A E. Crassipes is considered a problem in different aquatic ecosystems, due to its abundance could become a solution to design and build economic and efficient treatment plants, and especially for the production of biofuels such as bioethanol. The objective of this research is to design and implement a sustainable development process between phytoremediation and bioethanol production with E. crassipes, evaluating the incidence of chromium adhered to the biomass of this plant in the production of bioethanol. Materials and methods: A system was installed to evaluate the phytoremediation with E crassipes with water loaded with chromium, determining the effectiveness of this plant to remove this heavy metal even if it is alive in a body of water. After this process, we proceeded to bring the biomass loaded with chromium to bioreactors to evaluate the production of bioethanol, assessing three types of biomass, one without chromium adhered and the other two with chromium adhered to its plant structure. There was an impact of the ethanol production of the E crassipes due to the presence of chromium, but this production can be taken into account for the assembly of an integral system of phytoremediation and bioethanol production, making the most of this biomass.

The Digital Bangladesh initiative is a comprehensive strategy aimed at transforming Bangladesh into a digitally advanced, economically competitive, and socially inclusive nation. This term paper explores the multifaceted causes and effects of the initiative, including the roles of government policies, economic imperatives, social factors, and technological advancements. The initiative leverages emerging technologies such as artificial intelligence, blockchain, and the Internet of Things to drive innovation, improve public service delivery, and enhance quality of life. Economic growth, improved governance, enhanced social inclusion, and environmental sustainability are key outcomes of this digital transformation. However, challenges such as cybersecurity threats, the digital divide, and infrastructural constraints must be addressed to sustain progress. Looking forward, the future prospects of the Digital Bangladesh initiative are promising, with potential for significant advancements in various sectors. By prioritizing strategic policymaking, fostering public-private partnerships, and ensuring sustainability and resilience, Bangladesh can realize its vision of becoming a Digital, prosperous, and inclusive nation.

In the present work we study the properties of geodesic sub-$ (\alpha,b,s) $-preinvex functions on Hadamard manifolds and establish some basic properties in both general and differential cases. Further, we study sufficient conditions of optimality and proved some new inequalities under geodesic sub-($ \alpha,b,s $)-preinvexity.

This exploratory study investigates the role of wearable technologies in fostering emotional connections between human brands and customers. Given the rapid growth of the wearable technology market and the increasing importance of emotional connections in marketing, this research aims to uncover the potential of these technologies in strengthening the affective bond between brands and consumers. The mixed-method approach included semi-structured in-depth interviews with 25 marketing experts and an online survey of 300 consumers. Data analysis was conducted using thematic coding and statistical tests including Pearson correlation and multiple regression. Results indicated that wearable technologies can enhance emotional connections through personalized interactions (r=0.72, p<0.001), creating a sense of proximity (β=0.65, p<0.01), and facilitating two-way communications (β=0.58, p<0.01). These findings offer new perspectives for marketing strategies and customer relationship management in the digital age, highlighting the potential of wearable technologies as a powerful tool for building and maintaining emotional bonds between human brands and their audiences. The study contributes to the growing body of literature on technology-mediated brand relationships and provides practical implications for marketers seeking to leverage wearable technologies in their brand communication strategies.

The intention to repurchase is a key component in relationship marketing. However, minimal attention has been paid to how customers’ habitual behavior moderates the relationship between customers’ evaluation of benefits received from a service provider and the intention to revisit, specifically in a personal service business where customer-service provider interactions likely constitute the core of a sustainable relationship. To address this gap, the current study proposes and tests a comprehensive model to advance the theory of relationship marketing (RM) and additionally contributes to social exchange theory (SET) as well as the theory of repurchase decision-making (TRD) in the business service context. Structural equation modeling (SEM) was employed to examine the relationships of the research model. Based on data collected from 482 customers on their perceptions of hairstylists, the empirical findings revealed that relational benefits significantly affect post-experience behavior-satisfaction, trust and relationship commitment, and subsequently boost the intention to revisit. Furthermore, habit as an unconscious factor moderates the paths between revisit intention and its determinants. Although several limitations exist, the findings practically and theoretically make a contribution to the literature on relationship marketing.

This paper explores the relationships between marketing strategies, social media platforms, the adoption and diffusion of products and services, and organizational resilience to gain an understanding of the ability of organizations to cope with disruptive events (e.g., COVID-19). This can be achieved through effective marketing strategies and the efficient use of social media platforms. In fact, resilience thinking can help organizations maintain their operations by increasing the adoption and diffusion of their products and services through the use of effective marketing strategies. To achieve this article’s objectives, a literature review is conducted to help develop a conceptual framework that highlights a clear relationship between the previously discussed concepts. In addition, the novel nature of the relationship between marketing strategies and organizational resilience is dissected and its significance for organizations is demonstrated. In fact, the findings of this study suggest that effective marketing strategies that consider the "what," "who," and "how" dichotomies and the efficient use of social media to promote the adoption and diffusion of products and services can significantly enhance the resilience of organizations. These relationships can serve as a starting point for further studies examining and empirically analyzing marketing strategies and their positive effect on strengthening organizational resilience.

Development of Halal Tourism in Indonesia is the focus of the Indonesian government and MSMEs have an important role in supporting the development of halal tourism in Indonesia. This study aims to examine the relationship between marketing communication and Islamic financial literacy on Islamic financial inclusion and MSMEs performance in the halal tourism sector. A covariance-based SEM technique utilizing LISREL software was used to analyze the data from this investigation. Non-probability sampling was employed to collect the data, and the sample consists of 152 halal tourism entrepreneurs. We find that positive and significant association between Islamic financial inclusion and business performance. We also find that there are a positive and significant association between Islamic Financial Literacy and Islamic Financial Inclusion. Marketing communication and Islamic financial inlcuon a positive relationship but insignificant. This studi implies that to establish a halal tourist ecosystem for long-term development in Indonesia, commercial actors must lend their full support. This study demonstrates that they can thrive when MSMEs in the halal tourist ecosystem are backed by Islamic banking and Islamic rural banks. As a result, a more accommodating approach from Islamic banking is required to provide access to halal finance for business actors in Indonesia’s halal tourism ecosystem.

The public interest towards renewable and clean energy is an important part of shaping consumer behavior and policy towards these topics. A “big data” approach towards assessing the public interest for various topics consists in using freely available search frequency data for the Google search engine, through the Google Trends service. The search data frequency can be used to assess public opinion for a variety of topics, such as medicine, climate change and environmental concerns, finance, and economics etc. A study of the public interest towards wind energy topics is reported here. Six Google search keywords (“Wind power”, “Wind energy”, “Offshore wind”, “Wind farm”, “Wind turbine” and “Wind generator”) were investigated in the 2004–2020-time range. All keywords except “Offshore wind” show a steady decrease from a 2008 – 2010 maximum up to 2015, followed by a period limited change in the 2015 – 2020 range. The interest towards offshore wind topics follows a similar trend but increases in frequency starting from 2015 and reaches a maximum in 2018. Overall, the Google Trends data show a decrease of public interests towards most wind energy topics, with the exception of “Offshore wind”, for English speaking users, in the 2004–2020-time range.

Nowadays, customers play a very important and vital role in the field of global economy. As a result, companies give special significance to the customers to survive and grow in the field of economic competition in the modern world and increase their relationship with the buyers of their products and services throughout their lifetime. Marketing growth through mobile phones has provided further motives for performing more researches in the field of customer behavior and attitude in mobile marketing. The goal of the current study is to analyze the effective factors on customer behavior in mobile marketing. The variables used in this study are perceived ease of use, individual knowledge, user’s mobile phone technology, customers’ negative attitudes, and customers’ positive attitudes. The current research is practical in terms of objective and is descriptive-analytic in terms of methodology. Data were gathered by distributing a questionnaire among 284 students of Tehran University. Data were analyzed by structural equation modeling using Lisrel and Expert Choice software. Test results showed that ease of use, individual knowledge, mobile phone technology, positive attitude, and negative attitude variables have a meaningful effect on customer behavior in mobile marketing. The confirmation of all the assumptions of the research supports the importance of the customer behavior analysis in mobile phone services.

Can the smart city provide a new perspective for public and academic libraries? How does the smart city impact the libraries as cultural and scientific assets? And how can libraries contribute to the development of the smart city? An overview of recent library models, like the learning center or the green library, reveals affinities with the concept of the smart city, especially regarding the central role of information and the integration of technology, people and institution. From this observation, the paper develops the outline of a new concept of the smart library which can be described on four dimensions, i.e. smart services, smart people, smart place and smart governance. However, the smart library concept does not constitute a unique model or project but a process, a way how to get things done, less linear, less structured, more creative and innovative. Also, smartness may not be a solution for all library problems.

This article is an effort to scrutinize the role of Information Technology development in the chronological transformation of Urban Planning domain using the exploratory research approach. In this research, it is argued that the theoretical and practical understanding of Urban Planning should absorb and integrate the bright outcome of the rise of Information and Technology to foster congruent future urban development. The article addresses the trends of transformation in the urban planning domain through the myopic lens of the expansion of information and communications technology era followed by investigating the key drivers shaping the interaction between modern-day urban planning and information technology considering both the dark and bright sides into account.

Taiwan's bed and breakfast (B&B) development has been more than 25 years ago, from the first generation of retirement to the B&B industry, serving tourists from all over the world accom-modation, providing breakfast and accommodation mode to the present, after the change of employees from the second generation, more and more attention is paid to the cultivation and cultivation of business ability. With the advent of the era of AI technology networking, the ca-pabilities required for B&B operation are more focused on all aspects of service, and the good marketing ability of B&B can promote a green chimney-free tourism economy, which is also a favorite industry of various governments and the public. This study explores the basic vocational competency indicators required for running a B&B, with (1)EQ emotion management skills, (2)Financial management ability, (3)(SK) technical skills, and (4)Marketing and promotion management capabilities. Through the study method, the K-S Z test was determined by the con-sensus conclusion of expert reliability and validity p value

This study explores consumer perceptions of virtual reality (VR) in marketing, aiming to understand how immersive technology impacts engagement and brand perception. As VR continues to evolve and integrate into various marketing strategies, it becomes crucial to examine its effectiveness and the factors influencing consumer attitudes. Through a detailed thematic analysis, this research identifies key themes such as familiarity with VR technology, immersion and engagement, technical quality, accessibility, personalization, storytelling, social interaction, purchase intentions, and brand perception. The findings reveal that familiarity with VR enhances enthusiasm and comfort, leading to more positive attitudes towards VR marketing. The immersive and multi-sensory nature of VR provides a significant advantage over traditional advertising methods, fostering stronger emotional connections and increasing memorability. However, the quality of the VR experience is critical; high-quality graphics and seamless interactions are essential for maintaining positive consumer perceptions. Technical issues, such as lag and motion sickness, can negatively impact the experience, especially for those less acquainted with VR technology. Accessibility remains a challenge, with limited access to VR headsets restricting the reach of VR marketing campaigns. Personalization of VR content is highly valued, though it must be balanced with ethical considerations related to data privacy. The power of storytelling in VR enhances engagement by allowing consumers to actively participate in narratives. Social interaction within VR experiences adds an extra layer of enjoyment. The study also highlights the practical applications of VR marketing in high-involvement sectors and underscores the need for continuous innovation and consumer feedback to maximize the technology's impact. Overall, VR holds significant potential to transform marketing practices by offering immersive, engaging, and memorable experiences that deepen consumer connections and drive positive outcomes.

Consumer trust in supply chain certifications plays a pivotal role in shaping contemporary consumer behavior and marketing effectiveness. This qualitative research investigates consumer perceptions of supply chain certifications and their impact on purchasing decisions and brand loyalty. Through semi-structured interviews and focus group discussions with 30 participants, the study explores themes such as credibility, transparency, perceived value, and the influence of certifications on consumer trust. Findings reveal that consumers value certifications that signal ethical sourcing practices and sustainability commitments, viewing them as assurances of product quality and social responsibility. Credibility and transparency in certification processes emerged as critical factors influencing consumer trust, while perceived benefits such as environmental sustainability and fair labor practices positively influenced purchase intentions. Moreover, certifications were found to enhance brand loyalty by aligning with consumers' ethical values and beliefs. However, the study identifies challenges including high certification costs, complexity in compliance, and consumer skepticism, which hinder broader adoption and effectiveness of certifications. The implications of these findings suggest that businesses can enhance consumer trust and market competitiveness by investing in rigorous certification standards, clear communication strategies, and sustainable practices. Addressing barriers through improved transparency and consumer education is crucial for maximizing the impact of certifications on ethical consumption. Future research directions include longitudinal studies on certification impacts and comparative analyses across industries and global markets to further enrich understanding of consumer behavior and certification influences.

The marketing industry is rapidly evolving, necessitating educational programs to adapt and equip graduates with relevant skills and knowledge. This systematic literature review with bibliometric analysis (SLRBA) explores the integration of Problem-Based Learning (PBL) in marketing education. PBL is an instructional strategy that empowers students to solve real-life problems by integrating theory and practice, thus fostering critical thinking and decision-making skills. Our review synthesizes data from 71 sources, highlighting the definition of PBL, strategies to promote its implementation in marketing education, and the benefits and challenges associated with this approach. The findings indicate that PBL enhances student engagement, provides hands-on experience, and prepares students for real-world marketing challenges. Strategies such as using social media, serious games, e-learning, and feedback mechanisms are discussed for their effectiveness in promoting active learning and student participation. Despite its advantages, PBL faces challenges such as resource intensiveness, student resistance, and information integrity issues. This review underscores the importance of PBL in bridging the gap between theoretical knowledge and practical application, ultimately preparing marketing students to meet the demands of the industry. The paper concludes with recommendations for future research and best practices for implementing PBL in marketing education.

