirulina powder; C-phycocyanin; antioxidant activity

Online: 25 July 2018 (06:19:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0418.v1

Preparation of Hierarchically Porous Graphitic Carbon Spheres and Their Applications in Supercapacitors and Dye Adsorption

Saisai Li, Faliang Li, Junkai Wang, Liang Tian, Haijun Zhang, Shaowei Zhang

Subject: Chemistry And Materials Science, Nanotechnology Keywords: graphitic carbon spheres; catalytic graphitization; hierarchical pores; supercapacitors; dye adsorption

Online: 23 July 2018 (11:47:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0093.v1

Molecular Characterization of Phospholamban and Reninangiotensin System Genes Mutations and Clinical Epidemiology in Human Cardiomyopathy

Gnana Veera Subhashini, Beesetti Swarna latha, mavuluri jayadev, Emmanuel C, K M Cherian

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiomyopathy; hemodynamic and biochemical parameters; epidemiological and clinical Parameters; phospholamban angiotensin-1-converting enzyme

Online: 5 July 2018 (10:43:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0080.v1

Stress Relaxation Properties and Microscopic Deformation Structure in Bending of the C7025 and C7035 Alloy

Xiangpeng Xiao, Hai Xu, Jian Huang, Junfeng Wang, Jianbo Zhang

Subject: Engineering, Mechanical Engineering Keywords: C7025 alloy; C7035 alloy; stress relaxation; dynamic equation; microstructure

Online: 5 July 2018 (05:53:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0142.v2

Process and Prospect for Control and Prevention Impairment of Water-borne Iodine Excess in China

Peng Liu, Lijun Fan, Xiaohui Su, Fangang Meng, Hongmei Shen

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: ater-borne; iodine excess; impairement; control and prevention

Online: 8 February 2018 (15:21:11 CET)

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Preprint REVIEW | doi:10.20944/preprints201801.0001.v2

The Identification, Management, and Control of Scabies in Australian Aboriginal and Torres Strait Islander Communities

Timothy Mettam

Subject: Medicine And Pharmacology, Dermatology Keywords: Aboriginal; Australia; control; diagnosis; identification; prevention; scabies; sarcoptes scabiei; Torres Strait Islander; treatment

Online: 8 January 2018 (16:00:59 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201710.0153.v1

‘Parabiotic Evolution’: From Stochasticity in Geochemical and Subsequent Processes to Genes, Genomes and Modular Cells

Richard Egel

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Tree of Life; origins of species; cellular lineage escape; endogenous compartmentation; proto-organelles; eukaryogenesis; origins of sex; syntrophic biofilms; endosymbiosis

Online: 24 October 2017 (04:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0080.v1

Multimodal Metabolomics Combining UPLC-qToF-MS and GC-MS Data in Plasma and Brain Tissue

Amera A. Ebshiana, Stuart G. Snowden, Cristina Legido-Quigley

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: metabolomics; LC-MS; GC-MS; plasma; brain tissue

Online: 14 April 2017 (04:41:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0185.v1

Design, Fabrication and Analysis of Threshold-Value Judging Mechanism in MEMS Safety and Arming Device

Dakui Wang, Wenzhong Lou, Yue Feng, Fufu Wang

Subject: Engineering, Mechanical Engineering Keywords: MEMS S&A device; threshold-value judging mechanism; fabrication process; tensile test; theoretical, simulationand experimentalanalysis; parametric design method

Online: 24 March 2017 (10:12:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0790.v2

The generation of ROS by exposure to trihalomethanes promotes the IκBα/NF-kB/p65 complex dissociation in human lung fibroblast

Minerva Nájera-Martínez, Jhonatan Avilez-Alvarado, Nataraj S Pagadala, Ricardo Dzul-Caamal, María Lilia Domínguez-López, Jack Tuszynski, Armando Vega-López

Subject: Biology And Life Sciences, Toxicology Keywords: Antioxidant defenses; Hydrogen peroxide; IPT domain; Fibroblasts; NF-κ B nuclear translocation; Superoxide anion

Online: 11 July 2024 (10:24:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1751.v1