Effective communication in English is crucial for marketing professionals in the highly competitive global business landscape. This article emphasizes the importance of English language proficiency and the need for a tailored needs analysis for marketing professionals in the field of Business English. The comprehensive exploration of the needs analysis process outlines its methods and steps, highlighting its relevance in designing targeted language programs. By utilizing surveys, interviews, and observations, trainers and language instructors gain valuable insights into the specific challenges faced by marketing professionals, enabling them to develop customized skill-building approaches. The article also underscores the pedagogical implications of the needs analysis, stressing the significance of a personalized training program that addresses identified language gaps. Recognizing the collaborative nature of the process, the article concludes by discussing the implementation of the training program and the importance of tracking progress, ultimately displaying the tangible benefits of conducting a needs analysis in Business English for marketing professionals in terms of enhancing competitiveness and driving business growth.

(1) Background: The purpose of this study was to investigate the relationship between IMO and burnout while assessing the contribution of job demands and resources on increasing internal orientation and worker well-being and, consequently, the levels of perceived performance; (2) Methods: Data were collected between April and December 2021 by completing an online questionnaire, developed in the Google Forms platform. The following descriptive statistics were analyzed: measures of central tendency (mean), dispersion (standard deviation), minimum value and maximum value. Next, Pearson's correlation coefficient was calculated to analyze the relationship between the variables under study.; (3) Results: The results showed the mediating effect of IMO between performance feedback and perceived performance, while burnout mediates the relationship between emotional and technology demands and perceived performance. (4) Conclusions: These conclusions demonstrate that constructive feedback might help a more efficient performance through better internal communication and the positive effects of technology demands could be the result of the interaction between personal and organizational resources.

Purpose –The basic purpose of this paper is to find out the librarians perceptions, skills, most effective and constrains to use social media for the marketing purposes in the University libraries and to examine how these libraries perceive the importance of social media marketing. Design/methodology/approach –A nation-wide online survey on University libraries in the Pakistan was conducted to flourish this study, and a total number of 161 responses were used to analyze collected data. Findings –This study revealed the application of social media in university Libraries is very high .The results also disclosed that University libraries observe social media as a substantial tool to increase marketing of library sources and services anticipate to increase their use. Practical implications –The findings of this study can help as a parameter for University libraries when engaging social media for marketing purposes in their libraries. Originality/value –This study calculated the present situation of social media use for marketing in the University Libraries environment, a background that has been under-study in the literature, from these perspectives: perceptions, Skills, effectiveness, practices and constrains

Background: As the only place in a store where all customers must pass through and wait, the checkout lane may be particularly influential over consumer purchases. Because most foods and beverages sold at checkout are unhealthy (e.g., candy/sweets, sugar-sweetened beverages, and salty snacks), policymakers and advocates have expressed growing interest in healthy checkout policies. To understand the extent to which such policies could improve nutrition equity, we as-sessed the prevalence and sociodemographic correlates of purchasing items from checkout. Methods: We assessed self-reported checkout purchasing and sociodemographic characteristics in a national convenience sample of adults (n=10,348) completing an online survey in 2021. Re-sults: Over one-third (36%) of participants reported purchasing foods or drinks from checkout during their last grocery shopping trip. Purchasing items from checkout was more common among men; adults <55 years of age; low-income consumers; Hispanic, non-Hispanic American Indian and Alaska Native, and non-Hispanic Black consumers; those with at least a bachelor’s degree; parents; and consumers diagnosed with type 2 diabetes or pre-diabetes (p-values<0.05). Conclusions: Purchasing foods or beverages from store checkouts is common and more prevalent among low-income and racial and ethnic minority groups. These results suggest that healthy checkout policies have the potential to improve nutrition equity.

Given the high levels of overall volume of alcohol use, detrimental drinking patterns, and high levels of alcohol-attributable mortality and burden of disease, Lithuania implemented a series of alcohol control policies within a relatively short period of time (2008 to 2019). Based on their expected impact on alcohol consumption and alcohol-attributable harm, as well as their target population, the respective policies were classified using a set of objective criteria and expert opin-ion. The classification criteria included: positive vs. negative outcomes, mainly immediate versus delayed outcomes, and general population versus specific group outcomes. The judgement of the alcohol policy experts converged on the objective criteria, and, as a result, two tiers of inter-vention were identified: Tier 1 – general population interventions with an anticipated immediate impact; Tier 2 – other interventions aimed at the general population. In addition, interventions for specific populations were identified. This adaptable methodological approach to alcohol control policy classification is intended to provide guidance and support the evaluation of alcohol policies elsewhere, lay the foundation for the critical assessment of the respective policies to im-prove health and increase life expectancy, and to reduce crime and violence.

Development of both marketing and culture sector has a multi-directional nature showing relationships with the concept of sustainable development that should be considered on various levels of management of cultural sector, i.e. on the level of cultural policy of the state or region, and on micro-scale – in cultural institutions. This is because not only natural environment, economy and technology, but also society and culture constitute the area of sustainable development. Considering the assumptions of sustainable development by cultural institutions is related to implementing in this sphere the marketing concepts that are the expression of adoption of market orientation (on culture participant). The objective of the paper is to show the role of marketing in cultural institutions in the context of assumptions of sustainable development concept. The paper is based on literature studies and results of empirical research of quantitative character, which was conducted on a sample of 451 people managing cultural institutions in Poland. The research included general managers, managers and artistic directors, managers of marketing, promotion and sales departments, as well as owners of cultural institutions. Analysis of research results shows that culture participant has the highest position among groups of consumers of actions conducted by cultural institutions and development of offer diversity, comprised in the concept of sustainable development, emerges as factor stimulating development of culture market that is closely related to growth of the quality of cultural institution offer.

Feline infectious peritonitis (FIP) is a severe and invariably fatal disease affecting both domestic and wild felines with limited effective therapeutic options available. By considering the significant immunomodulatory effects of vitamin E observed in both animal and human models under physiological and pathological conditions, we have provided a full in-silico investigation of vitamin E and related compounds and their effect on the crystal structure of feline infectious peritonitis virus 3C-like protease (FIPV-3CLpro). This work revealed the β-tocotrienol and δ-tocotrienol analogues as inhibitor candidates for this protein, suggesting their potential as possible drug compounds against FIP or their supplementary use with current medicines against this disease.

In the age of digital revolution technology is being used more and more in education around the world to improve student learning. By enabling ongoing skill development and knowledge acquisition through digital platforms e-learning has become a crucial tool. Through E-Learning online learning is becoming increasingly popular and effective in addition to traditional methods of instruction as highlighted by the latest statistics from Badan Pusat Statistik Indonesia (BPS). In order to address the issues of scalability, interactivity and security in e-learning platforms. This study introduces a web-based learning environment that is focused on teaching programming. Leveraging the MERN stack, while also integrating TypeScript for improved code reliability, Next.js for accelerated React.js functionality, Tailwind CSS for responsive design. Backend features include media management with Cloudinary, secure video streaming with VdoCipher, data storage with MongoDB, and caching with Redis. Iterative development will be following agile methodology. In order to create a vibrant and encouraging learning environment the platform includes interactive course pages multimedia content real-time feedback mechanisms and community-building tools. Despite some early difficulties the implementation phase effectively achieved development goals. To further support international online learning initiatives further efforts will be directed toward improving platform security and functionality.

E-commerce is the general concept of using new technologies to establish chain communication between producers, sellers, suppliers, generally providers of goods and services on the one hand and buyers, consumers or customers in general on the other hand, in order to make a decision. The best ways are to optimize goods and services, reduce costs and open new channels. This article tried to propose an e-commerce model for fresh agricultural products, which can not only maximize producer and consumer satisfaction, but also reduce waste, increase marketing efficiency, and provide environmental protection and sustainable development. The proposed model is based on a coherent and real-time monitoring system, designed by managers and clarification for producers and consumers. The components of this system are manufacturers, retailers, banks, sales and purchase brokers, logistics systems, supervisors and management of the e-commerce system. This system manages information flow, money flow and goods flow accurately and transparently. In this presented model, the duties of each member and how they work were explained, and its implementation requirements were also specified. This model paves the way for the future of sustainable food and preserving the environment with two functions, reducing waste and increasing consumer satisfaction through the supply of unprocessed and fresh products.

This study describes the development of an image-based insect trap diverging from the plug-in camera insect trap paradigm. In short, a) it does not require manual annotation of images to learn how to count targeted pests and, b) it self-disposes the captured insects, and therefore is suitable for long-term deployment. The device consists of an imaging sensor integrated with Raspberry Pi microcontroller units with embedded deep learning algorithms that count agricultural pests inside a pheromone-based funnel trap. The device also receives commands from the server which configures its operation while an embedded servomotor can automatically rotate the detached bottom of the bucket to dispose of hydrated insects as they begin to pile up. Therefore, it completely overcomes a major limitation of camera-based insect traps: the inevitable overlap and occlusion caused by the decay and layering of insects during long-term operation, thus extending the autonomous operational capability. We study cases that are underrepresented in literature such as counting in situations of congestion and significant debris using crowd counting algorithms encountered in human surveillance. Finally, we perform comparative analysis of the results from different deep-learning approaches (YOLO7/8, crowd counting, deep learning regression) and we open-source the code and a large database of Lepidopteran plant pests.

Vitamin E facilitates testicular development and semen quality in farm animal. And most research tends to investigate antioxidant roles of Vitamin E in reproductive health; some research also find potential non-antioxidant roles of Vitamin E. To further uncover the mechanism by which Vitamin E modulates reproductive health, the paper reviews specific function of Vitamin E and candidate genes involved in male reproductive performance promoted by Vitamin E. The review found that cell proliferation (PDPN, BMP, Myc, AMPKa, GSK3β, PPARγ, CDK4, CDK6, Ki67, PCNA, Cyclin A2, Cyclin B1, Cyclin B3, BLM, REL, KLHL25)-, cell apoptosis (BCL-2, Caspase 9, Bax)-, spermatogenesis (CatSper1, CatSper2, NDRG1, CYP26B1, FSCN3, FLNA, SPCS3, YBX3, RARS)-, hormone receptor (PGR, FSHR, AR)-related genes are the underlying key points. And two miRNAs, miR-107 and miR-493-3p, which mediate cell cycle process, are also identified in response to Vitamin E treatment. The paper paves the way for a comprehensive understanding about effect of Vitamin E on testis development and semen quality in domestic animals.

Sexual issues and treatment side effects are not routinely discussed with men receiving treatment for prostate cancer and support to address these concerns is not consistent across settings. This study evaluates a brief e-learning resource designed to improve sexual wellbeing support and examine its effects on healthcare professionals’ sexual attitudes and beliefs. Healthcare professionals (n=44) completed an online questionnaire at baseline which included a modified 12-item sexual attitudes and beliefs survey (SABS). Follow-up questionnaires were completed immediately after the e-learning and at 4 weeks. Data were analysed using one-way, repeat measures ANOVAs to assess change in attitudes and beliefs over time. Significant improvements were observed at follow-up for a number of survey statements including ‘knowledge and understanding’, ‘confidence in discussing sexual wellbeing’ and the extent to which participants felt ‘equipped with the language to initiate conversations’. The resource was seen as concise, relevant to practice, and as providing useful information on potential side effects of treatment. Brief, e-learning has potential to address barriers to sexual wellbeing communication and promote delivery of support for prostate cancer survivors. Practical methods and resources should be included with these interventions to support implementation of learning and long-term changes in clinical behaviour.

E-learning with many outstanding advantages in training has drastically changed the self-study process due to the ability to personalize and effectively meet the learning activities of learners. E-learning and building an e-learning environment are currently paying attention and being deployed in many universities in Vietnam with different scope and levels. Especially in the current period, when science and technology are developing, many applications of technology and technology products have been applied in the field of education, changing the way of teaching and learning activities, the practice of both lecturers and students. Big Data and Artificial Intelligence (AI) technologies have replaced people not only for manual labor but also for intellectual labor, including the teaching of teachers. Many software applications have been used to replace people in the transmission of knowledge, testing, and evaluation of training quality, especially E-learning online training programs. However, in Vietnam today, the output quality of these online training programs has not been highly appreciated compared to similar programs in the world. The cause of this situation is that the training, teaching, and learning are not effective. Therefore, in this article, I will give some analysis, evaluate the current teaching and learning methods and propose solutions to enhance the interaction and initiative in the teaching and learning process of lecturers and students to improve the quality of online training in the future.

In this work, two embroidered textile moisture sensors are characterized with three different conductive yarns. The sensors are based on a capacitive interdigitated structure embroidered on a cotton substrate with an embroidered conductor yarn. The performance comparison of 3 different type of conductive yarns has been addressed. In order to evaluate the sensor sensitivity, the impedance of the sensor has been measured by means of a LCR meter from 20 Hz to 20 kHz on a climatic chamber with a sweep of the relative humidity from 30% to 65% at 20 ºC. The experimental results show a clear and controllable dependence of the sensor impedance with the relative humidity and the used conductor yarns. This dependence points out the optimum conductive yarn to be used to develop wearable applications for moisture measurement.