CP Violation: Differing Binding Energy Levels of Quarks and Antiquarks, and their Transitions in Λ-baryons and B-mesons

Dimitris M Christodoulou, Demosthenes Kazanas

Subject: Physical Sciences, Particle And Field Physics Keywords: CP Violation; Flavor Symmetries; Properties of Hadrons; Quark Masses; Quark-Gluon Plasma

Online: 22 July 2024 (14:44:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0147.v2

Heat Attainment and Retention in Surfers with and Without a Land-Based Warm-Up and Accompanying Passive Heat Retention

Christian J Cook, Benjamin G Serpell, Lauren J Hanna, Aaron Fox, Phillip J Fourie

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Surfing; Warm-Up; Performance

Online: 3 July 2024 (13:58:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0280.v1

Photochemical and Oxidative Degradation of Chamazulene Contained in Artemisia, Matricaria and Achillea Essential Oils and Setup of Protection Strategies

Simone Gabbanini, Jerome Ngwa Neba, Riccardo Matera, Luca Valgimigli

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Artemisia arborescence; blue color; analysis; UHPLC MS/MS; GC-MS; photodegradation; anti-oxidant; sunscreen

Online: 6 May 2024 (09:45:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1039.v1

Supramolecular Assemblies in Mn(II) and Zn(II) Metal-Organic Compounds Involving Phenanthroline and Benzoate: Experimental and Theoretical Studies

Mridul Boro, Subham Banik, Rosa M. Gomila, Antonio Frontera, Miquel Barceló-Oliver, Manjit K. Bhattacharyya

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: metal-organic compounds; supramolecular dimer; self-association; DFT; QTAIM; MEP

Online: 16 April 2024 (10:54:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1815.v1

Nutraceuticals and Pain Disorders of the Gut Brain Interaction in Infants and Children: A Narrative Review and Practical Insights

Silvia Salvatore, Mariagrazia Carlino, Simona Sestito, Daniela Concolino, Massimo Agosti, Licia Pensabene

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Nutraceutical; Complementary therapies; herbs; fibers; prebiotics; probiotics; abdominal pain; irritable bowel syndrome; infantile colic; FGIDs; FAPs; disorders of the gut-brain interaction

Online: 25 December 2023 (05:27:24 CET)

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Preprint ESSAY | doi:10.20944/preprints202308.1188.v1

Assessing the Current Performance of ChatGPT and the Implications in the Academic and Scientiﬁc Community: Failures, Misuse, and Challenges

Wilian Jesús Pech-Rodríguez, Eddie Nahúm Armendáriz-Mireles, Carlos Adrián Calles-Arriaga, José Amparo Rodríguez-Garcia, Enrique Rocha-Rangel

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: ChatGPT; Artificial intelligence; chatbot; Open AI; Digital engineering.

Online: 16 August 2023 (09:59:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0316.v1

“Superwobbling” and tRNA-34 wobble and tRNA-37 anticodon loop modifications in evolution and devolution of the genetic code

Lei Lei, Zachary Frome Burton

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: elongation factor Tu; evolution of the genetic code; four-way wobbling; genetic code degeneracy; inosine; mitochondria; queuosine; superwobbling; tRNA modification; tRNA wobble U modification

Online: 21 January 2022 (08:53:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0159.v1

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; neuro-immune; inflammation; oxidative and nitrosative stress; depression; mood disorders; schizophrenia; psychiatry

Online: 8 September 2021 (20:03:03 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202104.0351.v1

Effectiveness and Implications of Lecture Based Instruction in Maternal and Childcare to Students Social Competency Skills and Community Awareness

Cherry Rose Malgapo, Nieves Adjarani

Subject: Public Health And Healthcare, Primary Health Care Keywords: lecture based instruction; actual community-based instruction; maternal and child care; social competency skills; community awareness

Online: 13 April 2021 (12:47:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0523.v1

Reliability and Generalizability of Similarity-Based Fusion of MEG and fMRI Data in Human Ventral and Dorsal Visual Streams