Internet-led labour market has become so competitive forcing many organisations from different sectors to embrace e-recruitment. However, realising the value of the e-recruitment from a Requirements Engineering (RE) analysis perspective is challenging. This research is motivated by the results of a failed e-recruitment project conducted in military domain which is used as a case study in this research. After reviewing the various challenges faced in that project through a number of related research domains, this research focuses on two major problems which are the (1) difficulty of scoping, representing, and systematically transforming recruitment problem knowledge towards e-recruitment solution specification; and (2) the difficulty of documenting e-recruitment best practices for reuse purposes in an enterprise recruitment environment. In this paper, a Problem-Oriented Conceptual Model (POCM) with a complementary Ontology for Recruitment Problem Definition (Onto-RPD) is proposed to contextualise the various recruitment problem viewpoints from an enterprise perspective and to elaborate those problem viewpoints towards a comprehensive recruitment problem definition. The POCM and Onto-RPD are developed incrementally using action-research conducted on three real case studies: (1) Secureland Army Enlistment, (2) British Army Regular Enlistment, and (3) UK Undergraduate Universities and Colleges Admissions Service (UCAS). They are later evaluated in a focus group study against a set of criteria. The study showed that the POCM and Onto-RPD provide a strong foundation for representing and understanding the e-recruitment problems from different perspectives.

Despite the uptake of tobacco smoking declining in the UK, smoking is still the leading cause of preventable poor health and premature death. While improved approaches to smoking cessation are necessary, encouraging and assisting smokers to switch by using substantially less toxic non-tobacco nicotine products may be a possible option. To date few studies have investigated the rates of smoking cessation and smoking reduction associated with the free provision of electronic-cigarettes (e-cigarette) to smokers. In this study the Blu Pro e-cigarette was given to smokers for use in place of tobacco for 90 days. The rates of smoking abstinence and daily smoking patterns were assessed at baseline 30 days, 60 days and 90 days. The response rate was 87%. After 90 days, the complete abstinence rate was 36.5% from 0% at baseline. Frequency of daily smoking reduced from 88.7% to 17.5% (P<0.001) and median consumption of cigarettes/day from 15 to 5 (P<0.001). Median days per month participants smoked also dropped from 30 to 13 after 90-days (P<0.001). On the basis of these results there may be value in smoking cessation services and other services ensuring that smokers are provided with e-cigarettes at zero or minimal costs for at least a short period of time.

The contents of Education for Sustainable Development (ESD) should be included in teachers’ initial and advanced training programs. In order to determine the key competences for sustainability, creating a Sustainable Consciousness is one of the main foundations. However, there are not many empirical studies that deal with consciousness from education. In this context, e-portfolio appears as a tool that promotes reflection and critical thinking, key competences for consciousness development. This work intends to propose a categorization system to extract types of consciousness and identify trainee teachers’ levels of consciousness. For this research work, of an eminently qualitative nature, we have selected twenty-five portfolios of students in the last year of the School of Education at the University of Macerata (Italy). The qualitative methodological procedure followed allowed to deduce three bases that shape trainee teachers’ consciousness: thinking, representation of reality and type of consciousness. We concluded that the attainment of a Sustainable Consciousness in teachers requires activating and developing higher levels of thinking, as well as a projective and macrostructural representation of reality.

Clinical training in medical schools in Spain is performed by rotations in university hospitals. During these internships, students are expected to acquire and master basic procedural skills. However, the assessment tools available rarely check whether these skills are completely acquired by the students. We have used an e-portfolio to determine the optimal number of times the students need to repeat a procedure to be able to perform it independently. The results were compared with the actual performance during the internships. An e-portfolio collected qualitative information about the internships. Quantitative information was also requested about the number of times each clinical skill was performed. Later, a survey asked these students and their teachers the optimal number of times each skill should be repeated before it could be considered fully acquired. The questionnaire was answered by 98.6% of the students and 70.3% of their teachers. Out of the 21 clinical skills and procedures selected, both students and their tutors agreed in a similar optimal value in 16 of them; only in five of them, teachers thought that students needed a greater number of times than that selected by the students. When these optimal values were compared with the actual values recorded in the portfolio during the internships, it was found that about half of the clinical skills were carried out less frequently than expected, thus providing an important feedback about the internships. Quantitative information collected in portfolios reveals a moderate mismatch between students and tutors perceptions of their training needs.

For any odd positive integer $x$, define $(x_n)_{n\geqslant 0} $ and $(a_n )_{n\geqslant 1} $ by setting $x_{0}=x, \,\, x_n =\cfrac{3x_{n-1} +1}{2^{a_n }}$ such that all $x_n $ are odd. The 3x+1 problem asserts that there is an $x_n =1$ for all $x$. Usually, $(x_n )_{n\geqslant 0} $ is called the trajectory of $x$. In this paper, we concentrate on $(a_n )_{n\geqslant 1} $ and call it the E-sequence of $x$. The idea is that, we consider any infinite sequence $(a_n )_{n\geqslant 1} $ of positive integers and call it an E-sequence. We then define $(a_n )_{n\geqslant 1} $ to be $\Omega-$convergent to $x$ if it is the E-sequence of $x$ and to be $\Omega-$divergent if it is not the E-sequence of any odd positive integer. We prove a remarkable fact that the $\Omega-$divergence of all non-periodic E-sequences implies the periodicity of $(x_n )_{n\geqslant 0} $ for all $x_0$. The principal results of this paper are to prove the $\Omega-$divergence of several classes of non-periodic E-sequences. Especially, we prove that all non-periodic E-sequences $(a_n )_{n\geqslant 1} $ with $\mathop {\overline {\lim } }\limits_{n\to \infty } \cfrac{b_n }{n}>\log _23$ are $\Omega-$divergent by using the Wendel's inequality and the Matthews and Watts's formula $x_n =\cfrac{3^n x_0 }{2^{b_n }}\prod\limits_{k=0}^{n-1} {(1+\cfrac{1}{3x_k })} $, where $b_n =\sum\limits_{k=1}^n {a_k } $. These results present a possible way to prove the periodicity of trajectories of all positive integers in the 3x + 1 problem and we call it the E-sequence approach.

The majority of E-commerce transactions reveal private information such as customers' identities, order contents, and payment information during the transaction. Other personal information such as health conditions, religion, and even ethnicity may be also deduced. Even when deploying electronic cryptocurrencies such as Bitcoin, anonymity cannot be fully guaranteed. Also, many anonymous payment schemes suffer from possible double spending circumstances. E-commerce privacy is basically a difficult problem as it involves parties with concurring interests. Three major e-commerce requirements are highly difficult to resolve: anonymous purchase, anonymous delivery, and anonymous payment. This work presents a possible e-commerce system addressing all three anonymity requirements for electronic-items business on open networks. The system offers anonymous entities authentication mechanisms up to completing a fair anonymous e-commerce transaction. The system is based on deploying a physically clone-resistant hardware token for each relevant involved party. The tokens are made clone-resistant by accommodating a Secret Unknown Cipher (SUC) in each hardware-token as a digital PUF-like identity. A set of novel generic system-setups for units, protocols and e-commerce schemes is introduced. The proposed anonymization is basically attained by virtually-replacing relevant e-commerce entities by low-cost, unique and clone-resistant tokens/units using SUCs. The units act as trustable anonymous, authenticated and non-replaceable entities monitored by their acting users.

Escherichia coli is a gram-negative commensal bacterium living in human and animal intestines. Its pathogenic strains are cause of high morbidity which can adversely affect people by causing urinary tract infections, food poisoning, septic shock, or meningitis. Humans can contract E. coli by eating contaminated food—such as raw or undercooked raw milk, meat products, and fresh produce sold in open markets—as well as by coming into contact with contaminated settings like wastewater, municipal water, soil, and faeces. Some pathogenic strains of E. coli have been identified in Nigeria such as enterohemorrhagic (EHEC), as well as enterotoxigenic (ETEC), enteropathogenic (EPEC), enteroinvasive (EIEC), enteroaggregative (EAEC), and verotoxigenic (VTEC). This causes acute watery or bloody diarrhoea, stomach cramps, and vomiting. Apart from the virulence profile of E. coli, antibiotic resistance mechanisms such as the presence of blaCTX-M found in humans, animals and environmental isolates which are of great importance and require surveillance and monitoring for emerging threats in resource-limited countries. This review is aimed at understanding the underlying mechanisms of evolution and antibiotic resistance in E. coli in Nigeria and highlighting the use of improving One Health approaches to combat the problem of emerging infectious diseases.

Nipa palm is a plant of great value to communities due to its social, environmental, and economic benefits. Effective management of the supply chain for products derived from nipa palm resources is essential to provide communities with suitable channels for selling each type of product. This study aims to map the supply chain structure of six different nipa palm products. Data were collected through semi-structured interviews with 100 households engaged in nipa palm cultivation. The analysis focused on the characteristics of the products, existing challenges, and the current supply chain dynamics. The findings revealed that among the six products, palm sugar had the highest production volume. The most significant challenges identified were related to labor shortages and limited marketing channels. To achieve sustainable supply chain management, it is crucial to maintain a balance between supply and demand. The study recommends exploring appropriate marketing channels for each product, with particular emphasis on online platforms that allow communities to sell directly to consumers.

Our study is part of the ongoing discussion concerning influencer marketing as there seems to have been a shift and social media marketing is bigger than ever. Social media outlets are excellent vehicles for fostering relationships with consumers who can be susceptible to influencer advertising. Therefore, companies now pay for posts on users’ profiles to generate popularity for products. How this approach affects consumers’ buying behavior is an interesting research question. We reference Herbert Simon’s economics of attention as an appropriate theoretical construct for describing the reality of the internet. Based on unique survey data from 513 Polish respondents, the study applies econometric methods and supervised and unsupervised machine learning techniques to identify the primary consumer groups with different characteristics of engagement and sensitivity to influencer activities, revealing the possible drivers of purchase intent. The findings provide valuable insights into consumers’ informational preferences, demonstrating how social media influencers may attract attention and drive sales.

This study explores the impact of artificial intelligence (AI) on digital marketing strategies, emphasizing how AI technologies have transformed marketing practices. AI's ability to analyze vast amounts of data has significantly enhanced targeting and personalization, enabling marketers to deliver highly relevant and tailored content to specific consumer segments. The integration of AI in content creation has streamlined processes, improving efficiency while maintaining high standards of quality and relevance. Customer engagement has also been revolutionized through AI-driven tools such as chatbots and predictive assistance, which provide real-time, personalized support and enhance overall user satisfaction. Despite the numerous benefits, the adoption of AI in digital marketing presents challenges, including data privacy concerns, algorithmic bias, high implementation costs, and the complexity of integrating AI with existing marketing systems. The shortage of skilled professionals further complicates effective AI utilization. Looking forward, the potential for AI to drive innovation in digital marketing is substantial, with opportunities for advancements in personalization, predictive analytics, and the integration of emerging technologies like virtual and augmented reality. However, it is essential for businesses to navigate these developments carefully, addressing ethical considerations and ensuring responsible use of AI to maintain consumer trust and achieve sustained success. This study provides insights into the transformative effects of AI on digital marketing and offers a comprehensive overview of the associated benefits and challenges, highlighting the need for a balanced approach to leveraging AI technology.

Supply chain flexibility plays a pivotal role in enabling organizations to adapt their marketing strategies to evolving consumer preferences in dynamic market environments. This qualitative study explores how supply chain flexibility dimensions—responsiveness, agility, resilience, and sustainability—impact marketing strategy adaptation. Through semi-structured interviews and document analysis, insights were gathered from industry practitioners across diverse sectors. Key findings highlight that responsive supply chains facilitate quick adjustments in production, distribution, and sourcing to meet changing consumer demands. Agility enables rapid reconfiguration of operations to capitalize on market opportunities and respond to disruptions effectively. Resilient supply chains mitigate risks and maintain continuity during crises, safeguarding customer satisfaction and brand reputation. Integrating sustainability practices not only meets regulatory standards but also aligns with consumer preferences for eco-friendly products, enhancing corporate social responsibility. Technological advancements such as AI, IoT, blockchain, and cloud computing enhance supply chain visibility, optimize decision-making, and support real-time responsiveness. Despite benefits, challenges like legacy systems, organizational silos, resistance to change, and resource constraints hinder effective implementation. Overcoming these barriers requires strategic leadership, cross-functional collaboration, and continuous investment in technology and talent. Embracing supply chain flexibility empowers organizations to navigate complexities, drive innovation, and sustain competitive advantage. By aligning supply chain capabilities with marketing strategies, companies can enhance market responsiveness, customer satisfaction, and long-term growth in today's dynamic business landscape

This qualitative study explores the transformative role of digital technologies in enhancing supply chain efficiency and marketing effectiveness across diverse industries. The integration of Internet of Things (IoT), artificial intelligence (AI), blockchain, and advanced analytics has reshaped organizational practices, enabling real-time data collection, analysis, and decision-making in supply chain management (SCM) and marketing. Through semi-structured interviews with 25 professionals, including supply chain managers, marketing executives, and IT specialists, insights were gathered into the adoption, integration, and impact of digital technologies within organizational contexts. Key findings highlight IoT's contribution to enhancing supply chain visibility, predictive maintenance, and operational efficiency through continuous monitoring and data-driven insights. AI technologies support demand forecasting, inventory optimization, and personalized marketing strategies, improving customer engagement and satisfaction. Blockchain enhances supply chain transparency, traceability, and security, reducing risks associated with fraud and ensuring compliance with regulatory standards. Advanced analytics provide organizations with actionable insights into consumer behavior and market trends, guiding strategic decision-making and optimizing marketing campaigns. Despite these benefits, organizations face challenges such as technological complexity, integration issues, data privacy concerns, and organizational resistance to change. Strategic planning, leadership support, and investment in digital infrastructure are essential for overcoming these challenges and maximizing the potential of digital technologies. Future research directions include exploring sustainability initiatives in digital SCM, advancing AI-driven analytics, and understanding digital transformation in emerging markets.