Yalda Mohsenzadeh, Caitlin Mullin, Benjamin Lahner, Radoslaw Cichy, Aude Oliva

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: spatiotemporal neural dynamics; vision; dorsal and ventral streams; multivariate pattern analysis; representational similarity analysis; fMRI; MEG

Online: 23 October 2018 (06:41:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0121.v1

Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21^WAF1/CIP1 and p27^KIP1in Cancer Cells

Umamaheswari Natarajan, Thiagarajan Venkatesan, Vijayaraghavan Radhakrishnan, Shila Samuel, Appu Rathinavelu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: SAHA; RG7388; MDM2; p53; p21; cell cycle arrest; cell death

Online: 7 October 2018 (11:33:18 CEST)

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Alterations in gene expressions are often due to epigenetic modifications that can lead to significant influence on cancer development, growth, and progression. The main epigenetic modifications observed in human are methylation and acetylation. In this regard, the HDAC inhibitors (HDACi) such as SAHA (Vorinostat), which can exert epigenetic alterations through impacting the acetylation status of histones, are in clinical trials as a new class of drugs with promising effects on the cancer growth and metastatic process. The small molecule RG7388 is a newly developed inhibitor that is specific for an oncogene-derived protein called MDM2, which is in clinical trials for the treatment of various types of cancers. One of the common characteristics for these two drugs is their ability to induce p21 expression through distinct mechanisms in MCF-7 and LNCaP cells. This difference was expected trigger cell cycle arrest and cell death through intra-cellular mechanisms that are not identical. Hence, the molecular mechanism whereby SAHA can induce cell cycle arrest and trigger necrosis, apoptosis or necroptosis is still evolving. Similarly, the ability of RG7388 for producing anticancer effect is undergoing thorough investigation, since it can produce p53 dependent and p53 independent effects. In this study we performed experiments to measure the cell cycle arrest effects of SAHA and RG7388 on using MCF-7 and LNCaP cells. The cytotoxicity, cell cycle arrest and apoptosis/necroptosis effects of the treatments were assessed by using Trypan Blue Dye Exclusion (TBDE) method, MTT assay, Fluorescence assay with DEVD-amc fluorogenic substrate and Immunoblotting methods. Our results from MCF-7 and LNCaP cells confirmed that SAHA and RG7388 treatments were able to induce cell death via combination of cell cycle arrest and cytotoxic mechanisms. We are speculating that our findings could lead to the development of newer treatments for breast and prostate cancers using this type of combinations.

Preprint ARTICLE | doi:10.20944/preprints201808.0515.v1

Seed Rain and Seedling Establishment of Picea glauca and Abies balsamea after Partial Cutting in Plantations and Natural Stands

Laurent Gagné, Luc Sirois, Luc Lavoie

Subject: Biology And Life Sciences, Forestry Keywords: balsam fir; white spruce; seedlings; partial cut; plantation; naturals stands; light; seed rain

Online: 30 August 2018 (05:36:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201803.0115.v1

Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical Applications

Angela Di Baldassarre, Elisa Cimetta, Sveva Bollini, Giulia Gaggi, Barbara Ghinassi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: regenerative medicine; reprogramming; cardiac differentiation; secretoma; tissue engineering

Online: 15 March 2018 (05:02:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1227.v1

Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ Induced Kindled Epilepsy in rats; In Vivo and In Silico Study

Md. Niyaz Alam*, Lubhan Singh, Najam Ali Khan, Yahya I. Asiri, Mohd. Zaheen Hassan, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Md. Sarfaraj Hussain

Subject: Medicine And Pharmacology, Pharmacy Keywords: Moringa oleifera; curcumin, neuroprotective, pentylenetetrazole, oxidative stress.