Digital transformation is revolutionizing supply chain management, profoundly influencing marketing effectiveness across industries. This qualitative study explores the impact of digital transformation on supply chains and its implications for marketing strategies. Through in-depth interviews, case studies, and document analysis, the research elucidates how digital technologies such as IoT, blockchain, AI, and advanced analytics are reshaping supply chain dynamics. Key findings highlight enhanced supply chain visibility, improved decision-making capabilities, and strengthened collaboration among supply chain partners. These technological advancements empower organizations to optimize inventory management, anticipate market trends, and deliver personalized customer experiences, thereby enhancing operational efficiency and customer satisfaction. Furthermore, the study underscores the role of digital transformation in promoting sustainability and ethical practices within supply chains. Technologies like blockchain facilitate transparent and traceable supply chains, supporting initiatives for responsible sourcing and environmental stewardship. Despite the transformative benefits, the study identifies challenges including significant investment requirements, integration complexities, and data security concerns. Strategic approaches to technology adoption, robust cybersecurity measures, and employee training are essential for overcoming these challenges and maximizing the benefits of digital transformation. Overall, this study contributes to understanding how digital transformation drives innovation in supply chain management and enhances marketing effectiveness. By embracing digital technologies and aligning supply chain strategies with marketing objectives, organizations can navigate competitive landscapes, meet evolving consumer expectations, and achieve sustainable growth in the digital era.

This study explores the critical role of supply chain management (SCM) in shaping marketing strategies in emerging markets, where rapid economic growth and dynamic consumer behavior present both challenges and opportunities. Utilizing a qualitative approach, the research synthesizes insights from industry professionals across various sectors to elucidate how effective SCM practices can enhance marketing outcomes. Findings reveal that flexibility in supply chain operations is indispensable for adapting to the volatile market conditions typical of emerging economies, enabling companies to respond swiftly to changes in consumer demand and market trends. Advanced technologies such as predictive analytics, artificial intelligence, and the Internet of Things are identified as key enablers, providing real-time insights that align supply chain processes with marketing objectives. The ability to customize products and services to local preferences, supported by agile supply chains, emerges as a crucial factor in gaining a competitive edge. Cost management and optimization through efficient supply chain practices allow for competitive pricing and effective promotions, essential in price-sensitive markets. The study also highlights the importance of managing regulatory compliance, mitigating risks, and enhancing customer experience through integrated supply chain strategies. Cultural considerations and local market knowledge are critical for aligning product features and marketing messages with consumer expectations. Additionally, sustainability is becoming increasingly relevant, with environmentally conscious supply chains enhancing brand image and supporting marketing strategies. The impact of e-commerce and the role of supplier relationships further underscore the need for cohesive SCM and marketing integration. This research provides a comprehensive framework for understanding how supply chain capabilities can be leveraged to achieve marketing success in emerging markets, offering practical insights for companies seeking to navigate these complex environments effectively.

The present study seeks to assess the Brand Equity in the network of new fashion designers in the Canary Islands. To this end, we have adapted the Brand Equity model to an online context and proposed a set of metrics for four dimensions: estimate, relevance, awareness, and differen-tiation. The multidimensional approach to online Brand Equity was employed to measure the online Brand Equity of 129 fashion designers from the Canary Islands. The study's findings re-vealed that the number of social media profiles significantly impacts brand awareness and dif-ferentiation. Moreover, the digital maturity level influences brand relevance and overall Brand Equity . Our study highlights the practical value of web data-driven metrics for measuring online Brand Equity , which can be utilised for diagnostic, evaluative, or predictive purposes. The study's outcomes have substantial implications for marketers in the fashion industry aimed at improving online Brand Equity

This qualitative research explores the dynamics of collaborative marketing and supply chain strategies for enhanced product lifecycle management. Through in-depth interviews with industry stakeholders, key themes, challenges, and implications of collaboration emerge. Trust, communication, technology, strategic alignment, and sustainability are identified as critical factors driving successful collaboration. The study highlights the transformative potential of collaboration in driving innovation, efficiency, and customer satisfaction. Despite challenges such as aligning objectives and ensuring data security, collaborative strategies offer significant opportunities for value creation and differentiation. The findings underscore the importance of building trust, leveraging technology, and integrating sustainability considerations in collaborative efforts. Strategic alignment and cultural fit among partners are essential for overcoming differences and achieving common goals. The implications of the research extend to practitioners seeking to enhance collaboration in their organizations and researchers exploring collaborative practices in different industries and contexts. Future research could further explore the impact of collaboration on stakeholder perspectives and outcomes. By addressing challenges and leveraging opportunities, organizations can maximize the benefits of collaborative marketing and supply chain strategies to drive sustainable growth and competitive advantage in today's dynamic business landscape.

Numerous researchers acknowledge that occupational pension protects employees. However, the total occupational pension is shared by employees and employers in China, which is a cost. This study aimed to explore the occupational pension on corporate social responsibility (CSR) and organizational resilience. We drew upon insights from cost-stickiness and resource-based theories to develop a model that illuminates how occupational pension affected firms’ stance toward CSR in the context of the COVID-19 pandemic and how this, in turn, has result organizational resilience. This study categorized CSR into strategic and responsive activities based on cost stickiness. We selected a total of 34,145 observations of Chinese listed companies over the period 2010-2023 as a sample to investigate whether occupational pension changes CSR strategies. The results showed that the cost pressure to contribute to occupational pension drove firms to reduce their responsive CSR and boost their strategic CSR. Moreover, strategic CSR improved organizational resilience, but responsive CSR did not. This relationship between occupational pension and CSR was significantly and negatively moderated by the minimum wage and population aging. Whereas, the relationship between CSR and organizational resilience was significantly and positively moderated by digital transformation and marketing capabilities. This study has implications for decision-making regarding high-quality firm development.

The rapid penetration of social media has been redefining every facet of the old marketing and customer engagement tactics, not only for the low-end and mass products but also for luxury brands. In this context, brands are dealing with the challenge of keeping the balance between using mass marketing strategies concurrent with accentuating the exclusivity of their offerings. Social media can be considered a boon if brands employ them to reach the right audience and use the right platform by incorporating the right content. In this work, we propose a sector-specific, integrated, and holistic investigation of the social media strategies of luxury brands, together with the impact they generate in terms of the engagement level of the users as an indicator of their success. We provide empirical validation of the method in the sector of luxury fashion brands in the Italian market, providing qualitative and quantitative analysis of the content shared on social media, considering the type, timing, and modality of the sharing. We evaluate consumer-brand engagement in different contexts, including important live events in the field.

Soluble inorganic pyrophosphatase (sPPase), a pyrophosphate hydrolase, has been shown to play an important role in several physiological processes such as plant growth and development, metabolic activities, and response to abiotic stresses, but sPPase has been less studied in woody plants. In order to preliminarily verify whether the soluble inorganic pyrophosphatase in Eucommia ulmoides Oliver (E. ulmoides) has a role in resistance to drought stress, we amplified the EuSIP5 (E. ulmoides soluble inorganic pyrophosphatase 5) cDNA sequence from E. ulmoides by RT-PCR. In order to study the drought resistance of the Eucommia ulmoides soluble inorganic pyrophosphatase 5 (EuSIP5) gene, the cDNA sequence of the EuSIP5 gene was amplified from Eucommia ulmoides Oliver by RT-PCR. Bioinformatic analysis indicated that EuSIP5 might be an unstable amphipathic protein, mainly located in the cytoplasm. E. ulmoides, the highest expression of the EuSIP5 gene was found in male leaves and pericarp from April to October, and in leaves of E. ulmoides in July and September. During drought, the expression of EuSIP5 in seedling E. ulmoides leaves was significantly higher than that of the control. An overexpression vector harboring the EuSIP5 was constructed and introduced into the tobacco (Nicotiana tabacum cv. Xanthi). We found that during drought stress, the appearance of wilting was delayed by 4 days in transgenic tobacco plants (OE) compared with wild type plants (WT), and the expression of drought-related genes DET2, CYP85A1, P5CS, ERF1 and F-box was found to be increased in transgenic tobacco leaves, as well as the enzyme activities of the protective enzymes: peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) were significantly higher than those of the WT, and the malondialdehyde (MDA) content was lower than the WT. These results indicated that the introduction of EuSIP5 gene into tobacco increased the expression of drought-related genes, enhanced the anti-membrane oxidation ability of tobacco, and reduced the oxidative stress damage, thus improving the drought resistance of tobacco.

(1) E-governance is defined as the application of electronic means in the interaction between government and citizens and government and business, as well as in internal government operations to simplify and improve democratic, governmental, and business aspects of governance. Thus, e-governance is built from a paradigmatic dimension such as e-democracy (relationship between government and citizens) and an operational one such as e-government. The objective was to design and validate an instrument to measure e-governance based on three factors: a) e-administration, b) e-services, and c) e-democracy; (2) Methods: Based on the level of importance given to each factor (sample of 2042 Latin American citizens), as well as the relationships between them, an analysis of the importance of each factor is carried out; (3) Results: After the confirmatory analysis, the definitive instrument with which e-governance can be measured by other researchers and future research is obtained, considering the three selection factors, namely: e-administration, e-services and e-democracy; (4) Conclusions: This research contributes to political science through the design and validation of an instrument consisting of 39 items that can be used to measure e-governance according to the dimensions proposed by the United Nations Educational, Scientific and Cultural Organization.

Acute lymphoblastic leukaemia is currently treated with bacterial L-Asparaginase; however, its side effects bring up the special need for improved and efficient novel enzymes development. Previously, we obtained low anti-asparaginase antibody production and high serum enzyme half-life in mice with the P40S/S206C mutant; however, its specific activity was significantly reduced. Thus, our aim was to test single mutants, S206C and P40S, for in vitro and in vivo assays. Our results showed that the drop in specific activity was caused by P40S substitution. Besides, our single mutants were highly stable in biological environment simulation, unlike double mutant P40S/S206C. The in vitro cell viability assay demonstrated that mutant enzymes have higher cytotoxic effect than WT on T-cells derived ALL and on some solid cancer cell lines. The in vivo assays were performed in mice to identify toxicological effects, to evoke immunological response and to study the enzymes pharmacokinetics. From these tests, none of the enzymes was toxic; however, S206C evoked lower physiological changes and immune responses. In relation to pharmacokinetic profile, S206C has two-fold higher activity than WT and P40S two hours after injection. In conclusion, we present bioengineered E. coli asparaginases with high specific enzyme activity and lesser side effects.

Background Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM). Type 2 diabetes mellitus (T2DM) is a major public health concern worldwide, including in Pakistan. Cardiovascular problems linked with T2DM have a significant impact on people and society. The study's goal is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, lipid profiles, and cardiovascular complications such as ischemic heart disease (IHD) and stroke. Methods: This study was carried out on 260 subjects, divided into control D1: Diabetics without cardiovascular issues. D2: Diabetics with heart disease. D3: Diabetics with stroke. D4: Diabetics with both heart disease and stroke. Anthropometric parameters (age, BMI) and risk factors (smoking, diabetes duration, hypertension) were assessed in all groups. Serum levels of TC, TG, LDL, HDL, VLDL, creatinine, BSF, and HbA1c were measured. Apolipoprotein E gene polymorphism was determined using PCR-RFLP. Results: Hypertension, BMI, and dyslipidemia, defined as elevated levels of total cholesterol, triglycerides, LDL, HDL, and VLDL, as well as uncontrolled hyperglycemia (elevated fasting blood sugar and glycated hemoglobin) in T2DM, were linked to vascular complications such as IHD and stroke. Hypertension was prevalent in 75.4% of the population, with greater rates among the elderly. Stage 2 hypertension was more prevalent in all age groups. Apolipoprotein E gene polymorphism was discovered, with genotypes 3/3, 4/4, 2/3, and 3/4 being the most prevalent. Genotype 3/4 was more common in diabetics who had IHD/stroke or both problems, whereas genotype 2/3 was linked to DM and stroke. Conclusion: It is concluded that BMI, hypertension, hyperglycemia, atherosclerosis, and dyslipidemia are linked with cardiovascular complications of type 2 diabetes. Apolipoprotein E gene polymorphism is associated with cardiovascular disease in diabetic patients by affecting the lipid profile.