Online: 16 June 2023 (11:00:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1123.v1

Efficiency of Nitrogen Fertilization in Millet Irrigated with Brackish Water

Geocleber Gomes De Sousa, Francisco Hermeson Rodrigues Costa, José Thomas Machado de Sousa, Murilo De Sousa Almeida, Silas Primola Gomes, Claudivan Feitosa De Lacerda, Thales Vinícius De Araújo Viana, Samuel de Oliveira Santos, Francisco Barroso da Silva Júnior, Fernando Bezerra Lopes, Silvio Carlos Ribeiro Vieira Lima, Alexsandro Oliveira da Silva

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Nitrogen; Penissetum glaucum L.; Salinity, Plant nutrition; Photosynthesis

Online: 21 March 2024 (04:28:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0740.v1

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets

Niklas Sandler, Farnaz Shokraneh, Mahsa Bahman, Julius Lahtinen, Niko Hassinen, Sari Airaksinen, Soumya Verma, Ludmila Hrizanovska, Jana Lass, Jyrki Heinämäki, Urve Paaver, Anssi Karlstedt, Janika Tähnas, Christoph Klaas, Catharina Kern, Adeline Bienfait, Frédéric Lagarce, Dominic Fenske, Katrin Muehlenfeld, Julia Malik, Holger Scherliess, Samuli Ojala, Sara P Cruz, Mattias Paulsson, Katja Kammonen, Maria Rautamo, Hendrik Lueck, Herwig Heindl, Laurent Carrez, Antoine Pierrot, Ralf Harnish, Stephanie Stareprawo, Marija Tubic-Grozdanii, Stefanie Zibolka, Uli Loesch, Martina Jeske, Ulrich Griesser, Karin Hummer, Andreas Thalmeier, Marianne Leitner, Susan Bischoff, Ralph Heimke-Brinck, Janine Paulus-Rohmer, Karim Khouckh, Fabien Bruno, Anna Harjans, Torsten Hoppe-Tichy

Subject: Medicine And Pharmacology, Pharmacy Keywords: automated compounding; hospital and community pharmcies; pharm inks; integrated quality control

Online: 13 March 2024 (12:02:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1943.v1

Epigenetic Signatures of In Vitro and In Vivo Experimental Models Employed in Non-small Cell Lung Cancer and the Unique miR-148b-3p/PVT1/ZBTB7A Regulatory Network Discriminating Large Cell Lung Carcinoma

Magda Spella, Eleftherios Bochalis, Katerina Athanasopoulou, Argyri Chroni, Irene Dereki, Giannoula Ntaliarda, Ifigeneia Makariti, Georgios Psarias, Caterina Constantinou, Vasiliki Chondrou, Argyro Sgourou

Subject: Biology And Life Sciences, Life Sciences Keywords: Non-small cell lung cancer; epigenetic deregulation; micro-RNAs; long non-coding RNAs; epigenetically motivated transcription factors; epigenetic networks

Online: 30 October 2023 (14:00:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1170.v1

Relationship of Mediterranean Diet with Metabolic Syndrome and Its Components in Caucasian Subjects: A Cross-Sectional trial

Leticia Gómez-Sánchez, Marta Gómez-Sánchez, Olaya Tamayo-Morales, Cristina Lugones-Sanchez, Susana González-Sánchez, Ruth Martí-Lluch, Emiliano Rodriguez-Sanchez, Luis Garcia-Ortiz, Manuel Angel Gomez-Marcos

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Mediterranean diet; metabolic syndrome; Caucasian subjects; A cross-sectional trial

Online: 17 May 2024 (15:31:33 CEST)

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The primary aim of this study is to investigate the relationship of the Mediterranean diet (MD) with metabolic syndrome (MetS) and its components in Caucasian subjects between 35 and 74 years. The secondary aim is to analyze sex differences. Methods: A cross‑sectional trial. This study utilized data from the EVA, MARK, and EVIDENT studies, a total of 3417 subjects with a mean age of 60.14±9.14 years (57% men). MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured. Adherence to the MD was assessed with the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire used in the PREDIMED study. Good adherence was considered when the MD value was higher than the median value. Results: The mean value of the MEDAS questionnaire was 5.83±2.04; (Men 5.66±2.06 and women 6.04±1.99; p<0.001). Adherence to the MD was observed by 38.6% (34.3% men and 40.3% women; p<0.001). MetS was observed in 41.6% (39.0% men and 45.2%women p<0.001). In the multiple regression analysis after adjusting for possible confounders, the mean MD value showed a negative association with the number of MetS components per subject (β=-0.336), and with the different components of MetS: Systolic blood pressure (β=-0.011), Diastolic blood pressure (β=-0.029), glycemia (β=-0.009), Triglycerides (β=-0.004), Waist circumference (β=-0.026), except with the HDL-cholesterol value which showed a positive association (β=0.021); (p<0.001 in all cases). The adjusted logistic regression models showed that an increase in MDA decreases the probability of MetS (OR =0.56) and its components: blood pressure ≥130/85 mmHg (OR = 0.63), fasting plasma glucose ≥100 mg/dL (OR = 0.62); triglycerides ≥150 mg/dL (OR = 0.65); waist circumference ≥88 cm in women and ≥102 cm in men (OR = 0.74), and increases high-density lipoprotein cholesterol <40 mg/dL in men or <50 mg/dL in women (OR = 1.70); (p<0.001 in all cases). The results by sex were similar, both in multiple regression and logistic regression. Conclusion: The results of this study suggest that a greater adherence to the Mediterranean diet decreases the probability of presenting Mets globally and by sex.

Preprint ARTICLE | doi:10.20944/preprints202403.0643.v1

Phytophthora Communities Associated with Agathis australis (kauri) in Te Wao Nui o Tiriwa/Waitākere Ranges, New Zealand

Shannon Hunter, Ian Horner, Jack Hosking, Ellena Carroll, Jayne Newland, Matthew Arnet, Nick Waipara, Bruce Burns, Peter Scott, Nari Williams

Subject: Biology And Life Sciences, Other Keywords: Phytophthora; Agathis australis; kauri dieback; community structure; soil baiting; metabarcoding; New Zealand; epidemiology; invasive pathogen; forest management

Online: 11 March 2024 (18:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0063.v1

The Effect of Hydrogen Peroxide on Reducing the Colonization of Legionella spp. in a Hospital Water Network

Beatrice Casini, Francesco Aquino, Michele Totaro, Mario Miccoli, Irio Galli, Laura Manfredini, Valentino Serini, Anna Laura Costa, Benedetta Tuvo, Paola Valentini, Gaetano Privitera, Angelo Baggiani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hydrogen Peroxide; Legionella; Hospital; Disinfection

Online: 16 February 2017 (18:48:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0261.v1

Demographic Characteristics and Survival in Young Onset Colorectal Neuroendocrine Neoplasms

Deepak Vadehra, Sahithi Sonti, Beas Siromoni, Mrinalini Ramesh, Debduti Mukhopadhyay, Adrienne Groman, Kristopher Attwood, Renuka Iyer, Sarbajit Mukherjee

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: young-onset neuroendocrine neoplasms; young-onset adenocarcinoma; young-onset colorectal cancer (YOCRC)

Online: 5 September 2024 (06:04:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0292.v1

Reflectivity Thresholds and Optical Loss Predictions in Resonant Photonic Cavities

*Paulo Henrique Dias Ferreira, Douglas Ramos do Amaral, Vinicius Tribuzi, John Fredy Ricardo Marroquin, Jorlandio Francisco Felix, Filippo Ghiglieno

Subject: Physical Sciences, Optics And Photonics Keywords: Optical loss measurement; Fabry-Pé; rot interferometer; Waveguide reflectivity; Scattering losses; Photonic device optimization

Online: 4 September 2024 (08:12:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1796.v1

Resource Use Efficiency and Productivity of Potato Production in Kailali

Megh Raj Upadhyay

Subject: Business, Economics And Management, Economics Keywords: agriculture; farmers; resource use efficiency; productivity; returns to scale; potato

Online: 26 August 2024 (16:27:49 CEST)