Shiga-like toxin producing Escherichia coli (STEC) is a well-known cause of foodborne acute diarrheic diseases especially in children and the elderly. The potentially fatal complications associated with toxin production range from bloody diarrhoea and ischemic colitis to kidney failure, haemolytic-uremic syndrome (HUS) and colon perforation. We describe a case and literature review of STEC – induced colitis, highlighting the clinical features, and the necessary tools for the best diagnosis approach and management. Facing challenging differential diagnosis ranging from ischemic colitis, inflammatory bowel disease, to infectious process due to a pathogenic or opportunistic agent, we practiced a step-by-step exploration. Beginning with bacteriological investigation, imagistic screening, and colonoscopy, we could rule out some of initial suppositions and reach the final diagnosis, also considering the pathological results. Although antibiotics are not indicated in this pathology, our patient did receive antibiotics, given the risk of translocation and colon perforation, without associating any complications, as HUS or peritonitis. Detailed and rigorous investigations along with a multi-speciality team are required for a prompt medical support. Coping the symptoms and refraining from further complications are the mainstem of the treatment.

Urinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC) are a serious healthcare concern that must be treated with appropriate antibiotic therapy. However, antibiotic resistance among UPEC strains is increasing, particularly among individuals with recurrent illness. The proliferation of Extended-Spectrum Beta-Lactamase (ESBL) generating UPEC, as well as the increase of UPEC strains that display resistance to several antimicrobial drugs, adds to the difficulty of managing UTIs. UPEC strain genetic variants have a significant influence in their capacity to resist antimicrobial agents and adapt to changing environments. Understanding the genomic landscape of developing UPEC strains is critical for understanding the genetic basis of their resistance. Furthermore, tracking these genetic strains is critical for identifying patterns of resistance spread, directing infection control efforts, and educating.

Serotonergic neurons constitute one of the main systems of neuromodulators, whose diffuse projections regulate the functions of the cerebral cortex. Serotonin (5-HT) is known to play a crucial role in the differential modulation of cortical activity related to behavioral contexts. Certain aspects of the 5-HT signaling framework hint at its potential role as a modulator of activity-dependent synaptic changes within the critical period of the primary visual cortex (V1). Cells of the serotonergic system are among the first neurons to differentiate and operate. During postnatal development, ramifications from raphe nuclei become massively distributed in the visual cortical area, remarkably increasing the availability of 5-HT for the regulation of excitatory and inhibitory synaptic activity. A substantial amount of evidence has demonstrated that synaptic plasticity at pyramidal neurons of the superficial layers of V1 critically depends on a fine regulation of the balance between excitation and inhibition (E/I). Therefore, 5-HT could play an important role in controlling this balance, providing the appropriate excitability conditions that favor synaptic modifications. In order to explore this possibility, the present work used in vitro intracellular electrophysiological recording techniques to study the effects of 5-HT on the E/I balance of V1 layer 2/3 neurons, during the critical period. Serotonergic modulation of the E/I balance has been analyzed on spontaneous activity, evoked synaptic responses, and long-term depression (LTD). Our results pointed out that the predominant action of 5-HT implies a reduction of the E/I balance. 5-HT promoted LTD at excitatory synapses while blocking LTD at inhibitory synaptic sites, thus shifting the Hebbian alterations of synaptic strength towards lower levels of E/I balance.

Vitamin E is a group of eight compounds divided into two subgroups: four tocopherols (α-, β-, γ-, and δ-) and four tocotrienols (α-, β-, γ-, and δ-). α-Tocopherol is considered the most biologically active form. This review paper summarizes the current knowledge and historical progression of vitamin E research, with particular emphasis on its role in animal nutrition. Early studies in the 1920s identified vitamin E’s role in preventing neonatal mortality in rats. Over the following decades, scientists discovered the compound’s chemical structure and its importance for the immune system, skin health, anti-inflammatory properties, hormonal balance, and other bodily functions. Production of vitamin E products has evolved, starting with isolating the vitamin from natural sources and advancing to synthesizing it with greater efficiency and standardized potency units. Early animal studies focused on reproductive health and growth disorders, but further research demonstrated the importance of vitamin E in preventing encephalomalacia in domestic fowl and muscular dystrophy in rabbits and other animals. Today, vitamin E is commonly used as a feed additive to meet animals’ requirements and assure immune function and overall health. Despite much knowledge on vitamin E’s role in animal nutrition, many questions remain unanswered, and current research aims to determine optimal supplementation levels, interactions with other nutrients, impacts on gene expression, cell signaling and communication, and effects of supranutritional dosages in livestock. Vitamin E has a long and fascinating history in scientific research, with significant advancements in understanding its chemical structure and biological activity. In animal nutrition, vitamin E continues to play an important role in improving animal health, and ongoing research will continue to expand our understanding of its benefits and mechanisms of action.

On Feb. 6^th, 2020, FDA implemented the enforcement priorities against all flavored, cartridge-based e-cigarettes other than menthol and tobacco flavors. This ban undermined the products’ attraction to vapers, so e-cigarette manufacturers added flavorants of other attractive flavors into tobacco-flavored e-cigarettes and re-established attractions. Both the sales of e-cigarettes and posts on social media suggested that the manufacturers’ strategies are likely “successful”. The re-established attraction causes not only a public health issue, but also threats to the health of individual vapers. Research has shown an increase in toxicity associated with the flavorants commonly used in flavored e-cigarettes that are likely added in tobacco-flavored e-cigarettes based on tobacco-derived and synthetic tobacco free nicotine, and these other flavors are associated with higher clinical symptoms not often induced by only natural traditional tobacco flavors. The additional health risks posed by the flavorants are pronounced even without considering the interactions of toxicology of the different tobacco flavorants, and more research should be done to understand the health risks thoroughly and to take proper actions accordingly for regulation of these emerging products.

The adoption of recycling and proper disposal techniques for electronic waste is crucial in advancing sustainable development. The traditional approaches of motivating people for collection of electronic waste are often insufficient due to inadequate methods reaching out, given incentives, calculating appropriate incentives associate to the task of gathering the electronic waste and a lack of transparency in the entire process. Insufficient collection of electronic waste could result in the release of numerous harmful substances into the environment. Prior research studies have been carried out to tackle the issue of electronic waste management in a broad sense. The findings of those studies indicated diverse strategies, each of which is relevant solely to a restricted range of electronic waste reprocessing circumstances. The current study has presented a proposed technique for incentivizing tasks and activities associated to collection of electronic waste through the adoption of vector space technique. Blockchain smart contact technology, has been used to implemented the strategy. The method used involves various well defined mapping of tasks, nature of activities, and their magnitude in order to derived an incentive. Some scenarios for the calculations of incentives are presented, and the findings reveals the based case is by utilizing weighting scale scheme where each tasks and activities are mapped to its associated inventive rather than providing fixed incentive values. Ethereum was used as digital token for each unit of incentive. This concept has contributed in encouraging personal accountability in the management of e-waste collection in order to cultivate sustainable behaviors for a long term solution.

Extended-spectrum β-lactamase (ESBL) mediating resistance in Enterobacterales is a global public health issue, especially in low-and middle-income countries (LMICs) such as Cameroon. ESBL-producing Enterobacterales reduce therapeutic options and lead to the use of last resort drugs such as carbapenems even in vulnerable populations like children under five years. This study aims at determining the phenotypic and genotypic characteristics of ESBL-producing Escherichia coli (ESBL-Ec) isolated from children under five years with and without diarrhoea in two health care facilities in Dschang. A cross-sectional study was conducted from 3 February to 19 May 2022 in two hospitals in the city of Dschang, Cameroon. Stool collected were cultured on Eosine Methylen Blue (EMB) medium. Enterosystem 18 R kit was used for bacterial identification. Evaluation of the resistance patterns and detection of ESBL production were performed with, the Kirby Bauer disk diffusion method and CHROMagar® ESBL medium, respectively. The genomic DNA of ESBL-Ec was extracted using the boiling method and subjected to conventional and multiplex PCRs for detection of blaSHV, blaCTX-M and blaTEM genes. Data were entered into ExcelTM 2016. Epi info and R software were used for statistical analyses with a p-value <0.05 considered statistically significant. Out of the 125 children enrolled, 67.2% (84/125) were colonized by E. coli. Among these, 57.14% (48/84) were colonized by ESBL-Ec. ESBL- Ec isolates showed high levels of resistance to amoxicillin-clavulanic acid (96.22%), cefotaxime (75.47%), ceftriaxone (73.58%), ofloxacin (67.92%), levofloxacin (56.6%) and ciprofloxacin (54.71%). Children aged between 1-3 years (47.62%, p=0.09) and those who had taken an antibiotic one week prior to collection (70.83%, p=0.04) had a higher prevalence of ESBL-Ec with statistical significance. The majority of ESBL-Ec isolates (52.83%; 28/53) were co-producers of blaCTX-M and blaTEM. Infection prevention and control measures coupled with antimicrobial stewardship strategies need to be strengthened to reduce emergence and dissemination of ESBL-Ec among this vulnerable population.

Background: In the 2022 National Youth Tobacco Survey disposable e-cigarette devices are shown to be the most widely used e-cigarette devices amongst U.S. youth. In this paper we report the results of research designed to estimate the prevalence of use of BIDI® Stick branded e-cigarettes amongst youth (aged 13 to 17), and under-age young adults (aged 18 to 20) in the U.S. Methods: Cross sectional online survey of a nationally representative sample of 1,215 youth (13 17 years) recruited via the IPSOS probability-based KnowledgePanel and 3,370 young adults aged 18 to 24 - amongst whom 1,125 were aged 18 to 20. Results: Amongst youth aged 13 to 17, 0.91% [95% CI: 0.44-1.68] or 190,000 [95% CI: 90,000-350,000] youth reported having ever used a BIDI® Stick branded product and 0.04% [95% CI: 0.00-0.38] or less than 10,000 youth reported currently using a BIDI® Stick branded product. Amongst those young adults aged 18 to 20, 3.90% [95% CI: 2.49-5.81] or 470,000 [95%CI: 300,000-700,000] reported having ever used a BIDI® Stick product whilst 0.60% [95% CI: 0.17-1.55] or 70,000 [95% CI: 20,000-180,000] reported they now use a BIDI® Stick product “every day” or “some days”. Conclusions: The low prevalence of youth and underage adult current use of the BIDI® Stick e cigarette suggests that this product is not responsible for the recent growth in the use of disposable e-cigarettes by youth within the U.S. as demonstrated by the 2022 National Youth Tobacco Survey.

Magnetoelectric sensors based on microelectromechanical cantilevers consisting of TiN / AlN / Ni are investigated using finite element simulations in regard of the anisotropy of the E effect and its impact on the sensor sensitivity. The E effect is derived from the anisotropic magnetostriction and magnetization of single crystalline Nickel. The magnetic hardening of Nickel in saturation is demonstrated for the (110) as well as the (111) orientation. It is shown further, that magnetostrictive bending of the cantilever has a negligible impact on the eigenfrequency and thus sensitivity. The intrinsic E effect of Nickel decreases in magnitude depending on the crystal orientation when integrated into the magnetoelectric sensor design. The transitions of the individual magnetic domain states are found to be the dominant influencing factor on the sensitivity for all crystal orientations. The peak sensitivity was determined to 41.3 T-1 for (110) in-plane orientated Nickel at a magnetic bias flux of 1.78 mT. It is found, that the transition from domain wall shift to domain rotation along the hard axes yields much higher sensitivity than the transition from domain rotation to magnetization reversal. The results achieved in this work show that Nickel as hard magnetic material is able to reach almost identical sensitivities as soft magnetic materials, such as FeCoSiB.

Metabolites are essential intermediate products in metabolism, and metabolism dysregulation indicates different types of diseases. Previous studies have shown that cigarette smoke dysregulated metabolites; however, limited information is available with electronic cigarette (E-cig) vaping. We hypothesized that E-cig vaping and cigarette smoking altered systemic metabolites, and we propose to understand the specific metabolic signature between E-cig users and cigarette smokers. Plasma from non-smoker controls, cigarette smokers, and e-cig users were collected, and metabolites were identified by UPLC–MS (Ultraperformance liquid chromatography-mass spectrometer). Nicotine degradation was activated by e-cig vaping and cigarette smoking with increased concentrations of cotinine, cotinine N-oxide, (S)-nicotine, and (R)-6-hydroxynicotine. Additionly, we found significant decreased concentrations in metabolites associated with tricarboxylic acid (TCA) cycle pathways in e-cig users verses cigarette smokers, such as: D-glucose, (2R,3S)-2,3-dimethylmalate, (R)-2-hydroxyglutarate, O-phosphoethanolamine, malathion, D-threo-isocitrate, malic acid, and 4-acetamidobutanoic acid. Cigarette smoking significant up-regulated sphingolipid metabolites, such as D-sphingosine, ceramide, N-(octadecanoyl)-sphing-4-enine, N-(9Z-octadecenoyl)-sphing-4-enine, and N-[(13Z)-docosenoyl]sphingosine, verses e-cig vaping. Overall, e-cig vaping dysregulated TCA cycle realted metabolites while cigarette smoking altered sphingolipid metabolites. Both e-cig and cigarette smoke increased nicotinic metabolites. Therefore, specific metabolic signature altered by e-cig vaping and cigarette smoking could serve as potential systemic biomarkers for early cardiopulmonary diseases.