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Agriculture is the largest sector of Nepalese economy among the south-Asian developing countries that contributed 26.98 % share of Gross Domestic Product (GDP) in the year 2018/19. The capacity to derive maximum output by per unit of resource is resource use efficiency. Resource use efficiency of a producer explains the comparison between inputs and output value. Potato is staple vegetable in every parts of Nepal. Cobb-Douglas production function is used to predict the significance of inputs in income from cash crops. Due to lack of optimum utilization of available resources in cultivation of vegetable like lack of technical knowledge, low education level, and extensive service the productivity and production is low in Nepalese economy. It ensures vegetable security in Nepal. Though, there are extensive researches on the resource use efficiency and productivity issues on agriculture, very few papers explored in the case of Sudurpaschim province of Nepal OBJECTIVE: This study had the specific purposes: (1) To identify the factors affecting in resource use efficiency and productivity of potato production (2) to utilize the resource use efficiency and productivity in potato production and (3) to show the type of returns to scale in potato production. METHODS: Applying post-positivist paradigm and quantitative causal survey research design, it explored the resource use efficiency and productivity through the semi-structured questionnaire from 140 households by random sampling. Data analysis was carried out by multiple regression model using Cobb-Douglas production function. SPSS software was used to find quantitative results. From the analysis of data using mean, and SD, t-test, analysis of variance, Durbin-Waston test, Marginal Value Product and marginal Factor cost, findings of this research was emerged. RESULTS AND DISCUSSION: The major findings: education level, extension service, farm size and pesticide cost were significant variables in potato production; seed, hired labor, Family Yard Manure and pesticide cost were overused and needed to decrease their cost for optimum allocation and there was decreasing returns to scale in production. This study emphasized on increasing education level, extensive service and farm size for optimum utilization of resources and increasing returns to scale. SIGNIFICANCE: Barriers to Indian potatoes and increasing returns to scale are only possible through protection policy of government. For optimum use of resources and increasing returns to scale, government can introduce capital intensive technique. This study can be implied in policy making and improving existing situation of agriculture, and allocating budget.

Preprint ARTICLE | doi:10.20944/preprints202408.0788.v1

Physical Vulnerability and Landslide Risk Assessment in Tegucigalpa City, Honduras

Ginés Suárez, María José Domínguez-Cuesta

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Numerical methods and its applications; reliability and risk analysis; landslide susceptibility modeling and mapping

Online: 12 August 2024 (12:30:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0687.v1

Physiopathological Roles of White Adiposity and Gut Functions in Neuroinflammation

Eduardo Spinedi, Guillermo Horacio Docena

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Neuroinflammation; Hypertrophic White Adiposity; T2DM; Neurodegenerative Diseases; Central & Autonomic Nervous Systems; Immune System; , Gut-Brain Axis; Microbiota

Online: 9 August 2024 (17:03:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2158.v2

Potential Innovations in Modern‐Day Human and Animal Vaccine Development

Theodor-Nicolae Carp

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immune system; natural immunity; adaptive immunity; interferon system; plasmacytoid dendritic cells; lymphocytes; viruses; bacteria; fungi; DNA; RNA; evolution; molecular self camouflaging; innovation; vaccines

Online: 2 August 2024 (11:36:10 CEST)

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The vaccine industry has undoubtedly contributed massively in the medical world, with hundreds of millions of lives saved as a result of the successful development of prophylactic and therapeutic vaccines against various infectious and oncological diseases. Simultaneously, there has been an ongoing evolutionary battle between polymorphic microbes and the human immune system, and various microbes have developed counter-responses against the human host immune system, by creating diverse “holes” of vulnerability in the innate immune system. Such mechanisms may have resulted due to the lower prophylactic and therapeutic focus upon sharpening the innate immune lines as directly as necessary. The overall objective of vaccine-development should be the sharpening of all immune departments that are targeted by various microbial agents for the purpose of transient innate immune suppression and the distribution of the microbial count/load at a systemic level. Likewise, it could be viable for the clinical research community to start focusing upon filling in the “gaps” of vulnerability that are now present in the pathways responsible for the proper natural immune activation and proportionate signalling toward the adaptive immune system. Perhaps, through such a process, the “road” toward the adaptive immune system, which is “old” and filled with “holes”, could be gradually transformed into a perfectly uniform “highway”, with all the required signals transmitted robustly from the innate to the adaptive immune system, before microbes manage to translate the various pathogenic proteins that transiently prevent such transmission altogether, until it becomes too late for the immune response to possibly develop in a proportionate and non-harmful manner to the organism. Such a scenario would be possible, given that it is almost impossible for human evolutionary growth to eventually stall and not risk experiencing a decrease as a result. Simultaneously, it is important for human society to bind by the principles of maintaining a healthy and nature-friendly lifestyle, given the philosophical quote of “We are what we eat.” The overall objective should be the facilitation of human and animal immune evolution over viral and bacterial molecular self-camouflaging from all possible directions, as a sharper human and animal evolutionary growth resulting from such actions could “cost” the sharper evolutionary growth of microbes as such, given that evolutionary patterns are based upon the models observed in Physics, in Newton’s Third Law of Motion, as well as in the First Law of Thermodynamics, which concerns the Conservation of Energy.