In the recent century, the tourism industry and within it the tourism economy are one of the most important and fundamental sectors of engaged business. E-tourism can be used as a dynamic tool in up to date areas of informative information and tourism marketing will be considered as a suitable field for the tourism industry. The aim of this study was to investigate the relationship between climate change and the amount of revenues from the tourism industry relying on a tool called e-tourism, and informing and providing services through this way so that Iran can achieve a greater share of export of a single-product oil economy combined with economic growth and sustainable development goals. The method of this research is descriptive-analytical.

The purpose of this study is to find out the e-reputation management of the hotel industry, as well as the social media channels used as the tools of hotel e-reputation building. This study used a qualitative approach by analyzing the in-depth interviews with hotel marketing communication practitioners of 15 hotel companies in Bandung City. The findings identified that e-reputation is considered a crucial factor in determining hotel performance due to the change of customers’ behaviors today and identified also three types of e-reputation management activities implemented by hotel companies, such as online activities, offline activities, and online/offline activities. The results of this study have implications for the hospitality industry, as a reference for formulating their marketing strategies.

From professors overwhelmed by anxiety-driven e-mails from students, through faculty and administrative staff wasting valued time on e-mail minutia, misuse of electronic mail in the academy has become ubiquitous. After a brief overview of the unique features of e-mail communication, this study provides insight and guidelines to plan new educational activities on healthy and productive utilization of e-mail in the academy of the digital era. The overall aim is to prioritize scholarly deep work by focusing on teaching and research work, freeing working time wasted on unproductive use of e-mail.

In this work, an embroidered textile moisture sensor is presented. The sensor is based on a capacitive interdigitated structure embroidered on a cotton substrate with an embroidery conductor yarn composed by 99% pure silver plated nylon yarn 140/17 dtex. In order to evaluate the sensor sensitivity, the impedance of the sensor has been measured by means of a LCR meter from 20 Hz to 20 kHz on a climatic chamber with a sweep of the relative humidity from 25% to 65% at 20 ºC. The experimental results show a clear and controllable dependence of the sensor impedance with the relative humidity. Moreover, the reproducibility of the sensor performance subject to the manufacturing process variability and washing process is also evaluated. The results show that the manufacturing variability introduce a moisture measurement error up to 4%. The washing process impact on the sensor behavior after applying the first washing cycle implies a sensitivity reduction higher than 14%. Despite these effect, the textile sensor keeps its functionality and can be reused in standard conditions. Therefore, these properties point out the usefulness of the proposed sensor to develop wearable applications on health and fitness scope including the user needs to have a life cycle longer than one-time use

Health care workers (HCWs), specifically dentists, are at the front line for acquiring blood-borne virus infections. The highest proportion of occupational transmission is through percutaneous injuries via hollow-bore needles. Several studies around the world have reported that hepatitis viruses and human immunodeficiency virus are the main pathogens for most cases of occupationally acquired blood-borne infection. We aim to investigate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis E virus (HEV), and human immunodeficiency virus (HIV) among Mexican dentists. Methods. We included 159 dentists who attended the annual meeting at the Medica Sur Clinic & Foundation held in Mexico City in May 2016. A survey was applied in order to obtain data of occupational exposure to blood-borne viruses (BBV). Serum samples were screened serologically using enzyme-linked immunosorbent assays. Results. Two dentists (1.2%) were positive for antibodies against HCV antigen, one (0.6%) was positive for antibodies against HBV antigen and three (1.8%) were positive for the detection of IgG antibodies against HEV. Two cases (1.2%) were positive for antibodies against HIV. Conclusions. The infection by HEV was the most prevalent among dentists. However, the prevalence of BBV in dentists was similar to that in the general population.

Organ shortage is one of the most pressing issues with regard to human mortality. This issue is further complicated by the fact that HLA matching is required for patients, leading to restricted choices for transplant. If organs or tissues from non- or partially-HLA–matched donors could be edited such they evade cytotoxic T cells as well as natural killer cells, it would ameliorate the organ shortage problem.

In the present research, it has been tried to use the applied research bases in the field of business management with marketing orientation. Since there were wide and diverse spectrums in the field of economic activities in Isfahan province and Isfahan city, the model of economic sectors was used to categorize these activities. In this regard, the specific goals of the research in all five sectors of the model of economic sectors, drawing and prioritizing the components (indices) of the 7P marketing mix model in each of these economic sectors by the related individuals and members of subgroups of guilds and non-governmental organizations in Isfahan province, have been formed, specified and determined. Collecting data for processing and answer the question of this research, after designing a questionnaire in accordance with the AHP model standard, by spending a period of 2 months from September 2022 and ended in November 2022 , from the statistical population has been done.

This study explores the application of data mining techniques in marketing strategies, highlighting their impact on customer segmentation, predictive analytics, and personalization. Data mining has emerged as a transformative tool for businesses seeking to enhance their marketing effectiveness by providing deep insights into customer behavior and preferences. Techniques such as clustering, predictive modeling, and personalization are examined for their roles in improving marketing outcomes. Clustering methods, including K-means and hierarchical clustering, enable businesses to categorize customers into meaningful segments, allowing for more targeted marketing efforts. Predictive analytics, utilizing models like decision trees and neural networks, offers the capability to forecast future customer behaviors and trends, thereby optimizing resource allocation and strategy planning. Personalization techniques, such as collaborative filtering and dynamic recommendations, enhance customer engagement by delivering tailored content and offers. Despite these advantages, the study also addresses the challenges associated with data mining, including data privacy concerns, data quality issues, and the shortage of skilled personnel. These challenges underscore the need for effective data management practices and ethical considerations in the application of data mining. Furthermore, the integration of emerging technologies like artificial intelligence and real-time analytics is discussed as a means to overcome existing obstacles and drive future advancements in marketing strategies. The findings underscore the significant role of data mining in revolutionizing marketing practices and highlight the ongoing need for adaptation and innovation in response to evolving market dynamics.

This study investigates the transformative role of mobile applications in retail marketing strategies, focusing on how these digital tools have reshaped consumer engagement, personalization, and operational efficiency. Mobile applications have emerged as pivotal assets for retailers, facilitating direct communication with customers through real-time updates, personalized promotions, and tailored content. The integration of digital loyalty programs within mobile apps has streamlined rewards systems, making it easier for customers to engage with and benefit from loyalty initiatives. By leveraging data analytics, retailers can gain deep insights into consumer behavior, optimize inventory management, and refine marketing strategies. The incorporation of augmented reality (AR) and virtual reality (VR) technologies into mobile apps has introduced innovative ways for customers to interact with products and explore virtual showrooms, enhancing the overall shopping experience. Mobile commerce (m-commerce) has also seen significant growth, driven by the convenience and accessibility provided by mobile apps, which support seamless shopping experiences and mobile payments. Despite these advantages, challenges such as data privacy concerns and the need for continuous innovation remain. Retailers must address these issues to maintain consumer trust and stay competitive. Looking ahead, emerging technologies such as artificial intelligence (AI) and machine learning (ML) are expected to further enhance mobile app functionalities and personalization. The focus on sustainability is also influencing mobile app features, aligning with consumer values and expectations. Overall, mobile applications are set to play an increasingly critical role in shaping the future of retail marketing, offering new opportunities for engagement, innovation, and growth.

This study explores the impact of mobile technologies on consumer behavior in retail marketing, examining how advancements in mobile platforms have transformed shopping habits and interactions with brands. Mobile technologies have revolutionized the retail experience by providing unprecedented convenience, allowing consumers to shop at any time and from any location. This shift has led to a marked preference for mobile shopping over traditional methods, fundamentally altering consumer behavior. Key findings reveal that personalization plays a crucial role in enhancing consumer engagement and satisfaction, with mobile technologies enabling tailored recommendations and offers based on individual preferences. Access to real-time information, such as product details and price comparisons, empowers consumers to make more informed purchasing decisions, reflecting a shift towards deliberate and confident buying choices. Social media and social commerce have also become significant factors, with consumers discovering new products and brands through these platforms and benefiting from integrated shopping features. Impulse buying behavior has increased due to the convenience of mobile shopping, with promotional alerts and simplified payment processes contributing to spontaneous purchases. The integration of mobile technologies with physical store experiences has created a more seamless shopping journey, bridging the gap between online and offline interactions. However, challenges such as privacy concerns, data security, and information overload remain significant. Consumers are increasingly aware of data collection risks and may experience fatigue from excessive marketing messages. To navigate this evolving landscape, retailers must balance the advantages of mobile technologies with addressing these challenges to effectively meet consumer needs and expectations.

In contemporary marketing and consumer behavior research, supply chain transparency has emerged as a critical determinant of brand image and consumer trust. This qualitative study explores how transparency in supply chain communication shapes brand perception and influences consumer behavior. Through in-depth interviews with marketing professionals, consumers, and supply chain managers, this research examines the impact of transparent practices on consumer trust, brand loyalty, and market differentiation. Findings reveal that transparent disclosure of sourcing, production methods, and sustainability initiatives enhances consumer perception of brand authenticity and ethical responsibility. Effective communication strategies such as detailed product labeling, interactive digital content, and third-party certifications play a pivotal role in educating consumers and reinforcing brand credibility. Despite the benefits, the study identifies challenges including global supply chain complexity, lack of standardized metrics, and economic considerations associated with transparency implementation. Technological advancements like blockchain and data analytics offer solutions to improve supply chain visibility and traceability, supporting brands in meeting ethical standards and consumer expectations. Moreover, transparency facilitates effective crisis management and reputation recovery by enabling brands to promptly address supply chain issues and maintain consumer trust during disruptions. The research highlights cultural and regional variations in consumer expectations regarding transparency, underscoring the need for brands to tailor communication strategies to local values and preferences. As brands navigate these complexities, prioritizing transparency not only strengthens consumer relationships but also positions them as leaders in ethical business practices. Ultimately, this study contributes to understanding the strategic importance of supply chain transparency in fostering sustainable brand growth and resilience in a competitive global market.

This study investigates the impact of integrated marketing strategies on supply chain efficiency in retail businesses. Through qualitative research methods including in-depth interviews and case studies, the study explores how aligning marketing activities with supply chain operations influences various aspects of retail performance. The findings reveal that integrated marketing strategies lead to enhanced demand forecasting accuracy, improved customer satisfaction, and greater operational efficiency. By leveraging technology, such as artificial intelligence and data analytics, retailers can optimize inventory management, personalize offerings, and anticipate consumer preferences in real-time. Cross-functional collaboration and effective leadership emerge as crucial factors in fostering integration and overcoming challenges such as data management and cultural resistance. Additionally, the study highlights the significance of sustainability and entrepreneurship in driving integrated strategies, with implications for long-term competitiveness and brand reputation. The findings underscore the importance of viewing marketing and supply chain functions as interconnected elements of a holistic business strategy, rather than operating in silos. The study offers valuable insights for theory, practice, and future research, emphasizing the need for holistic and collaborative approaches to integration in the dynamic retail landscape. By embracing integrated marketing strategies, retailers can position themselves for success in an increasingly competitive market environment, driving innovation, efficiency, and customer satisfaction.

Acousto-Optical Tunable Filters (AOTFs) are a promising technology, exceptionally suited for advanced applications in spectroscopy and imaging across various scientific fields, including space exploration. This is due to their flexibility and high-speed functionality for precise wavelength selection via periodic modulation of the crystal’s refractive index using sound waves. These AOTFs are in turn driven by Radio Frequency (RF) signals through a transducer creating sound waves inside the crystal. This work presents a detailed comparison of three distinct topologies of Radio Frequency Power Amplifiers (RFPAs) for driving these AOTFs within the 30 to 300 MHz frequency range. The analysis focuses on three critical parameters: efficiency, bandwidth, and linearity, which are essential for optimizing the performance of AOTFs. By evaluating the trade-offs among these parameters, this research aims to identify the most effective design approach for RFPAs in this application context.

As the global overprovisioning of electronic devices continues to rise, the management of electronic waste (e-waste) has developed as a significant challenge. E-waste is comprised of hazardous materials; moreover, the toxic constituents in them can impact the environment and public health through improper disposal. On the beneficial side, this e-waste also contains some valuable materials. If the valuable materials are recovered, they can reduce the dependence on new, raw materials. Conventional linear models of production and consumption have led to a momentous buildup of e-waste, posing environmental and economic risks. This paper examines how the adoption of a circular economy approach can improve e-waste recycling in Nairobi by evaluating its economic recovery potential and e-waste residuals. It introduces metrics to assess the development of circular economy practices to help in the handling of e-waste residuals and examines the economic consequences associated with the adoption of circular strategies.

To encourage proper waste management from electrical and electronic devices (e-waste), it is necessary to invest heavily in the development of recycling technologies. One way to improve the process is to automate separating the shredded parts of e-waste using a robot. This paper's literature review, utilizing the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) framework, showcases potential robotic technologies for e-waste separation. However, the intricate design of these devices can pose significant challenges in their implementation. Various legal, organizational, and sociological obstacles have left Serbia's e-waste management practice underdeveloped, resulting in an unsatisfactory recycling rate. In this paper we examined the possibility of using robots on the precise example of recycling refrigerators in a recycling center in Eastern Serbia, concluding that such a solution would have multiple positive effects, both on the employees and the working environment, on the operations of the recycling center itself, and on increasing the e-waste recycling rate in the country.