Preprint ARTICLE | doi:10.20944/preprints202408.0023.v1

AI-Driven Personalization in Digital Marketing: Effectiveness and Ethical Considerations

Chris Bell, Ayoolu Olukemi, Peter Broklyn

Subject: Business, Economics And Management, Marketing Keywords: AI-driven personalization; digital marketing; effectiveness and ethical considerations

Online: 1 August 2024 (13:18:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2001.v1

Amphiphilic Fluorescein Triazoles: Synthesis and Visible Light Catalysis in Water

Alina Artemenko, Elza Sultanova, Diana Mironova, Aliya E. Akhatova, Ekaterina Bondareva, Daut R. Islamov, Konstantin Usachev, Svetlana E. Solovieva, Vladimir Burilov, Igor S. Antipin

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: CuAAC; photocatalysis; fluorescein derivatives; aggregation

Online: 25 July 2024 (09:25:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1687.v1

The Prognostic and Predictive Utility of CDX2 in Colorectal Cancer

Wei Yen Chan, Wei Chua, Kate Wilkinson, Chandika Epitakaduwa, Hiren Mandaliya, Joseph Descallar, Tara L Roberts, Therese M Becker, Weng Ng, Cheok Soon Lee, Stephanie Hui Lim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: colorectal cancer; caudal type homeobox transcription factor 2; biomarkers; prognostic; predictive; chemotherapy

Online: 22 July 2024 (07:53:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1574.v1

Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry

Giorgia Andreozzi, Angela Corvino, Beatrice Severino, Elisa Magli, Elisa Perissutti, Francesco Frecentese, Vincenzo Santagada, Giuseppe Caliendo, Ferdinando Fiorino

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Arylpiperazine; cancer; small molecules; anti-proliferative agents

Online: 19 July 2024 (10:53:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1360.v1

International Cooperation and Indonesia's Food Diplomacy in Facing Global Challenges

Septinus Saa

Subject: Social Sciences, Psychiatry And Mental Health Keywords: food security; international cooperation; food diplomacy

Online: 17 July 2024 (10:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0713.v1

Genomic Selection for Growth and Wood Traits in Castanopsis hystrix

Weihua Zhang, Ruiyan Wei, Yuanzhen Lin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Castanopsis hystrix; genomic selection; growth trait; wood trait; early selection; SNP

Online: 9 July 2024 (08:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0615.v1

Implementing Ethical Procurement Standards: Experiences and Challenges in Different Sectors

Mason Cooper

Subject: Business, Economics And Management, Business And Management Keywords: Ethical procurement; sustainability; supply chain management; corporate social responsibility; stakeholder engagement; regulatory compliance; supplier relationship management

Online: 8 July 2024 (11:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0573.v1

Challenges and Successes in Supplier Development: Experiences from Procurement Managers

Mason Cooper

Subject: Business, Economics And Management, Business And Management Keywords: supplier development; procurement management; communication; trust; performance measurement; innovation; risk management; compliance

Online: 8 July 2024 (08:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0523.v1

Exploring Supplier Relationships and Inventory Optimization in High-Technology Industries

Samuel Holloway

Subject: Business, Economics And Management, Business And Management Keywords: Supplier Relationships, Inventory Optimization, High-Technology Industries, Digital Transformation, Supply Chain Management, Technological Integration, Risk Management