Background: Dietary quality and the consumption of antioxidant-rich foods has been shown to protect against memory decline. Therefore, this double-blind, randomized, placebo-controlled study aimed to investigate the effects of a nutritional supplement on changes in cognitive performance. Methods: In adults aged 40 to 70 years with subjective memory complaints, participants were randomly allocated to take a supplement containing vitamin E, astaxanthin, and grape juice extract daily for 12 weeks or a matching placebo. The primary outcomes comprised changes in cognitive tasks assessing episodic memory, working memory, and verbal memory. Secondary and exploratory measures included changes in the speed of information processing, attention, and self-report measures of memory, stress, and eye and skin health. Moreover, changes in plasma concentrations of brain-derived neurotrophic factor, malondialdehyde, tumor-necrosis factor-α, and interleukin-6 were measured, along with changes in skin carotenoid concentrations. Results: compared to the placebo, nutritional supplementation was associated with larger improvements in episodic memory, a self-report measure of everyday memory, increased plasma brain-derived neurotrophic factor, decreased plasma malondialdehyde, and increased skin carotenoid concentrations. However, there were no group differences in changes in the remaining outcome measures. Conclusions: Twelve weeks of supplementation with a nutritional supplement was associated with improvements in episodic memory and several biological markers associated with cognitive health. Future research will be essential to extend and validate the current findings.

Abstract: There are a large number of cross-linked chemical bonds such as tight disulfide bonds, hydrogen bonds,and salt bonds in keratin, which makes it difficult to break the structural stability of the protein using conventional methods. The degradation of feather waste using keratinases produced by microorganisms has the advantage of being efficient and environmentally friendly. In this study, 23 strains capable of producing transparent circles were obtained via preliminary screening with skim milk as the sole carbon and nitrogen source, and 9 strains capable of degrading feathers were obtained via rescreening with feathers as the sole carbon and nitrogen source. Finally, through the determination of enzyme activity, the strain CY-A with a high ability to degrade feathers was obtained. The strain was identified as Bacillus tequilensis via morphological observation, physiological and biochemical identification, and 16 S rRNA molecular biology. The keratinase gene (bta) of Bacillus tequila was cloned, and its full-length gene sequence was 1110 bp, containing an open reading frame of 1089, encoding 369 amino acids (GeneBank accession number OR733336). The physicochemical properties, secondary structure, and tertiary structure of the recombinant protein were analyzed using bioinformatics tools such as ProtParm, SOPMA, MEGA, and SWISS-MODELS. It was found that the relative molecular mass was 37.953 kD and that the isoelectric point was 8.48. The protein was a hydrophilic protein. The keratinase bta gene was ligated to the expression vector pET28a(+) using T4 ligase, and the recombination expression plasmid pET28-bta was constructed and transformed into E. coli BL21(DE3) to obtain recombinant engineered bacteria. The expressed keratinase was purified using a Ni2+ affinity chromatography column to obtain recombinant bta keratinase bta with a molecular weight of 37.953 kD. The identification and characterization of this keratinase gene provides some theoretical basis for the further enhancement of keratinase activity by means of genetic engineering.

The pandemic was an enormous experience all over the world. The type of living, working and study were changed irreversibly. Facing the opportunity to establish old frames of education in universities is impossible. The adoption of new ways of teaching and assessments reveal their convenience and in the same way their weak points. In response to that stage, on 14 December 2022, the EU parliament accepted the "Digital Decade Policy Programme 2030", for the establishment of a digital transformation community (EU 2022). Trakia University had an online assessment system, quizzes for self-training, and final exams, developed in 2008 on Moodle virtual learning environment. During the pandemic, online exams and lectures were conducted using platforms like BigBlueButton in Moodle or Google Meets. The article gives the results of online exams before, during, and after the pandemic. The outcome, without doubt, displays the lowering knowledge level or performance during the social isolation due to COVID-19, and after, and the reasons are discussed. During the second year of the pandemic was mentioned also a high dropout of students. Now the situation is returning to the previous levels, before the pandemic, but the quality of education is not yet reached. The article values the grades results of session exams and has the intention to clarify the influence of the pandemic period on the excellence of high institution education.

Introduction: Dental students’ use of online material to supplement learning has been studied, but educator awareness and reaction to the findings of this research is unknown. This small local study aimed to investigate dental students’ use of online content as a learning tool from an educator’s perspective.Methods: Educators at an Irish dental school completed a survey based on dental students’ use of online learning. Quantitative descriptive analyses were carried out as appropriate on the data collected, and a subsequent focus group was held to gain deeper insight into survey results. Data were analysed for themes by deductive and inductive coding methods.Results: This study found a sample of educators were aware of some student behaviours around online videos. Most educators correctly thought that students are likely to refer to online videos to prepare for dental procedures. Several educators believed that teachers should incorporate videos into their learning, but do not themselves upload or recommend online videos. Most recalled discussing accuracy and/or relevancy of online content with their students. Fewer thought that students would discuss contradictory videos with them. Focus group participants expressed concern over the accuracy of online content. This along with a lack of time were some reasons deterring them from referring students to online videos. Conclusions: An opportunity exists for dental educators and their students to have local dialogue around (1) student use, critical appraisal, and sharing of dental procedural video material; and (2) perceived benefits and challenges of incorporating both school-produced and online videos into teaching and learning. Although arguably non-generalizable beyond this context, this study may inform future research and serve to spark conversations within schools regarding video use for teaching clinical dental procedures.

Information and telecommunications technology (ITT) have expanded into many aspects of modern life and have positively affected human life even in the most remote areas of developing countries. The rapid growth in ITT has led to an improvement in the capacity of computers but simultaneously to a decrease in the product’s lifetime as a result of which increasingly large quantities of e-waste are generated annually. It contains hazardous components that if it is not properly managed, can have adverse environmental and health effects. The management of e-waste poses significant challenges in developing countries. Due to the lack of adequate infrastructure, e-waste is burned or dumped in open areas. Informal and inefficient recycling practices are generally employed which further exacerbate pollution and health risks. So, the implementation of e-waste management, adequate recycling, and waste disposal facilities have become crucial concerns. This article reviews the concept of e-waste generation, challenges, disposal, and its impact on human health & environment in detail.

Higher education informatization (HEI) is an interdisciplinary field that examines the use and integration of information and communication technologies (ICTs) in higher education. This paper provides a bibliometric and visual analysis of the research trends, patterns, and topics in this field. Using the Web of Science database, we selected and analyzed 199 SCI and SSCI papers on HEI published from 2000 to 2023 by VOSviewer and CiteSpace software. The results indicate that the publication volume of HEI research has grown significantly in recent years, with China and the US being the most productive and influential countries. The author network shows the collaboration and contribution of different researchers and institutions, while the journal network reveals the multidisciplinary nature and scope of the field. The keyword network and the burst keyword analysis identify the main research themes and the emerging hot topics in HEI, such as online learning, big data, and artificial intelligence. The co-citation network of sources illustrates the theoretical and methodological foundations and influences of the field. The paper concludes with some implications and suggestions for future HEI research.

A rapid and efficient technique using an electronic nose based on a mass detector combined with headspace sampling (HS-SPME-MS e-nose) and chemometric tools was applied to classify beer samples between fresh and aged and between samples contained in aluminium cans or glass bottles, and to predict the shelf life of beer. The mass spectra obtained from the HS-SPME-MS e-nose contain information on the volatile compounds, recorded as the abundance of each ion at different mass-to-charge (m/z) ratios. The analysis was performed on 53 samples aged naturally for eleven months in the absence of light and with a controlled temperature of around 14° C +/- 0.5° C. Principal Component Analysis (PCA) was performed on the data, showing a grouping of samples between fresh and aged. Partial Least Square Discriminant Analysis (PLS-DA) allowed discriminating fresh from aged beers but was not able to discriminate samples packaged in aluminium cans or in glass bottles. Finally, Partial Least Square Regression (PLSR) was applied to build a prediction model and showed to be effective to predict beer shelf life.

Currently, with the rapid growth of the population, the demand for metals has increased, especially for the manufacture of electronic devices such as cell phones, computer equipment, among others. Once these devices stop working, most are sent to landfills, which represents a danger since these wastes contain metals and other materials that must be properly managed to prevent them from having a negative effect on the environment and the human being. On the other hand, e-waste contains valuable metals such as copper, gold, and silver, the concentration of which in these materials makes it cost-effective to recover. This paper presents a review of the extraction and recovery of valuable metals from electronic waste by hydrometallurgical methods, as well as patents and industrial processes related to the management and treatment of this waste.

ESBL-producing E. coli is a growing public problem in healthcare settings and the community. Between 2009 and 2018, a total of 187 ESBL-producing pathogenic E. coli isolates were confirmed, and clonal complex (CC) 10 was the predominant clone. This study aimed to characterize ESBL-producing pathogenic E. coli CC10 strains obtained from diarrheal patients to improve the understanding of CC10 distribution in the Republic of Korea. A total of 57 CC10 strains were selected for molecular characterizations, such as the identification of serotype, antibiotic resistance genes, genetic environments, plasmid profiles, and the genetic correlation between CC10 strains. In the CC10 isolates, the most prevalent serotype was O25:H16, followed by O6:H16. ESBL genes were identified as blaCTX-M, and the most dominant ESBL gene was blaCTX-M-15 (56%) and blaCTX-M-14 (30%). Most blaCTX-M genes were located on plasmids, and these plasmid profiles were confirmed as IncB/O/K/Z, IncF, IncI1 and IncX1. The mobile elements located up-and down-stream mainly included ISEcp1 (complete or incomplete) and IS903 or orf477 were found, respectively. Phylogenetic analysis showed that the CC10 strains were genetically diverse and divided into several distinct lineages. In this study, we found that CC10 ESBL-producing pathogenic E. coli has been steadily isolated; particularly, CTX-M-15-producing E. coli O25:H16 isolates were the major type related with distribution in CC10 clones during the last decade. Identification of ESBL-producing pathogenic E. coli CC10 isolates highlights the possibility of the emergence of resistant isolates with epidemic potential within this CC. Therefore, continuous monitoring will be conducted to prevent further spread of resistant ESBL-producing E. coli CC10 strains.

Atherogenic lipoproteins may impair vascular reactivity, leading to tissue damage in various organs, including the eye. This study aimed to investigate whether ophthalmic artery reactivity is affected in mice lacking the apolipoprotein E gene (ApoE-/-), a model for hypercholesterolemia and atherosclerosis. Twelve-month-old male ApoE-/- mice and age-matched wild-type controls were used to assess vascular reactivity using videomicroscopy. Moreover, vascular mechanics, lipid content, levels of reactive oxygen species (ROS), expression of pro-oxidant redox enzymes and of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) were determined in vascular tissue. Unlike the aorta, the ophthalmic artery of ApoE-/- mice developed no signs of endothelial dysfunction and no signs of excessive lipid deposition. Remarkably, levels of ROS, nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1), NOX2, NOX4, and of LOX-1 were increased in the aorta but not in the ophthalmic artery of ApoE-/- mice. Our findings suggest that ApoE-/- mice develop endothelial dysfunction in the aorta by increased oxidative stress via involvement of LOX-1, NOX1 and NOX2, whereas NOX4 may participate in media remodeling. In contrast, the ophthalmic artery appears to be resistant to chronic apolipoprotein E deficiency. Lack of LOX-1 expression/overexpression in response to increased ox-LDL levels may be a possible mechanism of action.

This study aimed to evaluate if the change of vehicle for CTZ (chloramphenicol, tetracycline, zinc oxide, and eugenol) paste improves the inhibition of Enterococcus faecalis in vitro. The vehicles evaluated alone and mixed with CTZ were eugenol, propylene glycol (PG), chitosan, su-per-oxidized solution (SOS), grapefruit-seed extract (GSE), and as a negative control, 0.9% saline solution. A clinical isolated of E. faecalis was morphological and biochemical characterized, in-cluding antimicrobial susceptibility was tested using 20 antimicrobial agents. Once character-ized, the clinical isolated was cultivated to performed Kirby–Bauer disc diffusion method with paper discs embedded with the different vehicles mixed or used alone, incubating at 37 ºC for 24 h. Data were analyzed by One-way ANOVA and the means were compared using Tukey test with a significance level of p<0.05. For vehicles used alone, GSE presented the greatest inhibition showing a statistically significant difference with the rest of the vehicles. When vehicles were mixed with the CTZ paste, PG showed a greater inhibition with a statistically significant differ-ence from the rest of the vehicles. In conclusion, the vehicle used to mix the CTZ paste plays an im-portant role in the inhibition of E. faecalis in vitro, therefore we consider that this can be an im-portant factor to achieve success in the use of this technique.

This research used an experimental study design in which 60 subjects were randomly assigned to either an experimental (image e-book guidance) group or a control (text guidance) group after meeting the admission conditions and agreeing to participate in the study. It was proven that providing image e-book guidance before surgery significantly changed the behavior of patients and promoted relief of urinary catheter discomfort through self-efficacy to reduce urinary catheter pain after surgery. It was found that providing image e-book guidance can shorten the time for health education and provide patients with repeated medical education and familiarity with health guidance, which can help to address the important clinical service demand issue and the shortage of nursing staff.

The development of mobile internet technology has enabled companies to use social media for E-commerce. Some companies use personified images and languages to communicate with consumers in this context. How does personified communication affect consumer behavior in social commerce? Are consumers willing to accept this new form of communication under social commerce? To answer these questions, this paper explores consumers' willingness to take per-sonified communication in the context of social commerce. It investigates the role of cognitive needs in regulating the internal mechanism and proposes some suggestions for enterprises to improve social media communication. Specifically, this paper presents an improved model based on the TAM model. In our model, perceived interaction is introduced as a new independent variable, and cognitive need is added as a regulatory variable, which is more suitable for social commerce. We conduct a questionnaire survey on the Internet and analyze data using AMOS and SPSS. The results show that perceived usefulness and perceived interaction positively im-pact attitude, which influences consumers' willingness to purchase. Furthermore, the cognitive need as the regulatory variable significantly affects the influencing path from perceived use-fulness to attitude and purchase intention.

We survey the diversity of antimicrobial resistance profiles of Escherichia coli (E. coli) isolates and molecular genotypes by means of phylogenetic groups circulating in complex aquatic habitats, such as sewage and receiving waters bodies as well as in clinical environment in Boeotia regional district of Greece. The predominant resistant profile among all environmental and clinical isolates was to penicillins - ampicillin (AMP) and piperacillin (PIP). ESBLs resistance related profiles were observed both in environmental and clinical isolates. Phylogenetic group B2 was the predominant in clinical isolates, whilst group A was dominant in environmental isolates. We report that reclaimed river water and wastewater are reservoirs of R and MDR E. coli to commonly used antibiotics in clinical practice posing putative threats for human and animal health.

Controlling water and food contamination by pathogenic organisms requires quick, simple, and low-cost methods. using affinity between mannose and type I fimbriae in the cell wall of Escherichia coli bacteria as evaluation elements compared to the conventional plate counting technique enables a reliable sensing platform for the detection of bacteria. In this study, a simple new sensor based on electrochemical impedance spectroscopy (EIS) for rapid and sensitive detection of Escherichia coli was developed. Biorecognition layer of the sensor was formed by covalent attachment of p-carboxyphenylamino mannose (PCAM) to gold nanoparticles (AuNPs) electrodeposited on the surface of glassy carbon electrode (GCE). The resultant structure of PCAM was characterized and confirmed using FTIR. The developed biosensor demonstrated a linear response with a logarithm of bacterial concentration (R2 = 0.998) in the range of 1.3 × 10 1~ 1.3 × 106 CFU.mL−1with the limit of detection of 2 CFU.mL−1 within 60 min. The sensor did not generate any significant signals with two non-target strains, demonstrating high selectivity of the developed biorecognition chemistry. Selectivity of the sensor and its applicability to analysis of the real samples was investigated in samples of tap water. Overall, the developed sensor has shown to be promising for the detection of E. coli pathogen in water due to its high sensitivity, short detection time, low cost, high specificity, and user-friendliness.

This article aims to provide a comprehensive understanding of vaping from various perspectives that contributes to the origin, development, achievement, and consequences of the greed of e-cigarette manufacturers. In our analysis, multiple elements of the social landscape, including economic, cultural, moral, psychological, and philosophical dimensions, contributed to the origin and development of the vaping greed and shaped people’s behaviors. Further discussion was made on how the specific characteristics of e-cigarette products and the marketing strategies of the companies, especially social media marketing, fostered the growth of such greed. Through interviews, we have also discussed the unfolding of this greed within the community of teenage vapers. The growth of the vaping greed was manifested in the large market share taken by the companies, but these all significantly harm people’s health and the communities. Nicotine and other chemicals in e-liquids promote each other’s negative effects in the mechanism leading to pulmonary symptoms and addiction, which are not limited to the physical level. We described that addiction could be transgenerational and can induce trauma both at an individual level and a community level. Overall, the greed of the vaping industry is a very complex system. The treatment of the greed shall be complicated as well: Besides the public health measures taken to treat the symptoms of the greed, we should educate individuals to be aware of their unfulfilled needs to regain authenticity and establish an infallible authority to enforce universal morality, which eradicates the complications of addiction and the root of the capitalists’ greed, respectively.

Economic globalisation has promoted the extensive circulation of commodities around the world, and international trade has increasingly been a strong booster for economic growth in China. As an foundation for national economy, the shift of agricultural products (AP) from production to distribution has become the focus of agricultural development, and in recent years, the international trade of agricultural products in China has been the highest in the world. While, cross-border e-commerce (CBE), as one of the important modes of agricultural products circulation, has brought new opportunities for China's fresh agricultural products to carry out online import and export trade under the favourable policies continuously introduced internationally. This research analyses status of APCBE in Yunnan Province, China, and propose strategies for developing CBE of Yunnan AP.

This study aimed to assess prescription transfer and medicines collection through Wasfaty, an electronic prescription service recently introduced in Saudi Arabia. A link to a cross-sectional online questionnaire was sent to all students and staff at the University of Jeddah, targeting beneficiaries who received e-prescriptions at the University Medical Centre (n = 2067). The questionnaire comprised 20 items under the following sections; demographics, patient perceptions and satisfaction with the Wasfaty service, and the availability of medicines. Of the 217 questionnaires received, the majority were filled by females (n = 125, 57.6%). Most were satisfied with the initial registration process of Wasfaty (n = 183, 84.1%). However, almost one-third of the participants reported that they could not find the prescribed medicines (n = 64, 29.7%), and most of them had to look for another pharmacy to obtain their treatment (n = 138, 63.9%). Respondents voiced their displeasure owing to the lack of access to certain pharmaceuticals, including anti-hypertensives and antidiabetics. This pilot study identified some challenges relating to the use of the Wasfaty service. Further attention to these challenges is required from the service providers, and a large-scale national study is warranted.

This article aims to investigate gaps in the law and policies on e-waste management in communi-ties of Thailand and suggests a guideline for improving, developing, and designing legal measures and state policies for more effective enforcement of the law on e-waste management in communities. The findings reveal that the currently applicable law of Thailand lacks effective approaches and rules for e-waste management. Also, there is not any implementation of key envi-ronmental principles for e-waste management in communities, such as the Polluter Pays Principle (PPP) that requires manufacturing companies to take part in being responsible for disposal ex-penses or the Public Participation principle that requires users, manufacturers, distributors, and government agencies to take parts in disposing e-waste. As a result, problems of e-waste in com-munities of Thailand have been continuously increasing. According to such problems, the authors suggest that legal measures on e-waste management in communities should be specifically de-signed by implementing key environmental principles as a basis in determining formats and guidelines of e-waste management, especially participation of all sectors that can help in solving and reducing e-waste in communities that is harmful to health, sanitation, and environment.

Digitalisation is one of the European Union's priorities. The European Parliament is shaping and helping to shape new legislation in this area. Digitisation should also help in the transition to a greener economy and in achieving climate neutrality. E-government is one area of digitisation that has been under way for several years in European countries. In this paper, we have focused on identifying different indices that are aimed at measuring digitalization or e-Government. The results of the analysis showed that there are several indices that focus on this area within the EU, such as EGDI, EPI, LOSI, DGI, e-Government benchmark, Eurostat - internet use, GII, DSGI, Going Digital toolkit and DESI. Subsequently, the index areas to be used in the DEA method to measure the effectiveness of e-Government related inputs and outputs within the EU were identified. As can be seen from the analysis, the DEA method has various uses. In order to be able to use the method properly it was necessary to select the most appropriate parameter and to verify their suitability by means of correlation analysis. Among the input and output indices were chosen Internet usage, DSGI, GII, e-Government benchmark, Interaction with public administration online. From the analysis 3 inputs and 3 outputs were used. After implementing the correlation, it can be said that the values between the selected sub-variables are suitable for DEA analysis. Two models were chosen for the calculation, namely CCR and BCC model. CCR model evaluated 10 states as efficient and BCC model evaluated 13 states as efficient. In addition, in the close analysis, we have taken a closer look at the CCR model's inference. Countries such as Denmark, Finland, Estonia, Malta, Portugal, etc. were efficient outliers. When comparing the regions within the EU, we can conclude that the countries of Northern Europe are the most efficient in the field of digitalization (e-Government). As many as 4 countries out of 7 are efficient. In a future study it would be useful to use the SBM model and try to measure the impact of digitalization on selected areas such as economy, society, environment, etc.

In recent years, online learning has become one of the most popular methods of educational delivery due to advances in technology, which has been made even more evident in the COVID-19 lockdown period. Online education has evolved into a distinct field of study within the educational system over the last few years. It is also important to note that parallel with the growth in this field, there has also been an increase in the number of scholarly journals that regularly publish research in this field, reflecting the importance of this field in the modern day. In spite of the fact that online learning offers a wide range of educational options, from short courses to full-time degrees, as well as being accessible, flexible, environmentally friendly, and affordable, there are also certain challenges associated with this educational approach. These challenges include the lack of social interaction, technical errors, a lack of hands-on training, and difficulties in assessing students. It is, therefore, imperative to ask the crucial question of whether online learning can replace traditional classroom learning or whether it can supplement it in hybrid models with it, as well as what factors and conditions are likely to determine this in the short- and long-term, as well as how it will be blended together in the future. The purpose of this commentary is to provide a brief summary of the current status of both learning models, as well as their pros and cons, in order to answer the question that was posed above.

Digital technologies play a key role in reviving the world economy. The EU has pledged to combine recovery support with resilient digital transformation. The COVID-19 pandemic highlighted the lack of digitization in Slovakia and the shortcomings of digital skills in citizens and communication with institutions. Digital skills are important and should form part of educational policy. ICT skills can help people succeed in the labour market and improve communication with public administration. Digitization and globalization increase the importance to communicate through the Internet, applications and other e-based gadgets. Digital skills are one of the essential parts of e-Government, so people can use e-Government services in communication with public administration. The current crisis citizens' use of online services. In-dices concerning the digital economy are analysed, such as the digital economy and society index DESI and e-government digital skills (EGDI) from 2018 to 2021 revealed a stagnant state in 2018 and 2019 and 2020, there was a decrease in basic digital skills". The next index is E-Government Digital Index It focuses on human capital and digital skills in these indices. The paper analyses and identifies the digital skills of citizens in the context of e-Government development and describes the use of e-Government services by EU citizens with a focus on the Slovak republic. The data were collected through a questionnaire survey with citizens in Slovak republic's digital skills according to selected categories, the use of e-Government services as well as awareness of e-Government services. Solutions that improve e-government in the Slovak Republic are gradually being implemented. Improving digital skills according to National Coalition for Digital Skills and professions in the Slovak republic and is one of the priorities of The Ministry of Education, Science, Research and Sport of the Slovak Republic which has adopted an action plan for 2019 – 2022 to improve the results in the DESI index by 2025 and focus on the digital skills required by employers. The survey revealed that in Slovakia, the majority of schools offer only weak support for digital education (about the EU-27 average of 68% and 45%, respectively). The research revealed also decreased level of digital literacy among young people. These competencies are very important to gain a position in the labour market in the digital society. The projects aim to support the development of digital skills of primary and secondary school students, and the integration of new technologies into teaching.

Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses and are known to have fatal health impacts. Specific mechanisms by which toxins present in smoke impair cell repair are still being researched and are of prime interest for developing more effective treatments. Current literature suggests toxins present in cigarette smoke and aerosolized e-vapor trigger abnormal intercellular responses, damage mitochondrial function, and consequently disrupt the homeostasis of the organelle’s biochemical processes by increasing reactive oxidative species. Increased oxidative stress sets off a cascade of molecular events, disrupting optimal mitochondrial morphology and homeostasis. Furthermore, smoking-induced oxidative stress may also amalgamate with other health factors to contribute to various pathophysiological processes. An increasing number of studies show that toxins may affect mitochondria even though exposure to secondhand or thirdhand smoke. This review assesses the impact of toxins present in tobacco smoke and e-vapor on mitochondrial health, networking, and critical structural processes including mitochondria fission, fusion, hyperfusion, fragmentation, and mitophagy. The efforts are focused on discussing current evidence linking toxins present in first, second, and thirdhand smoke to mitochondrial dysfunction

Modern electronic textiles are moving towards flexible wearable textiles, so-called e-textiles that have micro-electronic elements embedded onto the textile fabric that can be used for varied classes of functionalities. There are different methods of integrating rigid microelectronic components into/onto textiles for the development of smart textiles, which include, but are not limited to, physical, mechanical and chemical approaches. The integration systems must satisfy being flexible, lightweight, stretchable and washable to offer a superior usability, comfortability and non-intrusiveness. Furthermore, the resulting wearable garment needs to be breathable. In this review work, three levels of integration of the microelectronics into/onto the textile structures are discussed, the textile-adapted, the textile-integrated, and the textile-based integration. The textile-integrated and the textile- adapted e-textiles have failed to efficiently meet being flexible and washable. To overcome the above problems, researchers studied the integration of microelectronics into/onto textile at fiber or yarn level applying various mechanisms. Hence, a new method of integration, textile-based, has risen to the challenge due to the flexibility and washability advantages of the ultimate product. In general, the aim of this review is to provide a complete overview of the different interconnection methods of electronic components into/onto textile substrate.