Online: 5 July 2024 (11:56:55 CEST)

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This study explores the intricacies of supplier relationships and inventory optimization within high-technology industries, offering a comprehensive analysis of the strategic imperatives and operational challenges faced by firms in these sectors. By adopting a qualitative research methodology involving semi-structured interviews with supply chain professionals and documentary analysis, the study provides in-depth insights into the evolving dynamics of supply chain management. Findings reveal a marked shift towards collaborative and strategic supplier relationships, characterized by trust, transparency, and joint innovation initiatives. These partnerships are essential for enhancing operational efficiency, driving product development, and navigating market uncertainties. Additionally, the research underscores the critical role of advanced technologies, such as artificial intelligence and the Internet of Things, in optimizing inventory levels and improving supply chain visibility. The integration of these technologies facilitates precise demand forecasting and proactive inventory management, thereby reducing costs and enhancing service levels. However, the study also highlights significant challenges, including geopolitical uncertainties, supply chain disruptions, and cultural barriers, which necessitate robust risk management strategies and adaptive supply chain practices. Strategic implications for organizational leaders and policymakers include the need to invest in supplier development, embrace digital transformation, and enhance risk management frameworks to build resilient and agile supply chains. This study contributes valuable insights into the complex interplay between supplier relationships, inventory optimization, and technological integration in high-technology industries, offering actionable recommendations for practitioners and researchers seeking to drive innovation and maintain competitiveness in a dynamic global marketplace.

Preprint REVIEW | doi:10.20944/preprints202407.0239.v1

Simulating NVH Advances in Electric Vehicle Powertrains: Strategies and Challenges

Krisztián Horváth

Subject: Engineering, Automotive Engineering Keywords: EV powertrain; NVH; noise; acoustic simulation; noise reduction

Online: 3 July 2024 (04:22:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0121.v1

The Role of Interoceptive Sensitivity and Hypnotizability in Motor Imagery

Eleonora Malloggi, Zan Zelic, Enrica Laura Santarcangelo

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: hypnotizability; motor imagery; interoception; EEG power spectral density

Online: 2 July 2024 (13:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0508.v2

HCI and Data: Interacting in a New Era of Virtualization

Iván Durango, José A. Gallud, Victor M. R. Penichet

Subject: Computer Science And Mathematics, Information Systems Keywords: Human-Data Interaction; Human-Computer Interaction; Big Data; Data virtualization; Data Accessibility; Data Management; Data Privacy; Data Ethics; Data-Driven Decision-Making

Online: 1 July 2024 (08:12:01 CEST)

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The rapid technological progress has ushered in a new era of human-computer interaction, where the distinction between the physical and virtual realms is becoming increasingly blurred. This research paper explores the profound and multifaceted intersection of Human-Data Interaction (HDI) and Data Virtualization (DV), examining how emerging technologies can significantly enhance the exploration, comprehension, and utilization of complex, multidimensional data sets. Informed by the insights gleaned from prior research in this domain , the present study delves into the potential of DV techniques to improve HDI, with a particular focus on three experimental investigations conducted within the realms of education, healthcare, and retail. The findings reveal the benefits and potential challenges associated with the implementation of DV in these diverse contexts, offering valuable guidance for the design and development of future HDI systems. Drawing upon a diverse array of authoritative sources, this paper presents a holistic, forward-looking perspective on the future of HDI, underscoring the critical role that DV will play in shaping the next generation of human-computer interfaces and facilitating a deeper, more intuitive understanding of the digital world. Furthermore, the paper presents a preliminary framework for integrating HDI principles into standard design practices. This framework outlines key considerations and guidelines to help designers and developers incorporate HDI techniques more effectively into the development of data-driven applications and interfaces.The proposed framework outlines key considerations for enhancing data accessibility and comprehension, empowering users to exercise greater control over their data, and cultivating transparent dialogues between data providers and end-users. By establishing this conceptual foundation, the paper aims to facilitate the seamless integration of HDI principles into standard design practices, ultimately leading to more intuitive, user-centric, and ethically-grounded approaches to data interaction and utilization.

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